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Background: The Chinese hamster ovary cells transfected with human TSH receptor cDNA (hTSHR-CHO), expressing functional human TSH receptors, are known to be more sensitive in detection of thyroid stimulating antibodies than FRTL-5 cells. There has been no report on the usefulness of these cells to measure thyroid stimulation blocking antibody(TSBAb) activity which is frequently found in patients with primary myxedema, Methods: We established the optimal assay condition of measurement of TSBAb using hTSHR- CHO cells, and simultaneously measured TSBAb activities with FRTL-5 cells and with hTSHR- CHO cells in 49 patients with primary myxedema, compared them with their thyrotropin binding inhibitor immunoglobulin(TBII) activities. Results: 1) hTSHR-CHO cells specifically bound bTSH and were stimulated by bTSH in terms of cyclic AMP generation in a dose dependent manner. 2) Myxedema IgG suppressed TSH-stimulated cAMP production of hTSHR-CHO cells in a dose dependent manner reaching plateau at the concentration of I g/L. Normal pooled IgG has no suppressive action at the concentration of less than 1 g/L, but caused significant suppression at the concentration of greater than 1g/L. 3) TSBAb activities measured by hTSHR-CHO cells in 49 patients with primary myxedema were as follows: Four of 25 TBII-negative cases(16%) and 22 of 24 TBII-positive cases(92%) had TSBAb activities. Most of TSBAb positive patients(95%), especially in TBII positive cases, showed very high activities of more than 90%. 4) TSBAb activities measured by hTSHR-CHO cells and those by FRTL-5 cells were both positive in 24 patients(49%), both negative in 18 patients(37%), and were discrepant in 7 patients(14%). The TSBAb activities measured with hTSHR-CHO cells and those measured with FRTL-5 cells were significantly correlated(r=0.71, p$lt; 0.01). 5) Forty five percent of patients with primary myxedema had all of 3 kinds of activities(TBII, hTSHR-CHO cell TSBAb, FRTL-5 cell TSBAb), 37% of them had none of 3 activities and 18% of them had 1 or 2 kinds of activities only. Conclusion: The usefulness of hTSHR-CHO cells in measurements of TSBAb activities were confirmed. The TSBAb activities of most patients with primary myxedema measured by hTSHR- CHO cells were concordant with those measured by FRTL-5 cells. However, a small subset of patients(18%) had discrepant results in assays of TSH receptor antibodies according to the differences in TSH receptors(rat, human and porcine) used in assay. Such discrepancy may be explained by heterogeneity in epitopes for blocking TSH receptor antibodies. (J Kor Soc Endocrinol 12:18-32, 1997)
Yoo Dong-cho is the person who recorded two pieces of music, the sanjo and bongjangchwi, in 1937 by playing his tungso and recording the music thus produced into phonograph discs. He has remained a subject of research not only for musical performers but also for scholars, owing to his remarkable talent for rendering musical performances. This research was conducted for four years, with five field studies on the character of Yoo Dong-cho, the top tungso musical performer in the 1930s. Based on the information provided by the informants, this research was divided into two parts: (1) Yoo Dong-cho's art activities; and (2) the dates of his birth and death. The description of his art activities in this paper was based on the information provided by the informants, and the discussion of the exact dates of his birth and death was based on the records in the pulled-out family register. As for his art activities, Yoo Dong-cho enjoyed not only the folk music of sanjo and bongjamgchwi, which he recorded in phonograph discs, but also elegant music, such as that coming from the gayageum. As for the musical instruments that he played, he played diverse instruments, such as the tungso, gayageum, danso, sepiri, jingo, and drums. Although Yoo Dong-cho did not have many disciples, the few disciples that he had followed him endlessly, and he sometimes taught for a living. According to newspaper records and to the information provided by the informants, Yoo Dongcho taught elegant music rather than the sanjo. The tungso, however, was the musical instrument that he played best, and he always carried one with him. In the 1930s, Yoo Dong-cho was active in recording tungso music into phonograph discs, and in musical-performance broadcasting. This can be seen from the records of his radio broadcasting guestings in the mid-1930s, and from the records of the Victor edition of his tungso solo. Yoo Dong-cho was born on March 7, as the elder of two sons, Yoo su-yeong and Han Deok-san, in Jeonnam, Jangseong-gun, Buksangmyeon. His real name was Yoo Bong (柳鳳), and he belonged to the Munhwa (文化) Yoo (柳) family. Although Yoo Dong-cho was born in Jeonnam Janseong, he moved to Gochang Heungdeok-ri, Iksan Hwangdeung-ri, and Gimje Baeksan-myeon, and he settled down in Jeonbuk. For about 20 years in the last phase of his life, when he was most active in terms of rendering musical performances, he lived in Gimje Baeksan. It appears, however, that his activities were not limited to the Jeonbuk region but spanned the whole country. He died in 1946 at the age of 61 in Seungbang Village in Gimje Baeksan-myeon, and his grave is currently in Jeonnam Jangseong.
Thyroid stimulating antibody which results in the development of hyperthyroidism and goiter in Graves' patients used to be measured by using rat thyroid cells, FRTL-5. However, this assay has disadvantages: decreased sensitivity due to differences in species, and fastidious culture conditions for FRTL-5 cells. Thus, we recently created stably transfected Chinese hamster ovary(CHO) cells containing the human TSH receptor(hTSHR-CHO) and developed optimal conditions for the measurement of thyroid stimulating antibody using hTSHR-CHO cells. In this study, to evaluate the clinical relevance of thyroid stimulating antibody measurement using hTSHR-CHO cells, we measured thyroid stimulating antibody activities of IgGs from Graves' disease and other thyroid disease using hTSHR-CHO cells, and compared to those of thyroid stimulating antibody assays using FRTL-5 cells. 1) The cut off value of positive thyroid stimulating antibody activity measured in hTSHR-CHO cells was 145%(above the mean +2SD) which was lower than 165% in FRTL-5 cells. The intra-assay and inter-assay variances were 3.9% to 9.0% and 12.7% to 1.6%, respectively. 2) Thyroid stimulating antibody activity was detected in 90% of patients with untreated Graves' disease when patients initially presented. Further, in patients seen initially but already under therapy, 75% had positive values if they were hyperthyroid but only 43% had IgGs with activity if they were euthyroid. Patients in clinical remission after therapy showed positive values in 23% of cases. Only 2 of 25 patients with Hashimoto's thyroiditis showed weak thyroid stimulating antibody activity, none of 18 patients with nodular nontoxie goiter, 1 of 15 patients with primary myxedema, and 2 of 33 control patients with no thyroid disease. Thus, the detection frequency and specificity of the assay with hTSHR-CHO cells was excellent for this type bioassay. 3) The detection frequency of thyroid stimulating antibody activity by hTSHR-CHO cells assay system(90%) was higher than that by FRTL-5 cells assay system(66%) in untreated Graves' patients. Those two activities were positively correlated with each other(r=0.52, p$lt;0.001). However, some IgGs showed discrepancy of the thyroid stimulating antibody activity measured in hTSHR-CHO cells and in FRTL-5 cells; 56 of 87 patients were positive in both cells system, 8 of 87 were negative in both cells system, 1 of 87 was only positive in FRTL-5 cells and 22 of 87 were only positive in hTSHR-CHO cell system. Thus, 73%(22/30) of IgGs showing negative values of thyroid stimulating antibody activities in FRTL-5 cells were detected its activities in hTSHR-CHO cells system. In summary, thyroid stimulating antibody assay with hTSHR-CHO cells exhibited so excellent sensitivity and specificity that this technique should be used for clinical practice as well as basic research(J Kor Soc Endocrinol 10: 347-361, 1995).
Between the year of 1924 and 1943, 3 'Cho-sun Kinema' film companies has established and made each own Films. Firstly cho-sun kinema co. has opened in 1924 at Busan, the second big city of korea,. Joined by local big shots including a monk, a medical doctor, a gun shop owner. and that company made four films like 'the tragedy of the sea' 'the lover of the king' 'the make up of the God' Second one is cho-sun kinema production opened at seoul, the capital of korea. in 1926. The owner of company was a business man who runned 'the Yotoya', a hat shop. That company has made 6 films including 'Arirang' 'The Drifting Hero'. and soon became most popular and influential film company at that time, but internal conflict between Na woon gyu, the Star of the company, and other members. Third one was cho-sun kinema co. Known as another new company with cho-sun kinema production. Actually that company was same company of cho-sun kinema production. After several conflict between the Membersof that company, the company has changed system, a private owned to a joint stock company. so new cho-sun kinema co. is sequel of cho-sun kinema production.
Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.
The ministry of Yonggi Cho, which he began after his retirement, offers important lessons in the context of the modern mission. He work as the wholistic mission is recommended by both traditional and progressive parties. According to this trend, the Sharing of Love and Happiness Foundation can be considered as an example of the wholistic mission, which carries the Great Commission of God by the church. Thus, the writer wants to study the motivation, methods, and influence of “Sharing of Love and Happiness” of Yonggi Cho which belongs to a wholistic mission. The content of this paper is wholistic mission of NGO and “Sharing of Love and Happiness” in the ministry of Yonggi Cho. He made the Three-fold Blessing from the gospel of Jesus. It is a message which confirms that humans have a right to share in salvation of souls, all other matters, and in the well-being of their bodies. The ministry of Cho's wholistic mission structure is also to change the frame of old traditional dogmatics. He constructed the shape of wholistic mission through three-fold blessings and proved it, through Good People which is a NGO. The writer evaluates that the Sharing of Love and Happiness Foundation is a model of the wholistic mission, presenting the future ministry of the Korean Church.
'Mong-yu-rok(夢遊錄)' is a historical genre of Cho-sun(朝鮮) Dynasty. Most works of this genre were written in the Chinese characters, and produced especially in the hard times of the nation - for example, Cho-sun vs. Japan War[Hideyoshis Invasion of Korea in 1592], Cho-sun vs. Ching War[the Mandch Invasion of Korea in 1636], or the time just before the Japanese annexation of Korea. The stories included in Mong-yu-rok works are about the experience in dream and have the 'beginning of dream-experience during dreaming-awakening from sleeping' structure. <Gang-do-mong-yu-rok(江都夢遊錄)> is based on the experience of war in Gang-hwa-do(江華島, Gang-hwa island) during Cho-sun vs. Ching War. It is also written in the Chinese characters and its author is unknown. This work begins with a story about a monk who had a chance of watching the women's meeting in a dream. As he was a man of compassion, he arrived Yeon-mi-jung(燕尾亭, Yeon-mi pavilion) in Gang-hwa island to bury the bodies that had been neglected after the war. At night he was led to a certain place by women's various weeping, laughing, and crying sounds, and that meant he was already in dreaming. When the War broke out, the king and the ministers took refuge in Nam-han-san-seong(南漢山城, Nam-han mountain fortress) and the women of noble class including royal family took refuge in Gang-hwa island. However, all the high-ranking officials who took charge of defending the island ran away before the fights started, and the fortress was helplessly surrendered. And those countless women who took refuge in Gang-hwa island had committed suicides for keeping their dignity as a human being. They readily chose a suicide for their honor, because Cho-sun society rigidly called upon women to keep the chastity. Therefore those women in this work were the ghosts, that were not alive. Their appearances were horrible, which showed their tragic death. All those 14 women ghost characters came from the noble families except one woman. They poured out their words of rebukes, resentments, and sorrows. After all, it is the officials that they severely criticized in turn, who couldn't fulfill their responsibility during the war. The officials could be their own husbands, sons or fathers-in-law, in fact. This work very impressively used the sound image: at the last scene of women's meeting, the meeting place was filled with all women's wail. And which was effective enough to remind us a tutti in a symphony. <Gang-do-mong-yu-rok> reported the sufferings of women who had to take refuge in Gang-hwa island at the wartime. It would be hard to find a work which reflected the experience of women in war as realistic as this work, although many literary works about war were written after Cho-sun vs. Japan war & Cho-sun vs. Ching war. It is the literary works that were concerned about the concrete aspects of those women's death as a human even though they had to choose honorable suicide, while the historical documents briefly praised those women's death in formal manner and rhetoric. <Gang-do-mong-yu-rok> successfully described the miserable aspect of Cho-sun vs. Ching war and the women's voices in it became the fierce criticism about the failure of policy and the fall of the ideology at that time.
The Chinese Hamster Ovarian cells CHO-K1 are one of the most extensively used cells for the evaluation of gene expression and toxicology. However, these cells are frequently used for biomedical research without consideration of their cytogenetic characteristics. Therefore, we carried out to investigate the karyologic profiles, the frequency and type of chromosome aberration, and the distribution of telomeric DNA on chromosomes of the CHO-K1 cells. The GTG banding and fluorescence in situ hybridization on CHO-K1 cells were performed to characterize the karyotype and the distribution of telomeric DNA The present study revealed that the chromosome modal number of CHO-K1 cells was 2n=20; eight chromosomes appeared to be identical with those of the normal Chinese hamster, whereas the remaining 12 chromosomes were shown to be translocated, deleted, inversed, or rearranged from Chinese hamster chromosomes. The telomeric DNA on CHO-K1 chromosomes was intensively distributed at the centromeres rather than the ends of chromosomes. In addition, three chromosomes had interstitial telomeres and one marker chromosome entirely consisted of telomeric DNAs. The frequency and type of chromosome aberrations in CHO-K1 cells were examined. Of the 822 metaphase spreads, 68 (8.3%) cells resulted in chromosome aberrations of which the chromosome breakage was the most frequently occurred.
喚鶴堂 曺汝諶은 1518년 (中宗 13년, 戊寅)에 태어나고 1594년(宣祖 27년, 甲午) 77세에 卒한 호남의 대유학자이며 시인이었다. 字는 常仲 또는 誠仲이며 호는 喚鶴으로 自號한 것이다. 그는 號처럼 학과같이 살다 간 전형적인 선비였다. 중종, 穆陵盛世의 호남시단에서 송순, 임억령 등과 같은 시대에 살면서 그들과 詩友로서 교유하고 선비정신을 견지하면서 處士로 청정한 일생을 보냈던 환학당 조여심에 대한 조명은 아직껏 이루어지지 않았다. 그의 「行狀」을 쓴 서파 오도일이 “聲韻이 淸絶하고 色澤이 朗潤하여 근세의 문필가가 미칠 바 아니었다.”는 詩評을 하였고 그의 정자인 환학정의 騷客들 중 문장의 출중함에 감탄하지 않는 이가 없었으며 오랜 세월동안 일대에 ‘鶴仙'으로 전설처럼 불리고 있었음에도 그에 대한 정비된 문집이나 연구 자료가 일천 한 것은 안타까운 일이다. 그의 많은 전적들이 선조들의 遺文과 함께 書庫에 불이나 소실된 이유 때문에 세상에 드러나지 못하였다. 다행히 그의 정자인 환학정 편액들과, 흩어진 遺文들을 모아 후손들이 편집한 유일한 작품집인 『喚鶴堂遺稿』가 있고, 당시 환학정을 중심으로 교유했던 林億齡, 蘇世讓, 高敬命, 奇大升, 鄭澈 등의 문집에 자료가 다소 散在되어 있으며, 창평 鄕校 등에 그의 行錄이 남아있어 이를 취합하여 환학당 조여심을 세상에 알리게 된 것이다. 조여심은 종형인 觀水亭 曺汝忠과는 翫水亭을 共遊하면서 우애가 각별하였고, 종매형인 양곡 소세양은 그의 資稟을 각별히 자애하였다. 특히 指呼之間에 위치한 ‘息影亭'의 石川 林億齡과는 깊은 친교를 유지하며 그의 사상과 문학을 수렴하였다. 조여심의 시풍이 만년의 석천시와 닮아있음은 그의 영향을 받은 것이며 석천은 무려 20여수의 山居詩를 조여심에게 주었다. 그의 문집 『환학당유고』에는 환학정 「原韻」을 비롯한 수편의 교유시가 수록되어 있어 교유작가들의 문집에 남아있는 시들을 함께 취합하여 분석 자료로 삼았다. 삶의 志向이 陶淵明, 석만경, 엄자릉 등을 추종하였으며, 작품 전반에 흐르는 시의 성향은 守拙하고 平易하며 과장하지 않는 자연주의적 특징이 있다. 그의 律詩에서는 禪 사상과 道家思想의 여운이 감지되며 그의 山居詩 전반에서 느껴지는 것은 현실세계가 그의 포부를 수용해주지 못하는 屈原의 비애를 느낄 수 있고, 이를 엄자릉과 석만경과 같은 隱者的 삶과 도가사상에 기대어 독자적으로 아픔을 극복하려 했다고 볼 수 있다. 또한 그가 중건했던 三峰書舍[學求堂]를 통하여 교육에 끼친 업적과 당시 지방 私學 기관으로의 기능과 배출된 인사 등에 대하여 살펴보았다. 본 연구를 통하여 16세기 호남 문단의 方外作家로 남아 있었던 조여심을 조명함으로써 그의 작품세계와 그를 통한 交遊詩人 간의 인간관계와 시 성향, 문화 풍토 등이 점검되는 계기가 될 것으로 믿는다. Cho Yeo-sim(曺汝諶), who was the great Confucian scholar and poet, with the pen name called Hwan-Hak-Dang was born in the year of 1518, when is in the 13th year of King Jung-Jong(the year of Moon-In), and was died in 1594 at the age of 77, when is in the 27th year of King Sun-Jo(the year of Gab-O). His writing style was Sang-Jung or Sung-Jun and his pen name was titled for him self. He is atypical schol arlikea crane. Having made friends with them as a poetical friend and kept the classical scholar mind and lived righteously, while having lived in the same age as Song Sun, Lim Uk-ryung and others in the Honam world of poetry, he was not highlighted yet to the world. Do-Il Oh with the pen name of Soe Pa, who wrote ‘Haeng Jang', commented “Nobody in the recent ages can be beyond his rhythm transparent and integral and color bright and shiny.” It is regrettable there is no information on the literature or valuable material although every poet in Hwan-Hak-Jung, which is a pavilion, admired his prominence and he was called a legend as a traditional scholar like a crane. In the meantime, it turned out many of his literary work were burned down together with many other historic literatures of his ancestors. It is fortunate to be able to disclose his excellent reputation to the world since some frames of Hwan-Hak-Jung and scattered posthumous writings collected by his descendants were recreated as a posthumous work named ‘Hwan-Hak-Dang' and some parts of his work were described in the materials from Lim Uk-ryung, So Se-yang, Ko Kyung-myung, Ki Dae-seung and Jung Chul, and also some other parts of his work remained in the Confucian called Chang Pyung. Cho Yeo-sim made substantial communications with Song Sun[면仰亭], Ko Kyung-myung[霽峰], Ki Dae-seung[高峯], Jung Chul[ Jung[松江] in the center of Hwan Hak Jung and made a special friendship with Cho Yeo-choong[KwanSu-Jung, elder cousin] and his younger cousin, So Se-yang [陽谷] loved his work with a special interest. He also made a special relationship with Lim Uk-ryung[石川] from ‘Sik-Young-Jung' located nearby and digested his though and literature. That is why Cho Yeo-sim's poetical style is similar to that of poet Suk Chun(Nyun Man), who granted as many as about 20 poetry to Cho. Some original poetry including ‘Won Woon' poetry in his anthology named ‘Hwan Hak Dang' posthumous work and some other additional poetry were used in this analysis work. In addition, the impact of his accomplishments on the education through Sam Bong Seo Sa(Hak Goo Dang) he established and the functions as a provincial private institute and its people were also examined. It is believed and expected that this study is the excellent chance to rethink of his world of literature works and the relationship among his social poets by reviewing Cho Yeo-sim, who remained as an outside poet in the Ho Nam province in the 16th Century.
Background : Thyroid stimulating antibodies result in the development of hyperthyroidism and goiter in Graves disease. However, thyroid stimulating antibody activities do not correlate with the clinical features in many patients with Graves disease. The purpose of this study is to address this discrepancy between thyroid stimulating antibody activities and clinical features of Graves patients. Methods: We measured thyroid stimulating antibody activities simultaneously using human TSH receptor transfected Chinese hamster(hTSHR-CHO) cells and rat thyroid(FRTL-5) cells in 57 untreated patients with Graves disease, and compared their activities with clinical features including thyroid hormone levels. Results : The detection rate of thyroid stimulating antibody measured by hTSHR-CHO cells was 90% in 57 untreated Graves patients and it was higher than that measured by FRTL-5 cells. Thyroid stimulating antibody activity by hTSHR-CHO cells was significantly correlated with that by FRTL-5 cells(r=0.5, p$lt;0.001), however, 18 of 57(32%) patients showed marked discrepancy of thyroid stimulating antibody activity between in hTSHR-CHO and FRTL-5 systems. Thyroid stimulating antibody activity measured by hTSHR-CHO cells was significantly correlated with serum total T3, free T4 levels, and goiter size but not 99mTc-thyroid uptake. On the other hand, thyroid stimulating antibody activity measured by FRTL-5 cells was significantly correlated with goiter size and 99mTc-thyroid uptake but not thyroid hormone levels. The difference between function and goiter size with respect to thyroid stimulating antibody measurement in two cells system is, nevertheless, particularly evident in the free T4/goiter ratio in patients with high hTSHR-CHO and low FRTL-5 cell assay values. Conclusion: These findings suggest that thyroid stimulating antibodies in Graves disease are heterogeneous population in terms of responses to different origin of cells. Further, thyroid stimulating antibody activities measured by FRTL-5 cells tend to correlate better with goiter size and Tc-thyroid uptake, whereas thyroid stimulating antibody activities measured by hTSH-CHO cells correlate better with thyroid hormone levels(J Kor Soc Endocrinol 11:18-29, 1996).