Positive Effects of Soy Isoflavone Food on Survival of Breast Cancer Patients in China

Zhang, Ya-Feng,Kang, Hong-Bin,Li, Bi-Li,Zhang, Rui-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

Aim: Soy foods are the major source of isoflavones, which are believed to play important roles in genesis of breast cancer and its progression. We here conducted a prospective study to evaluate the association of soy isoflavone food consumption with breast cancer prognosis. Methods: A prospective study was performed from January 2004 and January 2006 in China. Trained interviewers conducted face-to-face interviews using a structured questionnaire to collect information on dietary habits and potential confounding factors. The relative risk [hazard ratio (HR)] and 95% CI were calculated from the Cox regression model for all significant predictors from cancer diagnosis to the endpoint of the study (event). Results: After a median follow up of 52.1 months (range, 9-60 months), a total of 79 breast cancer related deaths were recorded in our study, risk being inversely associated with a high intake of soy isoflavone. With an average intake of soy isoflavone above 17.3 mg/day, the mortality of breast cancer can be reduced by about 38-36%. We also found the decreased breast cancer death with high soy protein intake, with a HR (95% CI) of 0.71 (0.52-0.98). Stratified analysis with reference to the ER status, further demonstrated a better prognosis of ER positive breast cancer with a high intake of soy isoflavone (HR 0.59, 0.40-0.93). Conclusion: Our study shows the soy food intake is associated with longer survival and low recurrence among breast cancer patients. A cohort study with a larger sample size and long term follow-up is now needed.

Quality improvement effects of electrolyzed water on rice noodles prepared with semidry-milled rice flours

Rui Liu,Zhang-Long Yu,Yuan-Lin Sun,Li-Tao Tong,Li-Ya Liu,Li-Li Wang,Xian-Rong Zhou,Su-Mei Zhou 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.6

To investigate the effects of electrolyzed watertreatment on the qualities of rice noodles prepared withsemidry- milled rice flour, pasting properties and thermalproperties of rice flour, and the cooking and texturalproperties of rice noodles were determined. Higher peakviscosity and lower melting enthalpy were observed inelectrolyzed water (EW) treated rice flour. The hardness,gumminess and chewiness of rice noodle in slightly acidicelectrolyzed water treated rice noodles with availablechlorine concentration (ACC) 20.32 mg/L were increasedsignificantly (p\0.05). The cooking loss decreased significantlyin strong acidic electrolyzed water treated noodleswith ACC 10.09 mg/L treatment (p\0.05). Theresults indicated that EW could promote the gelatinizationof rice flour, and improve the textural qualities of ricenoodles. Therefore EW was appropriate to be used in ricenoodle production.

아이트래킹(Eye Tracking)을 활용한 재무제표 응시 결과 분석

Rui Yi Zhang,나형종,Ya Lei Liu,Jun Song,Yue Yan Liu 세명대학교 인문사회과학연구소 2024 人文 社會科學硏究 Vol.32 No.1

· Research topics: This paper presents research results on people's understanding of financial statements and information delivery power of financial statements using eye tracking technology. · Research background: In the field of social science, research that introduces eye-tracking experiments is also being conducted, but in the field of accounting, eye-tracking research through eye-tracking is insufficient. In this paper, research is conducted by introducing eye-tracking techniques to determine whether the disclosure form of financial statements in accordance with the current international accounting standards adopted in Korea has high information transmission power. · Differences from prior research: This study is a fusion and convergence study that innovatively used eye tracking techniques to study topics in the field of accounting. Through this, meaningful information is provided to understand the understanding and information delivery power of the current major financial statements adopted in Korea. · Research method: This paper presented the results of empirical analysis by conducting an experiment to gaze at financial statements using eye tracking technology. In addition, this study conducted a survey on financial statement information delivery power to verify the information delivery power of financial statements in accordance with the current international accounting standards adopted in Korea. · Research Results: As a result of i-Tracking research, it was found that in the statement of absence, most eyes were on current assets, non-current assets, current liabilities, non-current liabilities, and capital. In the statement of comprehensive income, it was found that most eyes were on the order of sales, cost of sales, net income and other comprehensive income, operating profit, and total comprehensive income. And it was found that relatively few eyes were on gross profit, sales and management expenses, and non-operating expenses. In the table of capital fluctuations, it was found that many people applied in the order of capital, excess issuance of stocks, and total capital. And it was found that relatively few people stared at retained earnings and other capital items. Lastly, in the cash flow table, it was found that people's eyes were on the order of operating cash flow, net increase and decrease of cash and cashable assets, investment cash flow, and financial activity cash flow. · Contributions and expected effects: First, the research methodology used in this study is a unique research methodology that is rarely used in the field of accounting, and is expected to provide good guidelines for research in the field of accounting by introducing various methods. Second, the research results of this paper provide meaningful information to understand the comprehension and information delivery power of the current major financial statements adopted in Korea, and further improvements are made to the form of financial statement disclosure to improve the usefulness of financial statement information. · 연구 주제: 본 논문은 아이트래킹 기술을 활용하여 사람들의 재무제표의 이해도 및 재무제표의 정보전달력에 관한 연구결과를 제시한다. · 연구 배경: 사회과학 분야에서도 아이트래킹 실험을 도입한 연구가 진행되고 있지만, 회계학 분야에서는 아이트래킹을 통한 시선 추적 연구가 미흡한 실정이다. 본 논문에서는 현행 한국 채택 국제회계기준에 의한 재무제표의 공시형태가 과연 높은 정보 전달력이 있는지를 규명하기 위해 아이트래킹 기법을 도입하여 연구를 수행한다. · 선행연구와의 차이점: 본 연구는 회계학 분야의 주제를 연구하는데 있어서 혁신적으로 아이트래킹 기법을 사용하여 실험을 수행한 융·복합 연구이다. 이를 통하여 한국 채택 현행 주요 재무제표의 이해가능성 및 정보전달력을 파악하는데 의미 있는 정보를 제공한다. · 연구방법: 본 논문은 아이트래킹 기술을 활용하여 재무제표를 응시하는 실험을 수행하여 실증분석 결과를 제시하였다. 또한 본 연구에서는 현행 한국 채택 국제회계기준에 의한 재무제표의 정보전달력을 검증하기 위하여 재무제표 정보전달력에 관한 설문조사를 수행하였다. · 연구결과: 아이트래킹 연구결과, 제무상태표에서는 유동자산, 비유동자산, 유동부채, 비유동부채, 자본 순으로 시선이 많이 가는 것으로 파악되었다. 포괄손익계산서에서는 매출액, 매출원가, 당기순이익·기타포괄손익, 영업이익, 총포괄손익 순으로 시선이 많이 가는 것으로 나타났다. 그리고 상대적으로 매출총이익, 판매비와 관리비, 영업외비용에는 시선이 적게 가는 것으로 나타났다. 자본변동표에서는 자본금, 주식발행초과금, 자본합계 순으로 사람들이 많이 응시하는 것으로 파악되었다. 그리고 상대적으로 이익잉여금과 기타자본항목은 사람들이 적게 응시하는 것으로 파악되었다. 마지막으로 현금흐름표에서는 영업활동 현금흐름, 현금및현금성자산의 순증감, 투자활동 현금흐름, 재무활동 현금흐름 순으로 사람들의 시선이 많이 가는 것으로 나타났다. · 공헌점 및 기대효과: 첫째, 본 연구에서 사용한 연구방법론은 회계학 분야에서 거의 사용되지 않는 독특한 연구방법론으로써 회계학 분야의 연구가 다양한 방법을 도입하여 발전하는데 있어서 좋은 가이드라인을 제시할 수 있을 것으로 기대된다. 둘째. 본 논문의 연구결과는 한국 채택 현행 주요 재무제표의 이해가능성 및 정보전달력을 파악하는데 의미 있는 정보를 제공하고, 더 나아가 재무제표 정보의 유용성을 향상시키기 위한 재무제표 공시형태에 대해서 개선점을 제시한다.

Tri-stimuli responsive carbon nanotubes covered by mesoporous silica graft copolymer multifunctional materials for intracellular drug delivery

Rui-Qian Zhang,Zhan-Qing Liu,Yan-Ling Luo,Feng Xu,Ya-Shao Chen 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-

To overcome premature drug leakage and instability in drug delivery systems, we designed tri-stimuliresponsive multiwalled carbon nanotubes covered by mesoporous silica graft poly(N-isopropylacryla-mide-block-poly(2-(4-formylbenzoyloxy) ethyl methacrylate) multifunctional materials via disulfidelinkages (MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA). The multifunctional materials could covalentlybind and physically load anticancer drug doxorubicin (DOX), and exhibited pH-, temperature- andreductant-induced multi-stimuli responsiveness, significantly enhancing drug loading capacity andimproving the release dynamics of drug. The DOX-loaded multifunctional materials exhibited theoptimal release behavior in cancer environments compared with in normal cells upon simultaneouslytriggered by these stimuli. It meant that the MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA could serve asefficient gatekeepers to control the mesopore on–off and thus to modulate drug release. Themultifunctional materials were proved to be low toxic, whereas the DOX-loaded counterparts had almostthe same toxicity as free DOX to cancer cells. Therefore, the developed multifunctional materials can beused as promising drug controlled delivery platforms for cancer therapy.

Identification of Genes Differentially Expressed in Wild Type and Purkinje Cell Degeneration Mice

박찬규,Rui Xiao,Youngsook Park,Vijaya R. Dirisala,Ya-Ping Zhang,엄상준,이훈택 한국분자세포생물학회 2005 Molecules and cells Vol.20 No.2

Purkinje cell degeneration (pcd) mice are characterized by death of virtually all cerebellar Purkinje cells by postnatal day 30. In this study, we used DNA microarray analysis to investigate differences in gene expression between the brains of wild type and pcd mice on postnatal day 20, before the appearance of clear-cut phenotypic abnormalities. We identified 300 differentially expressed genes, most of which were involved in metabolic and physiological processes. Among the differentially expressed genes were several calcium binding proteins including calbindin-28k, paravalbumin, matrix gamma-carboxyglutamate protein and synaptotagamins 1 and 13, suggesting the involvement of abnormal Ca2+ signaling in the pcd phenotype.

Research on Network Modeling Technique of Unified Spatial Dimension

Li, Ya-Ping,Yao, Jian-Guo,Zhang, Rui-Peng,Wang, Jun-Yu The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.4

For the modeling of spatial dimension in current chinese dispatch center is always incomplete, and the maintenance of model is always repeated again and again, a distributed modeling method based on IEC 61970 is proposed in this paper. It splits and merges the model by utilizing boundary comparison table and has no requirement for uniform naming, so it will not interrupt the online EMS system. The proposed method has designed an automatic flow control module, and users can take part in the process of modeling because fault-tolerant mechanism and safe returnable mechanism have been taken into account. Release-subscribe style is adopted by this method, so it can provide incorporate model management and release service to the control center. With this technology, the distributed modeling system can provide basic data and technical support to the online monitoring and security analysis function, and the problem of spatial dimension uniform modeling can be solved effectively.

Enhancing Astaxanthin Accumulation in Haematococcus pluvialis by Coupled Light Intensity and Nitrogen Starvation in Column Photobioreactors

( Wen-wen Zhang ),( Xue-fei Zhou ),( Ya-lei Zhang ),( Peng-fei Cheng ),( Rui Ma ),( Wen-long Cheng ),( Hua-qiang Chu ) 한국미생물 · 생명공학회 2018 Journal of microbiology and biotechnology Vol.28 No.12

Natural astaxanthin mainly derives from a microalgae producer, Haematococcus pluvialis. The induction of nitrogen starvation and high light intensity is particularly significant for boosting astaxanthin production. However, the different responses to light intensity and nitrogen starvation needed to be analyzed for biomass growth and astaxanthin accumulation. The results showed that the highest level of astaxanthin production was achieved in nitrogen starvation, and was 1.64 times higher than the control group at 11 days. With regard to the optimization of light intensity utilization, it was at 200 μmo/m2/s under nitrogen starvation that the highest astaxanthin productivity per light intensity was achieved. In addition, both high light intensity and a nitrogen source had significant effects on multiple indicators. For example, high light intensity had a greater significant effect than a nitrogen source on biomass dry weight, astaxanthin yield and astaxanthin productivity; in contrast, nitrogen starvation was more beneficial for enhancing astaxanthin content per dry weight biomass. The data indicate that high light intensity synergizes with nitrogen starvation to stimulate the biosynthesis of astaxanthin.

Comparison of Microbial Diversity and Composition in the Jejunum and Colon of Alcohol-Dependent Rats

( Yang Fan ),( Zhao Ya-e ),( Wei Ji-dong ),( Lu Yu-fan ),( Zhang Ying ),( Sun Ya-lun ),( Ma Meng-yu ),( Zhang Rui-ling ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.11

Alcohol dependence is a global public health problem, yet the mechanisms of alcohol dependence are incompletely understood. The traditional view has been that ethanol alters various neurotransmitters and their receptors in the brain and causes the addiction. However, an increasing amount of experimental evidence suggests that gut microbiota also influence brain functions via gut-to-brain interactions, and may therefore induce the development of alcohol use disorders. In this study, a rat model of alcohol dependence and withdrawal was employed, the gut microbiota composition was analyzed by high-throughput 16S rRNA gene sequencing, and the metagenome function was predicted by PICRUSt software. The results suggested that chronic alcohol consumption did not significantly alter the diversity and richness of gut microbiota in the jejunum and colon, but rather markedly changed the microbiota composition structure in the colon. The phyla Bacteroidetes and eight genera including Bacteroidales S24-7, Ruminococcaceae, Parabacteroides, Butyricimonas, et al were drastically increased, however the genus Lactobacillus and gauvreauii in the colon were significantly decreased in the alcohol dependence group compared with the withdrawal and control groups. The microbial functional prediction analysis revealed that the proportions of amino acid metabolism, polyketide sugar unit biosynthesis and peroxisome were significantly increased in the AD group. This study demonstrated that chronic alcohol consumption has a dramatic effect on the microbiota composition structure in the colon but few effects on the jejunum. Inducement of colonic microbiota dysbiosis due to alcohol abuse seems to be a factor of alcohol dependence, which suggests that modulating colonic microbiota composition might be a potentially new target for treating alcohol addiction.

Evaluation of suitable qRT-PCR normalization genes for various citrus rootstocks

He Wen,Xie Rui,Li Huan,Wang Yan,Chen Qing,Lin Yuanxiu,Zhang Yunting,Luo Ya,Zhang Yong,Tang Haoru,Wang Xiaorong 한국식물생명공학회 2022 Plant biotechnology reports Vol.16 No.1

Citrus rootstock can modify plant growth and enhance stress resistance. There are many genotypes and species used as citrus rootstocks. Although multiple citrus rootstocks whole genome sequence and transcriptome databases have previously been published, no suitable internal reference genes have been investigated for standardization of gene expression via quantitative real-time PCR. Here we reported the first systematic and comprehensive analysis of reference genes for quantitative real- time PCR standardization in various citrus rootstocks. The expression stability of ten candidate reference genes in diverse sample subsets of flooding, drought, alkaline and cold treatments was evaluated using four statistical algorithms, geNorm, NormFinder, BestKeeper and ΔCt method. The results demonstrated that the expression stability of reference genes varied under different experimental conditions. In addition, normalization of gene expression of 9-cis-epoxycarotenoid dioxygenase 3 (NCED 3), involved in abscisic acid biosynthesis, was conducted to further confirm the reliability of the reference genes. Overall, EF-1α, DIM 1, GAPC and UBC expressed much more stably. ACTIN and GAPDH were not recommended for normalization in given experimental conditions due to low stability. Our main contribution was to identify reference genes with suitable and stable expression in citrus rootstocks varied across selected experimental conditions. Furthermore, these results will provide valuable information for future research on citrus rootstocks.

Remarkable impact of steam temperature on ginsenosides transformation from fresh ginseng to red ginseng

Xu, Xin-Fang,Gao, Yan,Xu, Shu-Ya,Liu, Huan,Xue, Xue,Zhang, Ying,Zhang, Hui,Liu, Meng-Nan,Xiong, Hui,Lin, Rui-Chao,Li, Xiang-Ri The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3

Background: Temperature is an essential condition in red ginseng processing. The pharmacological activities of red ginseng under different steam temperatures are significantly different. Methods: In this study, an ultrahigh-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry was developed to distinguish the red ginseng products that were steamed at high and low temperatures. Multivariate statistical analyses such as principal component analysis and supervised orthogonal partial least squared discrimination analysis were used to determine the influential components of the different samples. Results: The results showed that different steamed red ginseng samples can be identified, and the characteristic components were 20-gluco-ginsenoside Rf, ginsenoside Re, ginsenoside Rg1, and malonyl-ginsenoside Rb1 in red ginseng steamed at low temperature. Meanwhile, the characteristic components in red ginseng steamed at high temperature were 20R-ginsenoside Rs3 and ginsenoside Rs4. Polar ginsenosides were abundant in red ginseng steamed at low temperature, whereas higher levels of less polar ginsenosides were detected in red ginseng steamed at high temperature. Conclusion: This study makes the first time that differences between red ginseng steamed under different temperatures and their ginsenosides transformation have been observed systematically at the chemistry level. The results suggested that the identified chemical markers can be used to illustrate the transformation of ginsenosides in red ginseng processing.