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Shin,Deug Yong,Im,Dong-Soo,Seong,Young Rim,Kim,Boo Sung,Hong,Eun-Gyeong,Choi,Jong Young,Byun,Byung Hun,Park,Young Min 가톨릭중앙의료원 가톨릭암센터 1998 암심포지움 Vol.- No.2
Mutations of the tumor-suppressor gene p53 have been found in 30-50% cases of hepatocellular carcinoma (HCC). In the this study, E1-negative adenoviral vector encoding wild-type p53 under the control of the human cytomegalovirus promoter (AdCMV-p53w) was constructed to evaluate its therapeutic efficacy against tumor nodules developing after injection of HuH7 cell lines in the 10 nude mice.
수질오염총량관리 단위유역 장기유황곡선 구축 -낙동강수계를 대상으로-
김경훈 ( Gyeong Hoon Kim ),권헌각 ( Heon Gak Kwon ),안정민 ( Jung Min Ahn ),김상훈 ( Sanghun Kim ),임태효 ( Tae Hyo Im ),신동석 ( Dong Seok Shin ),정강영 ( Kang-young Jung ) 한국환경과학회 2017 한국환경과학회지 Vol.26 No.8
For the development of flow duration curves for the management of 41 Total Maximum Daily Load (TMDL) units of the Nakdong River basin, first, an equation for estimating daily flow rates as well as the level of correlation (correlation and determination coefficients) was extrapolated through regression analysis of discrete (Ministry of Environment) and continuous (Ministry of Land, Infrastructure and Transportation) measurement data. The equation derived from the analysis was used to estimate daily flow rates in order to develop flow duration curves for each TMDL unit. By using the equation, the annual flow duration curves and flow curves, for the entire period and for each TMDL unit of the basin, were developed to be demonstrated in this research. Standard flow rates (abundant-, ordinary-, low- and drought flows) for major flow duration periods were calculated based on the annual flow duration curves. Then, the flow rates, based on percentile ranks of exceedance probabilities (5, 25, 50, 75, and 95%), were calculated according to the flow duration curves for the entire period and are suggested in this research. These results can be used for feasibility assessment of the set values of primary and secondary standard flow rates for each river system, which are derived from complicated models. In addition, they will also be useful for the process of implementing TMDL management, including evaluation of the target level of water purity based on load duration curves.
Yu, Gyeong Im,Kim, Su Kang,Park, Hae Jeong,Kim, Jong Woo,Chung, Joo‐,Ho,Shin, Dong Hoon Wiley Subscription Services, Inc., A Wiley Company 2012 Synapse Vol.66 No.11
<P><B>Abstract</B></P><P><B>Objective:</B> The aim of this study was to investigate the association between the exonic single nucleotide polymorphisms (SNPs) of <I>synapsin I</I> (<I>SYN1</I>) (rs1142636, Asn170Asn, Xp11.23) and <I>SYN2</I> (rs2289708, 3′‐untranslated region, 3p25) in schizopherenia. <B>Methods:</B> Two hundred eighty six schizophrenia patients and 304 control subjects were recruited. SNPs with a know heterozygosity and minor allele frequency (MAF) > 0.1 in Asian populations were selected and genotyped by direct sequencing. <B>Results:</B> The allelic frequencies of rs1142636 (<I>SYN1</I>) were associated with schizophrenia (<I>P</I> < 0.05), respectively. The allelic frequency of rs1142636 in all subjects was associated with schizophrenia [<I>P</I> = 0.000059, OR = 2.17 (95% CI = 1.47–3.18)]. The C allele frequency of rs1142636 was higher in schizophrenia (20.8%) than that in controls (10.8%). In the analysis of gender, the allelic frequency of rs1142636 was also strongly associated with female schizophrenia [<I>P</I> = 0.0001, OR = 2.65 (95% CI = 1.61–4.36)], but not with male schizophrenia. The C allele frequency of rs1142636 was higher in female schizophrenia (22.2%) than that in female controls (9.7%). The rs2289708 SNP (<I>SYN2</I>) did not show any association between schizophrenia and controls. <B>Conclusions:</B> These results suggest that the C allele of a synonymous SNP (rs1142636, Asn170Asn, Xp11.23) in <I>SYN1</I> may be a risk factor for the susceptibility of Koreran female schizophrenia. Synapse 66:979–983, 2012. © 2012 Wiley Periodicals, Inc.</P>
Mun, Kwang Ho,Yu, Gyeong Im,Choi, Bo Youl,Kim, Mi Kyung,Shin, Min-Ho,Shin, Dong Hoon The Korean Society for Preventive Medicine 2018 예방의학회지 Vol.51 No.5
Objectives: Several studies have investigated the effects of serum uric acid (SUA) levels on chronic kidney disease (CKD), with discrepant results. The effect of SUA levels on CKD development was studied in the Korean rural population. Methods: A total of 9695 participants aged ${\geq}40years$ were recruited from 3 rural communities in Korea between 2005 and 2009. Of those participants, 5577 who participated in the follow-up and did not have cerebrovascular disease, myocardial infarction, cancer, or CKD at baseline were studied. The participants, of whom 2133 were men and 3444 were women, were grouped into 5 categories according to their quintile of SUA levels. An estimated glomerular filtration rate of < $60mL/min/1.73m^2$ at the time of follow-up was considered to indicate newly developed CKD. The effects of SUA levels on CKD development after adjusting for potential confounders were assessed using Cox proportional hazard models. Results: Among the 5577 participants, 9.4 and 11.0% of men and women developed CKD. The hazard ratio (HR) of CKD was higher in the highest quintile of SUA levels than in the third quintile in men (adjusted HR, 1.60; 95% confidence interval [CI], 1.02 to 2.51) and women (adjusted HR, 1.56; 95% CI, 1.14 to 2.15). Furthermore, CKD development was also more common in the lowest quintile of SUA levels than in the third quintile in men (adjusted HR, 1.83; 95% CI, 1.15 to 2.90). The effect of SUA was consistent in younger, obese, and hypertensive men. Conclusions: Both high and low SUA levels were risk factors for CKD development in rural Korean men, while only high levels were a risk factor in their women counterparts.
Cha Joon-Yung,Shin Gyeong-Im,Ahn Gyeongik,Jeong Song Yi,Ji Myung Geun,Alimzhan Aliya,Kim Min Gab,Kim Woe-Yeon 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.5
Herbicides play a crucial role in maintaining crop productivity by reducing competition between weeds and crops. Protoporphyrinogen oxidase (PPO)-inhibiting herbicides trigger the photooxidative damage that destroys cell membranes. Tiafenacil is a recently developed pyrimidinedione-type PPO-inhibiting herbicide that has low IC50 values in plants and is less toxic in humans compared to other PPO inhibitors. Previous reports confirmed that mutations in Arabidopsis circadian clock-controlled gene GIGANTEA (GI) were insensitive to phytooxidants, including chloroplast biogenesis inhibitors and herbicides. Here, we examined whether GI regulates the resistance to tiafenacil. Both gi mutant alleles, gi-1 and gi-2, were resistant to tiafenacil with survival rates of 97% and 83%, respectively, under 1 μM tiafenacil treatments, while 56% of wild-type and GI-overexpressing plants (GI-OX) survived. Both gi mutants were insensitive to tiafenacil-induced inhibition of photosystem efficiency and alleviated photooxidative damage. The gi mutants showed significant increases in transcriptional expressions and enzyme activities of antioxidants compared to wild-type and GI-OX. Moreover, loss-of-function in GI enhanced resistance to tiafenacil-containing commercial herbicide Terrad’or Plus ®. Collectively, based on our results together with previous reports, mutations in GI confer resistance to herbicides with different MoAs and would be a crucial molecular target for non-target-site resistance strategies to develop herbicide-resistant crops.