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서승록,신승헌 대구대학교 산업기술연구소 1984 産業技術硏究 Vol.3 No.-
This paper was analnzed the 1,622 traffic accidents of kyounbuk area provided by the police bureau in 1982 and showed the precautionary measures of traffic accidents by using data sheets. This research suggestds as follows: 1. Strengthening of traffic rules and educations. 2. Investigation of accident patterns. 3. Improvement of driver's labour conditions. 4. Installation of safety devices. 5. Study of human engineering of traffic indicators. 6. Improvement of driving test
인정제,신용승,김헌영,김재우,송명환,박진수 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-
The contact forces between die components for the drawing of large size automotive panels introduce elastic deflections of the die components. Due to the deflections, the gap between blank holder and die varies locally resulting in nonuniform material flow. Such a nonuniform die gap usually requires correcting operation, so called die spotting, which is time consuming trial and error process. To reduce the die spotting time, the optimization of the blank holder bending deflection is needed. In this paper, we implemented an analysis procedure to predict the blank holder deflection. The analysis procedure and design of experiments techniques are applied to the optimization of balance block heights. The optimization results can be used as guidelines in actual die spotting process.
인정제,신용승,김헌영 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.3
In the drawing of large size automotive panels. elastic deflection of die components is induced by the contact force between them. The deflection is nonuniform and locally distributed, and results in nonuniform material flow. In order to arrange such a nonuniform die gap, a correcting operation, so called die spotting, is inevitable, which requires trial and error works and consuming time. A prediction of the bending deflection prior to a try-out must be useful to reduce the die spotting time. In this study, the drawing process of a front fender is simulated first, and the deflection of the blank holder is calculated from the contact force imposing on the blank holder. The balance block heights ensuring a uniform deflection are optimized by the analysis and design of experiments.
Kwon, Yo Han,Woo, Sang‐,Wook,Jung, Hye‐,Ran,Yu, Hyung Kyun,Kim, Kitae,Oh, Byung Hun,Ahn, Soonho,Lee, Sang‐,Young,Song, Seung‐,Wan,Cho, Jaephil,Shin, Heon‐,Cheol,Kim, Je Y WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.38
<P>The first ever demonstration of a cable‐type lithium ion battery architecture with outstanding omni‐directional flexibility is described by Je Young Kim, Heon‐Cheol Shin, and co‐workers on page 5192. The Front Cover image illustrates the unique battery architecture comprising a skeleton frame surrounding an empty space, that is, a hollow‐spiral anode with a multi‐helical structure. This design enables the battery to reliably power an LED screen or an MP3 player even under severe mechanical twisting and bending. </P>
Shin, Seung-Heon,Ye, Mi-Kyung,Kim, Jung-Kyu,Park, Kwan-Kyu S. Karger AG 2013 Pharmacology Vol. No.
<P>Abstract</P><P> Bee venom (BV) has long been used as an oriental traditional medicine for the control of pain and inflammation. However, BV’s anti-inflammatory mechanisms remain unclear. This study aimed to clarify the potential clinical efficacy of BV concerning the anti-inflammatory effect on nasal epithelial cell inflammation. Nasal polyp epithelial cells were obtained from patients. Cells were exposed to <I>Alternaria alternata, Aspergillus nigra, Dermatophagoides pteronyssinus</I>, <I>Dermatophagoides farina</I> and lipopolysaccharide with or without various concentrations of BV. Interleukin (IL)-6, IL-8, and granulocyte macrophage colony-stimulating factor were measured to determine the activation of epithelial cells. Nuclear factor-κB (NF-κB) and activator protein 1 expression and activity were determined with Western blot analysis and ELISA. Cytotoxicity of BV was measured using a CellTiter-96® aqueous cell proliferation assay kit. Cell survival was significantly decreased at BV concentrations exceeding 5 μg/ml. Fungi-induced cytokine production was more effectively inhibited by BV than house dust mite. <I>Alternaria</I> enhanced NF-κB expression, which was strongly inhibited by BV. BV appears to be relatively safe, and is of potential value for the treatment of airway inflammation and/or immunologic diseases.</P><P>Copyright © 2012 S. Karger AG, Basel</P>
Anti-allergic effect of bee venom in an allergic rhinitis mouse model.
Shin, Seung-Heon,Kim, Yee-Hyuk,Kim, Jeong-Kyu,Park, Kwan-Kyu Pharmaceutical Society of Japan 2014 Biological & pharmaceutical bulletin Vol.37 No.8
<P>Bee venom (BV) has been used as an anti-inflammatory and immune modulating agent in Oriental medicine. This study used a mouse model to investigate the anti-allergic effect of BV, which is used in the treatment of various inflammatory diseases in traditional medicine. BV was obtained from the National Institute of Agricultural Science and Technology of Korea. Female BALB/C mice were sensitized by intraperitoneal injection of ovalbumin (OVA). BV was administered nasally prior to the intranasal instillation of OVA. Allergic behavior, serum OVA-specific immunoglobulin E (IgE), interleukin (IL)-4, IL-10, and interferon-gamma (INF-γ) levels in nasal lavage fluid were measured. Hematoxylin-eosin and periodic acid-Schiff staining were performed to evaluate histological change. BV attenuated nasal symptoms and inhibited the production of OVA-specific IgE and IL-4 in sensitized mice. The degree of inflammatory cell infiltration and goblet cell hyperplasia was attenuated by BV. Thus, BV effectively reduced allergic inflammation in a mouse model of allergic rhinitis, suggesting its potential as a useful therapeutic agent to treat allergic rhinitis.</P>
( Seung Heon Lee ),( Kyung Ah Seo ),( Young Min Lee ),( Hyun Kyung Lee ),( Je Hyeong Kim ),( Chul Shin ),( Jae Gook Shin ),( Dong Hyun Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Low serum concentrations of drugs for multi-drug resistant tuberculosis (MDR-TB) have occasionally been associated with treatment failure. OBJECTIVE: We determined the prevalences of low serum concentrations of anti-MDR-TB drugs and the effects of serum levels according to the presence of 2 month-sputum conversion. Design: Venous blood was obtained 2hrs~6hrs after drug ingestion among 29 MDR-TB patients during each monthly visit, and the serum levels of moxifloxacin (Mf), prothionamide (PTH), and cycloserine (CS) were measured using high pressure liquid chromatography/tandem mass spectrometry (LC-MS/MS) method. Results: Among 89 blood samples, the prevalences of low serum concentrations of Mf, PTH, and CS below the minimal level of therapeutic range were 70.8% (17/24), 60.0% (27/45), and 75.0% (39/52), respectively. There were no differences between 2 month-sputum conversion group (n=25) and 2 month-sputum non-conversion group (n=4) in median drug concentration (μg/ml) of Mf (1.46 VS. 1.60), PTH (0.91 VS. 0.70), and CS (14.90 VS. 14.90), respectively (p>0.05). However, poor compliance rate was significantly higher in 2 month-sputum non-conversion group (75.0%, 3/4) than in 2 month-sputum conversion group (0%, 0/25) (p<0.01). Conclusion: The prevalences of low concentrations of anti-MDR-TB drugs were substantial. Prospective larger studies with timely samplings are needed to investigate the role of therapeutic drug monitoring.