지능박약 환자에서 Carbamazepine에 의해 발생한 골연화증 1예

김성훈,김동선,안유헌,최낙원,이창범,박용수,최웅환,김태화,김희수,백상현 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.2

Anticonvusant therapy with any of several agents, especially phenytoin, phenobarbital, and primidone causes disturbances in bone mineral metabolism. Anticonvulsants stimulate the hepatic microsomal mixed-oxidase enzymes and hence increase the rate of clearance of vitamin D and its metabolism. The severity of clinical manifestations in any given individual appears to be a function of the combined effects of variety of factors including drug type and total drug dose, dietary vitamin D intake, sunlight exposure, and physical activity level. We report a case of osteomalacia associated with long term carbamazepine therapy in a 21-year-old male with less exposure to sunlight(J Kor Soc Endocrinol 15:286?290, 2000).

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅱ) : 망간 신경독성을 이용한 파킨슨증 모델의 세포사 Studies on the Mechanism of Parkinsonism induced by Manganese

김종민,박창원,오정자,이보경,서경원,서수경,김규봉,김종원,김광진,김영옥,전범석,박찬웅,이선희 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

1960년대 이후 파킨슨병의 유발물질 중 한 후보로서 망간이 주목받으면서 많은 역학적, 병러학적 연구가 수행죄브다. 그러나 망간이 파킨슨병을 직접 일으키는지, 혹은 파킨슨병과 관련된 부위의 신경세포를 파괴시쿡 파킨슨증만을 초래하는 것인지가 아직 정립되지 않은 실정이다 본 연구에서는 실험동물모델에서 행등학적 변화 측정 및 병리학적, 샐화학적 연구를 통하여 망간의 과다노출글 따른 파킨슨병 유발 여부를 확인하고자 하였다. Sprague-Datylet· 렛드에 망간을 1, 2, 5, 10 mgAg/day의 응량으로 30일 등안 복강 투여하였을 때 모든 망간투여군에서 운동성 감소가 관찰되었다. 뇌조직의 망간 함량을 ion chromatograph?로 측정한 결과 중뇌 흑질과 기저핵 선조체에서 망간 함량의 뚜렷한 증가 소견이 관찰되었으며, 니슬염색체서 선조체의 신경세포수의 유의성 있는 감소가 관찰되었다. 그러나, 흑질의 TH효소 면역염색, GFAP 면역염색, 흑질과 선조체의 T릿효소 western blot 결과는 대조군과 차이가 없었다. 이상의 결과에서, 망간-파킨슨증 모델에서 파킨슨증어 유발되는 기전은 흑질 도파민성 신경 세포의 신호를 받는 선조체 씬경세포의 사멸에 의한 것으로 생각된다. 결론적으로, 망간 독성에 의한 파킨스증 모델에서는 파킨슨 병과는 달리 흑질 도파민성 신경세포의 세포사는 관여하지 않는 것으로 관찰되었다. Manganese(Mn) intoxication causes a parkinsonian syndrome. It may be difficult to distinguish Mn-induced parkinsonism from idiopathic Parkinson disease(IPD). Neuropathological descriptions on the brains with Mn intoxication showed the perferential damage in the globus pallidus and substantia nigra pars reticularis. Pathological reports on the substantia nigra pars compacta(SNpc), a mafor focus of pathologic changes in IPD, are discordant and controversial. The SNpc involvement is of critical importance for the elucidation of pathogenesis of IPD. Therefore, the neurodegeneration in SNpc was investigated in the experimental model of Mn neurotoxicity. Sprague-Dawley rats were administered with manganese chloride(1, 2, 5, 10 mg/kg/day, i.p.) for 30 days. Treated animals showed low levels of distance-traveled from locomotor activity tests. Ion chromatography revealed that Mn accumulation was significant in SN and basal ganglia in Mn-treated animals. Nissl staining showed neuronal loss of the striatum in all treated animals. The degree of neurodegeneration in SN was determined by immunohistochemical staining of tyrosine hydroxylase(TH). The numbers of TH-positive cells on nigral sections were not different from each groups(P>0.05). The densities of glial fibrillary acidic protein immunoreactivity from SN were similar between groups. TH-westen blotting showed no differences between treated animals and controls. In conclusion, the SNpc remains intact in Mn intoxication, and Mn-induced parkinsonism may be caused by damages of output pathways downstream to the nigrostriatal dopminergic system.

Bulk-micromachined, SOI-based half-bridge silicon strain gauges for high pressure applications

Kim, Jin Woong,Kim, Ki Beom,Kim, Joon Hyub,Min, Nam Ki IOP 2018 Journal of micromechanics and microengineering Vol.28 No.12

<P>This paper presents a new half-bridge silicon strain gauge fabricated on a silicon-on-insulator (SOI) substrate by MEMS bulk-micromachining technology. These gauges have holes etched through the wafer by deep reactive ion etching (DRIE) and a closed shape with four sides, unlike the current competitive devices with open structures. This unique design minimizes the shifting or rotation of gauge position and enhances the bonding strength during glass-frit bonding, leading to an improved sensor performance and yield, and hence, a reduction in sensor cost. The prototype half-bridge gauges were tested under strains ranging from  −170 to 170 <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0960-1317/28/12/125004/jmmaae592ieqn001.gif'/> and were shown to have a linear output with a typical gauge factor of about 112 and an average hysteresis of 0.0192% FS. In addition, the full bridge output for 0–50 bar pressure shows a typical sensitivity of about 0.345 mV/V/bar, a maximum thermal zero shift of  −7.33% FS, and a thermal sensitivity shift of  −0.17% FS/°C.</P>

Systematic Lymphadenectomy for Survival in Epithelial Ovarian Cancer : A Meta-Analysis

Kim, Hee Seung,Ju, Woong,Jee, Byung Chul,Kim, Yong Beom,Park, Noh Hyun,Song, Yong Sang,Kim, Seung Cheol,Kang, Soon-Beom,Kim, Jae Weon BMJ 2010 International journal of gynecological cancer Vol.20 No.4

<P>BACKGROUND: The role of systematic lymphadenectomy (SL) remains unclear for improving overall survival (OS) in epithelial ovarian cancer (EOC). To evaluate the role of SL in EOC, we performed a meta-analysis for comparing the efficacy for OS between SL and unsystematic lymphadenectomy (USL). METHODS: After the extensive literature search between January 1995 and December 2008, we analyzed 9 studies (2 randomized controlled trials [RCTs] and 7 observational studies) with 21,919 patients with EOC who underwent staging laparotomy including SL or USL. RESULTS: Although SL was a favorable factor for OS compared with USL (hazard ratio [HR], 0.72; 95% confidence interval [CI], 0.68-0.76), the efficacy of SL on increased OS could not be determined in all-stage and early-stage EOC owing to the lack of RCTs and the deviation of weight by large-scale observational studies, whereas SL improved OS in advanced-stage EOC (HR, 0.70; 95% CI, 0.67-0.75). Moreover, SL increased OS in patients with all-stage disease who underwent optimal debulking surgery (HR, 0.84; 95% CI, 0.69-0.99), whereas it could not improve OS statistically in early-stage and advanced-stage diseases. However, SL showed increased OS with marginal significance in advanced-stage EOC patients treated with optimal debulking surgery (HR, 0.82; 95% CI, 0.66-1.02). CONCLUSIONS: These findings suggest the possibility that SL can improve OS in advanced-stage EOC. However, the efficacy of SL on OS is still unknown because of the lack of RCTs, which requires more relevant studies for investigating the role of SL in EOC.</P>

류마티스 관절염에서 갑상선 자가항체 및 갑상선 기능에 관한 연구

김태영,이용욱,김동선,김성윤,이창범,김신규,박용수,최웅환,김태화,전재범,배상철,유대현 대한내과학회 2000 대한내과학회지 Vol.58 No.3

Background : Autoimmune thyroid diseases have been shown to occur in association with connective tissue disorders. This study was undertaken to elucidate the prevalence of thyroid autoantibodies and thyroid dysfunction in Korean patients with rheumatoid arthritis (RA). Methods : We have compared the prevalence of thyroid autoantibodies in 108 RA patients with 81 age-matched controls. Antimicrosomal antibody (AMA) and antithyroglobulin antibody (ATA) were measured by passive hemagglutinin assay. T3, T4, Free T4, and TSH were measured by chemiluminescence method. Rheumatoid factor was measured by nephelometry. Statistical analysis was performed by chi-square, Fisher's exact test, and Pearson correlation test . Results : 1) The presence of AMA/ATA in patients with RA was significantly higher (28.7%/26.7% in 108 patients) than that of controls (11.1%/9.9% in 81 controls). The positive rates of AMA/ATA in female patients were also higher (28.9%/28.9% in 97 patients) than those of female controls (15.5%/12.1% in 58 controls). 2) Thirty three (17.6%) of 187 patients with RA had the abnormalities of thyroid function; 14 (7.5%) revealed subclinical hypothyroidism, 5 (2.7%) revealed biochemical primary hypothyroidism, 7 (3.7%) revealed sick euthyroid syndrome, and 7 (3.7%) revealed hyperthyroidism. Conclusion : These results suggest that autoimmune thyroiditis is highly associated with RA in Korean patients, showing the increased prevalence of thyroid autoantibodies and thyroid dysfunctions. (Korean J Med 58:317-323, 2000)

Study of the prevalence of Parkinson's disease using dopamine transporter imaging.

Kim, Jong-Min,Kim, Ji Seon,Kim, Ki Woong,Lee, Seok Bum,Park, Joon Hyuk,Lee, Jung Jae,Kim, Yu Kyeong,Kim, Sang Eun,Jeon, Beom S Butterworths [etc.] 2010 Neurological research Vol.32 No.8

<P>To investigate the prevalence of Parkinson's disease (PD), a three-phase study was conducted.</P>

Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats

Kim, Young-Beom,Kim, Woong Bin,Jung, Won Woo,Jin, Xiangyan,Kim, Yoon Sik,Kim, Byoungjae,Han, Hee Chul,Block, Gene D.,Colwell, Christopher S.,Kim, Yang In American Diabetes Association 2018 Diabetes Vol.67 No.3

<P>Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotocin (STZ)-induced DM rats and vehicle-treated control rats revealed that g-aminobutyric acid (GABA) functions generally as an excitatory neurotransmitter in the AVP neurons of STZ rats, whereas it usually evokes inhibitory responses in the cells of control animals. Furthermore, Western blotting analyses of Cl- transporters in the SON tissues indicated that Na+-K+-2Cl(-) cotransporter isotype 1 (a Cl- importer) was upregulated and K+-Cl- cotransporter isotype 2 (KCC2; a Cl- extruder) was down-regulated in STZ rats. Treatment with CLP290 (a KCC2 activator) significantly lowered blood AVP and glucose levels in STZ rats. Last, investigation that used rats expressing an AVP-enhanced green fluorescent protein fusion gene showed that AVP synthesis in AVP neurons was much more intense in STZ rats than in control rats. We conclude that altered Cl- homeostasis that makes GABA excitatory and enhanced AVP synthesis are important changes in AVP neurons that would increase AVP secretion in DM. Our data suggest that Cl- transporters in AVP neurons are potential targets of antidiabetes treatments.</P>

Phosphatidylcholine and bipolar radiofrequency for treatment of localized fat deposits

Kim, In Su,Hyun, Moo Yeol,Park, Kui Young,Kim, Chan Woong,Kim, Beom Joon,Kim, Myeung Nam Informa Healthcare USA on behalf of Informa UK Ltd 2014 The Journal of dermatological treatment Vol.25 No.4

<P>Bipolar radiofrequency (RF) is capable of delivering higher energy fluencies direct to the dermis through a needle electrode. This produces heat when the tissue electrical resistance converts the electric current to thermal energy in the tissue. A 38-year-old man visited our clinic for reduction of submental fat deposit, but otherwise in overall good health. After deciding to perform phosphatidylcholine (PPC) injections subcutaneously, we concerned about edema and swelling of injection site lasted several weeks. We wanted to shorten the period of edema and swelling, and we decided to add bipolar RF treatment. After 1 week of PPC injection combined with RF treatment, overall volume of jowl was decreased and edema and swelling on the PPC injected site markedly subsided. This reduction of fat deposit lasts longer than 1 year. Follow-up for 1 year demonstrated that the cosmetic results were well maintained.</P>

What are ‘true normal’ liver stiffness values using FibroScan^®?: a prospective study in healthy living liver and kidney donors in South Korea

Kim, Seung Up,Choi, Gi Hong,Han, Woong Kyu,Kim, Beom Kyung,Park, Jun Yong,Kim, Do Young,Choi, Jin Sub,Yang, Seung Choul,Choi, Eun Hee,Ahn, Sang Hoon,Han, Kwang-Hyub,Chon, Chae Yoon Blackwell Publishing Ltd 2010 Liver International Vol.30 No.2

<P>Abstract</P><P>Aims</P><P>To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea.</P><P>Methods</P><P>Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome.</P><P>Results</P><P>LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of <5% of the hepatocytes. The mean age of our study population was 38.9 ± 11.9 years (35 men and 34 women), with a mean LS value of 4.6 ± 0.5 kPa (range 3.3–5.6 kPa). LS values were not significantly different between men (4.6 ± 0.6 kPa) and women (4.5 ± 0.5 kPa, <I>P</I>=0.636), nor were they significantly different according to age (<I>P</I>=0.851). Using the fifth and 95th percentiles, we determined the normal range of LS values to be 3.9–5.3 kPa.</P><P>Conclusions</P><P>We identified the normal range of LS values and found that LS values were not significantly influenced by age and gender.</P>

Wine drinking and epithelial ovarian cancer risk: a meta-analysis.

Kim, Hee Seung,Kim, Jae Weon,Shouten, Leo J,Larsson, Susanna C,Chung, Hyun Hoon,Kim, Yong Beom,Ju, Woong,Park, Noh Hyun,Song, Yong Sang,Kim, Seung Cheol,Kang, Soon-Beom Korean society of gynecologic oncology and colposc 2010 Journal of Gynecologic Oncology Vol.21 No.2

<P>Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies.</P>