유리섬유에 의한 피부질환 및 임상적 진단

임현술,김정란,정해관,김수근 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

This study was conducted to evaluate the health hazards and to develop diagnostic methods of glass fiber workers. We examined 40 male glass fiber workers(exposure group) and 57 male non-glass fiber workers (reference group) with a questionnaire, physical examination, chest x-ray and pathological examination in Mar, 1997. Also we examined 65 male glass fiber workers(exposure group) and 42 male non-glass fiber workers(reference group)with the same methods also we did some energy-dispersive x-ray analyses with a scanning electron microscopic examination in Sep, 1997. Most of the clinical symptoms were significantly more frequent among the exposure group than the reference group. Coughing(32.5%), itching of the nose(30.0%), irritation of eyes(27.5%), irritation of the nose(25.0%) and sputum(22.5%) were the major symptoms among the exposure group in Mar, 1997. Only itching of the nose was significantly more frequent in Sep, 1997. No cases of pneumoconiosis were observed among the groups and there were no differences in chest abnormalities between the exposure group with the reference group on both examinations. The prevalence of dermatosis among the exposure group was 20.0% (8cases) and the cumulative prevalence was 72.5%(29 cases) in Mar, 1997. The prevalence of dermatosis among the exposure group was 23.1% (15 cases)and the cumulative prevalence was 58.5%(38 cases) in Sep, 1997. Onset of dermatosis among the exposure group was most frequent within one month after handling. The frequent sites of skin lesions were the hands and arms on both examinations. Glass fiber induced skin lesions can be diagnosed by the scotch tape method or KOH mount and then can be examined under the light, polarizing and phase-contrast microcopies. Glass fibers can be identified by some energy-dispersive x-ray analyses with a scanning electron microscopic examination.

유용한 젖산균의 프로바이오틱 생균으로서의 주요 특성

정민용,임형택,백현동 경남대학교 환경문제연구소 2000 환경연구 Vol.23 No.-

In order to select probiotics with a high survival rate in gut and the growth inhibition of virulent pathogens to human beings or animals, we have examined a variety of microorganisms to assess the artificial gastric acid and bile acid. In addition, microbiological identification, antimicrobial activity, enzyme activity, and antibiotic resistance were performed. The selected strains survived for 24 h in artificial bile after incubation for 2 h in artificial gastric juice. Especially, MY4 strain showed higher survival for 2 h incubation in artificial gastric juice. As a result of API CHL 50 kit test, strains MY4, PT77, and PS-490 were tentatively identified as Lactobacillus plantarum, while strain PS653 was tentatively identified as Lactococcus lactis. All lactic acid bacteria were shown to inhibit the growth of Listeria monocytogenes ATCC 19111 dramatically within 24 h of incubation. In test of API ZYM kit, β-glucuronidase was not produced by any kind of lactic acid bacteria. All strains were resistant to antibiotics such as nisin, tetracycline, streptomycin, and rifamycin.

갑상선암 예측에 있어 초음파적 변수 분석

임현정,최영식,박요한,오경승,이강대 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: The introduction of high resolution sonography has made it possible to detect nodules in the thyroid gland. However, there has been no reliable sonographic sign for distinguishing between benign and malignant thyroid conditions. The aim of present study was to evaluate ultrasonographic (US) parameters in predicting thyroid cancer. Methods: One hundred fifty three patients who underwent thyroidectomy at Kosin Medical Center from January, 2000 to April, 2002 were included in the study. All patients were checked high resolutional US before surgery. Of the 153 patients 89 were malignant tumors and 64 benign. Malignant US parameters were defined as calcification, irregular margin, more taller than wide, and fat line obliteration. Calcification pattern was classified with single, punctated, and amorphous calcification. The US characteristics to predict malignancy were evaluated by means of multiple logistic regression analysis. Results: All of the malignant sonographic parameters such as calcification, 53 (89.8%) were thyroid carcinoma. The incidence rate of malignancy was 55.9% in solitary nodules and 65.7% in multiple nodules (p=0.303). Even though nodule size was less than 1.5㎝, the incidence of malignant tumor was 69.5% (p=0.04). Of 53 malignant nodules with calcification, the incidence of single, punctated, and amorphous calcification pattern was 6 (11.3%), 22 (41.5%), 25(47.2%), respectively. The sensitivity, specificity, positive and negative predictive value, and accuracy of sonographic parameters were 76.4%, 87.5%, 89.5%, 72.7% and 81.0%, respectively. Upon the correlation of US-guided FNA cytology with pathologic diagnosis, the sensitivity of ultrasound-guided FNA cytology in differentiating benign and malignant nodule was 85.9%, the specificity 100% and overall diagnostic accuracy was 91.2%. The sensitivity, specificity, and accuracy of US parameters associated to follicular neoplasm, all were 75.0%. Conclusion : All the malignant US parameters including calcification, irregular margin, and more tall than wide showed high level of sensitivity, specificity and accuracy. Of these parameter, calcification and irregular margin were more significants. The more presence of calcifications with punctated and amorphous pattern could suggest the higher possibility of malignancy. However, further study is needed for clinical application of malignant US parameters in the thyroid tumors.

리스페리돈과 올란자핀이 투여된 정신과 환자들에서 간 효소 변화에 대한 후?적 연구

임현국,배치운,박석준,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

지속적인 기립 작업에 의한 만성 하지 정맥 부전증 1예

정철,임현술,유선희 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.1

저자들은 10년 간 자동차 부품 조립공장에 근무하면서 지속적인 기립 작업에 의하여 하지 정맥류가 발생하였고 이후 하지 정맥 혈전증이 합병되어 통증과 부종을 수반하는 만성 하지 정맥 부전증으로 업무상 질병이 인정된 증례를 보고하는 바이다. 환례는 44세 여자로 1966년부터 우측 하지에 정맥류가 발생하였고 2001년 6월부터 시작된 하지 통증과 부종으로 2001년 7월 25일 정확한 진단을 위해 병원을 방문하였다. 과거력상 2001년 7월초 진단된 결핵 이외에는 혈관질환 등 기타질환을 앓거나 약물을 복용한 것이 없었고, 가족력과 사회력 조사에서도 정맥류와 관련된 특이한 점은 없었다. 환례는 현 직장에 1991년 입사하여 10년 간 동일한 조립공정 업무를 수행하였다. 작업은 계속 한 자세로 서서 일하는 형태였으며, 하루 총 작업식간은 8시간이었다. 진찰 소견상 우측 하지 후슬와부에 정맥류가 관찰되었고, 압박시 하지 통증과 부종이 관찰되었다. 입원시 실시한 우측 상행 하지정맥 조영술 검사상 호가장된 다수의 정맥이 장딴지에서 보이고 오금정맥이 하부 하지부에서는 불투명화 되지 않아 약 1개월간 병원에 입원하여 혈전증에 대한 항응고제 치료를 시행 받았다. 환례와 동일한 작업을 하는 동료근로자는 12명으로 작업 후 하지 통증은 모두 경험하였다고 하였으며, 이들 중 1례는 하지 정맥류가 관찰되었다. 프로트롬빈시간은 입원일 9.8초였다가 이후 정상으로 회복하여 퇴원시 11.5초를 보였으며, 활성 부분트롬보플라스틴시간도 입원 당시 퇴원시 33.4초로 회복되었다. 하지 통증 및 부종은 입원 중 점차 감소하였고 내원 당시 방사선 검사상 관찰되었던 하지 정맥 혈전도 소실되었다. 본 환례를 통하여 장시간 서서 일하는 근로자는 하지 정맥류에 대한 발생 가능성을 염두에 두고, 하지 통증이나 부종이 동반될 경우 혈전 여부 검사를 시행하여야 할 것이며, 그 원인추구에 있어서 반드시 직업관련성을 조사해 보아야 할 것이다. 작업장내 장시간 서서 하는 작업이 있을 경우에는 정기적인 검진을 통해 유소견자를 가려내고, 혈전증 예방을 위해 한 쪽 다리는 교대로 올려놓을 수 있는 발받침대를 설치하거나 작업 전 압력 스타킹을 신게 하는 등의 작업환경 개선에 대한 노력을 강조하여야 할 것이다. We report a case of chronic venous insufficiency with a history of 10 year standing work. The authors reviewed the clinical and hematologic features of the case. We also reviewed the job contents of her workplace. The worker was a 44-year old female who had worked in a mobile accessory factory for 10 years (1991-2001). She had been founded right leg varicous vein since 1996. The varicose veins induced severe pain and edema on June 2001. By venography, thrombus were detected and finally diagnosed as venous thrombosis on 25th July 2001. She regarded the occupational disease by longstanding work of standing position. She received anticoagulant treatment by one-month admission, and then improved the symptom and hematologic laboratory results. To prevent chronic venous insufficiency, we must modify working environments, begin comprehensive medical surveillance, educate workers on risk of lower leg venous problems, and increase workers awareness of safety regulations in the workplace.

Gullian Barre Syndrome 患者 1例에 대한 症例報告

임승민,안정조,최영,조현경,김민상,유병찬,오병렬,김윤식,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

Gullian Barre Syndrome is an acute symmetric polyradiculoneuropathy that typically presents as a progressive flaccid paralysis. The pathology is believed to be caused by both cellular and humoral immune processes The possibility of death is 3-5% and About 20% of patients require mechanical ventilaton. Recently We have experienced a patient who had suspected Gullian Barre Syndrome for 60days, his condition weakness and pain was impoved through the herb and acupucture Therefore I reported it for the treatment.

Night wear의 시장활성화 전략연구 : 20 · 30대 소비자를 중심으로

임숙자,김해정,목정현 이화여자대학교 생활환경대학 인간생활환경연구소 2005 인간생활환경연구소 논집 Vol.- No.3

This research was to find out the consumer's interest and design elements on the nightwear for women. The first objective was to envestigate the preferences image of nightwear. The second objective was to explore the design elements for the specific nightwear image. The data was collected by the use of two kinds measurements: the image scale developed by the researches, the sampled nightwear was collected in the main department nightwear devision. The survey step was 3 steps; experimented, pilot, and main reaserch. The subject's age, among 668, was from 20' to 30' and survey data was collected from April 2003 to April 2004. The used statistical analyses were factor analysis, frequency analysis, t-test, regression, ANOVA and Duncan test. The findings were; The nightwear image was discovered into five categories, Lovely, Sexy, Cute, Sophisticated and Comfort. The most preferred nightwear image was lovalble and comfortable. The most preferred colors were pink(23.6%), white(20.1%) and the most preferred fiber was cotton(62.3%).

국소성 분절성 사구체 경화증의 완전 관해 후 발병한 IgA 신병증 1예

임현민,김현정,박민석,주혜원,최원,김상현,박원도 인제대학교 2006 仁濟醫學 Vol.27 No.-

We report a rare case of primary glomerular disease with IgA nephropathy in a 43-year old man. 7-years ago, he was diagnosed with minimal change nephrotic syndrome. After treatment with steroid for 1-year, azotemia and proteinuria were improved. But, nephrotic range proteinuria was relapsed within 1 week after cessation of steroid. Renal biopsy revealed focal segmental glomerulosclerosis, and achived a complete remission with the use of steroids and cyclophosphamide. Then, he was followed up with normal renal function for 4-years. On admission, the patient showed generalized edema and marked proteinuria. In 3rd renal biopsy, mesangial proliferative glomerulonephritis with diffuse global sclerosis was observed. Electron microscopy showed electron-dense deposit on the mesangium with slight mesangial proliferation, and immunofluoroscence microscopy showed granular deposits of IgA and IgM. These features were consistent with IgA nephropathy, different from results of previous biopsies. The pathogenesis of IgA nephropathy occurred with primary FSGS is not clear, as well as treatment. Now, proteinuria is improving, steroid and cyclophosphamide are probably useful for the disease.

TV유아프로그램의 음악적 활용에 대한 연구

임현정 이화여자대학교 교육대학원 2003 이화교육논총 Vol.13 No.-

This study analyzed the music applied to children's hours of main 3 TV broadcasting stations, by component, function, and genre. 10 programs of each TV broadcasting company, 30 TV programs in total, which were broadcasted from February to March in 2002 were selected at random for analysis research. The examination results tell about the frequency and the continuation period of Music/Non-music Segment, instrumental music/vocal music, analysis on music's functions, and so on. Then, the applied music that functions as structural prompt was analyzed in the sides of melody, lyric lines, and tempo. The analysis result tells that the music segment occurs 565 times in total, which means 18.83 times' frequency per program in average, and that the continuation period of time was 30.27 seconds in average, which indicates 92%'s confidence coefficient(reliability). Non-music segment occurred 289 times in total, 9.63 times per program in average, and the mean continuation period of non-music was 30.56 seconds, which signified 92%'s confidence coefficient(reliability). 335 pieces of instrumental music were used in 30 programs in total, the instrumental music pieces were used 11.17 times per program. The vocal music pieces were used 230 times in total, and the average frequency rate was 7.67 times per program. The music that adopted structural prompt occurred 187 times in total; the music pieces included into the learning area occurred 19 times in total, the mean frequency rate was 4.63 times per program. The music pieces belonging to the social area occurred 23 times in total, the mean frequency rate was 0.83 times per program. Finally, The music pieces belonging to the body area occurred 25 times in total, the mean frequency rate was 0.83 times per program. The music applied for the purpose of discriminative stimulation occurred 77 times in total, the mean frequency rate was 2.57 times per program. The number of music pieces used as background music was 301, the mean frequency rate was 10.03 times per program. The music pieces that applied structural prompt were analyzed by lower ranked factors such as melody, lyric lines, and tempo. The analysis results are as follows; the occurrence frequency of the music pieces that adopted the existing structural prompt was 64 times in total(2.13 times per program in average), and the occurrence frequency of the music pieces that adopted the newly created structural prompt was 123 times in total, which means 4.10 times' occurrence per program in average, and the rate of 66.78%. The number of vocal music pieces that deliver their lyric lines at the first time was 177 in total. So the number of vocal music pieces whose lyric lines ware clearly conveyed was 5.9 per program, which means 94.65% 's occupation rate out of the whole frequency rate of the music pieces that applied structural prompt On the contrary, the number of vocal music pieces whose lyric lines were not conveyed was 10 in total(the occupation rate of 5.35%). The music pieces that applied the same melody repeatedly occurred 187 times in total, which means an occupation rate of 84.49% out of the whole structural-prompt-music's percentage. Similarly, the number of music pieces that used the same lyric lines repeatedly was 168, which signifies 89.84%'s occurrence rate With respect to voice colors, the most frequently used one was children's voice, secondly used voice color was that of adult/children, and the next order was male adult solo, female adult solo, adult group, and male children solo. As for the range of Melody, the most frequently used range was 8 degree range(1Octarve), which was used 66 times in total. The next order was 7 degrees, 6 degrees, 9 degrees, and 5 degrees. The degrees of below 4 or over 10 occurred rarely. As for the tempo range, the tempos of 121∼140 was used most frequently, 75 times in total. The next frequency order was 141∼160 range (67 times in total), then 161∼180 range and 101∼120 (19 times in total). Next, a slower range of 80∼100 occurred 6 times, and a very fast one of 180∼200 occurred I time I total. This study analyzed the structural and functional sides of the music pieces applied for children's educational programs on TV. Based on the results obtained this thesis, the main characters of the applied music were examined. Furthermore, the additional aim of this study is to offer basic materials for music therapy that can be used for children in the desirable and useful directions.

코우크로스로의 방출물에 노출된 근로자에서 발생한 폐암 증례

임현술,최정근,권은혜,김헌 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 소세포성 폐암으로 진단받은 56세 남자에대하여 과거 21년간 코우크스로에서 근무한 작업력과 폐암과의 관련성을 파악하고자 하였다. 방 법 : 증례에 대한 의무기록가 흉부컴퓨터단층촬영 및 조직검사, 세포검사를 검토하였다. 증례의 작업 내역, 공것 작업환경 측정 결과를 파악하였고 작업환경 측정과 동료근로자에 대한 역학조사를 실시하였다. 작업환경측정은 산업안전보건연구원에서 모든 근로자를 대상으로 2회 반복 측정하였으며, 측정시간은 근로자의 작업시간 전체를 포함한 1일 8시간으로 하였다. 시료채취 및 분석방법은 미국 국립산업안전보건연구소의 공정시험법과 미국 노동부 산업 안전보건청의 공정시험법을 이용하였다. 측정결과의 정확도를 높이소 오차를 줄이기 위하여 측정 전후에 적적한 보정을 실시하고 현장 공시료를 포함하였다. 동료 근로자 40명에 대하여 역학조사를 실시하였고 COEs의 노출정도를 평가하기 위하여 PAHs의 대사산물인 1-OHP와 2-naphthol을 소변에서 분석하였다. 결 과 : P제철 부속의원에서 1996년부터 1999년까지 COEs에 대하여 측정한 결과는 0.01-0.39 ㎎/㎥ 범위로 후발성 콜타르피치물질에 대한 노동부의 노출기준인 0.2 ㎎/㎥르 적용할 때 초과하는 경우가 있었다. 1999년 산업안전보건연구원에서 작업환경을 직접 측정한 결과 전체 측정 건수 136건 중 45건 (33.1 %)이 노출기준을 초과하였다. 동료 근로자 40명에 대한 역학조사에서 특별한 COEs에 의한 건강장해를 발견하지 못하였다. K업체와 S업체의 근로자에 대하여 충북대학교 의과대학 예방의학교실에서 측정한 요중 1-OHP와 2-naphthol은 대조군인 대학생에 비하여 유의하게 높았다(P<0.01). 결 론 : 중례는 21년간 코우크스 제조공정에서 COEs에 노출되었으며, 현재 작업환경측정 결과로 판단할 때 노출기준을 초과하여 노출되는 경우도 있다고 추정되며, 흡연은 COEs가 폐암 발생을 가중시키는 요인으로 작용하였다고 추정된다. 그러므로 증례의 폐암은 코우크스 제조공정에서 노출된 COEs와 관련이 있다고 생각하여 직업성암으로 판단하였다. Objectives : We report a case of lung cancer (small cell carcinoma) occurring in a worker exposed to coke oven emissions. Methods : We examined the chest CT and pathologic findings of the patient. We reviewed previous environmental measurements for coke oven emissions at the workers place of employment. Also we measured the airborne concentrations for coke oven emissions and total polycuclic aromatic hydrocarbons in the work area. Finally, we analyzed the 1-hydroxypyrene and 2-naphthol concentrations in the subjects urine and compared this with student controls. Results : This case was a 56-year-old male who had worked in a coke oven plant within a steel manufacturing factory for 21 years (1977-1998). The airborne concentrations of coke oven emissions at the worksite were above the permissible exposure level (0.2 ㎎/㎥) in 45 cases (33.1%) among 136 workers. The concentrations of 1-hydroxypyrene and 2-naphthol in the subjects urine were statistically significantly elevated as compared with those of controls (P<0.01). Conclusions : We confirmed that the lung cancer occurring in this patient was as an occupational disease due to exposure to coke oven emissions. To prevent occupational cancer in coke oven plant workers, we must remodel the engineering procedure, begin comprehensive medical surveillance, educate workers on risks and the benefits of smoking cessation, and increase awareness of safety regulations in the workplace.