Identification of kidney-specific binding peptide from phage displayed peptide library: Involvement of cisplatin-induced acute kidney injury molecule-1 (KIM-1)

Hyeonsoo Park,Yong Hyun Jeon,Sang hyun Kim,Sunhee Choi 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.1

동대문운동장 공원화사업 - 조성룡

Kyoungwan Kim,Seunghyun Na,Janggun Lee,Sunhee Park,Jongjin Lee,Seungjin Park 현대건축사 2007 월간 CONCEPT Vol.- No.101

혼종모형을 이용한 호스피스팀원의 영성적 자기돌봄 개념분석

장선희 ( Jang Sunhee ),이성주 ( Lee Sungju ),김민영 ( Kim Minyeong ) 한국정신간호학회 2023 정신간호학회지 Vol.32 No.4

Purpose: The study aimed to clarify the concept of spiritual self-care in hospice team members. Methods: To analyze the concept of spiritual self-care of hospice care team, the study was carried out using Schwartz-Barcott and Kim's hybrid model including theoretical, fieldwork and final analytic stages. In the theoretical stage, 'spirituality', 'spiritual well-being', 'spiritual health', 'spiritual care', and 'self-care' were set as search terms, and the resulting 107 related works of domestic and international literature were analyzed. In the field survey stage, data were collected from nurses and spiritual experts with more than 5 years of experience in spiritual self-care. Results: The concept of spiritual self-care is to realize the meaning and purpose of life while constantly maintaining relationships with oneself, neighbors, communities, and the absolute, utilize transcendence and internal resources, strengthen professional competence, maintain work-life balance, and achieve spiritual well-being. It was identified as a dynamic state to realize. The quality attributes of the concept of spiritual self-care were found to have 5 attributes and 15 indicators. Conclusion: The attributes and indicators derived through this study will be helpful in understanding the concept of hospice team members' spiritual self-care. In addition, as a way to continuously grow and train professional hospice team members, it can be used to develop a spiritual self-care assessment tool and an educational program to prevent burnout.

응급의료 영역 한국어 음성대화 데이터베이스 구축

김선희(Sunhee Kim),이주영(Jooyoung Lee),최서경(Seo Gyeong Choi),지승훈(Seunghun Ji),강지민(Jeemin Kang),김종인(Jongin Kim),김도희(Dohee Kim),김보령(Boryoung Kim),조은기(Eungi Jo),김호정(Hojeong Kim),장정민(Jungmin Jang),김준형(Jun Hyung 한국음성학회 2020 말소리와 음성과학 Vol.12 No.4

본 논문은 응급의료 환경에서 음성인식 성능을 향상시키기 위하여 실제 환경에서 데이터 수집 방법을 정의하고 정의된 환경에서 수집된 데이터를 전사하는 방법을 제안한다. 그리고 제안된 방법으로 수집되고 전사된 데이터를 이용하여 기본 음성인식 실험을 진행함으로써 제안한 수집 및 전사 방법을 평가하고 향후 연구 방향을 제시하고자 한다. 모든 음성은 기본적으로 16비트 해상도와 16 kHz 샘플링으로 저장되었다. 수집된 데이터는 총 166건의 대화로서 8시간 35분의 분량이다. 수집된 데이터는 Praat를 이용하여 철자 전사, 음소 전사, 방언 전사, 잡음 전사, 그리고 의료 코드 전사를 수행하여 다양한 정보를 포함한 텍스트 데이터를 구축하였다. 이와 같이 수집된 데이터를 이용하여 기본 베이스라인 실험을 통하여 응급의료 영역에서의 음성인식 문제를 실제로 확인할 수 있었다. 본 논문에서 제시한 데이터는 응급의료 영역의 1단계 데이터로서 향후 의료 영역에서의 음성인식 모델의 학습 데이터로 활용되고, 나아가 이 분야의 음성기반 시스템 개발에 기여할 수 있을 것으로 기대된다. This paper describes a method of building Korean conversational speech data in the emergency medical domain and proposes an annotation method for the collected data in order to improve speech recognition performance. To suggest future research directions, baseline speech recognition experiments were conducted by using partial data that were collected and annotated. All voices were recorded at 16-bit resolution at 16 kHz sampling rate. A total of 166 conversations were collected, amounting to 8 hours and 35 minutes. Various information was manually transcribed such as orthography, pronunciation, dialect, noise, and medical information using Praat. Baseline speech recognition experiments were used to depict problems related to speech recognition in the emergency medical domain. The Korean conversational speech data presented in this paper are first-stage data in the emergency medical domain and are expected to be used as training data for developing conversational systems for emergency medical applications.

Factors Affecting Sustainable Web Technology Adoption

Sunhee Kim(김선희),Ohbyung Kwon(권오병) 한국전자거래학회 2014 한국전자거래학회지 Vol.19 No.4

오늘날 지속가능성을 위한 사업 기회 창출을 위해 지속가능한 정보기술에 대한 수용이 사회적으로 미치는 영향에 대한 연구가 절실함에도 불구하고, 환경적 영향 요인 외의 여러 사회적 영향 요인들에 대한 연구는 많이 이루어지지 않았다. 본 연구에서는 지속가능한 웹기술 환경에서 소비자의 친사회적 행동이 지속가능한 정보기술 수용에 미치는 요인들을 탐구한다. 그리고 지속가능한 정보기술 개념에 대한 이론적 근거는 사회적 교환 이론에 두었다. 이론적 근거를 토대로 지속가능한 웹 서비스 신기술에 대한 소비자들의 사용 의도를 실증적으로 검증하였다. 실증적 연구 결과, 소비자들은 자신들이 웹 기술 서비스의 사회적 책임성과 사회적 유용성을 고려하여 수용 선택을 하는 것으로 나타났다. 본 논문은 지속가능한 정보 기술의 수용에 있어서 해당 기술이 가진 사회적 특성과 영향력을 처음으로 실증적으로 검증한 연구이다. 아울러 지속가능한 정보기술의 초기 도입 단계 수용에서 기술의 사회 책임적 특성과 유용성을 인식하는데 있어 소비자의 친사회적 성향이 중요한 선행 요인으로 작용한다는 것을 본 연구를 통해 밝혔다. Examination of the various impact factors on adoption sustainable IT can influence on the potential for creating sustainable businesses in today’s society. However, the societal factor out of environmental factors, which stimulates customer intention to use sustainable IT, has seldom been investigated. In this paper, we examine the adoption of sustainable web technology from the pro-social behavior perspective. The concept of sustainable IT is theoretically examined based on social exchange theory. An empirical investigation is conducted into customer intention to use new sustainable IT. The results indicate that customers care about the social responsibility and usefulness of the sustainable IT-based services they choose. In this study, the social features of web technology and their influences on adoption are verified empirically for the first time. In addition, pro-sociality is identified as necessary to a perception of the socially responsible features of information technology. Furthermore, pro-social adoption behavior in the beginning stages of sustainable IT use is elucidated.

Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by <i>Euphorbia</i> extracts

Kim, Dong-eun,Jung, Sunhee,Ryu, Hyung Won,Choi, Miri,Kang, Mingu,Kang, Hyunju,Yuk, Heung Joo,Jeong, Hyejeong,Baek, Jiyeon,Song, Jae-Hyoung,Kim, Janghwan,Kang, Hyojeung,Han, Sang-Bae,Oh, Sei-Ryang,Cho, Elsevier 2018 Journal of Functional Foods Vol.42 No.-

<P><B>Abstract</B></P> <P>Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three <I>Euphorbia</I> extracts as strong inducers from a screen of Korean medicinal plant extracts library. Expression of lytic genes were efficiently induced by each <I>Euphorbia</I> extract in SNU-719 (EBV-positive gastric carcinoma cells). <I>Euphorbia pekinensis</I>, out of three extracts, exhibited the most potent lytic-inducing activity. Importantly, treatment with <I>E. pekinensis</I> extract led to an obvious cytotoxic effect on SNU-719 cells, but little on MKN-74 cells (EBV-negative gastric carcinoma cells), indicating the selective oncolytic effect on EBV-positive gastric carcinoma. We further revealed that lytic-inducing activity of <I>E. pekinensis</I> was mediated by PKC/MEK signal. Moreover, we defined two structural analogs of PMA with strong lytic-inducing activity, suggesting their therapeutic applicability for the treatment of EBV-associated gastric carcinoma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Identification of three <I>Euphorbia</I> extracts with EBV lytic-inducing activity. </LI> <LI> <I>Euphorbia</I> extracts efficiently induce lytic replication in most of cell population. </LI> <LI> <I>Euphorbia</I> extracts induce EBV reactivation through modulating PKC/MEK pathway. </LI> <LI> PMA analogs in <I>Euphorbia</I> extracts contribute to lytic induction of EBV. </LI> <LI> <I>E. pekinensis</I> extract has an oncolytic effect selectively on EBV-positive gastric carcinoma cells. </LI> </UL> </P>

Realistic Circuit Model of an Impact-Based Piezoelectric Energy Harvester

Sunhee Kim,Suna Ju,Chang-Hyeon Ji,Seungjun Lee 대한전자공학회 2015 Journal of semiconductor technology and science Vol.15 No.5

A vibration-based energy harvester and its equivalent circuit models have been reported. Most models predict voltage signals at harmonic excitation. However, vibrations in a natural environment are unpredictable in frequency and amplitude. In this paper, we propose a realistic equivalent circuit model of a frequency-up-converting impact-based piezoelectric energy harvester. It can describe the behavior of the harvester in a real environment where the frequency and the amplitude of the excitation vary arbitrarily. The simulation results of the model were compared with experimental data and showed good agreement. The proposed model can predict both the impact response and long term response in a non-harmonic excitation. The model is also very useful to analyze the performance of energy conversion circuitry with the harvester.

Improved Metal Object Detection Circuits for Wireless Charging System of Electric Vehicles

( Sunhee Kim ) 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.8

As the supply of electric vehicles increases, research on wireless charging methods for convenience has been increasing. Because the electric vehicle wireless transmission device is installed on the ground and the electric vehicle battery is installed on the floor of the vehicle, the transmission and reception antennas are approximately 15-30 cm away, and thus strong magnetic fields are exposed during wireless charging. When a metallic foreign object is placed in the magnetic field area, an eddy current is induced to the metallic foreign object, and heat is generated, creating danger of fire and burns. Therefore, this study proposes a method to detect metallic foreign objects in the magnetic field area of a wireless electric vehicle charging system. An active detection-only coil array was used, and an LC resonance circuit was constructed for the frequency of the supply power signal. When a metallic foreign object is inserted into the charging zone, the characteristics of the resonance circuit are broken, and the magnitude and phase of the voltage signal at both ends of the capacitor are changed. It was confirmed that the proposed method has about 1.5 times more change than the method of comparing the voltage magnitude at one node.

Anti-inflammatory effects of a Houttuynia cordata supercritical extract

Sunhee Shin,Seong Soo Joo,Jeong Hee Jeon,박동선,Min-Jung Jang,Tae-Ook Kim,Hyun-Kyu Kim,황방연,김기연,Yun-Bae Kim 대한수의학회 2010 Journal of Veterinary Science Vol.11 No.3

Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.)reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-α and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased TNF-α and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase II-PGE2 pathways.

Realistic Circuit Model of an Impact-Based Piezoelectric Energy Harvester

Kim, Sunhee,Ju, Suna,Ji, Chang-Hyeon,Lee, Seungjun The Institute of Electronics and Information Engin 2015 Journal of semiconductor technology and science Vol.15 No.5

A vibration-based energy harvester and its equivalent circuit models have been reported. Most models predict voltage signals at harmonic excitation. However, vibrations in a natural environment are unpredictable in frequency and amplitude. In this paper, we propose a realistic equivalent circuit model of a frequency-up-converting impact-based piezoelectric energy harvester. It can describe the behavior of the harvester in a real environment where the frequency and the amplitude of the excitation vary arbitrarily. The simulation results of the model were compared with experimental data and showed good agreement. The proposed model can predict both the impact response and long term response in a non-harmonic excitation. The model is also very useful to analyze the performance of energy conversion circuitry with the harvester.