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Park, Jungmin,Ku, Minhee,Kim, Eunjung,Park, Yeonji,Hong, Yoochan,Haam, Seungjoo,Cheong, Jae-Ho,Park, Eun Sung,Suh, Jin-Suck,Huh, Yong-Min,Yang, Jaemoon Oxford University Press 2013 Integrative biology Vol.5 No.4
<P>We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.</P>
Jungmin Park,Hyojung Kim,Pyungho Choi,Bohyeon Jeon,Jongyoon Lee,Changyong Oh,Bosung Kim,Byoungdeog Choi 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.4
This study investigated the electrical and stability characteristics of Al 2 O 3 as a gate insulator, which was deposited by variousatomic layer deposition methods in top-gate staggered amorphous InGaZnO (a-IGZO) thin fi lm transistors. A trimethylaluminumprecursor was used as an Al source, and H 2 O gas (H 2 O device) and O 2 plasma with a long plasma time (O 2 LP device)and a short plasma time (O 2 SP device) were used as oxidants. The initial electrical characteristics, including the hysteresis,on–off current ratio, and subthreshold swing, were superior in the H 2 O device compared to the O 2 LP and O 2 SP devices. Inthe positive bias stress (PBS) results, the degradation characteristics showed a tendency similar to the transfer properties. However, under the negative bias illumination stress (NBIS), the stability of the H 2 O device was signifi cantly reduced comparedto the O 2 LP and O 2 SP devices. In this paper, the mechanism of instability, which has opposite results in terms of thePBS and NBIS for the three devices, was identifi ed using capacitance–voltage, three-terminal charge pumping as electricalanalysis techniques and secondary ion mass spectroscopy (SIMS) as a physical analysis technique. It was confi rmed thatthe surface oxidation of a-IGZO deteriorates the interfacial properties, causing the transfer characteristics to degrade. Thecarbon of the Al 2 O 3 fi lm identifi ed via SIMS analysis acts as a trap layer, causing deterioration in the PBS. Alternatively, inthe NBIS, it was observed that the carbon acts as a capture site for photo-excited holes, thereby promoting device stability.
Jungmin Choi,Hyungjik Oh,Chandeok Park,Sang-Young Park 한국항공우주학회 2017 International Journal of Aeronautical and Space Sc Vol.18 No.2
This study presents the orbit determination (OD) of a candidate Korea Regional Navigation Satellite System (KRNSS) using both inter-satellite links (ISLs) and ground observations. The candidate constellation of KRNSS is first introduced. The OD algorithm based on both ISL and ground observation is developed, and consists of three main components: dynamic model for Korean navigation satellites, measurement model for ISLs and ground observations, and the batch least-square filter for estimating OD parameters. As numerical simulations are performed to analyze the OD performances, the present study focuses on investigating the effects of ISL measurements on the OD accuracy of KRNSS. Simulation results show that the use of ISLs can considerably enhance the OD accuracy to one meter (design preference) under certain distributions of ground stations.
Park, Ji-Yeon,Lee, Jeong-Woo,Chung, Jin-Beom,Choi, Kyoung-Sik,Kim, Yon-Lae,Park, Byung-Moon,Kim, Youhyun,Kim, Jungmin,Choi, Jonghak,Kim, Jae-Sung,Hong, Semie,Suh, Tae-Suk Oxford University Press 2012 Journal of radiation research Vol.53 No.6
<P>A bio-anatomical quality assurance (QA) method employing tumor control probability (TCP) and normal tissue complication probability (NTCP) is described that can integrate radiobiological effects into intensity-modulated radiation therapy (IMRT). We evaluated the variations in the radiobiological effects caused by random errors (r-errors) and systematic errors (s-errors) by evaluating TCP and NTCP in two groups: patients with an intact prostate (G<SUB>intact</SUB>) and those who have undergone prostatectomy (G<SUB>tectomy</SUB>). The r-errors were generated using an isocenter shift of ±1 mm to simulate a misaligned patient set-up. The s-errors were generated using individual leaves that were displaced inwardly and outwardly by 1 mm on multileaf collimator field files. Subvolume-based TCP and NTCP were visualized on computed tomography (CT) images to determine the radiobiological effects on the principal structures. The bio-anatomical QA using the TCP and NTCP maps differentiated the critical radiobiological effects on specific volumes, particularly at the anterior rectal walls and planning target volumes. The s-errors showed a TCP variation of –40–25% in G<SUB>tectomy</SUB> and –30–10% in G<SUB>intact</SUB>, while the r-errors were less than 1.5% in both groups. The r-errors for the rectum and bladder showed higher NTCP variations at ±20% and ±10%, respectively, and the s-errors were greater than ±65% for both. This bio-anatomical method, as a patient-specific IMRT QA, can provide distinct indications of clinically significant radiobiological effects beyond the minimization of probable physical dose errors in phantoms.</P>
Shape Optimization of Flow Channels Using Lattice Boltzmann Method
Jungmin Park(박정민),Kyung Chun Kim(김경천) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12
A new optimality criterion algorithm is presented for producing modified shape designs for fluid flow inside channels. To compute the fluid motion in a channel, the Lattice Boltzmann Method (LBM) was used based on D2Q9 lattice spaces associated with the Bhatnagar-Gross-Krook (BGK) collision term. An experiential optimality method to design channels with the lowest pressure drop along the passage is introduced. The positions of solid cells and fluid cells are exchanged based on the strain rate tensor at the solid-fluid interface. To obtain the optimized shape, the cells are changed until the optimality condition is obtained with the restriction of constant fluid volume. Examples are presented to validate the algorithm, including an elbow tube as well as symmetrical and nonsymmetrical T-junction channels. The validation exercises demonstrate that the algorithm is suitable for optimal channel design.