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부산지역에서 유행한 계절인플루엔자바이러스의 유전자 특성 및 계통분석(’06~’08 절기)
Yon-Koung Park(박연경),Nam-Ho Kim(김남호),Seung-Hwa Choi(최성화),Mi-Oak Lee(이미옥),Sang-Kee Min(민상기),Seong-Joon Kim(김성준),Kyung-Soon Cho(조경순),Young-Nan Na(나영란) 한국생명과학회 2010 생명과학회지 Vol.20 No.3
2006년 10월부터 2008년 6월까지 총 인플루엔자 의사 환자 1,822건의 인후도찰물 및 비인후도찰물에서 277건의 인플루엔자바이러스를 분리했다. 절기별로는 2006~2007 절기의 1,154검체 중 52건(4.5%), 2007~2008절기의 668검체 중 210건(31.4%)에서 인플루엔자바이러스를 분리하였다. 인플루엔자바이러스 A/H1N1의 HA 유전자의 경우, 2008~2009 절기의 백신주인 A/Brisbane/59/2007과는 96.7%~97.7%, A/Solomon Islands/3/2006 96.5%~97.3%, A/New Caledonia/20/99와는 95.6%~96.6%의 유사성을 나타냈으며, NA 유전자의 경우, A/Brisbane/59/2007과는 97.8%~98.5%, A/Solomon Islands/3/2006과는 96.7%~97.6%, A/New Caledonia/20/99와는 96.8%~97.7%의 유사성을 보여 2008~2009절기의 백신주인 A/Brisbane/59/07과 가장 유사성이 컸다. 인플루엔자바이러스 A/H3N2의 분리주 중 1주를 제외한 모든 분리주가 HA 유전자에서 2008~2009 절기 백신주인 A/Brisbane/10/2007과는 98.4%~99.7%의 유사성을 보였고, A/Wisconsin/67/2005와는 96.5%~97.5%의 유사성을 보였으며, NA 유전자에서는 A/Brisbane/10/2007과는 98.9%~99.4%, A/Wisconsin/67/2005와는 98.0%~98.6%, A/California/7/2004와는 98.3%~98.9%의 유사성을 보였다. 인플루엔자바이러스 B의 HA 유전자의 경우는 2주를 제외하고는 2008~2009 절기의 백신주인 B/Florida/4/2006과는 96.5%~99.7%의 유사성을 보였으며, B/Malaysia/2506/2004와는 86.7%~87.7%의 유사성을 보여 B/Florida/4/2006과의 유사성이 크게 나타났다. NA 유전자의 경우는 reassortant분리주가 96.7%와 97.3%의 유사성을 나타내는 것을 제외하고는 B/Florida/4/2006에 98.9%~100%의 유사성을 나타냈으며, 분리주 유행시기의 백신주인 B/Malaysia/2506/2004와는 94.5%~96.7%의 유사성을 나타내어 2008~2009 절기의 백신주와 더 큰 유사성을 보였다. HA 유전자에서는 conserverd receptor binding site는 아미노산의 치환 없이 모든 분리주에서 잘 보존되어 있었으며, N-linked glycosylation site도 인플루엔자바이러스 A/H1 1주, A/H3 1주를 제외하고는 모두 같은 수의 N-linked glycosylation sites를 가졌으며, 인플루엔자바이러스 B의 경우는 2008~2009 절기의 백신주보다 1개가 많은 4개의 N-linked glycosylation sites를 가지고 있었다. Antigenic sites의 경우는 인플루엔자바이러스 A/H1의 Sb의 3개의 아미노산에서 백신주들과 다른 아미노산을 가지고 있으며, A/H3에서는 A, B, E 부위에서는 아미노산의 변화가 나타났고, C, D 부위에서는 변화가 없었다. 인플루엔자바이러스 B의 4개의 분리주에서는 150 loop와 160 loop에서 B/Florida/4/2006과 비교하여 1개의 아미노산에서 치환이 나타났으며, 190 helix에서 모든 분리주가 B/Florida/4/2006과 비교하여 1개의 아미노산에서 치환이 나타났다. To monitor newly emerged influenza virus variants and to investigate the prevalence pattern, our laboratory performed isolation of the viruses from surveillance sentinel hospitals. In the present study, we analysed influenza A/H1N1, A/H3N2, B viruses isolated in Busan during the 2006/07 and 2007/08 seasons by sequence analysis of the hemagglutinin (HA1 subunit) and neuraminidase (NA) genes. The isolates studied here were selected by the stratified random sample method from a total of 277 isolates, in which 15 were A/H1N1, 16 were A/H3N2 and 29 were B. Based on the phylogenetic tree, the HA1 gene showed that A/H1N1 isolates had a 96.7% to 97.7% homology with the A/Brisbane/59/2007, A/H3N2 isolates had a 98.4% to 99.7% homology with the A/Brisbane/10/2007, and B isolates had a 96.5% to 99.7% homology with the B/Florida/4/2006(Yamagata lineage), which are all the vaccine strains for the Northern Hemisphere in 2008~2009 season. In the case of the NA gene, A/H1N1 isolates had 97.8% to 98.5% homologies, A/H3N2 isolates had 98.9% to 99.4% homologies, and B isolates had 98.9% to 100% homologies with each vaccine strain in the 2008~2009 season, respectively. Characterization of the hemagglutinin gene revealed that amino acids at the receptor-binding site and N-linked glycosylation site were highly conserved. These results provide useful information for the control of influenza viruses in Busan and for a better understanding of vaccine strain selection.
Complete sequence-based screening of TPMT variants in the Korean population
Kim, Hyun-Young,Lee, Soo Hyun,Lee, Mi-Na,Kim, Jong-Won,Kim, Young-Ho,Kim, Mi Jin,Lee, Yoo Min,Kang, Ben,Choe, Yon Ho,Lee, Na Hee,Kim, Dong Hwan,Yoo, Keon Hee,Sung, Ki Woong,Lee, Soo-Youn,Koo, Hong Hoe Wolters Kluwer Health, Inc. All rights reserved. 2015 PHARMACOGENETICS AND GENOMICS Vol.25 No.3
Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs and its activity is largely influenced by polymorphisms of the TPMT gene. To date, more than 35 TPMT variants are known to be associated with reduced enzyme activity, but most studies on the TPMT genotype have included only common nonfunctional variants, such as TPMT*2 and TPMT*3. In this study, we carried out a complete sequencing analysis to screen all TPMT variants in Korean patients. A total of 900 Korean patients were genotyped for TPMT and 30 patients (3.3%) had the known TPMT variant alleles. TPMT*3C was found in 25 patients (2.8%): 24 patients with TPMT*1/*3 and one with TPMT*3/*3. Rare TPMT variants including TPMT*6, TPMT*16, and TPMT*32 were detected in five patients (0.6%) and a novel variant, TPMT*38 (c.514T>C, p.S172P), was identified in two patients. This is the first complete sequence-based screening study evaluating all TPMT variants in Asian populations.
( Na Ra Shim ),( Eun Jin Bae ),( Ji In Park ),( Sun Hwa Lee ),( Ha Jeong Lee ),( Dong Ki Kim ),( Yong Lim Kim ),( Shin Wook Kang ),( Chul Woo Yang ),( Yon Su Kim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Malnutrition is a common and crucial problem because it is associated with higher mortality in chronic dialysis patients. Subjective global assessment (SGA) has been proven as a clinically adequate method for assessing nutritional status in dialysis patients. We explored the relationships between initial and transitions of SGA and all-cause mortality. Methods: A nation-wide prospective observational cohort study included adult chronic dialysis patients. We selected patients who had baseline and 12 month follow-up SGA. SGA-7 score was categorized as well-nourished (SGA 6~7) and malnourished (SGA 1~5) groups. The changes of SGA were categorized by 4 groups (well-maintained, poorly-maintained, improving, and worsening group). Results: A total of 2,600 patients were selected and mean age was 55.7±14 years old and 57.2% of patients were male. The mean follow-up period was 28.5 months. During the follow-up period, 202 patients (7.8%) were died. The mortality rate in malnourished patients was higher in both incident (5.2% vs. 13%, p<0.001) and prevalent patients (6.3% vs. 20.4%, p<0.001). The survival rate was signifi cantly higher in well-nourished patients in 12 month follow-up (p<0.001). Moreover, in terms of SGA transition, improving and well-maintained groups had better survival rate than worsening group and poor-maintained group. These fi ndings were reproducible even afteradjustment of age, gender, smoking, BMI, comorbidity, serum albumin, cholesterol and hs-CRP (HR 2.913, 95% CI, 1.856-4.573, p<0.001). Conclusions: Malnutrition assessed by SGA was an independent predictor for allcause mortality. Furthermore, the transition of SGA was also correlated with mortality in chronic dialysis patients.
미분탄 물성이 난류 분류형 미분탄 화염의 휘발분 반응영역에 미치는 영향
성연모(Yon-Mo Sung),문철언(Cheor-Eon Moon),강영민(Young-Min Kang),안재우(Jae-Woo An),서상일(Sang-Il Seo),김성철(Sung-Chul Kim),김태형(Tae-Hyung Kim),나종문(Jong-Moon Na),최경민(Gyung-Min Choi),김덕줄(Duck-Jool Kim) 한국연소학회 2009 KOSCOSYMPOSIUM논문집 Vol.- No.39
The availability of 2-dimensional visualization by intensified high-speed camera for detecting volatile reaction region in pulverized coal flames, which is divided into three regions, such as particle heatup region, volatile reaction region and char reaction region, was evaluated by comparing with result from point measurements of chemiluminescence intensity. To investigate the effects of pulverized coal properties on volatile reaction region in turbulent jet pulverized coal flame, various pulverized coal properties such as five different types of pulverized coal, two particle sizes for a bituminous coal and three moisture contents for a sub-bituminous coal were taken into consideration. As a result, the length of volatile reaction region by 2-dimensional measurements was about 11.4% longer than that by point measurements. The obtained results give us useful information for evaluating practical pulverized coal flame. The temperature rise of 35 to 45 ㎛ coal particle was faster than 75 to 90 ㎛ ones, which resulted in shift of volatile reaction region toward upstream. The peak temperature of 35 to 45 ㎛ coal particle was also 35K higher. The coal moisture contents, however, has little effects on the structure of pulverized coal flame under 15% of water content.
소화성궤양 가이드라인 헬리코박터 파일로리 감염의 진단 및 치료 가이드라인
김나영 ( Na Young Kim ),김재준 ( Jae J Kim ),최연호 ( Yon Ho Choe ),김현수 ( Hyun Soo Kim ),김진일 ( Jin Il Kim ),정인식 ( In Sik Chung ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.5
Eleven years has passed since the guideline of the Korean College of Helicobacter and Upper Gastrointestinal Research group for H. pyori infection was produced in 1998. During this period the research for H. pyori has much progressed that H. pyori is now regarded as the major cause of gastric cancer. The seroprevalence of H. pyori in Korea was found to be decreased especially below the age of 40`s and in the area of Seoul·Gyeonggi province, and annual reinfection rate of H. pyori has decreased up to 2.94%. In the aspect of diagnostic tests of H. pyori the biopsy is recommended in the body instead of antrum in the subjects with atrophic gastritis and/or intestinal metaplasia for the modified Giemsa staining or Warthin Starry silver staining. The urea breath test is the test of choice to confirm eradication when follow-up endoscopy is not necessary. Definite indication for H. pyori eradication is early gastric cancer in addition to the previous indications of peptic ulcer including scar and Marginal zone B cell lymphoma (MALT type). Treatment is also recommended for the relatives of gastric cancer patient, unexplained iron deficiency anemia, and chronic idiopathic thrombocytopenic purpura. One or two week treatment of proton pump inhibitor (PPI) based triple therapy consisting of one PPI and two antibiotics, clarithromycin and amoxicillin, is recommended as the first line treatment regimen. In the case of treatment failure, one or two weeks of quadruple therapy (PPI+metronidazole+tetracycline+bismuth) is recommended. Herein, Korean College of Helicobactor and Upper Gastrointestinal Research proposes a diagnostic and treatment guideline based on currently available evidence. (Korean J Gastroenterol 2009;54:269-278)