Towards an Integrated e-CRM Framework in Internet Shopping Mall

Weihong Zhao(조위굉),Changsu Kim(김창수),Jongmoo Park(박종무) 한국전자상거래학회 2006 전자상거래학회지 Vol.7 No.1

  웹에 기반하여 새로운 고객확보 보다는 우량고객의 이탈방지와 고객과의 커뮤니티 형성, 그리고 신규 고객획득을 위한 고객관계관리 능력의 개선을 통하여 신규 서비스 제공 및 이익 극대화를 가능케 하는 고객관계관리 (e-CRM)가 전자상거래에 있어 핵심적인 요소로 인식되고 있다. 고객관계관리는 고객과 관련된 기업의 내ㆍ외부 자료를 분석 통합하여 고객 특성에 맞는 고객경영 활동을 전개하는 것으로서 전자상거래 분야에서 가장 주목받고 있는 영역이기 때문이다. 본 연구는 인터넷 쇼핑몰을 이용하는 고객들과 장기적인 관계를 유지하는데 영향을 미치는 심리적인 요인들을 고려한 고객관계관리에 대한 통합적 틀(framework)을 제시하였다. 즉, 인터넷쇼핑몰을 이용하는 고객들에게 주요한 영향을 미치는 인지된 서비스 질, 인지된 제품 질, 그리고 인지된 가격 적정성과 같은 세가지 주요 요인과 가치, 만족, 신뢰 사이의 인과적인 연관관계를 이해할 수 있는 고객관계관리의 통합적 틀을 개발하였다. 본 연구에서 제안한 통합적 고객관계관리 틀은 현재 전자상거래에서 그 중요성이 날로 증대되고 있는 고객관계관리를 성공적으로 개발하고 구현하는데 있어 유용한 지침을 제공할 것이다.   Customer relationship management (e-CRM) is one of the fastest growing management approaches in electronic commerce. Based on customer cognitive, affective and conative experiences in Internet Shopping Mall, this study, from the customer perspective, develops an integrated framework for e-CRM to explain the psychological process that causes the customer to maintain long-term exchange relationships with specific Internet online retailers. The integrated framework proposes a series of causal linkages among the key variables of perceived value (as cognitive belief), satisfaction (as affective experience) and trust (as cognitive relationship intention), affecting customer commitment to specific Internet online retailers. As well, three key exogenous variables, that is perceived service quality, perceived product quality, and perceived price fairness are integrated into the integrated framework. The integrated framework highlights some managerial implications for successfully developing and implementing an e-CRM strategy.

Adsorption of zinc (Ⅱ), cadmium (Ⅱ), and copper (Ⅱ) with PTFE Selective Resin containing primary amine N1923 and Cyanex925

Xiaowei Zhao,Weihong Zhou,Qiong Jia 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.6

In the present study, a synergistic extraction mixture, primary amine N1923 (RNH2) and Cyanex925 (B), was loaded on PTFE powder to prepare PTFE Selective Resin and was employed for the adsorption of zinc, cadmium, and copper from chloride medium. The effects of shaking time, resin amounts, concentration of metal ions, and experimental temperature on the distribution coefficients were determined. The stoichiometry of the adsorbed complexes was determined to be MCl2·(1/2)RNH2·B with the Selective Resin. The equilibrium constants and thermodynamic quantities (ΔH, ΔG, and ΔS) were calculated. Furthermore, the Freundlich isotherm proved to be more suitable than the Langmuir isotherm to indicate the effect of concentration of M2+ on the adsorption with PTFE Selective Resin.

Extraction of rare earths using mixtures of sec-octylphenoxy acetic acid and organophosphorus acids

Qiong Jia,Naizhong Song,Xiaowei Zhao,Weihong Zhou,Wuping Liao 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.4

The extraction of rare earths from nitrate medium using three organophosphorus acids, 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (HEHEHP), di-(2-ethylhexyl) phosphoric acid (D2EHPA), bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex272), and their mixtures with sec-octylphenoxy acetic acid (CA12) has been studied in detail. The mixtures have different extraction effects on various rare earths. Synergistic extraction effects are only found when light rare earths and yttrium (III) are extracted with mixtures of D2EHPA and CA12. The possibilities of separating the rare earths with these mixtures are investigated according to the extractabilities. It is feasible and advantageous to separate yttrium (III) from the lanthanoids (III) with HEHEHP + CA12 and D2EHPA+CA12 mixtures at proper extractant ratios. The separation of yttrium (III) from heavy rare earths is also possible with mixtures of Cyanex272 and CA12.

Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT

Shiyao Fu,Mingao Wang,Bin Li,Xu Li,Jianjun Cheng,Haitian Zhao,Hua Zhang,Aijun Dong,Weihong Lu,Xin Yang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu2+ that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a significant improvement in tumor accumulation. Methods A reprecipitation method was used to prepare the co-assembled nanocarrier, followed by the introduction of Cu2 + into the DDS (OABACe6 NPs). Then, by wrapping the surface of NPs with the cell membranes of 4T1 which is a kind of mouse breast cancer cells (CM@OABACe6/Cu NPs). and analysis of its structure and size distribution with UV– Vis, XPS, FT-IR, SEM, TEM, and DLS. The synergistic effects of in vitro chemotherapy, CDT and PDT and targeting were also validated by cellular and animal studies. Results It was shown that CM@OABACe6/Cu NPs achieved good tumor targeting and a significant improvement in tumor accumulation. In the composite nano-assembly, the NSMs work together with the Ce6 to provide effective and safe chemo and PDT. Moreover, the effect of reduced PDT due to the depletion of reactive oxygen species (ROS) by excess glutathione (GSH) in the tumor can be counteracted when Cu2 + is introduced. More importantly, it also confers CDT through a Fenton-like catalytic reaction with H2O overexpressed at the tumor site. Conclusions By constructing CM@OABACe6/Cu NPs with homologous targeting, we create a triple synergistic platform for cancer therapy using PDT, chemo, and CDT. We propose here a novel combinatorial strategy for designing more naturally co-assembled small molecules, especially for the development of multifunctional synergistic therapies that utilize NSMs.

Inheritance of Downy Mildew Resistance at Different Developmental Stages in Chinese Cabbage via the Leaf Disk Test

Shengju Zhang,Shuancang Yu,Fenglan Zhang,Longting Si,Yangjun Yu,Xiuyun Zhao,Deshuang Zhang,Weihong Wang 한국원예학회 2012 Horticulture, Environment, and Biotechnology Vol.53 No.5

Downy mildew, caused by Hyaloperonospora parasitica, is a destructive disease of the Chinese cabbage (Brassica rapa ssp. pekinensis). A rapid resistance/susceptibility test for H. parasitica was established by the inoculation of a leaf disk test. Four conditions were tested and the optimal condition was found when the inoculated leaf disk was placed into dark conditions at 16℃ for the first 24 hours after inoculation, followed by 5 days of light at 20℃and 23℃ for 4 hours and 5 hours, respectively, dark at 16℃ and 12℃ for 3 hours and 12 hours, respectively, and a final temperature of 16℃ for 24 hours. There was a good correlation between the resistance levels of leaf disks and the resistance of seedlings or adult plants, which indicated that testing leaf disks should be the preferred methods to predict the resistance of adult plants. Using this method, downy mildew resistance was investigated in a double haploid (DH) population at four developmental stages. The results showed that the genetic pattern, which was deduced from the DH segregation, was relatively similar, but varied slightly during plant development.

Identifification and development of a core set of informative genic SNP markers for assaying genetic diversity in Chinese cabbage

Peirong Li,Tongbing Su,Shuancang Yu,Huiping Wang,Weihong Wan,Yangjun Yu,Deshuang Zhang,Xiuyun Zhao,Changlong Wen,Fenglan Zhang 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.3

Rapid, economical, and reliable genotyping is an important requirement for germplasm analysis and cultivar identifi cationin crop species. Chinese cabbage ( Brassica rapa L. subsp. pekinensis (Lour.) Hanelt) originated in China and is now aneconomically important vegetable crop worldwide, especially in East Asia. In this study, we evaluated 1167 single nucleotidepolymorphisms (SNPs) among 166 representative Chinese cabbage inbred lines using a KASP genotyping assay. Onthe basis of polymorphisms and principal component analysis, we selected 60 core SNPs distributed on all Brassica rapachromosomes with allele frequencies suffi ciently balanced so as to provide adequate information for genetic identifi cation. The core set of SNPs was used for construction of a neighbor-joining dendrogram, in which the 166 inbred lines wereclustered into spring, summer, and autumn ecotype groups. Clustering of the ecotype groups was better resolved than thatachieved with 1167 and 360 polymorphic SNP datasets. Stability and resolution of the core SNP markers were tested using178 commercial hybrid Chinese cabbage cultivars to confi rm their utility in genetic identifi cation. The set of 60 informativeand stable SNP markers showed high discriminatory power and relatively uniform genomic distribution (4–9 markers perchromosome). The SNPs represent a cost-effi cient and accurate marker set for germplasm analysis and cultivar identifi cationand are suitable for molecular marker-assisted breeding in Chinese cabbage.

Genetic variations in DROSHA and DICER and survival of advanced non-small cell lung cancer: a two-stage study in Chinese population

Shuangshuang Wu,Yun Pan,Songyu Cao,Jiali Xu,Yan Liang,Yan Wang,Lei Chen,Yunyan Wei,Chongqi Sun,Weihong Zhao,Zhibin Hu,Hongxia Ma,Hongbing Shen,Jianqing Wu 한국유전학회 2015 Genes & Genomics Vol.37 No.7

MicroRNAs (miRNA) are a class of small, noncoding RNA molecules involved in carcinogenesis. Genetic variations in miRNA processing genes may affect the biogenesis of miRNAs, and consequently affect miRNAs regulation and development and progression of human cancer. Therefore, we hypothesized that polymorphisms in two main miRNA biosynthesis genes (DROSHA and DICER) may modulate the survival of advanced non-small cell lung cancer (NSCLC) patients in China. We selected 36 common tagging SNPs in DROSHA and DICER and evaluated the associations of these SNPs with survival of advanced NSCLC patients by a two-stage study in Chinese Han population (discovery cohort: 303 patients; replication cohort: 340 patients). Thirty-six SNPs were detected in the discovery cohort and 12 promising SNPs were validated in the replication cohort. The results showed that DROSHA rs3805525 was marginally associated with the survival of NSCLC patients in the replication cohort (dominant model: HR 0.69, 95 % CI 0.46–1.03, P = 0.071), which was in the same direction as that in the discovery cohort. When combing all patients into one group, three SNPs (rs3805525, rs17410035 and rs7719497) in DROSHA showed significantly associations with NSCLC survival (additive model: HR 0.82, 95 % CI 0.68–0.99 for rs3805525; HR 0.79, 95 % CI 0.62–1.00 for rs17410035; HR 0.76, 95 % CI 0.62–0.93 for rs7719497). Additionally, the combined analysis of those three SNPs showed a significant locus-dosage effect between number of favorable alleles and death risk of NSCLC (Trend P = 0.002). Genetic variations in DROSHA might be associated with the survival of advanced NSCLC patients in Chinese population.