The study of electronic, magnetic, magneto-optical and thermoelectric properties of XCr2O4 (X = Zn, Cd) through modified Becke and Johnson potential scheme (mBJ)

Shahid M. Ramay,M. Hassan,Q. Mahmood,Asif Mahmood 한국물리학회 2017 Current Applied Physics Vol.17 No.8

The electronic structure is analyzed to elucidate the magnetic and optical characters and the thermoelectric response of XCr2O4 (X ¼ Zn, Cd) stabilized in the cubic phase by using DFT based FP-LAPW method. The modified BeckeeJohnson (mBJ) functional is utilized to compute precise band structures (BS) and density of states (DOS), which confirm ferromagnetic semiconducting behavior. The origin of ferromagnetism explored by computing crystal field energy ðDCF Þ, John-Teller energy ðDJT Þ and exchange splitting energies DEXðdÞ and DEXðpdÞ. It is found that strong hybridization results in decay in Cr the magnetic moment and creates the magnetic moments at the nonmagnetic sites. The optical parameters reveal the suitability for energy harvesting devices. Finally, the BoltzTraP code has been implemented to study the thermoelectric properties, which show that increase in temperature increases the electrical conductivity, thermal conductivity and the power factor, while Seebeck coefficient reduces. Hence, the studied compounds are also suitable for thermoelectric devices to realize useful alternative energy sources.

Pressure waves in bubbly liquids

Shahid Mahmood,Ho-Young Kwak 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.9

It is well known that sound propagation in liquid media is strongly affected by the presence of gas bubbles that interact with sound and in turn affect the medium. An explicit form of a wave equation in a bubbly liquid medium was obtained in this study. Using the linearized wave equation and the Keller-Miksis equation for bubble wall motion, a dispersion relation for the linear pressure wave propagation in bubbly liquids was obtained. It was found that attenuation of the waves in bubbly liquid occurs due to the viscosity and the heat transfer from/to the bubble. In particular, at the lower frequency region, the thermal diffusion has a considerable affect on the frequencydependent attenuation coefficients. The phase velocity and the attenuation coefficient obtained from the dispersion relation are in good agreement with the observed values in all sound frequency ranges from kHz to MHz.

A SUBCLASS OF ANALYTIC FUNCTIONS DEFINED BY USING MITTAG-LEFFLER FUNCTION

( Tahir Mahmood ),( Muhammad Naeem ),( Saqib Hussain ),( Shahid Kjan ),( Şahsene Altinkaya ) 호남수학회 2020 호남수학학술지 Vol.42 No.3

In this paper, new subclasses of analytic functions are proposed by using Mittag-Leffler function. Also some properties of these classes are studied in regard to coefficient inequality, distortion theorems, extreme points, radii of starlikeness and convexity and obtained numerous sharp results.

Influence of ultrasonic radiation on extraction and green dyeing of mordanted cotton using neem bark extract

Khalid Mahmood Zia,Shahid Adeel,Fazal-ur- Rehman,Habiba Aslam,Muhammad Kaleem Khosa,Mohammad Zuber 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-

The current research presents the exploration of coloring potential of neem bark under the influence ofultrasonic treatment. It is found that good color strength is obtained when tannin from bark is extractedin acidified methanol medium and is used to dye irradiated cotton fabric. New shades and good ratings offastness were obtained when optimal fabric was mordanted with herbal biomolecules where excellentrating has been obtained after bio-mordanting the fabrics under optimal conditions. It is concluded thatUS treatment being green tool in natural dyeing has a great potential to isolate colorants from plantsources under mild conditions.

Lack of Association of the NPAS2 Gene Ala394Thr Polymorphism (rs2305160:G>A) with Risk of Chronic Lymphocytic Leukemia

Rana, Sobia,Shahid, Adeela,Ullah, Hafeez,Mahmood, Saqib Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: NPAS2 is a product of the circadian clock gene. It acts as a putative tumor suppressor by playing an important role in DNA damage responses, cell cycle control and apoptosis. Chronic lymphocytic leukemia (CLL) appears to be an apoptosis related disorder and alteration in the NPAS2 gene might therefore be directly involved in the etiology of CLL. Here, the Ala394Thr polymorphism (rs2305160:G>A) in the NPAS2 gene was genotyped and melatonin concentrations were measured in a total of seventy-four individuals, including thirty-seven CLL cases and an equal number of age- and sex-matched healthy controls in order to examine the effect of NPAS2 polymorphism and melatonin concentrations on CLL risk in a Pakistani population. Materials and Methods: Genotyping of rs2305160:G>A polymorphism at NPAS2 locus was carried out by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Melatonin concentrations were determined by enzyme linked immunosorbent assay (ELISA). Statistical analysis was performed using Statistical Package for Social Sciences software. Results: Our results demonstrated no association of the variant Thr genotypes (Ala/Thr and Thr/Thr) with risk of CLL. Similarly, no association of rs2305160 with CLL was observed in either females or males after stratification of study population on a gender basis. Moreover, when the subjects with CLL were further stratified into shift-workers and non-shift-workers, no association of rs2305160 with CLL was seen in either case. However, significantly low serum melatonin levels were observed in CLL patients as compared to healthy subjects (p<0.05). Also, lower melatonin levels were seen in shift-workers as compared to non-shift-workers (p<0.05). There was no significant difference (p>0.05) in the melatonin levels across NPAS2 genotypes in all subjects, subjects with CLL who were either shift workers or non-shift-workers. General Linear Model (GLM) univariate analysis revealed no significant association (p>0.05) of the rs2305160 polymorphism of the NPAS2 gene with melatonin levels in any of the groups. Conclusions: While low melatonin levels and shift-work can be considered as one of the risk factors for CLL, the NPAS2 rs2305160 polymorphism does not appear to have any association with risk of CLL in our Pakistani population.

Synthesis and characterization of hydroxyethyl cellulose (HEC)-TiO2-based polyurethane bionanocomposites

Muhammad Fiayaz,Khalid Mahmood Zia,Muhammad Asif Javaid,Saima Rehman,Shahzad Ali Shahid Chatha,Mohammad Zuber 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.12

A novel green series of hydroxyethyl cellulose (HEC) based polyurethane (PUs) prepolymersblended with TiO2 nanoparticles were synthesized by reaction of Isophorone diisocyanate (IPDI), hydroxyl-terminated polybutadiene (HTPB), and hydroxyethyl cellulose (HEC). The chain was further extended with 1,4-butanediol (BDO) to get final HEC based polyurethane bio nanocomposites (FPUNC). A mixture of HEC based polymer and TiO2 nanoparticles was formed in solution polymerization, in which the TiO2 nanoparticles dispersed depending on interaction of TiO2 nanoparticles with polymer chains. The molecular structure of the synthesized PU bionanocomposites was confirmed by FTIR. A series of FPUNCs was prepared by varying the percent composition of the TiO2 nanoparticles into the PU matrix. The morphology of the bionanocomposites was carried out by X-ray diffraction (XRD) studies and scanning electron microscopy (SEM). SEM images verified the good dispersion of TiO2 nanoparticles into PU matrix. The thermal stability of the synthesized FPUNCs was done by thermal gravimetric analysis (TGA), and the FPUNC12 with 5% contents of TiO2 nanoparticles showed better thermal stability. The resultant HEC-TiO2 based FPUNCs material have promising bio-degradable and bio functional materials with good thermal properties and have potential applications in the field of biomaterials.

Genome-wide analysis and expression profiling of YUCCA gene family associated with plant vigor in Japanese apricot (prunus mume Sieb. Et zucc)

Hayat Faisal,Bai Yang,Iqbal Shahid,Ma Chengdong,Ali Muhammad Moaaz,Shahid Muhammad Adnan,Hasan Mahmood Ul,Mosa Walid F. A.,Khan Ummara,Xiao Huang,Gao Zhihong 한국원예학회 2023 Horticulture, Environment, and Biotechnology Vol.64 No.5

Indole-3-acetic acid (IAA) is an important plant hormone required for various plant growth and developmental activities. YUCCA proteins are the enzymes for IAA synthesis that catalyze the rate-limiting step. However, the YUCCA gene family in Japanese apricot has not been thoroughly characterized. Here, we investigated the eff ect of rootstocks on scion growth of Japanease apricot and genes involved in auxin biosynthesis ( YUCCA ). Growth characteristics revealed that the height of ‘Longyan’ [ Prunus mume Sieb. et Zucc] plants with P. mume rootstock were signifi cantly shorter than ‘Longyan’ plants with P. persica rootstock. This study isolated 13 PmYUCCA genes from the Japanese apricot genome. Bioinformatics and expression studies were undertaken to investigate the functions and characteristics of YUCCA genes. The physicochemical properties, gene structure, conserved domains, conserved motif, and phylogenetic relationships of YUCCA genes were determined using bioinformatics analysis. Likewise, we analyzed the expression of PmYUCCA genes in Japanese apricot’s leaf and stem-bark (scion). The expression levels of PmYUCCA3 and PmYUCCA5 genes were noticeably lower in the leaves of ‘Longyan’/ P. mume graft combination than that of the ‘Longyan’/ P. persica graft combinations, suggesting their distinct roles in regulating growth vigor. This research explores the genome-wide identifi cation, characterization, and possible relationship between growth vigor and expression profi le analysis of the YUCCA gene family in Japanese apricot.

Ground state opto-electronic and thermoelectric response of cubic XSnO3 (X = Ba, Sr) compounds

M. Bilal Saddique,Muhammad Rashid,Adnan Afzal,Shahid M. Ramay,Farooq Aziz,Asif Mahmood 한국물리학회 2017 Current Applied Physics Vol.17 No.8

The density functional has been implemented to deliberate the cubic perovskite XSnO3 (X ¼ Ba, Sr) for their elastic, electronic, optical as well as thermoelectric characteristic. The XSnO3 (X ¼ Ba, Sr) illustrates good pact of lattice parameter for these iso-structural compounds having cubic perovskite structure. The generalized gradient approximation based on the exchange-correlation functional is applied for computing structural and mechanical characteristic, whereas the electronic, optical and thermoelectric properties have been studied by the functional suggested by Tran and Blaha that is termed as of modified Becke-Johnson (mBJ) functional. The thermodynamics stability is recognized through the expression of enthalpies of formation, which is further verified from the calculated structural properties of cubic perovskite XSnO3 (X ¼ Ba, Sr). Moreover, various elastic parameters such has bulk modules B, Cij, shear modulus G, Young's modulus Y, anisotropy factor, B/G ratio and Poisson's ratio n have also been reported. It has been observed by band structure computation that the studied compounds exhibit an indirect band gap between the unoccupied Ba/Sr 6s/5s and the occupied O 2p orbitals. Detailed study of optical properties is presented under the incident photon energy upto 28 eV. Our computed static dielectric constant ε2(0) and refractive index n(0) are comparable with other theoretical and experimental values. Thermoelectric properties are presented in terms of computed Seebeck coefficient, electrical and thermal conductivities and their variation with the rise in temperature suggest that the studied compounds may find applications in the construction of various thermo-electric devices.

A novel mutation in RDH5 gene causes retinitis pigmentosa in consanguineous Pakistani family

Neelam Sultan,Irfan Ali,Shazia Anwer Bukhari,Shahid Mahmood Baig,Muhammad Asif,Muhammad Qasim,Muhammad Imran Naseer,Mahmood Rasool 한국유전학회 2018 Genes & Genomics Vol.40 No.5

Retinitis pigmentosa (RP) is the most frequent genetically and clinically heterogeneous inherited retinal degeneration. To date, more than 80 genes have been identified that cause autosomal dominant, autosomal recessive and X linked RP. However, locus and allelic heterogeneity of RP has not been fully captured yet. This heterogeneity and lack of an accurate genotype phenotype correlation makes molecular dissection of the disease more difficult. The present study was designed to characterize the underlying pathogenic variants of RP in Pakistan. For this purpose, a large consanguineous family with RP phenotype showing autosomal recessive mode of inheritance was selected after a complete ophthalmological examination. Next generation sequencing was used for the identification of molecular determinant followed by Sanger-sequencing for confirmation. After sequence analysis a novel homozygous missense mutation, (c.602 C > T) in exon 4 of the RDH5 gene (MIM: 601617) was identified. This mutation resulted in substitution of phenyl alanine for serine at amino acid 201 (p.Ser201Phe) of the RDH5 gene. The same mutation was not detected in the 200 ethnically-matched control samples by Sanger sequencing. The identified mutant allele segregated in homozygous fashion in all the affected individuals of pedigree. Identification of this mutation reveals the allelic heterogeneity of RDH5 in patients with RP phenotype. The findings of this study demonstrate the clinical significance of next generation sequencing to understand the molecular basis of diseases and would help to reveal new proteins and their function in visual cycle will pave the way for early diagnosis, genetic counseling and better therapeutic inventions.

Gastric Carcinoma: Recent Trends in Diagnostic Biomarkers and Molecular Targeted Therapies

Majeed, Wafa,Iftikhar, Asra,Khaliq, Tanweer,Aslam, Bilal,Muzaffar, Humaira,Atta, Komal,Mahmood, Aisha,Waris, Shahid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Gastric cancer is generally associated with poor survival rates and accounts for a remarkable proportion of global cancer mortality. The prevalence of gastric carcinoma varies in different regions of world and across teh various ethnic groups. On the basis of pathological assessment, gastric cancer can be categorized as intestinal and diffuse carcinomas. The etiology is diverse, including chemical carcinogen exposure, and high salt intake Helicobacter pylori also plays a vital role in the pathogenesis of certain gastric carcinomas. The development of gastric cancer involves various alterations in mRNAs, genes (GOLPH3, MTA2) and proteins (Coronins). miRNAs, Hsa-mir-135b, MiR-21, miR-106b, miR-17, miR-18a, MiR-21, miR-106b, miR-17, miR-18a and MiRNA-375, miRNA-195-5p are the latest diagnostic biomarkers which can facilitate the early diagnosis of gastric carcinomas. Recent development in the treatment strategies for gastric carcinoma include the introduction of monoclonal antibodies, TKI inhibitors, inhibitors of PDGFR ${\beta}$, VEGFR-1, VEGFR-2, Anti-EGFR and anti-HER2 agents which can be applied along with conventional therapies.