Enhancement of bioactivity and bioavailability of curcumin with chitosan based materials

Khalid Mahmood Zia,Kashif Mahmood,Mohammad Zuber,Zill-i-Huma Nazli,Saima Rehman,Fatima Zia 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.12

Curcumin (CUR) has been investigated for its poor accessibility to a site of action or absorption and rapid metabolism to cope with the limited medication and cure applications. This article reviews numerous approaches, such as encapsulated surfactant/polymeric micelles, liposomes, micro/nano-spheres, nano-suspensions/composites, nanocomplex, films, and hydrogels for effective transfer of CUR to target sites. Chitosan (CS), and chitosan derivatives have been found to enhance therapeutic efficacy of CUR. CS/modified-CS based alginate, cyclodextrin, starch, dextran sulfate, ZnO, phytosomes, and poly(butyl) cyanoacrylate drug delivery matrices improved bioavailability, prolonged drug loading and permeability, sustained release rate, improved solubility and stability (prevent metabolic degradation) of CUR, consequently promoting various clinical applications. CS based polysaccharide, protein, and metal oxide drug delivery nano formulations advantageously participated to improve biological activities of CUR. We have attempted to summarize these delivery approaches, and reviewed future trends/strategies to permit the introduction of CUR as practical therapeutic drug.

Influence of ultrasonic radiation on extraction and green dyeing of mordanted cotton using neem bark extract

Khalid Mahmood Zia,Shahid Adeel,Fazal-ur- Rehman,Habiba Aslam,Muhammad Kaleem Khosa,Mohammad Zuber 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-

The current research presents the exploration of coloring potential of neem bark under the influence ofultrasonic treatment. It is found that good color strength is obtained when tannin from bark is extractedin acidified methanol medium and is used to dye irradiated cotton fabric. New shades and good ratings offastness were obtained when optimal fabric was mordanted with herbal biomolecules where excellentrating has been obtained after bio-mordanting the fabrics under optimal conditions. It is concluded thatUS treatment being green tool in natural dyeing has a great potential to isolate colorants from plantsources under mild conditions.

Synthesis and characterization of polyurethane based on aliphatic diisocyanate and stiff chain extenders

Mohammad Zuber,Khalid Mahmood Zia,Muhammad Ashair Iqbal,Zahida Tariq Cheema,Muhammad Ishaq,Tahir Jamil 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.1

The present research work was performed to study the properties of polyurethanes (PU) based on ali-phatic diisocayanate and the effect of chemical structure of chain extenders. Two series of PUs were synthesized via twosteps polymerization technique. The PU samples constituted on hexamethylene diisocayanate (HDI), hydroxy-termi-nated polybutadiene (HTPB) and blends 1, 4 butanediol (BDO)/bisphenol A (BPA) and or 1, 4 butanediol (BDO)/bisphenol S (BPS) were prepared. Structural characterization was done using Fourier transform infrared spectroscopyduring and after the synthesis. The FTIR analysis confirmed the existence of proposed bisphenol A (BPA) and bisphe-nol S (BPS) based PU structures. Differential scanning calorimeter (DSC) analysis gives information about the thermaltransition of all the polymer samples. Because of the difference of polarity between hard and soft segments of PU,microphase separation can occur. The degree of phase separation in the prepared PU was confirmed using scanningelectron microscope (SEM) technique. The SEM techniques present a distinctive chance to directly visualize the mor-phology of the polyurethanes.

Performance Behavior of Chitosan Based Water Dispersible Polyurethanes: Physicochemical Properties

Noureen Arshad,Khalid Mahmood Zia,Farukh Jabeen,Muhammad Naveed Anjum,Nadia Akram,Muhammad Kaleem Khosa 한국섬유공학회 2018 Fibers and polymers Vol.19 No.11

The research work was carried out to synthesize a series of novel chitosan based water dispersible polyurethanes (CS-WDPUs). The three step synthesis involves the formation of end capped PU-prepolymer was formed through the reaction between polyethylene glycol (PEG) (Mn=600 g/mole, dimethylolpropionic acid (DMPA) and isophorone diisocyanate (IPDI) followed by the preparation of neutralized NCO terminated PU-prepolymer, which lead to the chain extension by using the chitosan. The dispersion of the obtained product was carried out by adding proper proportion of water. The synthesized CS-WDPUs were applied onto the different qualities of plain weave poly-cotton printed and dyed textile swatches by employing pad-dry-cure procedures. The textile assets of the treated and untreated textile swatches were assessed, as color fastness, pilling resistance, tear and tensile strength. The results showed that the chitosan incorporation into PU backbone has significant effect on the assets of treated textiles. These synthesized CS-WDPUs are eco-friendly bio-based finishes with potential applications for polyester/cotton textiles.

Recent trends in environmentally friendly water-borne polyurethane coatings: A review

Aqdas Noreen,Khalid Mahmood Zia,Mohammad Zuber,Shazia Tabasum,Muhammad Jawwad Saif 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2

Environmentally friendly waterborne polyurethane (WPU) coatings are used extensively due to their low VOCs emission than solvent based PU coatings. Additionally, WPU coatings have low temperature flexibility, pH stability, water resistance, superior solvent resistance, outstanding weathering resistance and desirable chemical and mechanical properties. This review provides an overview on the recent developments of WPU coatings and their value added applications in the coatings and paint industry. UV-cured WPU coatings provide an important class of green and ecofriendly coatings with outstanding mechanical properties and rapid curing system. Hyper-branched polyurethanes (PUs) show interesting properties, such as high solubility, reactivity and good rheological behavior owing to multiple end groups, compact molecular structure and diminishing chain entanglement. Inherently, WPU coatings have reduced stiffness and mechanical strength that can be increased by the addition of nanoparticles, like Ag, Cu, TiO2, SiO2 and many more. Fire retardants, commonly phosphorous, are incorporated in the WPU structure to increase the flame retardancy of WPU coatings.

Synthesis and characterization of polyurethane/bentonite nanoclay based nanocomposites using toluene diisocyanate

Muhammad Fiayyaz,Khalid Mahmood Zia,Mohammad Zuber,Tahir Jamil,Muhammad Kaleem Khosa,Muhammad Asghar Jamal 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.4

Polyurethanes (PUs) prepolymers blended with bentonite nanoclay and without bentonite nanoclay wereprepared by the reaction of toluene-2,4-diisocyanate (TDI) and hydroxyl terminated polybutadiene (HTPB), and thechain was further extended with 1,4-butane diol (1,4-BDO) to get final polyurethane nanocomposites (PUNC). A mixtureof polymer and bentonite clay enriched in montmorillonite (MMT) was formed in solution polymerization, in whichMMT dispersed depending on interaction of MMT with polymer chains. The molecular structure of the monomersand the prepared PU nanocomposites was confirmed by FTIR. A series of PUNCs were prepared by varying the percentcompositions of bentonite nanoclay into the PU matrix. The existence of the clay in to the PU was confirmed byscanning electron microscope (SEM). SEM images verified the good dispersion of the bentonite nanoclay in PU matrix.

Synthesis and Characterization of Aqueous Curcumin Polyurethane Dispersions Using Isophorone Diisocyanate: Efficiency Evaluation as Textile Finishes

Noureen Arshad,Khalid Mahmood Zia,Muhammad Tahir Hussain,Muhammad Mubeen Arshad,Mohammad Zuber 한국섬유공학회 2022 Fibers and polymers Vol.23 No.7

This research is aimed at synthesizing some novel bio-based ecofriendly finishes for textile applications. A seriesof curcumin based aqueous polyurethane (PU) dispersions (CUR-WDPU-IPDI) was prepared using polyethylene glycol(PEG), isophorone diisocyanate (IPDI) and dimethylolpropanoic acid (DMPA) via conventional pre-polymer process. Thedual functionality is incorporated by hindering the polyurethane pre-polymer with isocyanate (-NCO) groups and curcuminwas utilized to extend the polymeric chain to achieve the CUR-WDPU-IPDI dispersion. Structural characteristics of thesynthesized polymer were investigated by Fourier Transform Infrared (FT-IR) spectrophotometer. The performance of PUdispersions for increasing the color fastness properties (washing, rubbing and perspiration fastness) of plain weave fabrics(poly/cotton, dyed and printed) was studied. Furthermore, the mechanical strength (pilling, tearing and tensile strength) of thesaid fabric (dyed, printed and white) was also evaluated. Results clearly exhibited that the color fastness properties andmechanical strength of the dyed, printed and white fabrics were improved significantly after treating with the PU finishes. These synthesized curcumin-based water dispersible polyurethanes (CUR-WDPU-IPDI) finishing agents are greenerproducts which are particularly derivatized from bio-resources. Owing to their biocompatibility, copious availability, lessnoxious, greener methodology and ecofriendly nature, these can be utilized as attractive ecofriendly alternatives for textileapplications.

Synthesis and characterization of hydroxyethyl cellulose (HEC)-TiO2-based polyurethane bionanocomposites

Muhammad Fiayaz,Khalid Mahmood Zia,Muhammad Asif Javaid,Saima Rehman,Shahzad Ali Shahid Chatha,Mohammad Zuber 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.12

A novel green series of hydroxyethyl cellulose (HEC) based polyurethane (PUs) prepolymersblended with TiO2 nanoparticles were synthesized by reaction of Isophorone diisocyanate (IPDI), hydroxyl-terminated polybutadiene (HTPB), and hydroxyethyl cellulose (HEC). The chain was further extended with 1,4-butanediol (BDO) to get final HEC based polyurethane bio nanocomposites (FPUNC). A mixture of HEC based polymer and TiO2 nanoparticles was formed in solution polymerization, in which the TiO2 nanoparticles dispersed depending on interaction of TiO2 nanoparticles with polymer chains. The molecular structure of the synthesized PU bionanocomposites was confirmed by FTIR. A series of FPUNCs was prepared by varying the percent composition of the TiO2 nanoparticles into the PU matrix. The morphology of the bionanocomposites was carried out by X-ray diffraction (XRD) studies and scanning electron microscopy (SEM). SEM images verified the good dispersion of TiO2 nanoparticles into PU matrix. The thermal stability of the synthesized FPUNCs was done by thermal gravimetric analysis (TGA), and the FPUNC12 with 5% contents of TiO2 nanoparticles showed better thermal stability. The resultant HEC-TiO2 based FPUNCs material have promising bio-degradable and bio functional materials with good thermal properties and have potential applications in the field of biomaterials.

Synthesis and properties of aqueous polyurethane dispersions: Influence of molecular weight of polyethylene glycol

Mohammad Zuber,Fatima Mumtaz,Khalid Mahmood Zia,Tahir Jamil,Rizwan Hussain 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.12

Aqueous polyurethane dispersions (PUDs) have recently emerged as important alternatives to their solventbased counterparts for various applications due to increasing health and environmental awareness. A series of aqueous polyurethane dispersions containing carboxylate anion as hydrophilic pendant groups were synthesized through step growth polymerization reaction using hexamethylene diisocyanate (HDI), 1,4-butanediol (1,4-BDO), dimethylol propionic acid (DMPA) and polyethylene glycol (PEG) of different molecular weight. Effect of PEG molecular weight was investigated on molecular structure, contact angle measurement, and physical and adhesive properties of PU emulsions. Fourier transform infrared spectroscopy (FT-IR) was used to check the completion of polymerization reaction. Contact angle measurement indicated that the hydrophilicity of polymer increases by increasing molecular weight of PEG with a corresponding decrease in contact angle. Results of T-peel test showed a decrease in peel strength by increasing molecular weight of PEG. Moreover, solid contents%, drying time and storage stability suggested fast drying properties and greater stability of aqueous PU dispersions.

A Study of Aerosol Properties over Lahore (Pakistan) by Using AERONET Data

Muhammad Ali,Salman Tariq,Khalid Mahmood,Asim Daud,Adila Batool,Zia-ul-Haq 한국기상학회 2014 Asia-Pacific Journal of Atmospheric Sciences Vol.50 No.2

It is well established that aerosols affect the climate in avariety of ways. In order to understand these effects, we require aninsight into the properties of aerosols. In this paper we present a studyof aerosol properties such as aerosol optical depth (AOD), singlescattering albedo (SSA) and aerosol radiative forcing (ARF) overmega city of Lahore (Pakistan). The data from Aerosol Robotic Network(AERONET) have been used for the period December 2009 toOctober 2011. The seasonal average values of AOD, asymmetryparameter (ASY) and volume size distribution in coarse mode wereobserved to be highest in summer. On the other hand, the averagevalues of Angstrom exponent (AE) and imaginary part of refractiveindex (RI) were found to be maximum in winter. The average valueof real part of RI was found to be higher in spring than in all otherseasons. The SSA exhibited an increasing trend with wavelength inthe range 440 nm - 1020 nm in spring, summer and fall indicating thedominance of coarse particles (usually dust). However, a decreasingtrend was found in winter in the range 675 nm - 1020 nm pointingtowards the dominance of biomass and urban/industrial aerosols. Asfar as aerosol radiative forcing (ARF) is concerned, we have foundthat during the spring season ARF was lowest at the surface of Earthand highest at top of the atmosphere (TOA). This indicates that theatmosphere was warmer in spring than in all the remaining seasons.