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1996-1997년 겨울철에 유행한 인플루엔자의 임상역학적 분석 및 원인 바이러스의 분리
김수정,정규영,이용화,기창석,이남용,이상일,김지희 대한감염학회 1997 감염 Vol.29 No.4
목적: 인플루엔자는 매년 겨울 전 세계적인 유행을 일으키는 급성 호흡기 질환으로 높은 이환률과 사망율을 보인다. 국내에서도 1996-1997년 겨울철에 다수의 보고가 있었으나 아직 체계적인 감시가 이루어지고 있지 못하다. 저자들은 이 기간 동안 인플루엔자 바이러스 감염의 역학적 특성과 임상상을 연구하여 인플루엔자 감시의 기초 자료를 제공하고자 하였다. 방법: 1996년 10월부터 1997년 4월까지 삼성서울병원 임상병리과에 인플루엔자 바이러스 배양 검사가 의뢰된 모든 검체를 대상으로 인플루엔자 바이러스의 분리율과 유행 양상, 그리고 환자들의 임상상을 후향적으로 조사, 분석하였다. 결과: 총 461명의 환자로부터 525례의 검체가 의뢰되어 총 98명의 환자로부터 인플루엔자 바이러스가 분리되었다. 인플루엔자 A형은 54명의 소아 환자와 4명의 소아 환자로부터 분리되었다. 아형과 항원 특성 검사를 시행한 31례의 인플루엔자 A형 중 한 예에서 A/Wuhan/359/95 유사주로 확인되었고 12례의 인플루엔자 B형 중 5례에서 B/Guangdong/8/97 유사주로 확인되었다. 인플루엔자의 유행 양상은 3월과 4월 중순, 두 번의 인플루엔자 최고 분리 시점이 관찰되었고, 가장 많은 불리 빈도를 보인 연령층은 인플루엔자 A형의 경우 1세 미만이었고 인플루엔자 B형의 경우 3-5세였으며 폐렴이 가장 흔한 호흡기 질환이었다. 결론: 저자들은 3차 의료기관에서 분리된 인플루엔자 바이러스에 대한 역학적, 임상적 특성을 연구하였다. 지역사회에 대한 광범위한 연구가 아니므로 국내의 전반적 상황과는 차이가 있을 것으로 생각되지만 우리나라에서도 인플루엔자 바이러스의 이환률이 낮지 않을 것으로 생각되며, 보다 조직적이고 전국적인 인플루엔자 감시가 이루어져야 할 것으로 사료된다. Background: Although influenza has been a leading cause of global morbidity and mortality, we have few data regarding the epidemioloical and clinical characteristics of influenza activity in korea. Since an outbreak of influenza was recognized during winter of 1996-1997, we analysed the epidemiological and clinical features of influenza activity in the hospital seeting. Methods: All clinical specimens requested for isolation of influenza virus at Samsung Medical Center from October 1996 to April 1997 were included. Mardin-Darby canine kidney (MDCK) cell line was used for virus culture. Isolated viruses were confirmed with immunostain followed by subtyping. The demograpic and clinical characteristics of the patients were reviewed retrospectively. Results: Ninety eight influenza viruses were isolatd from 461 patients (21.3%). Influenza A and B virus were isolated from 58 (54 children and 4 adults) and 40 pediatric patients, respectively. One of 31 influenza A viruses was confirmed as A/Wuhan/359/95-like strain and 5 of 12 influenza B viruses were confiremd as B/Guangdong/8/97-like strains. Two distinctive peaks of influenza activity were recognized and the most common age of patients was less than 1 year for influenza A, and 3 to 5 years for influenza B. Common lower respiratory infections were pneumonia followed by croup, bronchiolitis and laryngitis. Conclusion: We analyzed the epidemiological and clinical features of influenza activity during winter of 1996-1997. Although this study was performed not in the community but in the hospital setting, the morbidity caused by influenza may not be low in Korea. Therefore, nationwide surveillance for influenza activity is warranted.
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이용화 忠州大學校 2004 한국교통대학교 논문집 Vol.39 No.1
With the advent of the knowledge-based society, people are thinking that knowledge is a source of competitive power. Many enterprises are introducing and doing knowledge management(KM)in order to obtain the competitive power. Academic research has been performed to provide a guideline to enterprises that try to do knowledge management. However, most of previous studies were limited to developing a KM strategy of conceptual level or analyzing the KM strategies of companies through a case study. This study suggests a performance measurement method that can be used by the companies doing KM.
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李庸和 忠州大學校 1998 한국교통대학교 논문집 Vol.33 No.1
The sudden change of management environment forces to enterprise seeking to various plans. Among these various plans, Information technology is used to deal with the changing management environment. At this point of view, there are continuous efforts for adopting, the military's CALS refer to about the concept, development process emboding goal, core strategic point and emboding strategy of CALS.
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이용화 忠州大學校 2002 한국교통대학교 논문집 Vol.37 No.4
OECD and International Bank for Reconstruction and Development(IBRD) anounced at the report of world development which related to the knowledge management, the new paradigm of instituting industrial society is knowledge based economy.
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李庸和 忠州大學校 1987 한국교통대학교 논문집 Vol.20 No.2
An investgation item by the event of advertisement activity planning is as follows : 1) The Model of advertisement cost distribution in the region by n-unit advertisement activity. 2) The Model of adverisement cost in the advertisement time by n-time. In this paper we try to find a mathematics solution to the problems by game theory.
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합성 펩티드를 이용한 Interleukin-2수용체 β-Chain에 대한 단일클론항체의 제작
이희구,이홍수,이인애,최용경,최인성,정태화,김길현 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5
Hybridoma producing monoclonal antibodies reactive with the ß-chain of interleukin-2 receptor (IL-2R) were generated from mice immunized with a synthetic pepride of 19 amino acids. The synthetic peptide constitutes strongly hydrophilic region of extracellular domain of the IL-2R molecules(residues 32-50) as revealed by hydrophathy plot analysis. Hybridomas were screened by ELISA using Hut102 cells and the synthetic peptide as antigenic moiety, and by measuring the binding activity of antibodies to the Hut102 cell surface that was monitored by a flow cytometer. The antibodies were further screened by their inhibitory effect against the interaction between IL-2R and interleukin-2(IL-2). Antibodies were further characterized by immunoprecipitation followed by autoradiography to reveal that the antibodies recongnize the 75 KD protein molecules expressed on the Hut 102 cell surface and human peripheral blood mononuclear cells(PBMC) which confirms the antigenic moiety to be ß-chain of IL-2 recepter molecules.
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李庸和 忠州大學校 1996 한국교통대학교 논문집 Vol.31 No.1
Strategic Information System is a joined system of Information technology and Strategic Management theory which was introduced by M. E. Porter. The more the society developed rapidly, the more the management environment become complicated, with the ordinary management system, the company cannot survive anymore. As that reason, lately at the developed country, lots of companys use the strategic information system for achieving the relative advantage in management. In this research, strategic management system is suggested as a strategic management of a company.
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李庸和 충주대 2000 한국교통대학교 논문집 Vol.35 No.1
The change of management environment by application of information technology give to enterprise both threat and opportunity.It is require to enterprise establishing new management goal and strategy.Therefore the management organization and process have to restructured for matching the changing management environment, At this point, this research described about the impact application of information technology to the management organization.
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