작용시간 연장을 위해 고안된 이식형 혼합국소마취제의 효과

백운이,최병영,전영훈,임정옥 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Prolonged Regional Nerve Blockade from Implantable pellets Containing Mixture of Local Anesthetics and Biodegradable Polymer Background: The Currently available local anesthetics have limitations in action duration. The duration ranges from 3 to 8 hours. Long acting anesthetic agents are particularly desirable to manage postoperative pain, relieve severe pain associated with terminal cancer, and for nerve blocks carried out in pain clinics. In this paper mixture of local anesthetics was formulated into cylindrical pellet using biodegradable polymer and its efficacy and safety was evaluated. Methods: Pellets were prepared by modified melting process with biodegradable polyester 30 wt%, bupivacaine 35 wt%, lidocaine 35 wt% and dexamethasone 0.05 wt% of polymer and drug. In vitro release kinetics of local anesthetics from pellet were determined in PBS at pH 7.4. 37℃, and the released local anesthetics were analyzed by HPLC. Nine male Sprague Dawley weighing 300∼350 gm were implanted with pellets along the sciatic nerve and the sensory blockade was assessed by an analgesiometer. The duration data were analyzed by paired t-test using SAS 6.11 Results: Local anesthetics were released in a controlled manner in vitro. In general, 40~50% of the drug released for the first day, and thereafter approximately 5% released daily. Sensory blockade lasted to beyond 2 days at the dose of 7 mg/100 g bupivacaine and lidocaine respectively. All of the animals exhibited no systemic toxicity and complete recovery. Conclusions: The results indicated that the mixture pellet demonstrated efficient and safe in prolongation of sensory blockade for significant period of time. The mechanisms underlying the mixture effect are under investigation. (Korean J Anesthesiol 1998; 34; 493∼478)

국어과 교육에서의 신문 활용 방안 연구

김영경,임성운 順天大學校 師範大學 附屬 科學敎育硏究所 2002 科學과 敎育 Vol.10 No.-

This study showed that applying newspapers to Korean Language Education is helpful to develop a critical and a creative ability which need in Korean Language Education by making leaners do a variety of learning experiences and activities. It turned out that in class learners could use them in each field such as listening, speaking, writing, reading, the knowledge of Korean and literature by presenting new teaching method, panting to use newspapers. We used the style of newspapers as a way of maximizing learners' interest and education effect of learning novels. After reading novels, learners can change them into various styles, like articles, editorials, columns and so on. In addition, they can compile 'critical understanding' or 'interpretative text'. Therefor, newspapers is very useful to teach novels because the seventh course of education emphasizes 'Learners' acceptability an creative ability' of the literary work and 'an appreciative ability' in the social relation.

전해산성수를 이용한 새로운 내시경 소독 시스템(Cleantop WM-1??)의 소독효율

이준행,이풍렬,송재훈,이남용,임윤정,장재권,김영호,김재준,백승운,이종철,최규완 대한감염학회 2001 감염 Vol.33 No.2

Background : Electrolyzed acid water (EAW) is a new liquid chemical germicide containing a mixture of oxidizing species and prepared by mixing a small amount of salt with tap water in an electrolyzer. We attempted an in-use evaluation of the high-level disinfection capability of Cleantop WM-1□, a new endoscope reprocessing system using EAW. Methods : Forty-seven flexible endoscopes were randomly collected just after upper endoscopic examinations and were disinfected using Cleantop WM-1□. Parts of the endoscopes without contact to EAW were disinfected with 75% ethyl alcohol. Immediately after the disinfection procedure, samples were taken from the biopsy channel (S-1), tip of the insertion tube (S-2), the umbilical cord (S-3), and the angulation knob (S-4). Results : In EAW-disinfected parts of the endoscopes, the culture-positive rates were 4.3% (2/47) in S-1 samples and 12.8% (6/47) in S-2 samples. In ethyl alcohol-disinfected area, the culture-positive rates were 2.1% (1/47) in S-3 samples and 25.5% (12/47) in S-4 samples. The colony counts of culture-positive samples ranged from 1 to 144. Pseudomonas aerugi-nasa was recovered from the angulation knob of an endoscope, but other contaminating organisms were mostly : normal flora or opportunistic pathogens. Conclusion : Although part of the endoscopes disinfected with 75% ethyl alcohol were contaminated with more organisms than EAW-disinfected areas, Cleantop WM-1□ showed a relatively good disinfection efficacy in reprocessing patient-used endoscopes. (Korean J Infect Dis 33:133∼138, 2001)

The Aphyllophorales of Mungyong Saejae

(Young Woon Lim),(Yang Hee Kim),(Hack Sung Jung) 한국균학회 2000 Mycobiology Vol.28 No.3

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Fungal Interaction with Insects

Young Woon Lim 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

Fungi are characterized by eukaryotic microorganisms, growth with hyphal or yeast form, cell wall containing chitin, and both sexual and asexual reproduction. Many of fungi are associated with insects through the two ways: good or bad things. Good thing may include insect vector for fungal propagation and bad thing include entomophagous fungi to stink bug. Many specific examples of coevolution between fungi and insects have been recorded. Fungi provide the nutrients to insects while insects may vector them. Bark beetles are known as fungal vector as they bore through the tree bark to lay their eggs. Good example is the blue stain fungus Ophiostoma novo-ulmi causing the Dutch Elm disease, which is spread by Elm bark beetles (Scolytus spp.). Several bark beetles associated with coniferous forests also vector pathogenic fungi and decay fungi as well. In case study of the mountain pine beetle (MPB, Dendroctonus ponderosae Hopkins) that is a serious threat for mature lodgepole, we showed diversity of fungi associated on their body surface. Based on cultural morphology and sequence analysis of the internal transcribed spacer (ITS) and large subunit ribosomal DNA (LSU rDNA) region, 7 ascomycetes and 2 basidiomycetes were detected on the body surface. 14 ascomycetes and 1 basidiomycetes were represented in the ITS clone libraries. Recently NGS based Amplicon pyrosequencing discovered that much higher fungal diversity (191 OTU with 97% similarity) from MBP exterior.

Research Articles : Wood-rotting Fungal Flora of Kanghwa Island

( Young Woon Lim ),( Jin Sung Lee ),( Kyung Mo Kim ),( Hack Sung Jung ) 한국균학회 2005 Mycobiology Vol.33 No.4

Diversity of Denitrifying Bacteria Isolated from Daejeon Sewage Treatment Plant

Young-Woon Lim,Soon-Ae Lee,김승범,Hae-Young Yong,연선희,박용근,Dong-Woo Jeong,박진숙 한국미생물학회 2005 The journal of microbiology Vol.43 No.5

The diversity of the denitrifying bacterial populations in Daejeon Sewage Treatment Plant was examined using a culture-dependent approach. Of the three hundred and seventy six bacterial colonies selected randomly from agar plates, thirty-nine strains that showed denitrifying activity were selected and subjected to further analysis. According to the morphological and biochemical properties, the thirty nine isolates were divided into seven groups. This grouping was supported by an unweighted pair group method, using an arithmetic mean (UPGMA) analysis with fatty acid profiles. Restriction pattern analysis of 16S rDNA with four endonucleases (AluI, BstUI, MspI and RsaI) again revealed seven distinct groups, consistent with those defined from the morphological and biochemical properties and fatty acid profiles. Through the phylogenetic analysis using the 16S rDNA partial sequences, the main denitrifying microbial populations were found to be members of the phylum, Proteobacteria; in particular, classes Gammaproteobacteria (Aeromonas, Klebsiella and Enterobacter) and Betaproteobacteria (Acidovorax, Burkholderia and Comamonas), with Firmicutes, represented by Bacillus, also comprised a major group.

Diversity of Denitrifying Bacteria Isolated from Daejeon Sewage Treatment Plant

Lim Young-Woon,Lee Soon-Ae,Kim Seung Bum,Yong Hae-Young,Yeon Seon-Hee,Park Yong-Keun,Jeong Dong-Woo,Park Jin-Sook The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.5

The diversity of the denitrifying bacterial populations in Daejeon Sewage Treatment Plant was examined using a culture-dependent approach. Of the three hundred and seventy six bacterial colonies selected randomly from agar plates, thirty-nine strains that showed denitrifying activity were selected and subjected to further analysis. According to the morphological and biochemical properties, the thirty nine isolates were divided into seven groups. This grouping was supported by an unweighted pair group method, using an arithmetic mean (UPGMA) analysis with fatty acid profiles. Restriction pattern analysis of 16S rDNA with four endonucleases (AluI, BstUI, MspI and RsaI) again revealed seven distinct groups, consistent with those defined from the morphological and biochemical properties and fatty acid profiles. Through the phylogenetic analysis using the 16S rDNA partial sequences, the main denitrifying microbial populations were found to be members of the phylum, Proteobacteria; in particular, classes Gammaproteobacteria (Aeromonas, Klebsiella and Enterobacter) and Betaproteobacteria (Acidovorax, Burkholderia and Comamonas), with Firmicutes, represented by Bacillus, also comprised a major group.

Asian Patients with Genotype 1 HCV Achieve 99% SVR with 12 Weeks of Ledipasvir/Sofosbuvir: Integrated Analysis of Phase 3 Studies

( Young-Suk Lim ),( Sang Hoon Ahn ),( Kwan Sik Lee ),( Seung Woon Paik ),( Youn-Jae Lee ),( Sook-Hyang Jeong ),( Ju-Hyun Kim ),( Seung Kew Yoon ),( Hyung Joon Yim ),( Won Young Tak ),( Sang-Young Han 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Background: Similar to the United States and Europe, the majorityof patients with chronic HCV infection in Japan, Korea, and Taiwanare infected with HCV genotype (GT) 1. However, important differencesin viral and host characteristics exist between the infected populationsin these regions, including age, BMI, IL28B genotype andHCV GT1 subtype. The aim of this integrated analysis is to evaluatethe efficacy and safety of ledipasvir/sofosbuvir (LDV/SOF) in a largecohort of Asian patients with chronic GT1 HCV infection.Methods: This analysis combines data from subjects enrolled in twoPhase 3 trials: GS-US-337-0113 (Japan) and GS-US-337-0131 (Koreaand Taiwan) evaluating 12 weeks of LDV/SOF (90mg/400mg) in treatment-naive and treatment-experienced adults with chronic GT1 HCVinfection. The primary efficacy endpoint was SVR12.Results: Overall, 349 subjects were enrolled in Korea, Taiwan, andJapan, 67 (19%) had cirrhosis. The majority were female (58%), treatment-experienced (51%), GT1b infected (94%), and IL28B CC (62%).The mean age (range) was 57 (18-80) years old, BMI 24 (17-38)kg/m2, and HCV RNA was 6.6 (3.7-7.6) log10 IU/mL. HCV NS5ARAVs were detected in 23% (80/343) of subjects at baseline. Theoverall SVR12 rate was 99% (346/349); 2 subjects relapsed and 1subject prematurely discontinued treatment. All treatment-experiencedsubjects with cirrhosis (45/45) achieved SVR12. NS5A RAVswere detected at the time of relapse but no NS5B RAVs were detected.Serious AE and treatment discontinuations were rare (<2%). Adverseevents were generally mild in severity. No significant laboratory abnormalitieswere observed.Conclusions: A single tablet regimen of LDV/SOF administered oncedaily for 12 weeks is highly effective and well tolerated in Asianpatients with chronic GT1 HCV infection, including those with compensatedcirrhosis. Prior HCV treatment experience

Taxonomic Study on Korean Schizopora

(Young Woon Lim),(Hack Sung Jung) 한국균학회 2001 Mycobiology Vol.29 No.4

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