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Factors Affecting Psychological Burnout in Nurses Caring for Terminal Cancer Patients
Na-Ri Seo,염현이 한국호스피스완화의료학회 2022 한국호스피스.완화의료학회지 Vol.25 No.4
Purpose: This study aimed to investigate the impacts of end-of-life care competency and ethical dilemmas on psychological burnout in nurses who care for terminal cancer patients. Methods: A cross-sectional study of 160 nurses who cared for terminal cancer patients was conducted. The participants were recruited from the hospice-palliative care wards, hematology or oncology wards, or intensive care units of three general hospitals in a single metropolitan area. Data were collected using a self-administered survey to assess end-oflife care competency, ethical dilemmas, psychological burnout, and general sociodemographic characteristics. Data were analyzed using descriptive statistics, the independent ttest, analysis of variance, Pearson correlation coefficients, and hierarchical linear regression analysis using SPSS for Windows (version 26.0). Results: Psychological burnout was significantly correlated with end-of-life care competency (r=-0.23, P=0.003) but not with ethical dilemmas. The results of the hierarchical linear regression analysis indicated that endof- life care competency (β=-0.280, P=0.010) and ethical dilemmas (β=0.275, P=0.037) were significant predictors of psychological burnout, after adjusting for age, religious status, clinical experience, and unit type. Conclusion: The current study’s findings demonstrate that end-of-life care competency and ethical dilemmas are crucial factors that affect psychological burnout in nurses who care for terminal cancer patients. Substantive education programs must be developed to improve nurses’ competencies in end-of-life care and ethical dilemmas to decrease psychological burnout.
경피적 배액술로 치료 가능하였던 상염색체 우성 다낭신 환자의 간낭종 감염
서연석,최용호,김나리,한창희,최수정,이은영,홍세용 대한내과학회 2002 대한내과학회지 Vol.63 No.5
Even though it is a rare complication to have hepatic cyst infection in adult polycystic kidney disease, the patient is expected to be complicated with sepsis or acute cholangitis and die if not treated properly. The typical clinical manifestations of hepatic cyst infection are fever and right upper quadrant abdominal pain. Liver enzyme and serum bilirubin levels may be elevated. The clinical outcome of hepatic cyst infection is better when antibiotic and drainage are performed simultaneously than only antibiotic is used. We experienced a case of infected hepatic cyst from a 58-year-old male patient receiving hemodialysis with autosomal dominant polycystic kidney disease. Due to his persistent fever and leukocytosis during intravenous antibiotic therapy, we performed percutaneous drainage of hepatic cyst. Because the drainage fluid presented leukocytosis and deep yellow color, we diagnosed the case as a hepatic cyst infection. We applied both percutaneous drainage of infected liver cyst and antibiotic and we observed clinical improvement.
Free Radical Scavenging Activity of Methanol Extracts of Chungkukjang
Seo, Kyoung-Chun,Noh, Jeong-Sook,Yi, Na-Ri,Choi, Ji-Myung,Cho, Eun-Ju,Han, Ji-Sook,Song, Yeong-Ok The Korean Society of Food Science and Nutrition 2008 Preventive Nutrition and Food Science Vol.13 No.2
To further the goal of isolating Bacillus sp. from commercial chungkukjang (CKJ) for a development of a probiotic dietary adjunct using soymilk or milk, antioxidant activity of CKJ purchased from the Sunchang Traditional Village in Chunbook province was examined. Six CKJ samples were evaluated and 3 were selected based on the results of the physicochemical analysis and sensory evaluation for further antioxidant study. $IC_{50}$ for DPPH scavenging activity of methanol extracts of CKJ ranged from 238.1 to 345.7 ${\mu}g/mL$. CKJ exhibited over 80% scavenging of ${\cdot}OH$ and ONOO- at concentrations of 100 ${\mu}g/mL$ and 250 ${\mu}g/mL$, respectively. $O_2^-$ and NO scavenging activities of three CKJ were increased in a dose dependent manner with the concentration tested from 100 to 1000 ${\mu}g/mL$. In this study, the methanol extract of CKJ exhibited a great reduction capability and powerful free radical scavenging activity, especially against OH. and ONOO-, which are the most toxic radicals responsible for oxidative damage in the body. However, radical scavenging effects of CKJ on DPPH, $O_2^-$, and nitrite radical were rather moderate. In conclusion, CKJ may reduce the oxidative stress in the body by scavenging the free radicals.
( Na Young Yoon ),( Hye Young Wang ),( Minyoung Jung ),( Dong Hye Kim ),( Noo Ri Lee ),( Seong Jun Seo ),( Eunhee Choi ),( Hyeyoung Lee ),( Eung Ho Choi ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Hereditary factors of atopic dermatitis(AD) have been emphasized recently. AD-related gene mutations vary significantly across ethnicities. Objectives: We tried to find mutations infilaggrin(FLG), serine protease inhibitor Kazal-type 5(SPINK5) and kallikrein 7(KLK7) genes from Korean AD patients, and developa reverse blot hybridization assay(REBA) to apply forAD-related genes. Methods: We divided AD subjects into moderate to severe AD and mild AD groups, and also divided the subjects into extrinsic and intrinsic AD groups. We performed the functional studies for skin barrier state, and checked on genemutations using the REBA. Results: The mutant type(MT) of KLK7 was significantly more frequent in AD subjects than in control and higher in the moderate to severe group compared to the mild group. The MT frequency was not different between the intrinsic and extrinsic AD groups. In the SPINK5 mutation, AD subjects more frequently had the mixed type of 603-49A>T(Glu335Val), the MT of 1188T>C(His396His) and 2475G>T(Glu825Asp) compared to control, but there was no difference between intrinsic and extrinsic AD. Conclusion: We found a correlation between the KLK7 mutation and AD, the mutations in1188T>C and 2475G>T, and 603-49A>T of SPINK5 and AD which have not been reported in Asians including Koreans. Above all things, we verified that the REBA can be applied to detect multiple barrier-related gene mutations in AD easily, simply, and accurately.
Seo, Chang-Seob,Jeong, Soo-Jin,Yoo, Sae-Rom,Lee, Na-Ri,Shin, Hyeun-Kyoo Medknow PublicationsMedia Pvt Ltd 2016 Pharmacognosy magazine Vol.12 No.46
<P><B>Background:</B></P><P>Radix Sanguisorbae has long been used to treat diarrhea, enteritis, duodenal ulcers, and internal hemorrhage.</P><P><B>Objective:</B></P><P>We investigated the <I>in vitro</I> anti-inflammatory effects of Radix Sanguisorbae and performed quantitative analyses of three marker components, namely gallic acid, ellagic acid, and quercetin, using high-performance liquid chromatography coupled with a photodiode array detector.</P><P><B>Materials and Methods:</B></P><P>The three marker components were separated using a reversed-phase Gemini C<SUB>18</SUB> analytical column maintained at 40°C by the gradient elution with two solvent systems. We examined the biological effects of the three marker compounds, gallic acid, ellagic acid, and quercetin, by determining their anti-inflammatory activities in the murine macrophage cell line RAW 264.7.</P><P><B>Results:</B></P><P>All of the marker compounds exhibited inhibitory effects on prostaglandin E<SUB>2</SUB> production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, with no cytotoxicity. Particularly, ellagic acid significantly inhibited production of the proinflammatory cytokines tumor necrosis factor alpha and interleukin-6 in LPS-treated RAW 264.7 cells.</P><P><B>Conclusion:</B></P><P>Our results suggest that ellagic acid is the most potent bioactive phytochemical component of radix Sanguisorbae in the treatment of inflammatory diseases.</P><P><B>SUMMARY</B></P><P><P>Established high-performance liquid chromatography method was applied in the quantitative analysis of gallic acid, ellagic acid, and quercetin present in an extract from radix Sanguisorbae</P><P>Among the three compounds, the ellagic acid.(7.65.mg/g) is main component in radix Sanguisorbae</P><P>Ellagic acid significantly inhibited production of the proinflammatory cytokines tumor necrosis factor alpha and interleukin-6 in lipopolysaccharide-treated RAW 264.7 cells.</P></P> >[FIG OMISSION]</BR><P><B>Abbreviations used:</B> HPLC: High-performance liquid chromatography, PDA: Photodiode array, TNF-α: Tumor necrosis factor alpha, IL: Interleukin, LPS: Lipopolysaccharide, PGE<SUB>2</SUB>: Prostaglandin E<SUB>2</SUB>, NSAIDs: Nonsteroidal anti-inflammatory drugs, COX: Cyclooxygenase.</P>
Yoga Training Improves Metabolic Parameters in Obese Boys
Seo, Dae-Yun,Lee, Sung-Ryul,Figueroa, Arturo,Kim, Hyoung-Kyu,Baek, Yeong-Ho,Kwak, Yi-Sub,Kim, Na-Ri,Choi, Tae-Hoon,Rhee, Byoung-Doo,Ko, Kyung-Soo,Park, Byung-Joo,Park, Song-Young,Han, Jin The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3
Yoga has been known to have stimulatory or inhibitory effects on the metabolic parameters and to be uncomplicated therapy for obesity. The purpose of the present study was to test the effect of an 8-week of yoga-asana training on body composition, lipid profile, and insulin resistance (IR) in obese adolescent boys. Twenty volunteers with body mass index (BMI) greater than the 95th percentile were randomly assigned to yoga (age $14.7{\pm}0.5$ years, n=10) and control groups (age $14.6{\pm}1.0$ years, n=10). The yoga group performed exercises three times per week at 40~60% of heart-rate reserve (HRR) for 8 weeks. IR was determined with the homeostasis model assessment of insulin resistance (HOMA-IR). After yoga training, body weight, BMI, fat mass (FM), and body fat % (BF %) were significantly decreased, and fat-free mass and basal metabolic rate were significantly increased than baseline values. FM and BF % were significantly improved in the yoga group compared with the control group (p<0.05). Total cholesterol (TC) was significantly decreased in the yoga group (p<0.01). HDL-cholesterol was decreased in both groups (p<0.05). No significant changes were observed between or within groups for triglycerides, LDL-cholesterol, glucose, insulin, and HOMA-IR. Our findings show that an 8-week of yoga training improves body composition and TC levels in obese adolescent boys, suggesting that yoga training may be effective in controlling some metabolic syndrome factors in obese adolescent boys.