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( Jae-hyuk Han ),( Na-hyun Shin ),( Je-hoon Moon ),( Changhwan Yi ),( Soo-cheul Yoo ),( Joong Hyoun Chin ) 한국육종학회 2020 Plant Breeding and Biotechnology Vol.8 No.1
Saltol is one of the most well-known quantitative loci (QTLs) for salinity tolerance in rice. It has been used to develop highly tolerant rice varieties in saline and coastal areas in Southeast Asia, South Asia, and Africa. However, the functional activity of Saltol is not well known, and the molecular marker application of readily developed linked markers in Saltol has not always been successful in the rice breeding programs for salinity tolerance improvement. Interestingly, two BC<sub>2</sub>F<sub>9</sub> sister backcrossed inbred lines (BILs), which have been developed by marker-assisted backcrossing utilized the linked markers of Saltol to improve the salinity tolerance of MS11 (a temperate japonica growing in tropical condition). The BILs showed very different phenotypic and stress tolerance, although both contained the Saltol QTL. The genomic similarity of the two BILs was 73%, and we have identified the genomic sites of different genic constitutions between the lines utilizing background genotyping. The stress response of the two BILs showed difference in survival rate, grain yield under highly saline field condition, and SPAD, SES in hydroponic conditions. MS11-SaltolA showed salinity tolerance through Na<sup>+</sup>/K<sup>+</sup> homeostasis with relatively high K<sup>+</sup> ion uptake and low Na<sup>+</sup> ion uptake in the seedling stage. Further genomic analyses with whole genome resequencing is ongoing to study on gene interactions. The developed highly tolerant MS11-SaltolA can be used as an improved donor in rice molecular breeding for high salinity tolerance.
소아 마이코플라스마 폐렴의 다양한 임상 양상에 연관된 요인들
김유나 ( Yoo Na Kim ),박철휘 ( Chul Hyue Park ),김수희 ( Su Hee Kim ),유수진 ( Soo Jin Yoo ),김효빈 ( Hyo Bin Kim ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4
Purpose: Mycoplasma pneumonia (MP) is a major cause of community-acquired pneumonia in children and young adults. We aimed to investigate the factors that may influence on the clinical manifestations of MP in children. Methods: A total of 109 admitted children from October 2011 to February 2012 were prospectively enrolled with physical examination and laboratory tests (complete blood count, C-reactive protein [CRP], and particle agglutinin assay). The diagnosis of MP was made when there was an infiltration on the chest X-ray and the particle agglutination test was once over 1:640 or showed 4-fold increase in serial tests. They were grouped by age, fever duration after treatment, presence of pleural effusion and wheezing. Results: Preschool children showed shorter duration of fever (P=0.001), more wheezing (P<0.001), lower segmented neutrophil (P<0.001), and lower CRP levels (P=0.004) compared to schoolchildren. Prolonged fever (>3 days) and pleural effusion were developed in children with higher CRP (P=0.018 and P=0.007). Wheezing has been developed in children with younger age (P=0.007). Conclusion: Younger age was a risk factor to develop wheezing in MP and prolonged fever and pleural effusion were more likely to develop in children with higher CRP. (Allergy Asthma Respir Dis 2013;1:357-361)
소아 마이코플라스마 폐렴의 다양한 임상 양상에 연관된 요인들
김유나 ( Yoo Na Kim ),박철휘 ( Chul Hyue Park ),김수희 ( Su Hee Kim ),유수진 ( Soo Jin Yoo ),김효빈 ( Hyo Bin Kim ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: Mycoplasma pneumonia (MP) is a major cause of community-acquired pneumonia in children and young adults. We aimed to investigate the factors that may influence on the clinical manifestations of MP in children. Methods: A total of 109 admitted children from October 2011 to February 2012 were prospectively enrolled with physical examination and laboratory tests (complete blood count, C-reactive protein [CRP], and particle agglutinin assay). The diagnosis of MP was made when there was an infiltration on the chest X-ray and the particle agglutination test was once over 1:640 or showed 4-fold increase in serial tests. They were grouped by age, fever duration after treatment, presence of pleural effusion and wheezing. Results: Preschool children showed shorter duration of fever (P=0.001), more wheezing (P<0.001), lower segmented neutrophil (P<0.001), and lower CRP levels (P=0.004) compared to schoolchildren. Prolonged fever (>3 days) and pleural effusion were developed in children with higher CRP (P=0.018 and P=0.007). Wheezing has been developed in children with younger age (P=0.007). Conclusion: Younger age was a risk factor to develop wheezing in MP and prolonged fever and pleural effusion were more likely to develop in children with higher CRP.
Jeong, Na Young,Lee, Jee Suk,Yoo, Ki Soo,Oh, Soojung,Choe, Eunok,Lee, Hye-Jeong,Park, Bong Soo,Choi, Yung Hyun,Yoo, Young Hyun Rapid Science Publishers ; Kluwer Academic Publish 2013 Apoptosis Vol.18 No.2
<P>Fatty acid synthase (FASN) is overexpressed in a wide variety of human cancers, making it an attractive target for anticancer therapy. One of the most widely used inhibitors of FASN, cerulenin, is a natural product of Cephalosporium caerulens. Cerulenin is selectively toxic to human cancer cells in vitro. However, the mechanism by which FASN inhibition causes apoptosis in tumor cells remains unclear. Because of the widespread clinical interest in combining cerulenin with other chemotherapeutic agents, we performed this study to gain insight into the downstream effects of FASN inhibition that lead to apoptosis. Here, we observed the increased antitumor effect of cerulenin when combined with the topoisomerase inhibitor SN-38. We identified topoisomerase I as a potential mediator of cerulenin-induced apoptosis, possibly by upregulating intracellular polyunsaturation. Finally, we show that suppressing topoisomerase I catalytic activity results in synergistic effects between cerulenin and LY294002. Our results suggest that topoisomerase I could participate in cerulenin-induced apoptosis by upregulating intracellular polyunsaturation. These results will help determine the molecular basis of the cerulenin and SN-38 drug combination. Further investigation of this pathway will provide new insight into cancer cell metabolism and may aid in the design of additional cancer chemotherapeutic agents.</P>
Complete sequence-based screening of TPMT variants in the Korean population
Kim, Hyun-Young,Lee, Soo Hyun,Lee, Mi-Na,Kim, Jong-Won,Kim, Young-Ho,Kim, Mi Jin,Lee, Yoo Min,Kang, Ben,Choe, Yon Ho,Lee, Na Hee,Kim, Dong Hwan,Yoo, Keon Hee,Sung, Ki Woong,Lee, Soo-Youn,Koo, Hong Hoe Wolters Kluwer Health, Inc. All rights reserved. 2015 PHARMACOGENETICS AND GENOMICS Vol.25 No.3
Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs and its activity is largely influenced by polymorphisms of the TPMT gene. To date, more than 35 TPMT variants are known to be associated with reduced enzyme activity, but most studies on the TPMT genotype have included only common nonfunctional variants, such as TPMT*2 and TPMT*3. In this study, we carried out a complete sequencing analysis to screen all TPMT variants in Korean patients. A total of 900 Korean patients were genotyped for TPMT and 30 patients (3.3%) had the known TPMT variant alleles. TPMT*3C was found in 25 patients (2.8%): 24 patients with TPMT*1/*3 and one with TPMT*3/*3. Rare TPMT variants including TPMT*6, TPMT*16, and TPMT*32 were detected in five patients (0.6%) and a novel variant, TPMT*38 (c.514T>C, p.S172P), was identified in two patients. This is the first complete sequence-based screening study evaluating all TPMT variants in Asian populations.
( Soo-jin Cho ),( Ha-na Jang ),( Sung-jin Cho ),( Young-sam Yoon ),( Heung-min Yoo ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-
The scrapping rate is increasing as various incentives are provided for the early scrapping of internal combustion engine vehicles and the purchase of electric vehicles. As a results, the amount of waste generated by end-of-life vehicles (ELVs) is increasing. Many countries, including Korea, are directing ELVs to comply with a recycling rate of 95% (including 10% of energy recovery). However, the recycling rate in Korea has not been reached since 2015, as about 89%. For these reasons, emphasizes the importance of improving recycling rate of ELVs. To evaluate the recyclability and environmental properties of Automobile Shredder Residues (ASR) melting slag, characteristic analysis, leaching test and heavy metal analysis were conducted. The four types of bricks were manufactured using ASR melting slag; interlocking brick, clay brick, Asphalt paving aggregate, lightweight swelled ceramic brick. Density and absorption ratio of ASR slag were 2.24 g/㎤ and 0.34% respectively. The structure of slag from XRD analysis results were amorphous. Basicity (CaO/SiO<sub>2</sub>) was 1.01, this values are higher than general slag of municipal solid waste in Korea. The results of the leaching test, all of the pollutants measured in the satisfied the Korean standard. Heavy metals concentration in slag contained Fe, Al, Cr, Hg, and Cd very small amount relatively. The interlocking brick substituted sand and stone powder by melting slag using as aggregates. As increasing melting slag content, absorption decreased and bending strength increased. Clay brick was manufactured for replacing kaolin and feldspar by melting slag that substituted by 20%. The quality of clay bricks mixed over 15% melting slag was not better than standard. Asphalt paving aggregate was investigating the optimum condition of slag content in mixed asphalt, the mixture ratio showed that 61% broken stone of 13 mm, 6% screenings, 10% melting slag, 15% sand and 8% of filler. A lightweight swelled ceramic brick was manufactured by using melting slag, front glass and so on. Specific gravity and compressive strength were ranged from 0.38 to 0.51 and from 339.7 to 373.6 N/㎠. The four types of bricks satisfied each KS quality and waste recycling standard. This study, evaluated the possibility of material recycling using ASR. ASR was found to be effective not only for energy and material recovery, but also as a material recycling resource. Therefore, if the results of this study are applied for ASR recycling, it is expected that 95% of Korea ELVs recycling rate would be archived along with eco-friendly treatment.