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Sim, Hyun-Jaung,Kim, Min-Hye,Bhattarai, Govinda,Hwang, Jae-Won,So, Han-Sol,Poudel, Sher Bahadur,Cho, Eui-Sic,Kook, Sung-Ho,Lee, Jeong-Chae Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.4
Numerous studies highlight the potential benefits potentials of supplemental cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) through improved angiogenic effects. However, our recent findings show that excessive overexpression of COMP-Ang1 induces an impaired bone marrow (BM) microenvironment and senescence of hematopoietic stem cells (HSCs). Here, we investigated the underlying mechanisms of how excessive COMP-Ang1 affects the function of BM-conserved stem cells and hematopoiesis using K14-Cre;inducible-COMP-Ang1-transgenic mice. Excessive COMP-Ang1 induced peripheral egression and senescence of BM HSCs and mesenchymal stem cells (MSCs). Excessive COMP-Ang1 also caused abnormal hematopoiesis along with skewed differentiation of HSCs toward myeloid lineage rather than lymphoid lineage. Especially, excessive COMP-Ang1 disturbed late-stage erythroblast maturation, followed by decreased expression of stromal cell-derived factor 1 (SDF-1) and globin transcription factor 1 (GATA-1) and increased levels of superoxide anion and p-p38 kinase. However, transplantation with the mutant-derived BM cells or treatment with rhCOMP-Ang1 protein did not alter the frequency or GATA-1 expression of erythroblasts in recipient mice or in cultured BM cells. Together, our findings suggest that excessive COMP-Ang1 impairs the functions of BM HSCs and MSCs and hematopoietic processes, eventually leading to abnormal erythropoiesis via imbalanced SDF-1/CXCR4 axis and GATA-1 expression rather than Ang1/Tie2 signaling axis alterations.
CO2 농도 및 기온 상승이 현사시나무의 수분생리 특성에 미치는 영향
이솔지 ( Sol Ji Lee ),한심희 ( Sim Hee Han ),오창영 ( Chang Young Oh ),김기우 ( Ki Woo Kim ),김판기 ( Pan Gi Kim ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
기후변화에 적응력이 높은 조림수종을 탐색하기 위하여 CO2 농도 및 기온 상승이 현사시나무의 수분생리에 미치는 영향을 조사하였다. 현사시나무는 CO2 농도 및 기온이 상승된 조건에서 엽량 및 엽면적이 감소하였고, 섬모의 엽면 피복도가 현격하게 증가하였다. 또한, 기공전도도 및 증산속도는 낮은 값을 유지하였으며, 광도 및 CO2 농도 상승에 따른 변화가 거의 나타나지 않았다. 이로써 처리구의 수분이용효율 및 상태함수율은 대조구에 비해 높은 값을 가질 수 있었다. 이러한 결과로부터 CO2 농도 및 기온 상승된 조건에서 현사시나무는 엽면경계층과 기공저항의 증가로 수분손실을 억제하는 능력이 뛰어남을 알 수 있었다. 현사시나무는 수분스트레스에 대한 높은 가소성과 조직의 형태를 변화시키는 기작으로 기후변화 환경에 적응하고 있는 것으로 사료된다. This study was conducted to investigate the water physiology characters of Populus alba× glandulosa cuttings in response to elevated CO2 concentration and air temperature for selecting tree species adaptive to climate change. The poplars under the elevated treatment showed a decrease in the leaf number and area, compared with those under the ambient condition. Having denser leaf hairs, the poplars under the treatment maintained lower stomatal conductance and slower transpiration rate. These results indicate that increased leaf boundary layer and stomatal resistance of poplars under elevated treatment allowed higher water use efficiency and water retentivity. The phenotypic plasticity of leaves in response to water stress would probably enable the poplars to cope with possible climate change conditions.