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      • Morphine의 血漿 Corticosterone 增加作用에 미치는 副交感神經系藥物의 影響

        文永煥,全普權,申萬鍊 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

        Buckingham suggested that the effects of opioid substances on CRF secretion are probably due partially to direct actions on the hypothatamus and partially to alterations in the activity of cholinergic and noradrenergic neurons in the central nervous system. In this paper, the influences of cholinergic and anticholinergic drugs on the morphine-induced increase of plasma corticotserone level was studied in male mice. The results obtained were summarized as follows; 1. The dose-dependent increasing effect of morphine on plasma corticosterone was significantly inhibited by naloxone. 2. Pilocarpine (0.1-2.0㎎/㎏), physostigmine(10-200㎍/㎏), carbachol(10-200㎍/), and nicotine(0.1-2.0㎎/㎏) induced the dose-dependent increase of plasma corticosterone level. Particularly, the increasing effect of physostigmine and carbachol was marked. 3. The increasing effect of morphine on plasma corticosterone was markedly enhanced by pilocarpine, physostigmine or carbachol and was slightly enhanced by nicotine. The combined effect of morphine with pilocarpine or nicotine showed a tendency to be strengthened by atropine. But the combined effect of morphine and physostigmine was little changed by atropine and the combined effect of morphine and carbachol was inclined to be decreased by atropine. 4. Atropine(1.0㎎/㎏)and hexamethonium(10㎎/㎏)induced the marked increase of plasma corticosterone level. But by the combined treatment of them, the plasma corticosterone level showed the initial marked increase followed by the abrupt decrease downward to the control level. The increase induced by the combined treatment of atropine or hexamethonium with morphine was rather lower than that induced by a single treatment of atropine or hexamethonium. These results suggest that the increasing effect of morphine on plasma corticosterone level is mediated rather by its direct action on hypothalamus and its indirect action on central noncholiergic neurones than by its action on central cholinergic neuronal function.

      • 공과대학 컴퓨터 교육 향상 연구

        박영필,민병렬,문영현,김상식,조원철,홍준표,이홍림,김재희,오두환 연세대학교 산업기술연구소 1988 논문집 Vol.20 No.2

        In accordance with the rapid advance of computer technologies, industries as well as the academic world become to apply the computer to various fields in engineering. Therefore, more realistic and effective computer educations should be provided in engineering colleges. This study proposes some schemes to elevate currently offered computer- related educations in engineering colleges. For this study, 10 major domestic and foreign engineering colleges were surveyed in the aspects of computer- related courses and computer systems offered by the colleges.

      • KCI등재

        가토에서 딜티아젬과 시메티딘과의 약물상호작용

        이진환,최준식,문영민 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.3

        Diltiazem inhibits calcium channels and leads to vascular smooth muscle relaxation and negative inotropic and chronotropic effects in the heart. Diltiazem is almost completely absorbed after oral administration, but its extent of absolute oral bioavailability is reduced because of considerable first-pass hepatic metabolism. Diltiazem is able toe dilaterenal vasculature and can increase the glomerular filtration rate and renal sodium excretion. The purpose of this study was to report the pharmacokinetic changes of diltiazem after oral administration of diltiazem, 20㎎/㎏, in rabbits co-administered with cimetidine, 20㎎/㎏ and pretreated twice per day for 3 days at cimetidine dose of 20㎎/㎏. The area under the plasma concentration-time curve)AUC) of diltiazem was significantly higher in rabbits pretreated with cimetidine than that in control rabbits (p<0.01), showing about 149% increased relative bioavailability. The peak plasma concentration (C_max) and elimination half-life of diltiazem were increased significantly (p<0.05) in rabbits pretreated with cimetidine compared with those in control rabbits. This findings could be due to significant reduction of elimination rate constant by pretreated with cimetidine. The effects of cimetidine on the pharmacokinetics of oral diltiazem were more considerable in rabbits pretreated with cimetidine compared with those in control rabbits. The results suggest that the dosage of diltiazem should be adjusted when the drug would be co-administered chronically with cimetidine in a clinical situation.

      • 공구형상인자에 따른 공구응력 변화 특성

        이영문,손재환,김선일,정희철 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

        In this study, a series of FE-simulations, using the DEFORM software, on tool stersses of orthogonal cutting are carried out. As cutting input conditions, the tool shape factor such as tool relief angle and the cutting velocity are changed in the analyses. The results reveal that the patterns of stress distribution are same, that is signs of stress are divided at the points, wherever the chips leave the tool. And as the relief angle increases the more sterss concentration occurs at the tool tip.

      • 粉末法을 爲한 多重度 因子

        徐日煥,秋錦洪,李珍昊,林星秀,柳保盈,朴晶蘭,金憲俊,成百石,李正秀,金文執 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

        The multiplicity factor, which may be defined as the number of different planes in a form having identical interplanar spacing and identical intensity, is tabulated here for eleven Laue groups on the basis of their symmetries.

      • 자동차 변속기용 기어설계 프로그램 개발

        김영환,박태조,문영재 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

        A new interactive computer program for design and examination of the automobile transmission gear is developed. The design data of a shifted helical gear sets are calculated and the contact ratio and the strength condition are examined. The involute curve and a root fillet of the designed tooth profile are graphically presented, and the informations for tooth profile such as root point, weakest section point, etc. are obtained. The whole engaging gear shape and contact state are certificated in Autocad. To check the lubrication conditions, the minimum film thickness is calculated and compared with the surface roughness data. Therefore the computer program made in this paper gives more improved practical tool in designing a automobile gear set.

      • 스퍼터된 [NiFe/Ag] 적층박막의 적층율에 따른 자기저항 변화

        金永煥,朴允文,具燕秀 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2

        In this work, [NiFe/Ag]?? multilayers were deposited by magnetron sputtering method with NiFe and Ag targets. Before the deposition of multilayers, we investigated relationships between process parameters and deposition rate. Magnetoresistance(MR) is increased with increasing the annealing temperature, and it is expected to be affected by interfacial roughness on the basis of the analysis with XRD and AFM. High MR(3.7%) was found in [NiFe(30Å)/Ag(30Å)]?? Si(100) films in the case of increasing the interfacial area ratio of films. It was found that the maximum MR(4.2%) in [NiFe(35Å)/Ag(30Å)]?? Si(100) films when the thickness of NiFe layers was varied by 5Å respectively. Also, MR is increased as the stacking numbers of bilayer increased from 10 to 20.

      • 부산·경남지역 정부·공공기관의 홈페이지에 나타난 재활보조공학 서비스 사업 분석

        정혜영,김환희,장문영 대한재활공학회 2008 보조공학저널 Vol.2 No.1

        본 연구의 목적은 부산·경남지역을 대상으로 재활보조공학 서비스 제공에 대한 실태 조사를 통하여 서비스 현황을 파악하고 서비스 이용자들의 접근성을 높이는 것이다. 자료는 부산광역시와 부산시 보건소, 경상남도의 10개 시청과 10개 군청, 부산시에 위치한 장애인복지관, 경상남도에 위치한 장애인 복지관의 웹사이트 검색을 통해 수집하였다. 수집한 자료는 기관에 따른 재활보조공학 서비스 실태와 재활보조공학 기기의 영역에 따른 서비스 실태로 나누어 분석하였다. 기관에 따른 재활보조공학 서비스 현황을 살펴보면, 공공기관은 부산지역에 비해 경남지역에서 더 많은 재활보조공학 서비스가 제공되는 반면 장애인복지관의 경우 부산지역이 경남지역보다 더 많은 재활보조공학 서비스가 제공되고 있었다. 재활보조공학 기기의 영역별 현황을 살펴보면, 전체적으로 재활보조공학 기기의 다양성이 부촉하며 제공되는 재활보조공학 기기도 '운동성과 이동' 영역, '듣기와 듣기보조' 영역, '보기와 읽기보조' 영역에 집중되어 있음을 알 수 있었다. 재활보조공학 서비스를 필요로 하는 사람들이 서비스를 좀 더 빠르고 쉽게 제공받기 위해서는 지역별, 기관별 균형 있는 서비스 전달체계가 구축되어야 할 것이며 재활보조공학 기기의 다양성을 확보하는 제도적 장치가 마련되어야 할 것이다. This research was purposed to understand the present assistive technology service condition through investing the actual condition of the assistive technology service provided in Busan and Gyeongnam region, and promote the accessibility of the service users. The materials for this research were collected through the web sites of the public health centers in Busan, 10 city halls and 10 county offices in Gyeongnam region, and the rehabilitation centers for the disabled in Busan and Gyeongnam region. The actual condition of the assistive technology service and the diversity of the assistive technology devices according to each organization were analysed with these materials. The result of this research suggests that the public organizations in Gyeongnam region have provided more assistive technology service than ones in Busan, and the rehabilitation centers for the disabled in Busan have provided more assistive technology service than ones in Gyeongnam region, and that the diversity of assistive technology devices is insufficient, and the present devices of assistive technology are focused on mobility and transportation aids, hearing and listening aids, and vision and reading aids. Therefore, the diversity of assistive technoloey devices and the balance between institutions that provide assistive technology service should be devised.

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