귀인 훈련이 경도 정신지체아동의 무력감과 학업성취 및 태도에 미치는 효과

여광응,구유미,이정현,김선미 한국특수교육문제연구소 2001 특수교육저널 : 이론과 실천 Vol.2 No.1

이 연구의 목적은 경도 정신지체아동의 학습된 무력감을 감소시키기 위하여 체계적인 귀인훈련를 적용함으로써 학업성취능력과 학습태도 개선에 미치는 영향을 밝히는데 있다. 연구대상은 개인용 지능검사 결과 IQ 60-75사이이고 초등학교 특수학급에서 시간제 특수교육을 받고 있는 이동 3 명으로서 신체 및 언어장애와 같은 심한 장애가 없는 아동이다. 연구결과, 귀인훈련이 오랜 학교학습상황에서 겪게 된 학습의 실패상황에서 실패원인을 「능력」에 귀인하는 아동을 「노력」 에 귀인하도록 힘으로써 아동의 「학습된 무력감」 를 감소시키는데 효과적임이 밝려졌다. 즉,뺄셈학습과제의 수행속도가 귀인훈련 후 빨라졌으며 과제에 대한 흥미도 많이 증가하였다. 또한 귀인훈련이 경도 정신지체 아동의 학습태도를 개선하였다. 귀인훈련 후 아동의 실패과제에 대한 지속시간이 많이 늘어났으며, 아울러 실패과제에 대한 불안행동이 많이 감소하였고, 주의집중이 향상되며 학습태도가 바람직히게 변화된 것으로 나타났다. 이 결과는 귀인훈련을 통해 경도 정신지체아동의 학업성취도와 학습태도에 긍정적인 변화를 가져올 수 있음이 확인되었다. The purpose of the present study is to investigate how systematic atributional training affects leaming achievements and leaming attitudes for the children with mild mental retardation through decreasing their feelings of learned helplessness. For the study, three children with mental retardation, whose 1Qs range from 60 to 75, were selected from those who were enrolled at special classes of elementary schools. They do not have physical handicapped and language problems. The procedure applied to this study focused on the changes the reason for the learning failure from "their ability" to "their lack of effort".

유색미에 관한 연구 : Ⅲ. 유색미 유망계통에 대한 주요 생육 특성

김광수,최윤표,김선택,최현구,정종태,김보경,유지홍,이희봉 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

국내외 유색미 수집종을 돌연변이원에 의해 유기된 우수 계통과 수집종간 상호교배에 의해 선발된 CNU 20계통을 파종하여 얻어진 주요 작물학적 특성을 살펴보면 다음과 같다. 1. 간장은 유색 메벼인 CNU126 계통이 대조품종인 동진벼와 같이 가장 컸고 메성인 CNU 128계통에서 가장 작았다. 2. 주당 분얼수는 CNU3, CNU50. CNU56, CNU112 계통에서 가장 많았고 대조품종과 CNU 128 계통에서 10개 미만으로 가장 적게 나타났다. 3. 수장은 육성 계통 중 CNU88 계통에서 가장 길었으나 대조구보다 짧고, 육성계통 중에서는 CNU 126 계통이 가장 짧았다. 4. 주당 영화수는 대조구인 동진벼보다 CNU50 계통에서 2배 이상 많았고, CNU158 계통에서 가장 적게 나타났다. 5. 천립중은 CNU113 계통에서 30g이상으로 대조구와 같이 가장 무거웠고, CNU128 계통에서 20g으로 가장 적었다. 6. 주당 수량은 대조구의 26.6g에 비해 CNU50, CNU112 계통에서 두배정도 높았고, CNU128, CNU158, CNU200 계통에서 가장 낮게 타나났다. Aims of this study were carried out to develop the useful lines induced from mutation and pedigree breeding methods among the collected genetic resources from national and domestic areas. In this study, Stem height of CNU126 line and check among them were high, while CNU128 was lower than other lines. Spiklet length of CNU88 was longer, but that of CNU126 was shorter than check. Number of spiklets per plant of CNU50 among lines have twice time than check. 1,000 grains weight of CNU113 was higher than check. In yield per plant, CNU50 and CNU112 were higher than check, Dongjinbyeo.

Comparison of Liver Transplantation and Liver Resection for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Type I and Type II

Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1

Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.

Modification of Starch Composition Using Downregulation of GBSS1 gene in Japonica Rice

Hye-Jung Lee,Moo-Geun Jee,Dal-A Yu,Me-Sun Kim,Franz Nogoy,Mingmao Sun,Sailila E. Abdula,Kwon-Kyoo Kang,Illsup Nou,Yong-Gu Cho 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

There is a great consideration on rice eating quality aside from improving its tolerance to various stresses. High yielding and pest and disease tolerant rice is highly desirable but it is more commercially important if it also has a high eating quality. There are various factors contributing to the good eating quality of rice. This study focuses on modifying the expression of GBSS1 genes which are responsible for amylopectin and amylose synthesis in rice by using RNAi and antisense techniques. We have developed 40 transgenic plants with RNAi-GBSS1 gene and 60 transgenic lines with antisense-GBSS1 gene. The transgenic plants show diverse amylose contents in rice seed. We selected candidate lines according to PCR, RNA expression and amylose contents. A semi-quantitative RT-PCR was carried out to measure the expression level of GBSS1 gene at several time points after the flowering of transgenic plants. The expression level of GBSS1 gene in rice grains decreases over time and the mRNA expression among the transgenic plants were lower compare to its wild type. In the SEM analysis, the starch granule of wild type Gopumbyeo has very large structures accompanied with small ones around the area. However, the starch structures in transgenic plants were smaller and more uniform in size and shape throughout the viewing area

Effects of oxyfluorination on a multi-walled carbon nanotube electrode for a high-performance glucose sensor

Yu, Hye-Ryeon,Kim, Jong Gu,Im, Ji Sun,Bae, Tae-Sung,Lee, Young-Seak Elsevier 2012 Journal of industrial and engineering chemistry Vol.18 No.2

<P><B>Abstract</B></P><P>A glucose sensor electrode was prepared with multi-walled carbon nanotubes (MWNTs) because of its effect on surface modification through oxyfluorination. The oxyfluorination of MWNTs was carried out with F<SUB>2</SUB>:O<SUB>2</SUB> ratios of 7:3, 5:5 and 3:7, which are labeled F7O3-MWNT, F5O5-MWNT, and F3O7-MWNT, based on the oxyfluorination conditions. The hydrophilic functional groups were introduced effectively on the hydrophobic carbon surface. In addition, the amorphous area of the MWNTs was affected by oxyfluorination. The reactivity of the glucose sensor was affected by the oxyfluorination treatment and the existence of amorphous on MWNTs. The optimum O/F percentage was approximately 50%. Therefore, the oxyfluorination conditions are important with amorphous MWNTs. The sensitivity was improved based on the effects of improved interface affinity between the enzyme and the carbon electrode. In addition, the presence of an amorphous area on MWNTs seems to be beneficial for efficient glucose oxidase immobilization, which results in high-performance glucose sensing.</P>

Expression of hMLH1, hMSH2 and hMSH6 in small intestinal carcinomas.

Gu, Mi Jin,Bae, Young Kyung,Kim, Aeri,Hong, Seung-Mo,Yu, Eunsil,Kim, Jihun,Jang, Kee-Taek,Chang, Hee-Kyung,Jung, Eun Sun,Bae, Han-Ik,Yoon, Ghil Suk,Kim, Joon Mee,Kim, Jung Yeon,Kim, Gwang Il,Oh, Young G. Thieme 2012 Hepato-gastroenterology Vol.59 No.119

<P>Although primary small intestinal carcinoma (SIC) is morphologically similar to colorectal carcinoma and shares many of the genetic changes of carcinogenesis, little is known about the role of defective mismatch repair (MMR) genes involved in the SIC. The aim of this study is to investigate the role of defective MMR genes and correlation between clinicopathological factors and loss of MMR protein in SIC.</P>

Low Thoracic Skeletal Mass is a Risk Factor for the Recurrence of Aspiration Pneumonia in Stroke Patients with Dysphagia Disorder

( Yu Jin Hong ),( Eung Gu Lee ),( Bo Mi Gil ),( Yong Hyun Kim ),( Sun Im ),( Hye Seon Kang ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Ojbectives This study aimed to investigate whether thoracic skeletal muscle mass index at the diagnosis of aspiration pneumonia is a predictor for the recurrence of aspiration pneumonia and to explore predicting factors for the recurrence of aspiration pneumonia in stroke patients with dysphagia disorder. Methods We retrospectively reviewed the data of patients with aspiration pneumonia who diagnosed with dysphagia disorder due to stroke from Jan. 2014 to Jul. 2020 in The Catholic University of Korea Bucheon St. Mary’s Hospital. Aspiration pneumonia was defined based on clinical signs of symptoms suggestive of pneumonia and radiologic findings of pneumonic infiltrations in the dependent portion of lung. We measured thoracic muscle volume by using the cross-sectional area (CSA) of the erector spinae muscle (ESMCSA , cm2) at the 12th vertebral region. CT scans at the time of diagnosis of aspiration pneumonia were used for analysis and respective CSA were divided by height squared (m2) to yield the muscle index at T12 (T12MI, cm2/m2) to normalize for stature. Multivariate logistic regression models were performed to investigate relationships between clinical parameters and recurrence of aspiration pneumonia. Results During study period, a total of 268 stroke patients with dysphagia disorder and developed aspiration pneumonia were analyzed. Mean T12MI of patients with and without recurrence of aspiration pneumonia was 708.1±229.9 cm2/m2 and 622.3±184.1 cm2/m2, respsectively (P=0.001). Multivariate logistic regression revelaed that lower T12MI (P=0.038) and older age (P=0.007) were the independent predictor of recurrence of aspiration pneumonia in stroke patients with dysphagia disorder. Conclusion Low thoracic muscle index at the diagnosis of aspiration pneumonia predicts recurrence of aspiration pneumonia in stroke patients with dysphagia disorder.

Peroxiredoxin 6 Overexpression Induces Anxiolytic and Depression-Like Behaviors by Regulating the Serotonergic Pathway in Mice

( Sun Mi Gu ),( Eunhye Yu ),( Young Eun Kim ),( Seong Shoon Yoon ),( Dohyun Lee ),( Jin Tae Hong ),( Jaesuk Yun ) 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.4

Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase and calcium-independent phospholipase activity. Recently, we reported that PRDX6 plays an important role in dopaminergic neurodegeneration in Parkinson’s disease. However, the relationship between PRDX6 function and emotional behavior remains elusive. In the present study, we examined depression- and anxiety-like behaviors in PRDX6-overexpressing transgenic (PRDX6-Tg) mice using the forced swim test, tail suspension test, open field paradigm, and elevated plus-maze. PRDX6-Tg mice exhibited depression-like behaviors and low anxiety. In particular, female PRDX6-Tg mice exhibited anxiolytic behavior in the open field test. Furthermore, the serotonin content in the cortex and 5-hydroxytryptophan-induced head twitch response were both reduced in PRDX6-Tg mice. Interestingly, levels of dopa decarboxylase expression in the cortex were decreased in male PRDX6-Tg mice but not in female mice. Our findings provide novel insights into the role of PRDX6 in 5-HT synthesis and suggest that PRDX6 overexpression can induce depression-like behaviors via downregulation of the serotonergic neuronal system.

흰쥐 해마에서 경련에 의해 발현 유도된 MKP-1에 의한 MAPK 활성 조절

유범희,강웅구,안용민,정선주,전송희,박주배,김용식 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 전기경련 충격(Electroconvulsive shock, ECS) 및 카이닌산(kainic acid)에 의한 경련은 흰쥐 해마에서 mitogen activated protein kinase(MAPK)를 활성화시키며, 동시에 MAPK 불활성화 효소인 MAPK phosphatase-1(MKP-1)의 발현을 일으킨다. 이 연구의 목적은 경련에 의해 발현된 MKP-1이 역시 경련에 의해 활성화된 MAPK의 불활성화에 관여하는지를 알아보고자 하는 것이다. 방 법 : 흰쥐에 ECS를 가하여 해마에서 MKP-1 발현을 일으킨 뒤 다시 ECS를 가하고, 두 번째 ECS에 의한 MAPK의 일시적 활성화가 MKP-1의 발현상태에 의해 영향받는지를 알아보았다. 또한 흰쥐에 지속적인 MAPK 활성화 및 MKP-1 발현을 일으키는 카이닌산을 투여한 뒤 해마에서 MKP-1의 발현과 MAPK 활성과의 관계를 알아보았다. 결 과 : ECS후 해마에서 타이로신 인산화 면역블롯 및 효소활성으로 측정한 MAPK의 인산화 및 활성은 MKP-1의 발현이 일어나 있는 경우와 그렇지 않은 경우 사이에 차이를 보이지 않았다. 카이닌산의 투여에 의해 MAPK 활성화가 일어나는 경우, 뒤이어 MKP-1 발현이 일어나지만, 이렇게 발현된 MKP-1은 MAPK 활성을 충분히 감소시키지 못하였다. 결 론 : MKP-1은 흰쥐 해마에서 ECS 및 카이닌산에 의한 MAPK의 활성화를 차단하는데 큰 역할을 하지 않는다. Objectives : Both electroconvulsive shock(ECS)- and kainic acid-induced seizures activate mitogen-activated protein kinases(MAPKs) in rat hippocampus. They can also induce the expression of MAPK phosphatase-1(MKP-1) in rat hippocampus. MKP-1 is known as a specific MAPK deactivator. This study aimed to elucidate the role of MKP-1 in the deactivation of MAPKs in rat hippocampus. Methods : In order to induce MKP-1 in the hippocampus, ECS was given to the rats. At the time points when MKP-1 was sufficiently induced, the second ECS was given to them and the subsequent phosphorylation or activation of MAPKs were measured in the hippocampus. A second group of rats were injected with kainic acid and the relationship between MKP-1 expression and MAPK phosphorylation was examined in their hippocampi. Results : The expression of MKP-1 did not influence the phosphorylation or activation of MAPKs following ECS in rat hippocampus. Kainic acid-induced expression of MKP-1 did not significantly reduce the phosphorylation of MAPKs. Conclusion : MKP-1 did not play a significant role in the deactivation of MAPKs which were activated by ECS or kainic acid in rat hippocampus.

Primary diffuse large B-cell lymphoma of the vulva: a case report

Sun Yeon Kim,Ju Hwan Koo,Juhun Lee,Yu-Jin Koo,Mi Jin Gu,Dae-Hyung Lee 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.-

Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin lymphoma (NHL) and is estimated to account for approximately 30% of all NHL cases. NHL can also occur in the female genital tract and accounts for approximately 1.5% of all NHL cases. Many doctors have difficulty diagnosing or treating vulvar DLBCL because of its very low prevalence. A 55-year-old woman presented with a solid mass on the right side of the vulva. No significantly enlarged lymph nodes were observed in the inguinal region. She underwent excisional biopsy at our institution. DLBCL was diagnosed based on histological examination. According to the Hans algorithm, the lesion was diagnosed as a non-germinal center B-cell-like subtype. The patient was referred to a hematologic oncologist. The disease stage was classified as IE according to the Ann Arbor staging classification. The patient received four cycles of chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone and localized radiation therapy with 36 Gy in 20 fractions. She showed complete remission and maintained this status on the latest computed tomography scan. Gynecologists should rule out lymphoma in patients presenting with a vulvar mass.