Incidence of Dental Discoloration After Tetracycline Exposure in Korean Children: A Nationwide Population-Based Study

Lee Ji Young,Kim Eun Hwa,Lee Myeongjee,Shin Jehee,Lim Sung Min,Baek Jee Yeon,Kim MinYoung,Ahn Jong Gyun,Kang Chung-Min,Jung Inkyung,Kang Ji-Man 대한소아감염학회 2024 Pediatric Infection and Vaccine Vol.31 No.1

Purpose: Tetracycline is not recommended for children under 12 by guideline due to the risk of tooth discoloration. We aimed to assess the incidence of dental discoloration in Korean children prescribed tetracyclines and investigate whether its risk was greater in tetracyclineexposed children than in the general population. Methods: This population-based cohort study using the Health Insurance Review and Assessment service database included children aged 0–12 years exposed to tetracyclines for at least 1 day between January 2008 and December 2020. The primary outcome was the incidence rate of dental discoloration ≥6 months after prescription, and the standardized incidence ratio (SIR) was evaluated as secondary outcome. Results: 56,990 children were included—1,735 and 55,255 aged <8 and 8–12 years, respectively. 61% children were prescribed tetracycline for <14 days with mostly secondgeneration tetracyclines, doxycycline (61%) and minocycline (35%). The 5- and 10-year cumulative incidence rates of dental discoloration were 4.1% (95% confidence interval [CI], 3.0–5.7%) and 5.7% (95% CI, 4.1% to 7.8%), respectively, in the 0–7 years age group and 0.8% (95% CI, 0.7% to 0.9%) and 1.3 (95% CI, 1.1% to 1.4%), respectively, in the 8–12 years age group. Tetracycline exposure did not increase such risk compared to that in the general population (SIR, 1.08; 95% CI, 0.69 to 1.60). Conclusions: The incidence of dental discoloration was lower than previously suggested. Relieving the age restriction for prescribing tetracyclines may be considered.

미세먼지가 영유아의 아토피 피부염에 미치는 영향

이주은(Jueun Lee),이명지(Myeongjee Lee),권정현(Jung Hyun Kwon),김경남(Kyung-Nam Kim),예신희(Shinhee Ye),하은희(Eun-Hee Ha) 환경독성보건학회 2016 한국독성학회 심포지움 및 학술발표회 Vol.2016 No.6

On the goodness-of-fit tests for gamma generalized linear models

조성일,Lee Myeongjee,이우주 한국통계학회 2021 Journal of the Korean Statistical Society Vol.50 No.1

An omitted covariate in the regression function leads to hidden or unobserved heterogeneity in generalized linear models (GLMs). Using this fact, we develop two novel goodness-of-ft tests for gamma GLMs. The frst is a score test to check the existence of hidden heterogeneity and the second is a Hausman-type specifcation test to detect the diference between two estimators for the dispersion parameter. In addition to these developments, we reveal the undesirable behavior of the deviance test for gamma GLMs, which is still used by many scholars in practice. Exploiting real-world data, we demonstrate the application of our proposed method.

Effects of maternal and cord blood PFC concentrations on birth outcome and postnatal growth at age of 36 month

( Eunhee Ha ),( Myeongjee Lee ),( Eun Mi Jung ),( Eun Jin Kwon ),( Surabhi Shah-kulkarni ) 한국모자보건학회 2016 한국모자보건학회 학술대회 연제집 Vol.2016 No.2

Background and Aim Perfluorinated compound (PFC) is a widely distributed class of chemical in consumer and industrial products including surfactants, paper coating, fabric, food packaging, and surface protectants. The aim of this study is to compare the PFC concentrations between mothers and their children and examine the effects of maternal and cord blood PFC concentrations on birth outcome and postnatal growth at age of 36 month. Method We collected blood samples and data from 30 pregnant women and newborn through a retrospective cohort study of Ewha Birth & Growth between 2006 and 2010 in Ewha Womans Medical care. Outcomes were included anthropometry and body composition at birth and at age of 3 years of children were obtained from medical records after birth and automatic electronic scale by trained nurses. We analyzed maternal and cord samples for perfluorinated compounds (PFCs) by high-performance liquid chromatograph coupled with a Triple Quad LC-MS/MS system. Multiple linear regression analysis and generalized estimating equation model were used to estimate the association between PFCs exposure and child growth after adjusting for maternal age, maternal height and weight, gestational age, parity and gender. Results Among PFCs, PFHxA, PFBS, and PFDS were not detected. PFTeDA, PFHpA, and PFNA were significantly correlated between mother and child, and PFTrDA showed borderline significance. Higher concentration of maternal PFDoDA decreased child's weight at birth by -1.13 (-1.63 - 0.63) and height by -4.80 (-7.63 - 1.96), but higher concentration of maternal PFDA increased child height at the 36-month time point by 4.75 (0.28 - 9.22), In the analyses using GEE, which concerns the time from birth to 36 months, higher concentrations of maternal PFOA and PFDA increased child's weight by 0.23 (0.008 - 0.44) and 1.12 (0.41 - 1.84), respectively. Higher concentration of maternal PFDA also increased child’ s height by 2.58 (1.23 - 3.94) in the GEE model. Higher concentration of cord blood PFCs increased child’ s abdominal circumference by 1.40 (0.003 - 2.81) as well. On the other hands, higher cord blood PFOA concentration decreased child’ s height at the age of 36 months with borderline significance (-0.94 (-1.96 - 0.08)),and in the GEE model, higher concentration of PFOA in cord blood decreased child’ s height by -0.65 (-1.06 - 0.23). Conclusion Our finding indicates that higher concentration of maternal PFDoDA may negatively affect birth weight. However, it also may positively affect postnatal growth. Further studies with a larger sample size are need to be conducted to examine the biological plausibility of these effects.

Renal growth slope in children with congenital and acquired solitary functioning kidneys

최승면,신현주,Yoon Haesung,Lee Myeongjee,이용승,한상원,이미정 대한초음파의학회 2021 ULTRASONOGRAPHY Vol.40 No.3

Purpose: This study aimed to analyze the renal growth slope in children with congenital and acquired solitary functioning kidneys. Methods: This retrospective study included all renal ultrasonography examinations performed in children in the agenesis, multicystic dysplastic kidney (MCDK), or nephrectomy group between September 2002 and February 2019. We reviewed the images and recorded the contralateral kidney size only when there was no focal lesion. Linear mixed model or piecewise linear mixed model analyses with a time point of 24 months of age were performed. Results: There were 132 patients, including 26 patients in the agenesis group, 35 in the MCDK group, and 71 in the nephrectomy group. The nephrectomy group showed the largest baseline kidney size (7.4 cm vs. 5.3 cm in the agenesis group [P<0.001] and 5.2 cm in the MCDK group [P<0.001]) and the smallest overall growth slope (0.04 cm/mo vs. 0.06 cm/mo in the agenesis group [P=0.004] and 0.07 cm/mo in the MCDK group [P<0.001]). However, considering the time point of 24 months for reaching adult renal function, there were significant changes in slope, from 0.1 cm/mo before 24 months of age to 0.03 cm/mo after 24 months of age in all three groups (P<0.001), without a significant difference among the groups. Conclusion: Significant changes were found in the renal growth slope before and after 24 months of age, with no significant difference between congenital and acquired solitary functioning kidneys

Preliminary Methodology for Linking Data

Eunhee Ha,Jueun Lee,Byung-Hak Jeon,Myeongjee Lee 환경독성보건학회 2015 한국독성학회 심포지움 및 학술발표회 Vol.2015 No.10

Respiratory Syncytial Virus Outbreak Without Influenza in the Second Year of the Coronavirus Disease 2019 Pandemic: A National Sentinel Surveillance in Korea, 2021–2022 Season

Kim Jong-Hun,Kim Ha Yan,Lee Myeongjee,Jong Gyun Ahn,Baek Jee Yeon,Min Young Kim,Huh Kyungmin,Jaehun Jung,Ji-Man Kang 대한의학회 2022 Journal of Korean medical science Vol.37 No.34

Background: This study aimed to investigate whether respiratory syncytial virus (RSV) and influenza virus (IFV) infections would occur in 2021–2022 as domestic nonpharmaceutical interventions (NPIs) are easing. Methods: Data were collected from the Korean Influenza and Respiratory Virus Monitoring System database. The weekly positivity rates of respiratory viruses and number of hospitalizations for acute respiratory infections were evaluated (January 2016–2022). The period from February 2020 to January 2022 was considered the NPI period. The autoregressive integrated moving average model and Poisson analysis were used for data analysis. Data from 14 countries/regions that reported positivity rates of RSV and IFV were also investigated. Results: Compared with the pre-NPI period, the positivity and hospitalization rates for IFV infection during 2021–2022 significantly decreased to 0.0% and 1.0%, respectively, at 0.0% and 1.2% of the predicted values, respectively. The RSV infection positivity rate in 2021–2022 was 1.8-fold higher than that in the pre-NPI period at 1.5-fold the predicted value. The hospitalization rate for RSV was 20.0% of that in the pre-NPI period at 17.6% of the predicted value. The re-emergence of RSV and IFV infections during 2020–2021 was observed in 13 and 4 countries, respectively. Conclusion: During 2021–2022, endemic transmission of the RSV, but not IFV, was observed in Korea.

Marked impact of preeclampsia on cancer risk: A Nationwide Population-Based Cohort Study

( Kyung Jin Eoh ),( Eun Hwa Kim ),( Myeongjee Lee ),( Inkyung Jung ),( Young Tae Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: To evaluate the cancer risk in a cohort of women with newly diagnosed preeclampsia. Methods: This nationwide, population-based retrospective cohort study used data from the 10-year claims database of the Korean National Health Insurance from January 2008 to December 2020. Patients diagnosed with preeclampsia between 2009 and 2013 were included; those who underwent appendectomy but were not diagnosed with preeclampsia during the study period served as controls. Participants diagnosed with cancer before enrollment were excluded. Cancer occurrence in both groups was identified and compared according to the diagnostic codes for different organ sites using the International Classification of Diseases, 10th revision. Results: In total, 42,380 patients with preeclampsia and 105,327 controls were analyzed, and the incidence rates of cancer were 333.1 and 376.97 per 100,000 person-years, respectively. Patients with preeclampsia had significantly increase cancers of gallbladder and biliary tract (hazard ration [HR], 5.492; 95% confidence interval [CI], 1.23124.501; p=0.0256), breast (HR, 1.168; 95% CI, 1.0181.340; p=0.0270), and thyroid (HR, 1.210; 95% CI, 1.0971.335; p=0.0020). In contrast, significantly decreased risk was observed in cancers of ovary (HR, 0.444; 95% CI, 0.2650.743; p=0.0001), and leukemia (HR, 0.364; 95% CI, 0.1640.806; p=0.0127). Conclusion: Preeclampsia had a significant impact on cancer risk of gallbladder and biliary tract, breast, thyroid, ovary, leukemia.

Diagnostic Image Feature and Performance of CT and Gadoxetic Acid Disodium-Enhanced MRI in Distinction of Combined Hepatocellular- Cholangiocarcinoma from Hepatocellular Carcinoma

Hyunghu Kim,Seung-seob Kim,Sunyoung Lee,Myeongjee Lee,김명진 대한자기공명의과학회 2021 Investigative Magnetic Resonance Imaging Vol.25 No.4

Purpose: To find diagnostic image features, to compare diagnostic performance of multiphase CT versus gadoxetic acid disodium-enhanced MRI (GAD-MRI), and to evaluate the impact of analyzing Liver Imaging Reporting and Data System (LI-RADS) imaging features, for distinguishing combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC). Materials and Methods: Ninety-six patients with pathologically proven CHC (n = 48) or HCC (n = 48), diagnosed June 2008 to May 2018 were retrospectively analyzed in random order by three radiologists with different experience levels. In the first analysis, the readers independently determined the probability of CHC based on their own knowledge and experiences. In the second analysis, they evaluated imaging features defined in LI-RADS 2018. Area under the curve (AUC) values for CHC diagnosis were compared between CT and MRI, and between the first and second analyses. Interobserver agreement was assessed using Cohen’s weighted κ values. Results: Targetoid LR-M image features showed better specificities and positive predictive values (PPV) than the others. Among them, rim arterial phase hyperenhancement had the highest specificity and PPV. Average sensitivity, specificity, and AUC values were higher for MRI than for CT in both the first (P = 0.008, 0.005, 0.002, respectively) and second (P = 0.017, 0.026, 0.036) analyses. Interobserver agreements were higher for MRI in both analyses (κ = 0.307 for CT, κ = 0.332 for MRI in the first analysis; κ = 0.467 for CT, κ = 0.531 for MRI in the second analysis), with greater agreement in the second analysis for both CT (P = 0.001) and MRI (P < 0.001). Conclusion: Rim arterial phase hyperenhancement on GAD-MRI can be a good indicator suggesting CHC more than HCC. GAD-MRI may provide greater accuracy than CT for distinguishing CHC from HCC. Interobserver agreement can be improved for both CT and MRI by analyzing LI-RADS imaging features.

Longitudinal Association Between Glomerular Filtration Rate and Lung Function in Korean General Population: A Prospective Cohort Study

( Sinyoung Kwon ),( Hyung Woo Kim ),( Hye Jung Shin ),( Myeongjee Lee ),( Ji Ye Jung ),( Youngmok Park ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0