3T Multi Voxel Spectroscopy에서 SENSE와 NEX 변화에 따른 정상인 뇌 대사물질 변화 분석

성열훈,임재동,이재현,조성봉,우동철,최보영,Seong, Yeol-Hun,Rhim, Jae-Dong,Lee, Jae-Hyun,Cho, Sung-Bong,Woo, Dong-Chul,Choe, Bo-Young 한국의학물리학회 2008 의학물리 Vol.19 No.4

자기공명분광법(magnetic resonance spectroscopy: MRS)은 인체내 대사물질을 정량분석하여 병변의 조기진단 및 정밀진단에 도움을 주고 있으며, 최근 임상에 이용되고 있는 자기공명분광법은 single voxel spectroscopy (SVS) 기법과 multi voxel spectroscopy (MVS) 기법이 있다. 본 연구에서는 SENSE와 NEX를 변화시킨 multi voxel spectroscopy (MVS)의 데이터와 기존 single voxel spectroscopy (SVS)의 데이터를 비교 분석하여, 각각의 데이터의 유의성 차이를 평가하고자 하였다. 정상 성인 지원자 13명(남자: 5명, 여자: 8명, 평균 41세, 표준편차 11.65세)을 대상으로 chemical shift image (CSI)를 이용한 MVS검사를 시행하였다. 장비는 3.0T Achieva Release Version 2.1 (Philips Medical System, Netherland)을 이용하였고, 8 channel head coil을 사용하여 brain thalamus 부위에서 CSI spectrum을 1 slice 획득하였다. Scan parameter로는 FOV (field of view): $230{\times}184mm^2$, TR (time to repetition): 2000 msec, TE (time to echo): 288 msec, matrix: $15{\times}12$, VOI(view of interest): $110{\times}110mm^2$, voxel size: $15{\times}15{\times}15mm^3$로 하였다. SENSE factor (S)와 NEX (N)는 S1*N1, S2*N1, S2*N2, S3*N2로 변화하여 스펙트럼을 획득하였고, 각 scan time은 5분 54초, 3분 32초, 6분 20초, 4분 20초였다. 얻은 모든 MRS 데이터는 jMRUI 3.0 Version 프로그램에서 분석하였고, SENSE factor와 NEX를 변화시켜 얻은 MVS data 그룹들이 정상 성인 뇌 대사물질의 변화에 영향을 주는지 검증하기 위해 그룹 간에 ANOVA분석을 실행하여 P 값이 0.05보다 크게 나오면 그룹들 사이에 유의한 차이가 없다고 분석하였다. NAA/Cr과 Cho/Cr의 상대적 비율은 MV와 SVS사이에서는 유의한 차이가 없었다. 즉, SENSE factor와 NEX를 변화시켜 얻은 MVS data에서 정상 성인 뇌조직의 대사물질의 변화를 관찰한 결과, S1*N1의 NAA/Cr은 $1.45{\pm}0.03$, Cho/Cr은 $0.88{\pm}0.03$이고, S2*N1의 NAA/Cr은 $1.44{\pm}0.03$, Cho/Cr은 $0.87{\pm}0.05$, S2*N2의 NAA/Cr은 $1.43{\pm}0.02$, Cho/Cr은 $0.87{\pm}0.04$이며, S3*N2의 NAA/Cr은 $1.45{\pm}0.03$, Cho/Cr은 $0.87{\pm}0.03$으로 나타났다(F-value : 1.37, D.F : 3, P-value : 0.262). 그러나 데이터의 질을 측정하기 위한 MVS 데이터의 NAA Peak line-width는 SVS 데이터의 NAA Peak line-width 보다 약 3배 정도 넓었다. 본 연구에서는 MVS에서 SENSE factor와 NEX 값을 다양하게 변화시킨 MVS의 데이터와 SVS의 데이터가 큰 차이가 없음을 확인하였다. 즉, 어는 특정 부위의 뇌 조직의 대사물질은 MVS와 SVS 기법 모두 큰 차이가 없음을 확인할 수 있었다. 그러므로 MVS는 SVS보다 광범한 부위를 짧은 시간 안에 검사할 수 있으므로 매우 유용한 방법이라고 사료된다. To evaluate the metabolic changes in normal adult brains due to alterations SENSE and NEX (number of excitation) by multi voxel MR Spectroscopy at 3.0 Tesla. The study group was composed of normal volunteers (5 men and 8 women) with a mean ($\pm$ standard deviation) age of 41 (${\pm}11.65$). Their ages ranged from 28 to 61 years. MR Spectroscopy was performed with a 3.0T Achieva Release Version 2.0 (Philips Medical System-Netherlands). The 8 channel head coil was employed for MRS acquisition. The 13 volunteers underwent multi voxel spectroscopy (MVS) and single voxel spectroscopy (SVS) on the thalamus area with normally gray matter. Spectral parameters were as follows: 15 mm of thickness; 230 mm of FOV (field of view); 2000 msecs of repetition time (TR); 288 msecs of echo time (TE); $110{\times}110$ mm of VOI (view of interest); $15{\times}15{\times}15$ mm of voxel size. Multi voxel spectral parameters were made using specially in alteration of SENSE factor (1~3) and 1~2 of NEX. All MRS data were processed by the jMRUI 3.0 Version. There was no significant difference in NAA/Cr and Cho/Cr ratio between MVS and SVS likewise the previous results by Ross and coworkers in 1994. In addition, despite the alterations of SENSE factor and NEX in MVS, the metabolite ratios were not changed (F-value : 1.37, D.F : 3, P-value : 0.262). However, line-width of NAA peak in MVS was 3 times bigger than that in SVS. In the present study, we demonstrated that the alterations of SENSE factor and NEX were not critically affective to the result of metabolic ratios in the normal brain tissue.

鹽分最小感應値와 血壓의 聯關性에 關한 疫學的 硏究

趙聲鍾,宋東彬,車喆煥 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.3

High blood pressure has become a common finding in Korean population and a major public health problem leading to an increased mortality and morbidity in recent years. With this accumulating evidence has come increasing incentive to find safe and simple methods for preventing and controlling hypertension. Reduction of dietary salt has been advocated by some for such method. The effect of dietary salt intake to hypertension however is still not clear and it is a matter of controversy particulary on whether the method of reducing dietary salt would be effective in controlling the hypertension of the general population. The purpose of this study was to investigate this controversial matter by assessing the degree of association between dietary salt intake and blood pressure using the method of detecting salt recognition threshold in general population. A total of 680 rural and urban inhabitants were studied from June 1984 to January 1985. The result of study is as followings; 1. The relationship between salt recognition, threshold and optimal gustation of salt was observed to be high in pilot study with a correlation coefficient of 0.729 (p<0.001). 2. In hypertensive group, mean systolic and diastolic blood pressures (BP) were significantly higher in those having high salt recognition threshold (SRT) than those of low SRT. The same evidence could be observed neither in normotensive nor in total population groups. That is, in hypertensive group, the mean systolic BP for those of high SRT was higher than those of low SRT by 8.8 mmHg in male and 8.8mmHg in female, and the mean diastolic BP for those of high SRT was also higher than those of low SRT by 4.3 mmHg in male and 8.5mmHg in female respectively. 3. There was no significant difference in the prevalence rate of hypertension among those of high SRT compared with those of low SRT. 4. In multiple regression analysis using age, body mass index (weight/hight²), socioeconomic status, amount of alcohol consumption, amount of cigarettee smoking, family history of hypertensi no and salt recognition threshold as independent variables, the multiple correlation coefficients turned out to be from 0.36 to 0.47 indicating that these variables explain 13 to 22 percent of the variances of systolic and diastolic pressures. The variables showing relatively higher beta coefficients were age, body mass index and alcohol consumption in male, where as the body mass index, age and family history were the corresponding variables in female. The relationship of salt recognition threshold to blood pressure was turned out to be very low. These findings indicate that dietary salt intake would have a significant effect on blood pressure in hypertensive group (may include the salt sensitive individuals), while no relationship could be observed in normotensive group.

프레탈 정(실로스타졸 100 mg)에 대한 엘지실로스타졸 정의 생물학적 동등성

조혜영,임동구,신상철,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Cilostazol has both antithrombotic and cerebral vasodilating effects, and one of the mechanism is the selective inhibition of platalet cyclic AMP phosphodiesterase. Bioequivalence of two cilostazol tablets, the Pletaal^TM (Korea Otsuka Pharmaceutical Co.) and the LG Cilostazol^TM (LG Chemical Co.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen normal male volunteers (20∼29 years old) were randomly divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of Pletaal^TM or LG Cilostazol^TM tablet (100㎎ cilostazol), blood samples were taken at predetermined time intervals and the serum cilostazol concentrations were determined using an HPLC method with UV/VIS detector. The pharmacokinetic parameters (AUC_t, C_max and T_max) were calculated and ANOVA was utilized for the statistical analysis. The results showed that the differences in AUC_t, C_max and T_max between two tablets based on the Pletaal^TM tablet were -5.39%, 2.32% and 4.26%, respectively. The powers (1-β) for AUC_t, C-max, and T_max were 83.81%, 96.02% and 91.04%, respectively. Minimum detectable differences (Δ) and 90% confidence intervals were all less than ±20%. All these parameters met the criteria of KFDA for bioequivalence, indicating that LG Cilostazol^TM tablet is bioequivalent to Pletaal^TM tablet.

한국형 출혈열 환자에서 분리한 한타 바이러스의 핵산 분석

조종태,윤성철,안규리,한진석,김성권,이정상 단국대학교 1998 論文集 Vol.33 No.-

Hemorrhagic fever with renal syndrome(HFRS)is an infectious disease showing diverse clinical manifestations according to different serotypes of hantavirus. On the assumption that the antigenicity, nucleotide and amino acid sequence diversity of hantaviruses, as well as immune response diversity of individual KHF patients may be present, this study was performed to analyse the genetic diversity of hantaviruses isolated from patients with KHF. In the 13 samples hantaviral RNAs were extracted, cDNAs of partial M segment were amplified by RT-PCR using genus-reactive primer, amplified cNNAs were analyzed by direct sequencing method, and then the nucleotide and deduced amino acid sequences were compared with previously known sequences of four serotypes of hantavirus isolated from rodent hosts and each other by the computer assistance. The results were as follows. The nucleotide and amino acid sequences of 11 samples among the 13 human isolates showed 90.3∼95.5%, 86.7∼97.9% the other 1 samples 82.7%, 71.9% homology respectively to those of Hantaan virus 76-118 strain, and another 1 sample showed 83.7%, 75.3% homology respectively to those of Seoul virus B1 strain isolated from rodent host. The nucleotide and amino acid sequences of 7 among 12 Hantaan samples showed differences within 5%, 10% respectively each other and high genetic similarities, but those of the oehr 5 among 12 Hantaan samples showed low genetic similarities each other. In conclusion, hantaviruese isolated from KHF patients showed genetic diversity compared with previously known hantaviruses isolated from rodent hosts.

항우울제와 연관된 성기능 장애에 대한 조사

조성일,이영식,서동수,나철,민경준 한국정신신체의학회 2003 정신신체의학 Vol.11 No.1

동력전달용 인벌류트 기어의 CAD화 기술에 관한 연구

조성철,변문현 忠南大學校 産業技術硏究所 1995 산업기술연구논문집 Vol.10 No.2

The purpose of this study is to develop a design system of an involute gear for power transmittion using personal computer system. Input data for gear design are pressure angle 20。, transmitted power, gear volume, gear ratio, addendum ratio of rack, dedendum ratio of rack, edge radius of rack, allowable contact stress, and allowable bending stress etc. Contact strength, bending strength, and scoring are considered as the design constraints. The BZS(belt zone search) has been used to find out an optimum design of a gear system. The developed gear design system can design the optimized gear that minimize the number of pinion teeth with face tooth.

마이크로 컴퓨터 시스템에서의 다수사용자를 위한 관계 DBMS

조성배,최윤철 연세대학교 자연과학연구소 1988 學術論文集 Vol.20 No.-

SQL형식의 질의어를 제공하는 다수사용자 관계 DBMS를 PC로 구성된 근거리 네트워크 환경하에서 설계, 구현하였다. A multi-user relational DBMS with SQL-type query is designed and implemented in PC-LAN environment.

幼兒自閉症의 單一光子放出電算化斷層撮影所見과 精神病理와의 相互關係에 關한 硏究

曺洙哲,李明哲,金相殷 서울醫大 1990 精神醫學 Vol.15 No.1

Le Corbusier 건축의 구조와 외피에 나타나는 모듈러 시스템에 관한 연구

조성현,김철규 嶺南大學校 工業技術硏究所 2001 工業技術硏究所論文集 Vol.29 No.2

As for structural system, which constitutes his construction, there are column inside dimension and span which constitutes plane, and as for constructions for section, there are C.H and slab, and as for constructive factors for envelope, there are window and closing panel of outer wall , and as for opening, there are punching window and wave window. With these constructive parts and opening of envelope, his construction composes volume and mass. The relation of structure and directly and indirectly adapted for rate and measure calculation of the constructive body. As for indirectly adapted case, we can find it from most of his later constructions, it is living place in which human beings life is, and it is adapted mainly for small space. In his construction, he tried to tell human scale and sense of musical rhythm through modulor. In other words, he played sense of space and musical scale by adapting mainly and repetitive modulor of opening, and In small space for daily life, he made the size of space into the space which human can perceive. And, if we interpret modulor in modem meaning, it is an establishment of radius of human act. And, we can make organic and harmonic design of space if we use modulor as origin of human centered measurement calculation, and if we adapt space after dividing by use.

고분자 복합재료를 위한 액정중합체(I)

조철형,조성휴,조병욱,김정규,김숭평,권중근 조선대학교 생산기술연구소 1983 生産技術硏究 Vol.1983 No.-

Copolyesters containing oxybenzoate as a rigid rod molecule and methylene group and dimethyl tetramethyl disiloxane as flexible spacers were prepared by room temperature solution polymerization for the purpose of the developement of polymeric composite materials. The thermal properties and the characteristics of the polymers were investigated by DSC and a polarizing microscope. The polymers may be formed nematic liquid crystal phase, and the thermodynamic characteristics of their mesophase to isotropic phase transition could be explained on the basis of its structural features.