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Yoon, Dukyong,Ahn, Eun Kyoung,Park, Man Young,Cho, Soo Yeon,Ryan, Patrick,Schuemie, Martijn J.,Shin, Dahye,Park, Hojun,Park, Rae Woong Korean Society of Medical Informatics 2016 Healthcare Informatics Research Vol.22 No.1
<P><B>Objectives</B></P><P>A distributed research network (DRN) has the advantages of improved statistical power, and it can reveal more significant relationships by increasing sample size. However, differences in data structure constitute a major barrier to integrating data among DRN partners. We describe our experience converting Electronic Health Records (EHR) to the Observational Health Data Sciences and Informatics (OHDSI) Common Data Model (CDM).</P><P><B>Methods</B></P><P>We transformed the EHR of a hospital into Observational Medical Outcomes Partnership (OMOP) CDM ver. 4.0 used in OHDSI. All EHR codes were mapped and converted into the standard vocabulary of the CDM. All data required by the CDM were extracted, transformed, and loaded (ETL) into the CDM structure. To validate and improve the quality of the transformed dataset, the open-source data characterization program ACHILLES was run on the converted data.</P><P><B>Results</B></P><P>Patient, drug, condition, procedure, and visit data from 2.07 million patients who visited the subject hospital from July 1994 to November 2014 were transformed into the CDM. The transformed dataset was named the AUSOM. ACHILLES revealed 36 errors and 13 warnings in the AUSOM. We reviewed and corrected 28 errors. The summarized results of the AUSOM processed with ACHILLES are available at http://ami.ajou.ac.kr:8080/.</P><P><B>Conclusions</B></P><P>We successfully converted our EHRs to a CDM and were able to participate as a data partner in an international DRN. Converting local records in this manner will provide various opportunities for researchers and data holders.</P>
Hwang, Yoon J.,An, Jae Sang,McCord, Marian G.,Park, Shin Woong,Kang, Bok Choon The Korean Fiber Society 2003 Fibers and polymers Vol.4 No.4
Polypropylene nonwoven fabrics were exposed to He/$O_2$ atmospheric pressure glow discharge plasma. Surface chemical analysis and contact angle measurement revealed the surface oxidation by formation of new functional groups after plasma treatment. Weight loss (%) measurement and scanning electron microscopy analysis showed a significant plasma etching effect. It was investigated in low-stress mechanical properties of the fabrics using Kawabata Evaluation System (KES-FB). The surface morphology change by plasma treatment increased surface friction due to an enhancement of fiber-to-fiber friction, resulting in change of other low-stress mechanical properties of fabric.
Predicting As Contamination Risk in Red River Delta using Machine Learning Algorithms
Zheina J. Ottong,Reta L. Puspasari,Daeung Yoon,Kyoung-Woong Kim 대한자원환경지질학회 2022 자원환경지질 Vol.55 No.2
Excessive presence of As level in groundwater is a major health problem worldwide. In the Red River Delta in Vietnam, several million residents possess a high risk of chronic As poisoning. The As releases into groundwater caused by natural process through microbially-driven reductive dissolution of Fe (III) oxides. It has been extracted by Red River residents using private tube wells for drinking and daily purposes because of their unawareness of the contamination. This long-term consumption of As-contaminated groundwater could lead to various health problems. Therefore, a predictive model would be useful to expose contamination risks of the wells in the Red River Delta Vietnam area. This study used four machine learning algorithms to predict the As probability of study sites in Red River Delta, Vietnam. The GBM was the best performing model with the accuracy, precision, sensitivity, and specificity of 98.7%, 100%, 95.2%, and 100%, respectively. In addition, it resulted the highest AUC of 92% and 96% for the PRC and ROC curves, with Eh and Fe as the most important variables. The partial dependence plot of As concentration on the model parameters showed that the probability of high level of As is related to the low number of wells’ depth, Eh, and SO₄, along with high PO₄³⁻ and NH₄⁺. This condition triggers the reductive dissolution of iron phases, thus releasing As into groundwater.
Sang-Woong Yoon,Laskar, J. IEEE 2009 IEEE transactions on components and packaging tech Vol.32 No.4
<P>This paper presents a folded inductor implemented with a multichip module, which involves a laminate organic packaging technology with an unfilled via process. The folded inductor had an increased inductor layer surface area because of the unfilled vias along the inductor layer. Thus, the quality (<I>Q</I>) factor of the inductor improved as the series resistance, resulting from the skin effect, decreased. The <I>Q</I>-factor for a folded inductor showed a maximum improvement of 32% by including contact resistances, in comparison with the <I>Q</I> -factors of a normal planar inductor.</P>
Kim, Dae-Yoon,Nah, Changwoon,Kang, Shin-Woong,Lee, Seung Hee,Lee, Kyung Min,White, Timothy J.,Jeong, Kwang-Un American Chemical Society 2016 ACS NANO Vol.10 No.10
<P>The preparation of materials exhibiting structural colors has been intensively studied in biomimetic science and technology. Utilizing a newly synthesized cholesteric liquid-crystal (CLC) monomer (abbreviated as BP1CRM), we have prepared CLC films. Photoinitiated copolymerization of this monomer with a common achiral liquid-crystalline monomer produced free-standing films with homogeneous and nanoscale pitch distributions. Employing the thermal sensitivity of the CLC monomer, chirophotonic crystal reflectors were prepared exhibiting a range of colors. The free-standing and circular-polarizing chirophotonic crystal films maintain excellent thermal, mechanical, and chemical stabilities, and the composition can readily be applied as polarized optical films and smart paints.</P>
Kim, Yu J.,Kim, Ju‐,Young,Yoon, Jin Y.,Kyung, Sun Y.,Lee, Sang P.,Jeong, Sung H.,Moon, Chanil,Park, Jeong‐,Woong Blackwell Publishing Ltd 2011 Basic & clinical pharmacology & toxicology Vol.109 No.1
<P><B>Abstract: </B> Cigarette smoking is the principal cause of chronic obstructive pulmonary disease (COPD), especially emphysema, which is characterized by alveolar wall destruction and airspace enlargement. Apoptosis of lung structural cells is involved in the pathogenesis of COPD. Xanthine derivatives (aminophylline or theophylline) have been used for the treatment of COPD as a bronchodilator. But the effects of xanthine derivatives on apoptosis of the lung structural cells remain poorly understood, even though it is known that theophylline protects against ultraviolet irradiation–induced cell death in corneal epithelial cells. This study was designed to determine whether aminophylline would protect against cigarette smoke extract (CSE)–induced apoptosis in lung fibroblasts. We demonstrated that aminophylline protected against apoptosis of MRC‐5 cells at a relatively lower therapeutic range (10 μg/ml), resulting in a significant increase in cell viability occurring at 20% concentration after 8‐hr exposure. Annexin staining decreased from 68 ± 4% of the control to 12 ± 2% of aminophylline (10 μg/ml) pre‐treatment after 20% CSE exposure for 12 hr (<I>p </I><<I> </I>0.05). Aminophylline decreased caspase 3 and 8 activities and nuclear condensation or fragmentation in MRC‐5 cells after exposure to 20% CSE for 12 hr compared with control and high levels of aminophylline (>50 μg/ml) pre‐treatment. These findings suggest that aminophylline protected apoptosis of MRC‐5 cells through the inactivation of caspases 3 and 8 and could be an effective agent to reduce cigarette smoking–induced lung structural cell apoptosis.</P>
Identification of Proteins Binding to Decursinol by Chemical Proteomics
( Hyo Jin Kang ),( Tae Sung Yoon ),( Dae Gwin Jeong ),( Young Mo Kim ),( Jin Woong Chung ),( Jong Seong Ha ),( Sung Sup Park ),( Seong Eon Ryu ),( Sang Hee Kim ),( Kwang Hee Bae ),( Sang J. Chung ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.8
Low-temperature adsorption of hydrogen on ion-exchanged Y zeolites
Jhung, S.H.,Sun Lee, J.,Woong Yoon, J.,Pyo Kim, D.,Chang, J.S. Pergamon Press 2007 International journal of hydrogen energy Vol.32 No.17
Ion-exchanged Y zeolites with several alkali metal cations and proton have been used to analyze the effect of electrostatic field or basicity on the hydrogen adsorption at low temperature and low pressure. The adsorption capacity per surface area, isosteric heat of adsorption (-ΔH<SUB>ads</SUB>), surface coverage and micropore occupancy increase with the decreasing electronegativity of the metals that are introduced in the zeolite. Ion-exchanged zeolites also favorably adsorb hydrogen at relatively low pressures when the electronegativity of the metal is low. This work demonstrates that zeolites with strong electrostatic fields or high basicity are beneficial for high hydrogen uptake especially at low pressure and low temperature.
Molecular sensing and discrimination by a luminescent terbium–phosphine oxide coordination material
Ibarra, Ilich A.,Hesterberg, Travis W.,Chang, Jong-San,Yoon, Ji Woong,Holliday, Bradley J.,Humphrey, Simon M. The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.64
<P>PCM-15 is a robust and recyclable sensor for the effective discrimination of a wide range of small molecules. Sensing is achieved by direct attenuation of the luminescence intensity of Tb(<SMALL>III</SMALL>) ions within the material. A competition study involving trace amounts of NH<SUB>3</SUB> in H<SUB>2</SUB> gas shows that PCM-15 can be used to quantitatively detect trace analytes.</P> <P>Graphic Abstract</P><P>PCM-15 is a robust and recyclable sensor for the effective discrimination of a wide range of small molecules. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc44575e'> </P>