Extracting Features of Human Knowledge Systems for Active Knowledge Management Systems

Yuan Miao,Robert Gay,Chee Kheong Siew,Zhi Qi Shen 한국지능정보시스템학회 2001 한국지능정보시스템학회 기타 간행물 Vol.- No.-

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers

Qi Fei-Yan,Zhu Zhou-Hai,Li Meng,Guan Ying,Peng Qi-Yuan,Lu She-Ming,Liu Zhi-Hua,Wang Ming-Feng,Miao Ming-Ming,Chen Zhang-Yu,Li Xue-Mei,Bai Jie,Yao Jian-Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.11

Background: Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear. Objective: This study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population. Methods: The haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293. Results: Significant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X2 = 4.611, 1 df, p = 0.032) and strong cigarette smoke flavor intensity preference (X2 = 4.5383, 1 df, p = 0.033) in participants. Furthermore, in the in vitro cellular calcium assay, total particle matter (TPM), N-formylnornicotine and cotinine, existing in cigarette smoke, activated TAS2R38-PAV but not TAS2R38-AVI-transfected cells. Conclusion: Our data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.

Influencing Factors of High PTSD Among Medical Staff During COVID-19: Evidences From Both Meta-analysis and Subgroup Analysis

Qi, Guojia,Yuan, Ping,Qi, Miao,Hu, Xiuli,Shi, Shangpeng,Shi, Xiuquan Occupational Safety and Health Research Institute 2022 Safety and health at work Vol.13 No.3

Background: PTSD (Post-traumatic stress disorder, PTSD) had a great impact on health care workers during the COVID-19 (Corona Virus Disease 2019, COVID-19). Better knowledge of the prevalence of PTSD and its risk factors is a major public health problem. This study was conducted to assess the prevalence and important risk factors of PTSD among medical staff during the COVID-19. Methods: The databases were searched for studies published during the COVID-19, and a PRISMA (preferred reporting items for systematic review and meta-analysis) compliant systematic review (PROSPERO-CRD 42021278970) was carried out to identify articles from multiple databases reporting the prevalence of PTSD outcomes among medical staff. Proportion random effect analysis, I² statistic, quality assessment, subgroup analysis, and sensitivity analysis were carried out. Results: A total of 28 cross-sectional studies and the PTSD results of doctors and nurses were summarized from 14 and 27 studies: the prevalences were 31% (95% CI [confidence interval, CI]: 21%-40%) and 38% (95% CI: 30%-45%) in doctors and nurses, respectively. The results also showed seven risks (p < 0.05): long working hours, isolation wards, COVID-19 symptoms, nurses, women, fear of infection, and pre-existing mental illness. Two factors were of borderline significance: higher professional titles and married. Conclusion: Health care workers have a higher prevalence of PTSD during COVID-19. Health departments should provide targeted preventive measures for medical staff away from PTSD.

Analysis of the failure mechanism and support technology for the Dongtan deep coal roadway

Chen, Miao,Yang, Sheng-Qi,Zhang, Yuan-Chao,Zang, Chuan-Wei Techno-Press 2016 Geomechanics & engineering Vol.11 No.3

The stability of deep coal roadways with large sections and thick top coal is a typical challenge in many coal mines in China. The innovative Universal Discrete Element Code (UDEC) trigon block is adopted to create a numerical model based on a case study at the Dongtan coal mine in China to better understand the failure mechanism and stability control mechanism of this kind of roadway. The failure process of an unsupported roadway is simulated, and the results suggest that the deformation of the roof is more serious than that of the sides and floor, especially in the center of the roof. The radial stress that is released is more intense than the tangential stress, while a large zone of relaxation appears around the roadway. The failure process begins from partial failure at roadway corners, and then propagates deeper into the roof and sides, finally resulting in large deformation in the roadway. A combined support system is proposed to support roadways based on an analysis of the simulation results. The numerical simulation and field monitoring suggest that the availability of this support method is feasible both in theory and practice, which can provide helpful references for research on the failure mechanisms and scientific support designing of engineering in deep coal mines.

Law and Early Warning of Vertical Sluice Cluster Displacements in Soft Coastal Soil

Xing Yang,Cong Yuan,Miao Hou,Chengyang Zhou,Yan Ju,Fei Qi 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.2

The vertical displacement, which is the product of natural sources and human activities, is the key factor affecting the sluice safety. This study provides a systematic approach used for analyzing the law and early warning of sluice cluster vertical displacements in coastal soft soil locations. Two important methods, including probability analysis and principal component analysis (PCA), are used to obtain the necessary information in this study. Among them, PCA is mainly used to identify the risk indices during vertical deformations of sluice cluster. As case studies, 27 sluices in a cluster in Northern Jiangsu Province's coastal area in China are chosen and 14 variables related to sluice uplift, settlement and differential settlement deformations are used. The PCA and additional evidence from the sluice deformation law are used to identify three variables as risk indices, including maximum differential settlement (MMDS), maximum cumulative vertical settlement (MCVS) and maximum cumulative vertical uplift (MCVU). This study divides the risk levels into five grades (i.e., Level 1 to Level 5) based on the selected risk indices and determines their risk thresholds based on the in-situ deformation data from 2010 to 2020. In general, the results demonstrate that the newly proposed approach exhibits an acceptable performance. However, the influence of epistemic and aleatory uncertainties on this study is worthy of further discussion in the future.

Experimental investigation of the preferred Strouhal number used in self-resonating pulsed waterjet

Deng Li,Youping Chen,Yong Kang,Zu’an Wang,Xiaoliang Wang,Qi Fan,Miao Yuan 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.9

Self-resonating pulsed waterjet (SRPW) is superior to plain waterjet in many ways and is being employed in numerous applications. To further improve the performance of SRPW, the optimal value of the preferred Strouhal number (S d ), which is used to determine the chamber length of a self-resonating nozzle, was experimentally studied at inlet pressures of 10 MPa and 20 MPa. The axial pressure oscillation peak and amplitude were used to evaluate the performance of SRPW, in order to find the optimum S d value. Results show that S dvalue determines the self-resonance behavior of an organ-pipe nozzle and greatly affects the intensity of the axial pressure oscillation. Under the experimental conditions, the optimum S d values are 0.315 and 0.278 respectively, corresponding to inlet pressures of 10 MPa and 20 MPa. Compared with the default value of 0.3 obtained from air jet experiment, the optimum S d value at inlet pressure of 10 MPa is a little larger and oppositely a bit smaller at inlet pressure of 20 MPa. Thus, if the inlet pressure is not considered, S d value of 0.3 is reasonable for determining the chamber length of a self-resonating nozzle for generating effective SRPW.

Effects of enzymolysis and fermentation of Chinese herbal medicines on serum component, egg production, and hormone receptor expression in laying hens

Mei Hong Jiang,Tao Zhang,Qing Ming Wang,Jin Shan Ge,Lu Lu Sun,Meng Qi Li,Qi Yuan Miao,Yuan Zhao Zhu Asian Australasian Association of Animal Productio 2024 Animal Bioscience Vol.37 No.1

Objective: In the present study, we aimed to investigate the effects of enzymolysis fermentation of Chinese herbal medicines (CHMs) on egg production performance, egg quality, lipid metabolism, serum reproductive hormone levels, and the mRNA expression of the ovarian hormone receptor of laying hens in the late-laying stage. Methods: A total of 360 Hy-Line Brown laying hens (age, 390 days) were randomly categorized into four groups. Hens in the control (C) group were fed a basic diet devoid of CHMs, the crushed CHM (CT), fermented CHM (FC), and enzymatically fermented CHM (EFT) groups received diets containing 2% crushed CHM, 2% fermented CHM, and 2% enzymatically fermented CHM, respectively. Results: Compared with crushed CHM, the acid detergent fiber, total flavonoids, and total saponins contents of fermented CHM showed improvement (p<0.05); furthermore, the neutral and acid detergent fiber, total flavonoids, and total saponins contents of enzymatically fermented CHM improved (p<0.05). At 5 to 8 weeks, hens in the FC and EFT groups showed increased laying rates, haugh unit, albumin height, yolk color, shell thickness, and shell strength compared with those in the C group (p<0.05). Compared with the FC group, the laying rate, albumin height, and Shell thickness in the EFT group was increased (p<0.05). Compared with the C, CT, and FC groups, the EFT group showed reduced serum total cholesterol and increased serum luteinizing hormone levels and mRNA expressions of follicle stimulating hormone receptor and luteinizing hormone receptor (p<0.05). Conclusion: These results indicated that the ETF group improved the laying rate and egg quality and regulated the lipid metabolism in aged hens. The mechanism underlying this effect was likely related to cell wall degradation of CHM and increased serum levels of luteinizing hormone and mRNA expression of the ovarian hormone receptor.