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Tran Hong Quang,Seok Bean Song,Bui Thi Thuy Luyen,Nguyen Phuong Thao,BUIHUU TAI,Nguyen Xuan Nhiem,Phan Van Kiem,Chau Van Minh,Nguyen Thi Thanh Ngan,김영호 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 6.2 to 9.1 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with EC50 values ranging from 4.1-12.7 μM. Compounds 4 and 5 exhibited PPARα, PPARγ, and PPARβ(δ) transactivational activities in a dose-dependent manner, with EC50 values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 μM, respectively.
Minh Mang Thang, the Mysterious Vietnamese Prescription Containing Korean Ginseng
Thi Hong Van Le,Van Dan Nguyen,Manh Hung Tran 고려인삼학회 2024 인삼문화 Vol.6 No.1
Emperor Minh Mang (明命), the second ruler of the Nguyen Dynasty in Vietnam, reigned from 1820 to 1841. He is widely regarded by contemporary historians as the most distinguished monarch of his dynasty, despite some controversial policies. One aspect of his extraordinary legacy is the remarkable 142 offspring he sired - 78 princes and 64 princesses - earning him the unprecedented distinction of having the most progeny among kings in world history. Vietnamese people suppose Minh Mang's prolific reproductive success to the consumption of a specially prescribed medicine known as Minh Mang Thang (明命湯, MMT). This medicine, often associated with sexual potency and fertility, is characterized by intriguing names such as "One night Five sexes ," "One night Six sexes born Five babies ," or "Six sexes Three pregnancies ." Vietnamese folklore vividly recounts Minh Mang's exceptional sexual prowess, attributing it to the use of MMT. MMT formulations, which include various herbs, notably Korean ginseng, may incorporate additional botanical ingredients depending on their intended purpose. This paper aims to explore the origins, history, ingredients, and applications of MMT, unraveling the mystery behind this mystical prescription that has inspired several oriental medicinal researchers. Through this investigation, we seek to shed light on the cultural and historical contexts surrounding Minh Mang's use of MMT and its enduring impact on traditional Vietnamese medicine and folklore. Vietnam boasts a legendary herbal medicine recipe associated with Emperor Minh Mang, bearing the intriguing names "One night Five sexes ",1) "One night Six sexes born Five babies ",2) and "Six sexes Three pregnancies ".3) This unique medicinal concoction, simply known as Minh Mang Thang (MMT),4) has been the subject of numerous handed-down prescriptions. This paper aims to delve into the history, origin, prescription, and uses of MMT.
Quang, Tran Hong,Ngan, Nguyen Thi Thanh,Minh, Chau Van,Kiem, Phan Van,Nhiem, Nguyen Xuan,Tai, Bui Huu,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Song, Seok-Bean,Kim, Young-Ho Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited $TNF{\alpha}$-induced NF-${\kappa}B$ transcriptional activity in HepG2 cells in a dose-dependent manner, with $IC_{50}$ values ranging from 6.2 to 9.1 ${\mu}M$. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with $EC_{50}$ values ranging from 4.1-$12.7{\mu}M$. Compounds 4 and 5 exhibited $PPAR{\alpha}$, $PPAR{\gamma}$, and $PPAR{\beta}({\delta})$ transactivational activities in a dose-dependent manner, with $EC_{50}$ values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 ${\mu}M$, respectively.
Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
Phan Van Kiem,Tran Thu Huong,Eun Mi Choi,김영호,Tran Hong Quang,Le Thi Hong Nhung,Nguyen Xuan Cuong,Chau Van Minh 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside(2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-β-glucopyranoside (5), (-)-lyoniresinol (6), and α-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by pectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 (30 μM) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
Chemical constituents of the Annona glabra fruit and their cytotoxic activity.
Hien, Nguyen Thi Thu,Nhiem, Nguyen Xuan,Yen, Duong Thi Hai,Hang, Dan Thi Thuy,Tai, Bui Huu,Quang, Tran Hong,Tuan Anh, Hoang Le,Kiem, Phan Van,Minh, Chau Van,Kim, Eun-Ji,Kim, Seung Hyun,Kang, Hee Kyoun Swets Zeitlinger 2015 PHARMACEUTICAL BIOLOGY Vol.53 No.11
<P>Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range of biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine as an anticancer drug. Phytochemical investigation of this plant led to the isolation of acetogenins, ent-kauranes, peptides, and alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, and antimalaria.</P>
Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
Kiem, Phan Van,Quang, Tran Hong,Huong, Tran Thu,Nhung, Le Thi Hong,Cuong, Nguyen Xuan,Minh, Chau Van,Choi, Eun-Mi,Kim, Young-Ho 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-$\beta$-glucopyranoside (5), (-)-lyoniresinol (6), and $\alpha$-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 ($30\;{\mu}M$) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
Truong Duong Thuy Thi,Tran Trang Huyen Thi,Nguyen Tam Thanh Thi,Tran Van Hong Thi 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.5
BACKGROUND/OBJECTIVES Although children of ethnic minority groups are experiencing a transition from a predominance of undernutrition to overnutrition, there is little evidence of a dual-malnutrition burden. Therefore, this study examined the double burden of malnutrition among school-aged ethnic minority children living in mountainous areas and its association with their diets. SUBJECTS/METHODS A cross-sectional study was conducted from September 2019 to March 2020 in 3 mountainous areas of Northern Vietnam among 1,556 ethnic minority school-aged children. The prevalence of under-nutrition (stunting and thinness) and over-nutrition (overweight and obesity) were measured using the WHO 2006 child growth standards (height-for-age and BMI-for-age Z-score). Nutritional practices were evaluated by the frequency of food consumption based on a 4-level scale. RESULTS The percentage of children with stunting and thinness were 14.0% and 5.4%, respectively, while the figure for overweight/obesity was 9.4%. The factors positively associated with stunting were living in a family with more than 2 children or being Muong/other ethnicities compared to the Tay ethnicity. Children who consumed fish/shrimps/crabs or milk weekly/daily were less likely to be undernourished compared to those who never consumed these foods. By contrast, children who never consumed foods rich in vitamin A precursors and vitamin A and fruit or consumed daily snacks/junk food were more likely to be overweight/obese. CONCLUSIONS Undernutrition remains a common issue among school-aged children and adolescents of ethnic minority groups, while over-nutrition exists simultaneously. Public health nutrition programs promoting adequate diets and positive lifestyle changes related to nutrition are essential to tackle the double burden of malnutrition among ethnic minority children.