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Trend of Cancer Incidence in Nepal from 2003 to 2012
Poudel, Krishna Kanta,Huang, Zhibi,Neupane, Prakash Raj Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Trends in cancer incidence is a key tool to identify the pattern of cancer of any country. This retrospective study was performed to present the trends of change in cancer incidence in Nepal.The total number of cancer cases in males was 26,064 while the total number of females cancer cases was 29,867 throughout the 10 years from 2003 to 2012. The cancer incidence per 100,000 in males was 12.8 in 2003 and 25.8 people in 2012. Similarly, in females, the crude incidence rate was 15.1 in 2003 and 26.7 per 100,000 in 2012. Cancer incidence was low at early age but it was increased with age in both sexes in Nepal. Lung cancer was the most common cancer in males throughout, while it was the third most common cancer in females. Cervix uteri was the most common site of cancer in females throughout the 10 years, with a clear trend for increase in breast cancer within this time.
Poudel, Tej Narayan,Khanal, Hari Datta,Lee, Yong Rok The Royal Society of Chemistry 2018 NEW JOURNAL OF CHEMISTRY Vol.42 No.6
<P>An unprecedented methodology for the preparation of diverse <I>S</I>-alkyl 2-aminoarylthioates has been developed based on cesium carbonate-promoted direct ring opening of 3-chlorooxindoles with thiols. This novel protocol proceeds <I>via</I> cascade sulfenylation, aerial oxidation, C2-C3 bond cleavage, and decarboxylation. The resulting products from this transformation exhibit potential for application as fluorescent sensors for the detection of Fe<SUP>3+</SUP> ions. In addition, this methodology provides a concise pathway for the construction of a variety of biologically interesting quinazolin-4(3<I>H</I>)-ones in good yields.</P>
Poudel, Seeta,Lee, Youngseok Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.7
Neurodegeneration can result in memory loss in the central nervous system (CNS) and impairment of taste and smell in the peripheral nervous system (PNS). The neurodegeneration seen in Parkinson's disease (PD) is characterized by functional loss of dopaminergic neurons. Recent studies have also found a role for dopaminergic neurons in regulating taste memory rewards in insects. To investigate how taste memories and sugar sensitivity can be affected in PD, we utilized the $DJ-1{\beta}$ mutant fruit fly, $DJ-1{\beta}^{ex54}$, as a PD model. We performed binary choice feeding assays, electrophysiology and taste-mediated memory tests to explore the function of the $DJ-1{\beta}$ gene in terms of sugar sensitivity as well as associative taste memory. We found that PD flies exhibited an impaired ability to discriminate sucrose across a range of sugar concentrations, with normal responses at only very high concentrations of sugar. They also showed an impairment in associative taste memory. We highlight that the taste impairment and memory defect in $DJ-1{\beta}^{ex54}$ can be recovered by the expression of wild-type $DJ-1{\beta}$ gene in the dopaminergic neurons. We also emphasized the role of dopaminergic neurons in restoring taste memory function. This impaired memory property of $DJ-1{\beta}^{ex54}$ flies also allows them to be used as a model system for finding supplementary dietary foods that can improve memory function. Here we provide evidence that the associative taste memory of both control and $DJ-1{\beta}^{ex54}$ flies can be enhanced with dietary supplementation of the medicinal plant, omija.
Comparison of Different Deep Learning Optimizers for Modeling Photovoltaic Power
Poudel, Prasis,Bae, Sang Hyun,Jang, Bongseog The Basic Science Institute Chosun University 2018 조선자연과학논문집 Vol.11 No.4
Comparison of different optimizer performance in photovoltaic power modeling using artificial neural deep learning techniques is described in this paper. Six different deep learning optimizers are tested for Long-Short-Term Memory networks in this study. The optimizers are namely Adam, Stochastic Gradient Descent, Root Mean Square Propagation, Adaptive Gradient, and some variants such as Adamax and Nadam. For comparing the optimization techniques, high and low fluctuated photovoltaic power output are examined and the power output is real data obtained from the site at Mokpo university. Using Python Keras version, we have developed the prediction program for the performance evaluation of the optimizations. The prediction error results of each optimizer in both high and low power cases shows that the Adam has better performance compared to the other optimizers.
Poudel, Tej Narayan,Karanjit, Sangita,Khanal, Hari Datta,Tamargo, Ramuel John Inductivo,Lee, Yong Rok American Chemical Society 2018 ORGANIC LETTERS Vol.20 No.18
<P>An efficient synthesis of highly π-extended carbazoles is described via an unexpected domino [5 + 3 + 1] annulation approach. The Cu(I)-/base-promoted reactions of 2-nitrocinnamaldehydes with benzyl cyanides provide diverse benzo[<I>b</I>]carbazoles. The reaction is proposed to proceed via a sequential Michael addition/intramolecular addition of an enol into a nitro group, 6π- electrocyclization, and the final oxidative aromatization as supported by density functional theory calculations. Some of the synthesized carbazoles showed significant potential in fluorescence sensing of Cu<SUP>2+</SUP> ions.</P> [FIG OMISSION]</BR>
( Poudel Jeeban ),김원태 ( Won Tae Kim ),엄태인 ( Tae In Ohm ),오세천 ( Sea Cheon Oh ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.5
반탄화는 200~300 oC의 불활성분위기에서 바이오매스를 전처리하는 열처리공정이며 이러한 반탄화 공정은 바이오매스에 함유된 섬유질성분의 분해온도에 크게 영향을 받은 것으로 알려져 있다. 본 연구에서는 사탕수수 부산물의 반탄화 특성에 관한 연구를 수행하였으며 반탄화 온도 및 반탄화 시간에 따른 에너지 수율, 발열량 및 발생가스 그리고가연분과 회분의 관계에 중점을 두었다. 또한 본 연구에서는 TGA(Thermogravimetric Analyzer)를 이용한 사탕수수 부산물의 반탄화 반응에 대한 활성화 에너지의 변화도 함께 고찰하였다. 본 연구로부터 반탄화 온도에 따라 회분 및 발열량은 증가하였으나 가연분 및 에너지 수율은 감소하였으며 또한 산소성분을 함유한 일산화탄소가 탄화수소 화합물,CxHy보다 더 낮은 온도에서 분해되기 시작하는 것을 확인할 수 있었다. Torrefaction is a thermal treatment process to pre-treat biomass at temperature of 200~300 oC under aninert atmosphere. It was known that torrefaction process strongly depended on the decomposition temperature of the lignocellulosicconstituents in biomass. In this work, the torrefaction characteristics of baggase has been studied. This studyfocuses on the relation between the energy yields, heating values, gas emission, volatile and ash constituents with torrefactiontemperatures and times. The activation energies of baggase torrefaction has been studied by using TGA (ThermogravimetricAnalyzer). From this work, it was seen that ash constituents and heating values were increased withtorrefaction temperature, while volatile constituents and energy yields decreased. It was also found that carbon monoxidecontaining oxygen were decomposed at a lower temperature than those of hydrocarbon compounds, CxHy.