Identification and Characterization of New Invasion Relating Molecules of Oral Squamous Cell Carcinoma

Takashi Takata,Yasusei Kudo,Hiroko Hatano,kuko Ogawa,Samadarani Siriwardena,Shoïro Kitajima,Masae Kitagawa,Mutsumi Miyauchi 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.2

Oral squamous cel1 carcinoma(OSCC) is the most common malignancy of head neck region. Typically OSCC cells s how persist ent invasion that frequently leads to local recurrence and distant lymphatic metastasls However, molecular mechanisms of invasion of OSCC remain poorly understood. Her e we identifi ed periostin, interferon induced transmembrane protein l (IF1TM1) and wingless-type MMTV integration site family, member 5B(WNT5B) , as invasion promoting molecules in OSCC by comparing gene expression profiles between a parent OSCC cell line(MSCC-l) and its highly invasive clone(MSCC-1nvl). Overexpression of periostin, IFITMl and WNT5B mRNAs were confirmed in MSCC-1nvl by RT-PCR. Transfection of these molecules promoted invasion of OSCC cells Moreover , siRNA t r eatment of these molecules suppressed invasion of cancer cells in vitro I nter estingly, Periostin, 1F1TMl and WNT5B were highly expressed in OSCCs in comparison with nonnal tissues. 1n an orthotopic mouse model of OSCC, periostin-overexpressing cells metas tasized spontaneously to cervical lymph nodes and t o t he lung through their aggressive invasiveness. These findings suggest that peri ostin, IFITMl and WNT5B play important roles for invasion and of OSCC and can be prognostic markers and therapeutic t argets of OSCC.

Neuroimmune interactions and kidney disease

Sho Hasegawa,Tsuyoshi Inoue,Reiko Inagi 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.3

The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a wellstudied neuroimmune interaction involving the vagus nerve. CD4-positive T cells expressing β2 adrenergic receptors and macrophages expressing the alpha 7 subunit of the nicotinic acetylcholine receptor in the spleen receive neurotransmitters such as norepinephrine and acetylcholine and are key mediators of the cholinergic antiinflammatory pathway. Recent studies have demonstrated that vagus nerve stimulation, ultrasound, and restraint stress elicit protective effects against renal ischemia-reperfusion injury. These protective effects are induced primarily via activation of the cholinergic anti-inflammatory pathway. In addition to these immunological roles, nervous systems are directly related to homeostasis of renal physiology. Whole-kidney three-dimensional visualization using the tissue clearing technique CUBIC (clear, unobstructed brain/body imaging cocktails and computational analysis) has illustrated that renal sympathetic nerves are primarily distributed around arteries in the kidneys and denervated after ischemia-reperfusion injury. In contrast, artificial renal sympathetic denervation has a protective effect against kidney disease progression in murine models. Further studies are needed to elucidate how neural networks are involved in progression of kidney disease.

Hemoptysis due to pulmonary infarction in COVID-19

( Sho Yamada ),( Akimasa Sekine ),( Takashi Ogura ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4

Three-Dimensional Mapping of Agricultural Fields Using 3D LiDAR and Simultaneous Localization and Mapping Algorithm

( Sho Igarashi ),( Yutaka Kaizu ),( Kenji Imou ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

In recent years, robotic technology has been adopted in agriculture to improve productivity and competitiveness. Precise and robust environmental perception is an important requirement to resolve issues such as safe interaction with obstacle and localization for autonomous robot vehicle. Accordingly, we propose the use of a Simultaneous Localization and Mapping algorithm, to generate local maps of agricultural fields. In our study, the 3D data required for the mapping process were collected using 3D LiDAR(Velodyne VLP-16). The resulting 3D map is formed by a 3D point cloud data, and its distance accuracy was evaluated. Evaluation of distance accuracy was made by comparing with positioning data with absolute coordinates measuring by dual-frequency Global Navigation Satellite System(GNSS). The results show that the mean deviation error and RMSE are approximately 0.03 m and 0.13 m, respectively. We conclude that our 3D point clouds maps have acceptable quality and can support process automation of fields by autonomous robot vehicle.

Numerical Analysis of Drag and Heating Reduction by Directed Energy Air Spike

Sho Sasamoto,Etsuo Morishita 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-

It is well known to the aerospace engineering community that aerodynamic drag and heating are extremely critical issues at hyper velocities. Directed Energy Air Spike (DEAS) is a method to deposit a small amount of energy in the flow ahead of a blunt body and to reduce the drag and the heating. The hypersonic flow at M=7 past the blunt body is investigated numerically. The axis-symmetric bodies are studied. The compressible Navier-Stokes Equations are solved by the AUSM-DV scheme. The effects of heat addition and its location are of a particular interest in the present calculation. And the computational results show that optimum amount and location of the heat addition could be determined aerodynamically. The present calculations also confirm that DEAS is a very effective method for the drag and heat transfer reduction at hypersonic speeds.

Highly Accurate Analysis of the Cervical Neural Tract of the Elderly Using ZOOM DTI

Sho Furuya,Motoyuki Iwasaki,Takumi Yokohama,Daisuke Ohura,Tomoyuki Okuaki 대한척추신경외과학회 2018 Neurospine Vol.15 No.2

Objective: To investigate the fractional anisotropy (FA) values of the cervical spinal cord in elderly individuals using zonally magnified oblique multislice (ZOOM) diffusion tensor imaging (DTI). Methods: Fourteen healthy elderly volunteers (group E) and 10 young volunteers (group Y) were enrolled. We assessed the FA, apparent diffusion coefficient (ADC), and λ1–λ3 values using 3-T magnetic resonance imaging. The region of interest was contoured entirely inside the spinal cord, with no gray/white matter distinction, in order to avoid including the cerebrospinal fluid. Results: As lower cervical levels were approached, the FA values gradually decreased, while the ADC values increased. The mean FA values at each cervical level were as follows in groups E and Y: 0.71 and 0.70 at the C2/3 level, 0.66 and 0.66 at the C3/4 level, 0.63 and 0.62 at the C4/5 level, 0.57 and 0.57 at the C5/6 level, and 0.58 and 0.57 at the C6/7 level, respectively. The mean ADC values in groups E and Y were 1.06 and 0.99 at the C2/3 level, 1.05 and 1.06 at the C3/4 level, 1.14 and 1.06 at the C4/5 level, 1.18 and 1.21 at the C5/6 level, and 1.39 and 1.46 at the C6/7 level, respectively. There were no significant differences between the elderly and young participants. Conclusion: In both asymptomatic elderly and young individuals, the FA values gradually decreased and the ADC values increased moving towards lower cervical levels. Age did not affect the FA values, even though mild cord compression was evident due to spondylotic changes. ZOOM DTI has the potential to provide more information than conventional DTI.

Minimum variation log-aesthetic surfaces and their applications for smoothing free-form shapes

Sho Suzuki,R.U. Gobithaasan,Péter Salvi,Shin Usuki,Kenjiro T. Miura 한국CDE학회 2018 Journal of computational design and engineering Vol.5 No.2

The log-aesthetic curve, which includes the logarithmic (equiangular) spiral, clothoid, and involute of a circle, achieves a control over curvature distribution by defining its shape as an integral form of its curvature and they are expected to be utilized for the field of design. However, it is very difficult to extend it to surfaces and the existing formulations have some problems that they cannot use arbitrary boundary curves. In this paper, we propose ‘‘minimum variation log-aesthetic surface” as a new formulation for the log-aesthetic surface. Based on variational principle our method can generate surfaces by minimizing the objective function newly proposed in this paper for given arbitrary boundary curves.

Endoscopic Interventions for the Early and Remission Phases of Acute Biliary Pancreatitis: What are the More Concrete and Practical Situations for Performing Them?

Sho Hasegawa,Shinsuke Koshita,Yoshihide Kanno,Takahisa Ogawa,Toshitaka Sakai,Hiroaki Kusunose,Kensuke Kubota,Atsushi Nakajima,Yutaka Noda,Kei Ito 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6

Background/Aims: The use of endoscopic intervention (EI) for acute biliary pancreatitis (ABP) remains controversial because theseverity of biliary obstruction/cholangitis/pancreatitis is not reflected in the indications for early EI (EEI). Methods: A total of 148 patients with ABP were included to investigate 1) the differences in the rate of worsening cholangitis/pancreatitis between the EEI group and the early conservative management (ECM) group, especially for each severity of cholangitis/pancreatitis, and 2) the diagnostic ability of imaging studies, including endoscopic ultrasound (EUS), to detect common bile ductstones (CBDSs) in the ECM group. Results: No differences were observed in the rate of worsening cholangitis between the EEI and ECM groups, regardless of theseverity of cholangitis and/or the existence of impacted CBDSs. Among patients without impacted CBDSs and moderate/severecholangitis, worsening pancreatitis was significantly more frequent in the EEI group (18% vs. 4%, p=0.048). In patients in the ECMgroup, the sensitivity and specificity for detecting CBDSs were 73% and 98%, respectively, for EUS, whereas the values were 13% and92%, respectively, for magnetic resonance cholangiopancreatography. Conclusions: EEI should be avoided in the absence of moderate/severe cholangitis and/or impacted CBDSs because of the high rateof worsening pancreatitis. EUS can contribute to the accurate detection of residual CBDSs, for the determination of the need forelective EI.

Duration of Trade: Comparative Analysis of Homogeneous and Differentiated Products in Asia

Sho HANEDA 한국무역학회 2019 한국무역학회 국제학술대회 Vol.2019 No.08

Incidence of metastasis in circumflex iliac nodes distal to the external iliac nodes in cervical cancer

Sho Takeshita,Yukiharu Todo,Kazuhira Okamoto,Satoko Sudo,Katsushige Yamashiro,Hidenori Kato 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.4

Objective: A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. Methods: A retrospective chart review was carried out for 531 patients with cervical cancer who underwent lymph node dissection between 1993 and 2014. CINDEIN metastasis was pathologically identified by microscopic investigation. After 2007, sentinel lymph node biopsy was performed selectively in patients with non-bulky cervical cancer. The sentinel node was identified using 99mTc-phytate and by scanning the pelvic cavity with a γ probe. Results: Two hundred and ninety-seven patients (55.9%) underwent CINDEIN dissection and 234 (44.1%) did not. The percentage of International Federation of Gynecology and Obstetrics stage IIb to IV (42.4% vs. 23.5%, p<0.001) was significantly higher in patients who underwent CINDEIN dissection than those who did not. CINDEIN metastasis was identified in 1.9% overall and in 3.4% of patients who underwent CINDEIN dissection. For patients with stage Ia to IIa disease, CINDEIN metastasis was identified in 0.6% overall and in 1.2% of patients who underwent CINDEIN dissection. Of 115 patients with sentinel node mapping, only one (0.9%) had CINDEIN detected as a sentinel node. In this case, the other three lymph nodes were concurrently detected as sentinel lymph nodes. Conclusion: CINDEIN dissection can be eliminated in patients with stage Ia to IIa disease. CINDEIN might not be regional lymph nodes in cervical cancer.