Synthesis and Characterization of KTiNbO₅ Nano-particles by Novel Polymerizable Complex Method

Wang, Ning-Ning,Lan, Yun-Xiang,He, Jie,Dong, Rui,Hu, Jin-Song Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.9

The layered $KTiNbO_5$ was successfully synthesized with titanium(IV) isopropoxide and niobium oxalate by a novel polymerized complex (PC) method. The morphology and structure of the as-prepared sample was characterized by means of High-Resolution Transmission Electron Microscope, powder X-ray diffraction, and Laser Raman Spectroscopy. The spectral response characteristic was recorded by using UV-vis Diffuse Reflectance Spectroscopy. Results show that $KTiNbO_5$ as-prepared by PC method presents an uniform morphology of nano-particles, the mean particle sizes is ca. 28 nm corresponding to the (002), and the crystal structure can be well indexed to the orthorhombic phase. The sample as-prepared by PC method has higher band gap energy than that of the sample prepared by a solid-state reaction method due to the quantum size effect.

Service Deployment Strategy for Customer Experience and Cost Optimization under Hybrid Network Computing Environment

Ning Wang,Huiqing Wang,Xiaoting Wang 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.11

With the development and wide application of hybrid network computing modes like cloud computing, edge computing and fog computing, the customer service requests and the collaborative optimization of various computing resources face huge challenges. Considering the characteristics of network environment resources, the optimized deployment of service resources is a feasible solution. So, in this paper, the optimal goals for deploying service resources are customer experience and service cost. The focus is on the system impact of deploying services on load, fault tolerance, service cost, and quality of service (QoS). Therefore, the alternate node filtering algorithm (ANF) and the adjustment factor of cost matrix are proposed in this paper to enhance the system service performance without changing the minimum total service cost, and corresponding theoretical proof has been provided. In addition, for improving the fault tolerance of system, the alternate node preference factor and algorithm (ANP) are presented, which can effectively reduce the probability of data copy loss, based on which an improved cost-efficient replica deployment strategy named ICERD is given. Finally, by simulating the random occurrence of cloud node failures in the experiments and comparing the ICERD strategy with representative strategies, it has been validated that the ICERD strategy proposed in this paper not only effectively reduces customer access latency, meets customers' QoS requests, and improves system service quality, but also maintains the load balancing of the entire system, reduces service cost, enhances system fault tolerance, which further confirm the effectiveness and reliability of the ICERD strategy.

Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line

Wang, Ning-Ning,Zhao, Li-Jun,Wu, Li-Nan,He, Ming-Feng,Qu, Jun-Wei,Zhao, Yi-Bing,Zhao, Wan-Zhou,Li, Jie-Shou,Wang, Jin-Hua Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Objectives: To establish a taxol-resistant cell line of human ovarian carcinoma (A2780/Taxol) and investigate its biological features. Methods: The drug-resistant cell line (A2780/Taxol) was established by continuous stepwise selection with increasing concentrations of Taxol. Cell morphology was assessed by microscopy and growth curves were generated with in vitro and in vivo tumor xenograft models. With rhodamine123 (Rh123) assays, cell cycle distribution and the apoptotic rate were analyzed by flow cytometry (FCM). Drug resistance-related and signal associated proteins, including P-gp, MRPs, caveolin-1, PKC-${\alpha}$, Akt, ERK1/2, were detected by Western blotting. Results: A2780/Taxol cells were established with stable resistance to taxol. The drug resistance index (RI) was 430.7. Cross-resistance to other drugs was also shown, but there was no significant change to radioresistance. Compared with parental cells, A2780/Taxol cells were significantly heteromorphous, with a significant delay in population doubling time and reduced uptake of Rh123 (p<0.01). In vivo, tumor take by A2780 cells was 80%, and tumor volume increased gradually. In contrast, with A2780/Taxol cells in xenograft models there was no tumor development. FCM analysis revealed that A2780/Taxol cells had a higher percentage of G0/G1 and lower S phase, but no changes of G2 phase and the apoptosis rate. Expression of P-gp, MRP1, MRP2, BCRP, LRP, caveolin-1, PKC-${\alpha}$, Phospho-ERK1/2 and Phospho-JNK protein was significantly up-regulated, while Akt and p38 MARK protein expression was not changed in A2780/Taxol cells. Conclusion: The A2780/Taxol cell line is an ideal model to investigate the mechanism of muti-drug resistance related to overexpression of drug-resistance associated proteins and activation of the PKC-${\alpha}/ERK$ (JNK) signaling pathway.

Skin Lesion Image Segmentation Based on Adversarial Networks

( Ning Wang ),( Yanjun Peng ),( Yuanhong Wang ),( Meiling Wang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.6

Traditional methods based active contours or region merging are powerless in processing images with blurring border or hair occlusion. In this paper, a structure based convolutional neural networks is proposed to solve segmentation of skin lesion image. The structure mainly consists of two networks which are segmentation net and discrimination net. The segmentation net is designed based U-net that used to generate the mask of lesion, while the discrimination net is designed with only convolutional layers that used to determine whether input image is from ground truth labels or generated images. Images were obtained from “Skin Lesion Analysis Toward Melanoma Detection” challenge which was hosted by ISBI 2016 conference. We achieved segmentation average accuracy of 0.97, dice coefficient of 0.94 and Jaccard index of 0.89 which outperform the other existed state-of-the-art segmentation networks, including winner of ISBI 2016 challenge for skin melanoma segmentation.

Synthesis and Characterization of KTiNbO5 Nano-particles by Novel Polymerizable Complex Method

Ning-ning Wang,Yun-xiang Lan,Jie He,Rui Dong,Jin-song Hu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.9

The layered KTiNbO5 was successfully synthesized with titanium(IV) isopropoxide and niobium oxalate by a novel polymerized complex (PC) method. The morphology and structure of the as-prepared sample was characterized by means of High-Resolution Transmission Electron Microscope, powder X-ray diffraction, and Laser Raman Spectroscopy. The spectral response characteristic was recorded by using UV-vis Diffuse Reflectance Spectroscopy. Results show that KTiNbO5 as-prepared by PC method presents an uniform morphology of nano-particles, the mean particle sizes is ca. 28 nm corresponding to the (002), and the crystal structure can be well indexed to the orthorhombic phase. The sample as-prepared by PC method has higher band gap energy than that of the sample prepared by a solid-state reaction method due to the quantum size effect.

Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study

Wang Qi,Dai Huajie,Hou Tianzhichao,Hou Yanan,Wang Tiange,Lin Hong,Zhao Zhiyun,Li Mian,Zheng Ruizhi,Wang Shuangyuan,Lu Jieli,Xu Yu,Liu Ruixin,Ning Guang,Wang Weiqing,Bi Yufang,Zheng Jie,Xu Min 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3

Background and Purpose We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR). Methods We leveraged the summary statistics of GM (n=18,340 in the MiBioGen consortium), blood metabolites (n=115,078 in the UK Biobank), and stroke (cases n=60,176 and controls n=1,310,725 in the Global Biobank Meta-Analysis Initiative) from the largest genome-wide association studies to date. We performed bidirectional MR analyses to explore the causal relationships between the GM and stroke, and two mediation analyses, two-step MR and multivariable MR, to discover potential mediating metabolites. Results Ten taxa were causally associated with stroke, and stroke led to changes in 27 taxa. In the two-step MR, <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family, <i>Desulfovibrio</i> genus, apolipoprotein A1 (ApoA1), phospholipids in high-density lipoprotein (HDL_PL), and the ratio of apolipoprotein B to ApoA1 (ApoB/ApoA1) were causally associated with stroke (all <i>P</i><0.044). The causal associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were validated using the weighted median method in an independent cohort. The three GM taxa were all positively associated with ApoA1 and HDL_PL, whereas <i>Desulfovibrio</i> genus was negatively associated with ApoB/ApoA1 (all <i>P</i><0.010). Additionally, the causal associations between the three GM taxa and ApoA1 remained significant after correcting for the false discovery rate (all q-values <0.027). Multivariable MR showed that the associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were mediated by ApoA1 and HDL_PL, each accounting for 6.5% (<i>P</i>=0.028) and 4.6% (<i>P</i>=0.033); the association between <i>Desulfovibrio</i> genus and stroke was mediated by ApoA1, HDL_PL, and ApoB/ApoA1, with mediated proportions of 7.6% (<i>P</i>=0.019), 4.2% (<i>P</i>=0.035), and 9.1% (<i>P</i>=0.013), respectively. Conclusion The current MR study provides evidence supporting the causal relationships between several specific GM taxa and stroke and potential mediating metabolites.

Lumbar Endoscopic Unilateral Laminotomy With Bilateral Decompression Surgery in Severe Lumbar Stenosis Under Electrophysiological MonitoringFocused on Full-Visualized Trephine/ Osteotome

Ning-Ning Dou,Hao-lin Wang,Shao-Zhen Hu,Zheng-Nan Huang,Jun Zhong,Shi-Ting Li 대한척추신경외과학회 2023 Neurospine Vol.20 No.3

Objective: Although endoscopic drill has the advantages in manipulation and hemostasis, whose low efficiency and blurred vision reduce the efficacy of lumbar endoscopic unilateral laminotomy with bilateral decompression (LE-ULBD). The present study was designed to evaluate the safety and efficacy of full-visualized trephine/osteotome in the LE-ULBD surgery for severe lumbar stenosis. Methods: Fifty-seven severe lumbar stenosis patients who underwent LE-ULBD between January 2020 to January 2023 were enrolled, who were divided into drill and visualized trephine groups. The medical records including demographics, operative duration, intraoperative electrophysiological findings, postoperative hospital stay or hospital stay, postoperative outcomes and complications were retrospectively reviewed and analyzed. Results: A total of 57 patients included 15 in drill and 42 in trephine group were enrolled in the study. There was significant difference in the pre- and postoperative visual analogue scale and Oswestry Disability Index scores in both groups (p < 0.05). The mean operative duration in the trephine group (101.05 ± 12.18 minutes) was shorter than that in the drill group (134.67 ± 9.68 minutes) (p < 0.05). There was no statistical difference between the 2 groups in electrophysiological monitoring, posthospital stays, postoperative outcomes and complications. Abnormal free-electromyography (EMG) were recorded in 2 (13.3%) and 5 patients (11.9%) in the drill and trephine group. Intraoperative somatosensory evoked potential changes occurred in 3 (20%) and 3 patients (7.1%) in the drill and trephine group and all patients recovered immediately when surgery ended. No serious complications and recurrence occurred in all the patients. Conclusion: Full-visualized trephine/osteotome has been approved to be convenient, safe and efficient in our study, which combined with translaminar inside-out technique and EMG monitoring especially free-EMG may offer a new choice in LE-ULBD surgery for lumbar stenosis patients.

한국어 학습자의 현대시 학습 불안감 연구 -중국 내 대학에 재학 중인 고급 학습자를 대상으로-

NING WANG 서울대학교 국어교육연구소 2023 국어교육연구 Vol.51 No.-

This study examines the layered anxiety experienced by Korean learners academically reading modern poetry, and thus formally conceptualizes the phenomenon of “modern Korean poetry learning anxiety.” Sixty-one advanced Korean learners attending D university in China were surveyed. A "Modern Korean Poetry Study Anxiety Questionnaire" was newly designed as a measurement tool based on the existing Foreign Language Classroom Anxiety Scale. Eight factors of modern poetry learning anxiety were extracted using SPSS Ver. 26, and significant differences in the degree of learning anxiety were identified based on four learner variables: gender, region of origin, Korean language learning period, and Korean literature learning career. When learner's anxiety level was divided into three degrees of difficulty—"high-medium-hardness”—there was a significant difference in the degree of learning anxiety according to the level of anxiety under factors 1–6 among the eight factors. Finally, multiple regression analysis was performed to examine the impact of each factor on overall learning anxiety. 본 연구는 ‘한국 현대시 학습 불안감’이라는 개념을 중심으로 한국어 학습자들이 경험하는 현대시 학습에 대한 불안감을 다층위적으로 고찰하고자 한다. 본 연구는 중국 내 D대학교에 재학 중인 학문 목적의 고급 한국어 학습자 총 61인을 선정하여 설문조사를 실시하였다. 본 연구에서는 기존의 '외국어 교실 불안 척도(FLCAS)'를 바탕으로 <현대시 학습 불안 설문지>를 측정 도구로 새로이 설계하였다. SPSS Ver. 26을 활용하여 통계분석을 실시한 결과, 총 8개의 현대시 학습 불안 요인이 추출되었으며, ‘성별’, ‘출신지역’, ‘한국어 학습기간’, 그리고 ‘한국문학 학습경력’의 총 4가지 학습자 변인에 따라 학습 불안 정도에 유의미한 차이가 확인되었다. 또한 학습자의 불안 수준을 ‘고-중-경도’의 세 층위로 나눌 때, 요인①-⑥하에서 불안 수준에 따른 학습 불안 정도에 유의미한 차이가 나타났다. 마지막으로 각 불안 요인이 전체 현대시 학습 불안에 미치는 영향력에 대해 고찰해 보았다. 학습 불안감이 한국 현대시 교육-학습 과정에 영향을 주는 것이 명백하다. 이에 학습자의 현대시 학습 불안감을 완화시킬 수 있는 다양한 교육 방법이 마련되어야 한다.

Novel Carrier-Based PWM Strategy of a Three-Level NPC Voltage Source Converter withoutLow-Frequency Voltage Oscillation in the Neutral Point

Ning Li,Yue Wang,Wanjun Lei,Ruigen Niu,Zhao’an Wang 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.3

A novel carrier-based PWM (CBPWM) strategy of a three-level NPC converter is proposed in this paper. The novel strategy can eliminate the low-frequency neutral point (NP) voltage oscillation under the entire modulation index and full power factor. The basic principle of the novel strategy is introduced. The internal modulation wave relationship between the novel CBPWM strategy and traditional SPWM strategy is also studied. All 64 modulation wave solutions of the CBPWM strategy are derived. Furthermore, the proposed CBPWM strategy is compared with traditional SPWM strategy regarding the output phase voltage THD characteristics, DC voltage utilization ratio, and device switching losses. Comparison results show that the proposed strategy does not cause NP voltage oscillation. As a result, no low-frequency harmonics occur on output line-to-line voltage and phase current. The novel strategy also has higher DC voltage utilization ratio (15.47% higher than that of SPWM strategy), whereas it causes larger device switching losses (4/3 times of SPWM strategy). The effectiveness of the proposed modulation strategy is verified by simulation and experiment results.

Baseline-free damage detection method for beam structures based on an actual influence line

Ning-Bo Wang,Wei-Xin Ren,Tian-Li Huang 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.4

The detection of structural damage without a priori information on the healthy state is challenging. In order to address the issue, the study presents a baseline-free approach to detect damage in beam structures based on an actual influence line. In particular, a multi-segment function-fitting calculation is developed to extract the actual deflection influence line (DIL) of a damaged beam from bridge responses due to a passing vehicle. An intact basis function based on the measurement position is introduced. The damage index is defined as the difference between the actual DIL and a constructed function related to the intact basis, and the damage location is indicated based on the local peak value of the damage index curve. The damage basis function is formulated by using the detected damage location. Based on the intact and damage basis functions, damage severity is quantified by fitting the actual DIL using the least-square calculation. Both numerical and experimental examples are provided to investigate the feasibility of the proposed method. The results indicate that the present baseline-free approach is effective in detecting the damage of beam structures.