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Jin, Jun-Jang,Ko, Il-Gyu,Kim, Sung-Eun,Shin, Mal-Soon,Kim, Sang-Hoon,Jee, Yong-Seok Korean Society of Exercise Rehabilitation 2014 JER Vol.10 No.2
<P>Multiple sclerosis is one of the autoimmune diseases in the central nervous system. Multiple sclerosis occurs through multiple mechanisms, and it is also mediated in part by an apoptotic mechanism. Swimming exercise has been recommended for the prevention and treatment of chronic diseases. In the present study, we investigated the effects of swimming exercise on short-term memory in relation with apoptotic neuronal cell death in the hippocampus following induction of multiple sclerosis. For this study, step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, immunohistochemistry for caspase-3 were performed. The animal model of multiple sclerosis was made by bilateral intracerebral ventricle injection of ethidium bromide. The rats in the swimming exercise groups were forced to swim for 30 min once daily for 14 consecutive days, starting 3 days after induction of multiple sclerosis. In the present results, short-term memory was deteriorated in the multiple sclerosis-induced rats. The number of TUNEL-positive and caspase-3-positive cells in the hippocampal dentate gyrus was increased in the multiple sclerosis-induced rats. Swimming exercise alleviated multiple sclerosis-induced short-term memory impairment by suppressing apoptotic neuronal cell death in the hippocampus. These effects of swimming exercise may aid symptom relief in the incurable neurodegenerative diseases.</P>
Kim, Sung-Eun,Ko, Il-Gyu,Kim, Bo-Kyun,Shin, Mal-Soon,Cho, Sehyung,Kim, Chang-Ju,Kim, Sang-Hun,Baek, Seung-Soo,Lee, Eun-Kyu,Jee, Yong-Seok Elsevier 2010 Experimental Gerontology Vol.45 No.5
<P><B>Abstract</B></P><P>Aging leads to functional changes in the hippocampus, and consequently induces cognitive deficits, such as failure of memory. Neurogenesis in the hippocampal dentate gyrus continues throughout life, but steadily declines from early adulthood. Apoptosis occurs under various pathologic and physiologic conditions, and excessive apoptotic cell death can cause a number of functional disorders in humans. Apoptosis in the hippocampus also disturbs cognitive functions. In this study, we examined the effect of treadmill exercise on memory in relation to neurogensis and apoptosis in the hippocampal dentate gyrus of old-aged rats. The present results showed that loss of memory by aging was associated with a decrease in neurogenesis and an increase in apoptosis in the hippocampal dentate gyrus. Treadmill exercise improved short-term and spatial memories by enhancing neurogenesis and suppressing apoptosis in the hippocampal dentate gyrus of old-aged rats. In the present study, we showed that treadmill exercise is a very useful strategy for preventing failure of memory in the elderly.</P>
매립장 침출수 처리시 음식물 폐수 및 재활용 세척폐수의 연계처리에 의한 생물학적 처리효율 향상
최영익 ( Young-ik Choi ),고말석 ( Mal-seok Ko ),윤태경 ( Tae-kyung Yoon ),한영립 ( Young-rip Han ) 한국환경기술학회 2012 한국환경기술학회지 Vol.13 No.1
The present research aimed to suggest proper operating process methods for food waste flowing out from a food treatment plant of recycled wasted products and leachate from the landfill site. Leachate has relatively high concentration of total phosphorous and total nitrogen. The washing water of the recycled wasted products shows that the concentration of organic matters like BOD and COD are relatively very high. The C/N ratio of leachate is very low (an average of 0.32), but after adding food waste water and the recycled wasted products washing water, the average of C/N ratio was around 0.83. It increased by almost three times. Accordingly, it can be evaluated that the contribution of organic matters for denitrification in food waste water and the recycled wasted products washing water is significantly high. In stead of simply handling food waste water and the recycled wasted products washing water, the methods capable of utilizing it as external carbon sources should be actively investigated in linkage with a leachate treatment process. A method capable of raising process efficiency is that the food waste water and the recycled wasted products washing water are utilized as external carbon sources etc. The phosphorous could be treated well by using chemical coagulation processes.