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액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구
임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.
신규개발된 제초제 metamifop 현탁농축액제에 대한 급성독성평가
이동연,이상훈,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Metamifop, (R)-2-[4-[(6-chloro-2-benzoxazolyloxyphenoxy]-N-(2-fluorophenyl)-N-methyl propanamide, was newly developed by Dongbu Hannong Chemicals in Korea. In the present study we conducted acute oral toxicity and acute dermal toxicity test. The values of LD_(50) of metamifop was found to be over 5,000 mg/kg for ICR mice. On the other hand, metamifop showed no acute dermal toxicity to SD rats.
Carbosulfan의 피부자극성, 안점막 자극성 및 피부감작성등의 알러지성 효과에 관한 연구
이상훈,이동연,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Many studies have been published on the human health effects of carbosulfan toxicity. Carbosulfan used as an insecticide can produce an irritating and allergenic effect when acting on the skin. In this study, a sensitization test on albino guinea pigs and intradermal reactivity and occular irritation test on albino rabbits were carried out with carbosulfan. Signs of acute skin inflammation appeared along with the clinical symptom of chronic dermatosis caused by the solution irritating characteristics. Moreover, carbosulfan showed severe eye irritation with conjuctival redness and severe opacity on cornea. Preventive measures should involve workers' obligatory instructions on the noxious impact on human skin and strict observance of industrial safety rules.
Pyriminobac-methyl과 azimsulfuron 합제의 신규제형인 분산형 정제에 대한 독성 평가
백경진,이동연,이상훈,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Dispersible tablets disintegrate either to form a stabilized suspension rapidly in water, or to disperse instantaneously in the rice field without the aid of water. In this study, the newly formulated dispersible tablet form of herbicidal combination, pyriminobac-methyl and azimsulfuron, was evaluated the safety for human and animals in the toxicological viewpoints. The LD_(50) value of dispersible tablet form for pyriminobac-methyl and azimsulfuron was above 2,500 mg/kg for the oral route and above 2,000 mg/kg for the dermal route. It is considered to have low acute oral and dermal toxicity based on the findings of the present studies. In addition, the combination of pyriminobac-methyl and azimsulfuron showed mild skin irritant under the conditions of this study and conjunctival redness and slight opacity on cornea appeared from 1 hour after application.
Molecular Epidemiology of Viral Conjunctivitis in the Southern Region of South Korea, 2012-2016
Duck Woong Park,Min Ji Kim,Kwang gon Kim,Sun Ju Cho,Hye Jung Park,Ji Hyun Shin,Yi Deun Ha,Mi Hee Seo,Jang Hoon Kim,Yeon Lee,Myoung Doo Park,Hi-Mo Yoon,Eun Sun Kim,Young Jin Hong,Hyeyoung Kee,Jae Keun 대한미생물학회 2018 Journal of Bacteriology and Virology Vol.48 No.2
Yu, Jeong Il,Park, Hee Chul,Choi, Doo Ho,Noh, Jae Myoung,Oh, Dongryul,Park, Jun Su,Chang, Ji Hyun,Kim, Seung Tae,Lee, Jeeyun,Park, Se Hoon,Park, Joon Oh,Park, Young Suk,Lim, Ho Yeong,Kang, Won Ki The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.1
Purpose: A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. Materials and Methods: Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated. Results: A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires. Conclusion: Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer.
Park, Jung Hyuk,Baek, Sung-Doo,Cho, Jin Il,Yoo, Jee Young,Yoon, Soo-Young,Kim, Sunghee,Lee, Suyeon,Kim, Youn Sang,Myoung, Jae-Min Elsevier 2019 Composites. Part B, Engineering Vol.175 No.-
<P><B>Abstract</B></P> <P>Transparent encapsulation materials were fabricated by combining inorganic mesoporous silica nanoparticles (MSNPs) and a transparent polyurethane acrylate (PUA)-based resin. The surfaces of the synthesized MSNPs were successfully modified by a two-step sol-gel method with the coupling agent [3-(methacryloyloxy)propyl]trimethoxysilane (MPS). The bare and MPS-modified MSNPs possessed good hygroscopic properties (20% and 17%, respectively). The optimized MSNP-PUA composite containing 2 wt% MPS-modified MSNPs exhibited a high transparency (94.8%) with low haze (2.1%) and excellent encapsulation properties (lasted 576 h in a moisture permeability test at 85 °C and 85% RH).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mesoporous silica nanoparticles (MSNPs) are successfully synthesized by a hydrothermal method. </LI> <LI> The surface of MSNPs is successfully modified by MPS. </LI> <LI> Hygroscopic MPS-modified MSNPs are uniformly dispersed in polyurethane acrylate resin. </LI> <LI> The fabricated MSNP-PUA composites are optically transparent and possess excellent encapsulation properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>