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Miji Lee,Duhak Yoon,전진태,어성국,강성호 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.11
A breed of cattle, i.e., Korean cattle (Hanwoo), was identified based on the DNA mobilities of their microsatellites (MSs) by capillary gel electrophoresis (CGE) with a laser-induced fluorescence (LIF) detector. The MS markers were used for the accurate identification of species-specific genes. The DNA mobilities of the MS markers of Hanwoo and Holstein were measured using a CGE system with a fused-silica capillary (inner diameter of 75 μm, outer diameter of 365 μm, and total length of 50 cm). The capillary was dynamically coated with 1.0% (w/v) polyvinylpyrrolidone (Mr = 1,000,000) and then filled with a mixture of 1.3% (w/v) poly(ethylene oxide) (Mr = 600,000) and 1.9% (w/v) poly(ethylene oxide) (Mr = 8,000,000) as a sieving gel matrix. The species-specific genes of Hanwoo and Holstein were clearly distinguished within 33 min. This CGE assay technique is expected to be a useful analytical method for the fast and accurate identification of breeds of cattle.
The Association Between Alcohol Use and Suicidal Ideation Among Employees
Miji Lee,Ung Lee,Jae-Hyun Park,Young-Chul Shin,Mikyung Sim,Kang-Seob Oh,Dong-Won Shin,Sang-Won Jeon,Jinmi Seol,Sung Joon Cho 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.10
Objective The risk of suicide is assessed by identifying the relationship between alcohol-use patterns and suicidal ideation in Korean employees. Methods The study involved 13,858 employees who underwent workplace mental health screening at the Workplace Mental Health Institute of Kangbuk Samsung Hospital over a 6-year period between 2014 and 2019. Analysis was performed separately for Alcohol Use Disorders Identification Test-Korea (AUDIT-K) items related to the frequency/volume of alcohol consumption (items 1 to 3, AUDIT-C) and those regarding alcohol dependence/related problems (items 4 to 10, AUDIT-D/P). Subjects were then classified into three groups on the basis of the presence or absence of clinical depression and suicidal ideation. The groups’ sociodemographic factors and clinical features of depression, anxiety, and alcohol-use patterns were analyzed with a chi-square test as well as one-way analysis of variance, followed by a post hoc test using the Bonferroni correction. Results AUDIT-K and AUDIT-D/P scores were significantly associated with the presence or absence of clinical depression as well as the presence or absence of suicidal ideation (p<0.05). However, no significant differences were found among the three groups with regard to the AUDIT-C score (p=0.054). Conclusion Identifying or treating alcohol dependence/related problems can help lower the occurrence of mental health problems, and suicidal ideation in particular, in employees and reduce social costs.
Lee, Miji,Lee, Hyang Ah,Park, Mira,Park, Hee Kyoung,Kim, Yeon Sun,Yang, Seung Chel,Kim, Hye-Ryun,Kim, Jayeon,Song, Haengseok CSIRO Publishing 2018 Reproduction, fertility, and development Vol.30 No.11
<P> Decay accelerating factor (DAF) is upregulated in the fetoplacental trophoblast, which protects the fetus from maternal complement injury. DAF was found to be downregulated in the endometrium of patients with repeated implantation failure. Thus, we examined the molecular mechanisms of DAF expression regulation by ovarian steroid hormones in the mouse uterus. Immunofluorescence staining demonstrated its exclusive localisation in the apical region of the epithelium in the uterus. Oestrogen (E2) significantly induced Daf mRNA in a time-dependent manner. Progesterone (P4) did not have any significant effect on Daf expression; however, it negatively modulated E2-induced DAF expression and RU486 effectively interfered with the inhibitory action of P4 in the uterus. During early pregnancy DAF was higher on Day 1 of pregnancy, but significantly decreased from Day 3, which is consistent with its E2-dependent regulation. Interestingly, DAF expression seemed to be influenced by the implanting blastocyst on Day 5 and it was gradually increased during preimplantation embryo development with peak levels at blastocyst stages. We demonstrated that E2-dependent DAF expression is antagonised by P4-progesterone receptor signalling in the uterine epithelium. Spatiotemporal regulation of DAF in the uterus and preimplantation embryos suggest that DAF functions as an immune modulator for embryo implantation and early pregnancy in mice. </P>
李美智(Lee, Miji) 한국사학회 2010 史學硏究 Vol.- No.99
본고는 고려가 선택하여 사용한 거란에 대한 지칭 표현을 주요 소재로 하여 고려가 구상했던 거란과의 관계는 어떠한 것이었는지를 이해해보고자 하였다. 명시적인 거란 지칭어 외에 戎狄?賊?仇? 등과 같은 유표적 지칭 표현 및 고려가 구상하고 있던 거란과의 관계를 짐작하게 하는 交隣?請和 등의 표현 역시 거란 지칭 표현이라는 큰 범주에 포함하여 검토하였으며, 해당 지칭 표현의 발화자와 청자 및 발화 상황을 종합적으로 살펴보았다. 태조대에서 성종대에 걸쳐 나타나는 無道?禽獸之國?强惡之國?戎狄 등의 거란 지칭 표현을 발화 맥락 속에서 분석해 본 결과, 이와 같은 부정적인 지칭어들은 정책적으로 선언되거나 혹은 고려 내부적 목적을 달성하기 위한 수사로써 사용된 측면이 있었음이 확인된다. 거란과의 관계를 지칭하는 표현들을 통해서는 당시 고려가 거란과의 관계를 어떻게 인식하고 있었는지 보다 직접적으로 확인할 수 있는데, 고려는 이를 자주 隣으로 묘사하였고 거란을 修好의 대상으로 파악하였다. 최승로가 태조대의 대외관계를 사대와 교린으로 나누었던 것을 보면 고려는 거란과의 관계를 중원 왕조와의 사대 관계와는 구분되는 교린 관계로 파악한 것으로 보인다. 고려와 중원 왕조 간에는 책봉이라는 외교 형식을 통해 양국간에 상하관계가 선명하게 드러났지만, 국초 거란과의 교린 관계는 五代 및 송과의 관계와는 구분되나 아직 뚜렷한 질서나 구체적인 외교 형식이 성립하지 않았다는 특징이 있었다. 이는 외부 정치체들과 개별적인 관계를 구축하고 각각에 맞는 외교 관계를 수행해가던 고려 대외정책의 한 단면을 보여준다. The address terms which the Koryo used in 918-993 for the Khitans, were reexamined in the paper. The Koryo described the Khitans as "immoral(無道)", "bestial nation(禽獸之國)", "tough and vicious country(强惡之國)", "barbarians (戎狄)". Previous researches have argued that these phrases directly shows how much the Koryo disdained the Khitans. However, the neutral phrases for the Khitans, such as "they(彼)", "that country(彼國)", "the foreign country(外國)", are also used in the same period. Moreover, if we re-read the despising terms in the "context" including the speaker, the listener(s), and the communication situation, it is not convincing that the Koryo selected those terms only to contemn the Khitans. This paper also focused on the terms used when the Koryo defined their relations with the Khitans. The frequently chosen word was "neighbouring (隣)". Another significant phrase that reveals the Koryo"s conception on the relations with the Khitans was "getting along with the neighbours(交隣)". The Koryo differentiated "getting along with the neighbours(交隣)" from "serving the powerful(事大)". Why and how the Koryo separate those two different foreign relations is further argued in the paper.