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Tran Hoang Hai,Le Hong Phuc,Doan Thi Kim Dung,Nguyen Thi Le Huyen,Bui Duc Long,Le Khanh Vinh,Nguyen Thi Thanh Kieu,Massanori Abe 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.2
Magnetic resonance imaging (MRI) has become a major and promising topic in medical researching because of its numerous potential applications. Due to the specic uptake by macrophage and not entirely captured by liver and spleen at first-pass, Superparamagnetic nanoparticles (SPIONs) are widely investigated as diagnostic tracer for magnetic resonance imaging (MRI). Surfactantcoated Fe3O4 particles (6 nm diameter) have been synthesized by using a wet chemical method (co-precipitation). Our study concentrated on synthesizing magnetic nanoparticles Fe3O4 coating oleic acid and Dextran and Starch polysaccharides.
Hoang Vinh Tran,Hai Van Nguyen,Doanh Viet Vu,Thu Dieu Le,Binh Thanh Nguyen,Dang Hai Le 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.2
We report here a simple approach for synthesis of carbon coated magnetite (C@MFe2O4, M=Co, Ni, Fe) with shell@core nanostructured composites that we used as magnetic-nanosorbents for direct yellow (DYG) and moderacid red (RS) as pollutant textile dyes removal via an adsorption process. The synthesized C@MFe2O4 was characterized by TEM, SEM, EDX, XRD, FT-IR and VSM techniques. TEM results indicated that C@MFe2O4 nanocomposites have 20-30 nm of MFe2O4 nanoparticle core and 2-3 nm in thickness of the amorphous carbon shell. The synthesized C@MFe2O4 nanocomposites have the zero point charge (pHZPC) at 5.5, which suggests that DYG and RS, anionic dyes can be adsorbed onto the C@MFe2O4 nanosorbents in the acidic medium. Adsorption of DYG and RS onto magnetic nanosorbents was optimized and adsorption thermodynamic parameters were evaluated, clearly indicating that the adsorption of RS onto synthesized magnetic-nanosorbents was facile more than that DYG. The adsorption isotherm data showed that the adsorption processes of DYG and RS onto Fe3O4 or C@MFe2O4 nanosorbents are more suitable for the Langmuir model than Freundlich model. The maximum adsorption capacity (qmax) of DYG dye onto Fe3O4, C@Fe3O4 and C@CoFe2O4 adsorbents was 14.641, 36.232 and 7.85mg g1, respectively; meanwhile, these values were 41.152, 61.728 and 39.683mg g1 for RS dye. These obtained data indicate that the developed Fe3O4, C@Fe3O4 and C@CoFe2O4 nanoparticles can be used as recoverable and recyclable adsorbents for not only organic pigments adsorption but also for heavy metal ion removal or protein extraction as well.
Hoang, Van Thanh,Luu, Duc Binh,Toan Do, Le Hung,Tran, Ngoc Hai,Nguyen, Pham The Nhan,Tran, Minh Sang,Tran, Minh Thong Materials Research Society of Korea 2020 한국재료학회지 Vol.30 No.12
A combination of Polycarbonate (PC) material and Polymethylmethacrylate (PMMA), fabricated using an injection molding machine, has been investigated to determine its advantages, as studied in Ref. 1). This paper aims to investigate the optimization of PMMA/PC blend for both tensile yield strength and impact strength. Furthermore, interaction effects of process conditions on mechanical properties including tensile yield strength and impact strength of PMMA/PC blend by injection molding process are interpreted in this study. Tensile and impact specimens are designed following ASTM, type V, and are fabricated by injection molding process. The processing conditions such as melt temperature, mold temperature, packing pressure, and cooling time are applied; each factor has three levels. As a result, in comparison with optimization of separated responses, mechanical properties of PMMA/PC are found to decrease when optimizing both tensile and impact strengths simultaneously. The melt temperature is found to be the most significant interaction parameter with the mold temperature and packing pressure. In addition, there is more interaction between the mold temperature and cooling time. This investigation provides a useful understanding of the control of injection molding processing of polymer blends in optical application.
Vo Minh Hoang Do,Long Giang Bach,Diem-Huong Nguyen Tran,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen,Thai Thanh Hoang Thi 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2
Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of unsatisfied drug release, high tendency of interfering with cellular membranes, and rapid clearance by reticuloendothelial system. In this study, low generation polyamidoamine (PAMAM) dendrimer G3.0 is developed and surface modified with methoxypolyethylene glycol (PAMAM G3.0-mPEG) to overcome its limitations. Specifically, PAMAM G3.0 conjugated with mPEG at different ratios are investigated to effectively eliminate its charge-associated toxicity, in which PAMAM G3.0-mPEG- 8 is chosen for oxaliplatin (OX) loading. Results reveal that OX-loaded PAMAM G3.0-mPEG-8 has desirable size, good entrapment efficiency, and sustained release with minimum drug leakage. In addition, Resazurin assay indicates that the toxicity of loaded OX is reduced as compared to free drug but still maintain substantially anticancer activity on HeLa cells, suggesting the potential application of PAMAM G3.0-mPEG-8 for OX delivery in cancer therapy.
Biomedical and Environmental Applications of Chitosan-based Nanomaterials
( Jae Kweon Park ),( Lam Dai Tran ),( Hoang Vinh Tran ),( Trang Thu Mai ),( Thu Phuong Ha ),( Binh Hai Nguyen ),( Hoang Thai ),( Hoang Dinh Vu ),( Dien Gia Pham ),( Phuc Xuan Nguyen ) 한국키틴키토산학회 2011 한국키틴키토산학회지 Vol.16 No.1
Being naturally abundant resources and having many interesting physicochemical and biological properties, chitin/chitosan have been found useful in many fields. This paper describes the strategy to design a multifunctional, chitosan based nanomaterials and their biomedical and environmental applications. Different physicochemical methods including FESEM/TEM, PPMS were used to characterize the obtained nanomaterials. For each application, a series of specific characterizing methods were used for evaluating the applicability/capacity of materials.
Tran, Khanh Long,Phung, Xuan Son,Kim, Bao Giang,Phan, Thi Hai,Doan, Thi Thu Huyen,Luong, Ngoc Khue,Pham, Thi Quynh Nga,Nguyen, Tuan Lam,Hoang, Van Minh,Le, Thi Thanh Huong Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Evidence shows that tobacco advertising and promotion activities may increase tobacco consumption and usage, especially in youth. Despite the regulation on prohibiting advertisement of any tobacco product, tobacco advertisement and promotion activities are still common in Vietnam. This article presents current exposure to tobacco advertising and promotion (TAP) among school children aged 13 to 15 years in Vietnam in 2014 and potential influencing factors. Data from the Global Youth Tobacco Survey 2014 in Vietnam covering 3,430 school aged children were used. Both descriptive and analytical statistics were carried out with Stata 13 statistical software. Binary logistic regression was applied to explain the exposure to TAP among youth and examine relationships with individual factors. A significance level of p<0.05 and sampling weights were used in all of the computations. In the past 30 days, 48.6% of the students experienced exposure to at least 1 type of tobacco advertising or promotion. Wearing or otherwise using products related to tobacco was the most exposure TAP type reported by students (22.3%). The internet (22.1), points of sales (19.2) and social events (11.5) were three places that students aged 13-15 frequently were exposed to TAP. Binary logistic results showed that gender (female vs male) (OR = 0.61, 95%CI: 0.52 - 0.71), susceptibility to smoking (OR = 2.12, 95%CI: 1.53 - 2.92), closest friends' smoked (OR = 1.43, 95%CI: 1.2 - 1.7) and parents smoking status (OR = 2.83, 95%CI: 1.6 - 5.01) were significantly associated with TAP exposure among school-aged children. The research findings should contribute to effective implementation of measures for preventing and controlling tobacco use among students aged 13-15 in Viet Nam.
Hai Le Xuan,Quoc-Dong Hoang,Soon Geul Lee,Dat Pham Xuan,Hoang Tran Viet,Minh Pham Van,Hung Pham Van,Hung Pham Viet,PHAM DUC TUAN,Duc Anh Nguyen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2
Ballbots, which have been studied for over ten years, are under-actuated mobile robots that operate using the inverted pendulum paradigm. Controlling a ballbot poses a number of challenges, including maintaining the stable upright posture from the ground in all directions and making sure it follows the desired trajectory. External factors such as a minor change in contact surface properties or fabrication errors can affect the system's stabilization and transfer capabilities. In this study, an adaptive hierarchical sliding mode control algorithm based on an artificial neural network is developed to make the ballbot robust to external factors. The use of the proposed controller ensures system stability despite uncertainties including friction, accidental centrifugal forces and gravity that occur when the ballbot follows the reference trajectory. The system stability is guaranteed on the basis of Lyapunov theory. Control efficiency and robot stability under system uncertainties are demonstrated by numerical simulation.
Hoang, Van-Hai,Ngo, Van T. H.,Cui, Minghua,Manh, Nguyen Van,Tran, Phuong-Thao,Ann, Jihyae,Ha, Hee-Jin,Kim, Hee,Choi, Kwanghyun,Kim, Young-Ho,Chang, Hyerim,Macalino, Stephani Joy Y.,Lee, Jiyoun,Choi, S American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor <B>1</B>, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.</P> [FIG OMISSION]</BR>
Hai Thi Hong Truong,김수연,Hung Ngoc Tran,Thuy Thi Thu Nguyen,Long Tien Nguyen,Toan Kim Hoang 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.4
We report the development of a codominant sequence characterized amplified region (SCAR) marker linked to resistance to a Korean R. solanacearum isolate in tomato line Hawaii 7996. Bulked segregant analysis was employed for rapid identification of RAPD markers linked to resistance genes. Genomic DNA from six resistant F9 recombinant inbred lines (RILs) and six susceptible F9 RILs, which derived from a cross between S. lycopersicum Hawaii 7996 (resistant parent) and S. pimpinellifolium WVa 700 (susceptible parent) were pooled in to an R-pool and an S-pool, respectively. A total of 800 RAPD primers were screened and only six primers (UBC#176, 205, 287, 317, 350, and 676) showed polymorphism between R- and S- pools. Of these, only two markers UBC#176 and 317 revealed a 100% linkage in the individual plants comprising the contrasting bulks. Of these, the marker UBC#176 was converted into a co-dominant SCAR marker and designated as SCU176-534. The marker SCU176-534 was confirmed by genotyping the individual of the R- and S- pools and gave the same result as UBC#176. When the marker SCU176-534 was further validated for association with resistance and its potential for maker-assisted selection (MAS) in 92 tomato lines and cultivars, the results showed that none of these carries the resistance gene. Thus, SCAR marker SCU176-534 can be used in early selection of resistant lines when Hawaii 7996 is used as a parent in a breeding program.