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질의의 지역성을 이용한 효율적인 하이브리드 검색 서비스
이상환(Sanghwan Lee),한재일(Jae-Il Han),김철수(Chulsu Kim),황재각(Jaegak Hwang) 한국IT서비스학회 2009 한국IT서비스학회지 Vol.8 No.3
Since the development of the Distributed Hash Tables (DHTs), the distributed lookup services are one of the hot topics in the networking ares. The main reason of this popularity is the simplicity of the lookup structure. However, the simple key based search mechanism makes the so called "keyword" based search difficult, it not impossible. Thus, the applicability of the DHTs is limited to certain areas. In this paper. we find that DHTs can be used as the ubiquitous sensor network (USN) metadata lookup service across a large number of sensor networks. The popularity of the Ubiquitous Sensor Network has motivated the development of the USN middleware services for the sensor networks. One of the key functionalities of the USN middleware service is the lookup of the USN metadata, by which users get various information about the sensor network such as the type of the sensor networks and/or nodes, the residual of the batteries, the type of the sensor nodes. Traditional distributed hash table based lookup systems are good for one sensor network. However, as the number of sensor network increases, the need to integrate the lookup services of many autonomous sensor networks so that they can provide the users an integrated view of the entire sensor network. In this paper, we provide a hybrid lookup model, in which the autonomous lookup services are combined together and provide seamless services across the boundary of a single lookup services. We show that the hybrid model can provide far better lookup performance than a single lookup system.
An Approach for Synthesis and Characterization of Zirconia Nanopowder via Microwave Thermal Process
Athar, Taimur,Han, Sanghwan,Ko, Taegyung,Lee, Ik-Mo Taylor Francis 2009 Synthesis and reactivity in inorganic, metal-organ Vol.39 No.5
<P> We applied a simple, versatile and an efficient non-toxic methodology based on microwave irradiation process to prepare a gel from n-zirconium butoxide without using any solvent at ambient temperature to open new possibilities to control particle size distribution, surface chemistry and agglomeration. The alkoxy-derived gel changed to tetragonal zirconia powder on heating at 400°C with crystalline particles size (3 ∼ 5 nm). Zirconia exhibited strong luminescence under a UV laser. The presence of a organic moieties as impurities exhibit a strong luminescence in zirconia powder. From the structural analysis it is concluded that the morphology of the oxide strongly depends on the nature of the precursors and the synthetic methology.</P>
An Integrated Low Temperature Approach for the Synthesis of Titania via Sol-Gel process
Athar, Taimur,Han, Kyusuk,Han, Sanghwan,Ko, Taegyung,Lee, Ik-Mo Taylor Francis 2009 Synthesis and reactivity in inorganic, metal-organ Vol.39 No.5
<P> Colloidal titania particles with nanosize size distribution were prepared via sol-gel process by using oxo-titanium alkoxide as a molecular precursor. The transformation from oxo-titanium alkoxide to metal oxide was studied by IR, UV, thermal analysis, X-ray and TEM. TEM and XRD techniques were used to characterize the microstructure and crystallite morphology. The experimental results show that the titania has a good crystallinity with a particle size (5 nm), shape and with favorable surface morphology. These results support that titania has strong implications for the interaction between the oleic acid used as surfactant and Ti nanoparticle to enhance the stability with controlled functional properties.</P>
A human antibody against human endothelin receptor type A that exhibits antitumor potency
주만석,Ahn Hye-Mi,Han Seong-Gu,Ko Sanghwan,Na Jung-Hyun,조미경,임충수,Ko Byoung Joon,Yu Yeon Gyu,이원규,김연재,Jung Sang Taek 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Endothelin receptor A (ET A ), a class A G-protein-coupled receptor (GPCR), is involved in the progression and metastasis of colorectal, breast, lung, ovarian, and prostate cancer. We overexpressed and purified human endothelin receptor type A in Escherichia coli and reconstituted it with lipid and membrane scaffold proteins to prepare an ET A nanodisc as a functional antigen with a structure similar to that of native GPCR. By screening a human naive immune single-chain variable fragment phage library constructed in-house, we successfully isolated a human anti-ET A antibody (AG8) exhibiting high specificity for ET A in the β-arrestin Tango assay and effective inhibitory activity against the ET-1-induced signaling cascade via ET A using either a CHO-K1 cell line stably expressing human ET A or HT-29 colorectal cancer cells, in which AG8 exhibited IC 50 values of 56 and 51 nM, respectively. In addition, AG8 treatment repressed the transcription of inhibin βA and reduced the ET A -induced phosphorylation of protein kinase B and extracellular regulated kinase. Furthermore, tumor growth was effectively inhibited by AG8 in a colorectal cancer mouse xenograft model. The human anti-ET A antibody isolated in this study could be used as a potential therapeutic for cancers, including colorectal cancer.