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Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats
Wu, Chunyan,Hwang, Su Hyeon,Jia, Yaoyao,Choi, Joobong,Kim, Yeon-Ji,Choi, Dahee,Pathiraja, Duleepa,Choi, In-Geol,Koo, Seung-Hoi,Lee, Sung-Joon American Society for Clinical Investigation 2017 The Journal of clinical investigation Vol.127 No.11
A New Model-free Robust Adaptive Control of Cable-driven Robots
Yaoyao Wang,Lufang Liu,Mingxing Yuan,Qingxun Di,Bai Chen,Hongtao Wu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.9
For high performance control of cable-driven robots, a new model-free robust adaptive control is proposed using adaptive proportional-integral-derivative nonsingular fast terminal sliding mode (PID-NFTSM) in this paper. The designed control scheme has three elements, which are time-delay estimation (TDE) and a new PIDNFTSM manifold and a combined adaptive reaching law. The TDE element is applied to achieve the lumped system dynamics and hence founds a practical model-free structure. Meanwhile, a new PID-NFTSM manifold is designed to inherit the advantages of the NFTSM and high-order SM (HOSM) and integral SM (ISM) controls. Because of this design, the PID-NFTSM manifold can effectively ensure the non-singularity and high comprehensive control performance. Then, by combining the fast-TSM-type reaching law and a constant speed one with adaptive gain, we design a new combined adaptive reaching law for performance reinforcement. Benefiting from above three parts, our proposed control is model-free, highly precise and strongly robust. Stability is analyzed using Lyapunov theory. The effectiveness of our control is proved by comparative simulation studies. For high performance control of cable-driven robots, a new model-free robust adaptive control is proposed using adaptive proportional-integral-derivative nonsingular fast terminal sliding mode (PID-NFTSM) in this paper. The designed control scheme has three elements, which are time-delay estimation (TDE) and a new PIDNFTSM manifold and a combined adaptive reaching law. The TDE element is applied to achieve the lumped system dynamics and hence founds a practical model-free structure. Meanwhile, a new PID-NFTSM manifold is designed to inherit the advantages of the NFTSM and high-order SM (HOSM) and integral SM (ISM) controls. Because of this design, the PID-NFTSM manifold can effectively ensure the non-singularity and high comprehensive control performance. Then, by combining the fast-TSM-type reaching law and a constant speed one with adaptive gain, we design a new combined adaptive reaching law for performance reinforcement. Benefiting from above three parts, our proposed control is model-free, highly precise and strongly robust. Stability is analyzed using Lyapunov theory. The effectiveness of our control is proved by comparative simulation studies.
A Bacillus coagulans and its Application in Pine Pollen Fermentation
Shanyan Yang,Yaoyao Wu,Chubo Luo,Zhihong Di,Yunpeng Wu,Jie Zhang,Yaomei Xu 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6
In the study, a potential L-lactic acid-producing bacillus-strain LT1 was isolated. It was identified as Bacillus coagulans based on its morphological, physiological, biochemical properties, and phylogenetic similarity of 16S rDNA. The fermentation conditions of pine pollen by strain LT1 were optimized using Box-Behnken design and response surface methodology. Optimum values of the tested variables for production of viable counts were an inoculum size of 9.22%, temperature= 49.21℃, and an initial pH of 6.82. Under optimized conditions, the viable count was 5.49×109 CFU/mL. Finally, the single factor experiment as preliminary research for fermentation product treatment was performed.
Fuli Liu,Kejian Shi,Jiaojiao Dong,Zhousheng Jin,Yiquan Wu,Yaoyao Cai,Tingting Lin,Qianqian Cai,Le Liu,Yujian Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.7
Ganoderic Acid A (GA) has many pharmacologicaleffects such as anti-tumor, antibacterial, anti-inflammatory,and immunosuppressive effects. However, the protectiveeffect of GA on liver injury has not been reported. Thisstudy aimed to investigate the action of GA on insufficientmethionine and choline combined with high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats. NAFLD model was established by insufficient methionineand choline combined with high fat feeding to rats. The levelsof Acetyl-CoA carboxylase, fatty acid synthase, sterolregulatory element binding protein, liver X receptors, AMPactivatedprotein kinase, peroxisome proliferator-activatedreceptor α, PPARg coactivator 1α and NF-κB pathway inthe liver were detected by western blot. The results of thisstudy demonstrated that the expression of GA can not onlysignificantly decrease the live weight and liver weight perbody weight of HFD mice, but also restore the alanine aminotransferase,aspartate aminotransferase, total bilirubinlevels, triglyceride and cholesterol in serum. In addition,the expression of GA increased the levels of high-densitylipoprotein cholesterol in serum, ameliorated pathologicalchanges and decreased NAS score of mice’s liver. In conclusion,the treatment with GA could improve NAFLD in ratsby regulating the levels of signaling events involved in freefatty acid production, lipid oxidation and liver inflammation.
Xiao Song,Tong Mengyuan,Rao Yang,Li Yuhang,Ye Zhizong,Shen Yixiang,Hou Hao,Gao Guoqiang,Wu Guangning,Jin Yaoyao,Zhou Jie,Liu Jie 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.1
Along with the operating velocity and traction power increasing continuously, the issue related to the safety and reliability of the high-voltage traction power system for high-speed trains have gradually been exposed during the practical service process. When the train passes a neutral section settled roughly per 15 km between two neighboring substations, the on-board vacuum circuit breaker (VCB) must to be operated for changing the input powers with diff erent phases. At the moment of switching on or off the VCB, the arc between the contacts in the arc-extinguishing chamber may be triggered, which tends to result in the operational overvoltage. Due to numerous inductances and capacitances existing in the traction power supply system, the overvoltage may lead to high-frequency electromagnetic oscillation spreading along the transmission routes. The on-board high-voltage equipments within the power supply system may suff er from the impulse brought from the VCB operational overvoltage frequently, which is possible to cause the insulation aging or breakdown issue. To investigate the characteristic of the operational overvoltage of VCBs, a ‘train-rail-catenary’ power supply model is built based on the measured impedance parameters, which has been verifi ed by the experimental tests. The generating mechanism with the infl uence factors of the operational overvoltage when switching on or off the VCB has been explored, meanwhile the distribution of the train body overvoltage on each carriage has also been presented.