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Idrees, Muhammad,Xu, Lianguang,El Sheikh, Marwa,Sidrat, Tabinda,Song, Seok-Hwan,Joo, Myeong-Don,Lee, Kyeong-Lim,Kong, Il-Keun MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.23
<P>The PPARs (peroxisome proliferator-activated receptors) play critical roles in the regulation of lipid and glucose metabolism. PPARδ, a member of the PPARs family, is associated with decreased susceptibility to ectopic lipid deposition and is implicated in the regulation of mitochondrial processes. The current study aimed to determine the role of PPARδ in fatty acid β-oxidation and its influence on PEPCK for the lipogenic/lipolytic balance during in vitro bovine oocyte maturation and embryo development. Activation of PPARδ by GW501516, but not 2-BP, was indicated by intact embryonic PEPCK (cytosolic) and CPT1 expression and the balance between free fatty acids and mitochondrial β-oxidation that reduced ROS and inhibited p-NF-κB nuclear localization. Genes involved in lipolysis, fatty acid oxidation, and apoptosis showed significant differences after the GW501516 treatment relative to the control- and 2-BP-treated embryos. GSK3787 reversed the PPARδ-induced effects by reducing PEPCK and CPT1 expression and the mitochondrial membrane potential, revealing the importance of PPARδ/PEPCK and PPARδ/CPT1 for controlling lipolysis during embryo development. In conclusion, GW501516-activated PPARδ maintained the correlation between lipolysis and lipogenesis by enhancing PEPCK and CPT1 to improve bovine embryo quality.</P>
Muhammad IDREES,Romana BANGASH,Hanana KHAN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.3
This study was conducted to determine whether there is a significant relationship between board structure and board committee qualities and corporate cash holdings in Pakistan. For this objective, 168 listed enterprises on the PSX for the period 2016 to 2020 were chosen as a sample from a population of 436 non-financial firms. Multiple regression analysis was used in the study to discover a relationship between board structure and board committee features and cash holdings. The study’s findings revealed that board size, executive directors, and board independence have no significant impact on the firm’s cash holding because they play no important part in the firm’s cash holding. Auditors, audit committee size, audit committee meetings, and the compensation committee, on the other hand, have no major impact on the firm’s cash holdings because they are not relevant indicators to compare with cash holdings. While board meeting frequency and leadership structure both have a negative influence on cash holding, board meeting frequency increases firm costs, whereas leadership structure causes agency problems. Results were supported by the pecking order theory, cash flow theory, and agency theory.
Idrees, Muhammad,Batool, Saima,Ullah, Hidayat,Hussain, Qaiser,Al-Wabel, Mohammad I.,Ahmad, Mahtab,Hussain, Amjad,Riaz, Muhammad,Ok, Yong Sik,Kong, Jie Elsevier 2018 Journal of molecular liquids Vol.266 No.-
<P><B>Abstract</B></P> <P>In the present investigation, poultry manure and farmyard manure-derived biochars were applied as cost-effective adsorbents for manganese (Mn) removal from aqueous media. Effects of functional parameters such as solution pH, contact time, temperature and concentration on the Mn removal efficiency of biochars were evaluated. Poultry manure-derived biochar exhibited greater adsorption efficiency than farmyard manure-derived biochar due to its porosity and surface functionality. The maximum adsorption was achieved at pH 6, temperature 298 K and contact time of 3 h. The adsorption isotherm data was well fitted to the Freundlich model indicating multilayer adsorption onto heterogeneous surfaces of the biochars. Thermodynamics calculations affirmed that Mn adsorption onto biochars was spontaneous and exothermic process governed by hydrogen bonding type of electrostatic interaction. Post-adsorption spectroscopic analysis of Mn-loaded biochars evidenced the binding of Mn with active surface functionalities of biochars.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biochar, a by-product of pyrolysis, was prepared as a low cost adsorbent precursor. </LI> <LI> Effect of derived biochars on Manganese removal efficiency was investigated. </LI> <LI> FBC and PBC characteristics were analyzed. </LI> <LI> Langmuir and Freundlich models were used for equilibrium modeling. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Muhammad Idrees Afridi,Muhammad Qasim,Ilyas Khan 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.9
In the present paper, we study the entropy analysis of boundary layer ow over a slender stretching sheet under the action of a non uniform magnetic field that is acting perpendicular to the ow direction. The effects of viscous dissipation and Joule heating are included in the energy equation. Using similarity transformation technique the momentum and thermal boundary layer equations to a system of nonlinear differential equations. Numerical solutions are obtained using the shooting and fourth-order Runge-Kutta method. The expressions for the entropy generation number and Bejan number are also obtained using a suggested similarity transformation. The main objective of this article is to investigate the effects of different governing parameters such as the magnetic parameter (M2), Prandtl number (Pr), Eckert number (Ec), velocity index parameter (m), wall thickness parameter (ff), temperature difference parameter ( ), entropy generation number (Ns) and Bejan number (Be). All these effects are portrayed graphically and discussed in detail. The analysis reveals that entropy generation reduces with decreasing wall thickness parameter and increasing temperature difference between the stretching sheet and the uid outside the boundary layer. The viscous and magnetic irreversibilities are dominant in the vicinity of the stretching surface.
Shah Syed Bilal,Sartaj Lubna,Hussain Shahid,Ullah Nabi,Idrees Muhammad,Shaheen Asma,Javed Muhammad Sufyan,Aslam Muhammad Kashif 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.2
Cannabis sativa (C. sativa) is a widespread medicinal plant used for humans and cattles infectious diseases. The current study is carried out to assess phytochemical, antimicrobial, antioxidant, α-amylase inhibition and cytotoxic activity of the Cannabis sativa plant. An appropriate amount of phytochemicals like tannins, flavonoids, lycopene, and β-carotenes is found in C. sativa plant during the phytochemical screening. Among these phytochemicals of C. sativa plant, tannin shows outstanding activity. The plant extracts are assessed for antimicrobial activity against different seven bacterial strains. Notably, the stem part of C. sativa is found to exhibit higher antimicrobial potential than root and leaf. Among the extracts, the antioxidant assays (evaluated through % inhibition of linoleic acid peroxidation assessment) of n-hexane extract of leaf part was highest (80.70%) compared to the others. The plant also contains a potent α-amylase inhibitory potential, the root extract shows maximum inhibition of α-amylase. The cytotoxic effect [evaluated through hemolytic activity as (%) lysis of RBCs against human erythrocytes] of the plant extracts is found insignificant ranging from 1.97 to 5.88. The plant C. sativa keeps a significant amount of bioactive phenolic combinations accompanied by high antimicrobial and antioxidant activities.
Iqra Mir,Sania Aamir,Syed Rizwan Hussain Shah,Muhammad Shahid,Iram Amin,Samia Afzal,Amjad Nawaz,Muhammad Umer Khan,Muhammad Idrees 질병관리본부 2022 Osong Public Health and Research Persptectives Vol.13 No.2
The coronavirus disease 2019 (COVID-19) pandemic rapidly spread globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, is a positive-sense single-stranded RNA virus with a reported fatality rate ranging from 1% to 7%, and people with immune-compromised conditions, children, and older adults are particularly vulnerable. Respiratory failure and cytokine storm-induced multiple organ failure are the major causes of death. This article highlights the innate and adaptive immune mechanisms of host cells activated in response to SARS-CoV-2 infection and possible therapeutic approaches against COVID-19. Some potential drugs proven to be effective for other viral diseases are under clinical trials now for use against COVID-19. Examples include inhibitors of RNA-dependent RNA polymerase (remdesivir, favipiravir, ribavirin), viral protein synthesis (ivermectin, lopinavir/ritonavir), and fusion of the viral membrane with host cells (chloroquine, hydroxychloroquine, nitazoxanide, and umifenovir). This article also presents the intellectual groundwork for the ongoing development of vaccines in preclinical and clinical trials, explaining potential candidates (live attenuated-whole virus vaccines, inactivated vaccines, subunit vaccines, DNA-based vaccines, protein-based vaccines, nanoparticle-based vaccines, virus-like particles and mRNA-based vaccines). Designing and developing an effective vaccine (both prophylactic and therapeutic) would be a long-term solution and the most effective way to eliminate the COVID-19 pandemic.
( Muhammad Ibrahim Rajoka ),( Sobia Idrees ),( Usman Ali Ashfaq ),( Beenish Ehsan ),( Asma Haq ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.1
Thermostable enzymes derived from Thermotoga maritima have attracted worldwide interest for their potential industrial applications. Structural analysis and docking studies were preformed on T. maritima β-glucosidase enzyme with cellobiose and pNP-linked substrates. The 3D structure of the thermostable β-glucosidase was downloaded from the Protein Data Bank database. Substrates were downloaded from the PubCehm database and were minimized using MOE software. Docking of BglA and substrates was carried out using MOE software. After analyzing docked enzyme/substrate complexes, it was found that Glu residues were mainly involved in the reaction, and other important residues such as Asn, Ser, Tyr, Trp, and His were involved in hydrogen bonding with pNP-linked substrates. By determining the substrate recognition pattern, a more suitable β-glucosidase enzyme could be developed, enhancing its industrial potential.