안양대학교 교양교육과정 개선을 위한 기초 연구

이태섭,최양미 안양대학교 1999 논문집 Vol.18-19 No.-

The purpose of this study is to investigate the present conditions of liberal education and to make some suggestions to improve liberal education of Anyang University. Thus, the data were collected from 314 students of Anyang University using a questionnaire and analyzed by SAS. Based on the results of this study, following conclusions can by made for developing the liberal education of Anyang University. 1. It is required to examine the credit ratio of compulsory courses of liberal education. There is a tendency to reduce the credit ratio of compulsory courses in general. 2. It is required to analyze the organizations, contents and methods of the optional courses of liberal education in detail, in order to offer students the liberal education courses which have ideological openness of liberal education and principles of general education. 3. It is required to make every efforts for enhancing the level of liberal education, especially, with lecturer's own efforts, there should be supports from University in order to maintain reasonable class sizes and use various media.

관광현상체계의 원활성에 미치는 영향요인 분석과 경주시의 과제

이태종,송건섭 경주대학교 지역개발연구소 1998 地域開發論叢 Vol.- No.1

아침 식사시간의 다른 사람들에서 혈장 그렐린의 변화

이상엽,김윤진,김형회,손한철,전태용,심문섭 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2

연구배경 : 최근 식욕조절인자로 관심이 집중되고 있는 그렐린(ghrelin)은 식사 전후로 독한 일중변동을 보인다. 하지만, 지금까지는 실험적으로 일정한 열량의 표준 음식을 일정한 식사시간에 공급한 이후 그렐린의 농도 변화를 관찰하였다. 저자 등은 평소 아침 식사시간이 각기 다른 사람들에서 아침 식사 전후의 혈장 그렐린 농도 변화를 관찰하여 향후 외래 환경에서도 그렐린 관련 연구가 가능하도록 기초 자료를 제공하고자 하였다. 방법 : 연구에 대한 설명을 듣고 동의한 23.4 ~ 35.5세 사이의 비교적 건강한 동양인 남자 4명을 대상으로 하였다. 신체 계측을 한 후 이중 에너지 방사선 측정법 (Lunar prodigy, GE medical systems, Waukesha, Wisconsis, USA, 이하 DEXA)으로 체지방을 측정하였다. 연구 대상자 모두 평소 아침 식사시간이 일정하였지만 연구 시작 2주전부터 아침 식사시간을 엄격히 고정하도록 하였다. 스트레스가 없는 상태에서 아침 식사를 하지 않는 지원자는 오전 6시 30분부터, 나머지는 아침식사 시간 1시간 전부터 1시간 간격으로 점심 식사 전인 오전 11시 30분까지 채혈하였다. 각각의 검체로 부터 혈장 그렐린은 상업적인 방사선면역측정법 (Phoenix Pharmaceuticals, Inc., Belmont, CA)으로 측정되었다. 랩틴은 Ⅰ-125 표지 랩틴을 이용한 이중항체 방사선면역측정법으로, 혈장 인슐린은 항체 부착관을 이용한 방사선면역측정법으로, 혈당은 포도당산화 효소법에 의해 Synchron LX 20 (Beckman Coulter, Inc, Fullerton, USA)으로 측정하였다. 결과 : 연구 대상자의 체질량지수는 22.9 ~ 27.1 kg/㎡이었고, 허리둘레는 80.3 ~ 93.3 cm이었다. DEXA로 측정한 결과 전체 체지방과 체부지방 비율은 각각 27.1 ~ 31.8%와 32.7 ~ 32.4%이었다. 아침 식사를 하지 않는 자를 제외한 나머지 연구 대상자의 아침 식사 직전의 식후 2시간의 혈장 그렐린 농도는 각각 113.0 ~ 800.0 pg/mL, 78.3 ~ 553.0 pg/mL이었고 랩틴 농도는 각각 4.9 ~ 5.1 ng/mL, 4.4 ~ 4.7 ng/mL 이었다. 혈장 그렐린 랩틴 농도는 아침 식사 직전에 비해 식사 2시간 후 각각 7.2 ~ 30.9%와 7.8 ~ 10.2%감소되었다. 아침식사를 하지 않는 대상자의 경우 인슐린과 혈당치가 변화가 없음에도 불구하고 혈장 그렐린 농도는 오전 7시 30분에 가장 낮았다. 그 외 연구 대상자에서는 각기 다른 시간이더라도 아침 식사 2시간 후의 혈장 그렐린 농도가 가장 낮았다. 결론 : 평소 아침 식사시간이 다른 사람들에게서 혈장 그렐린 농도는 각기 다른 아침 식사 2 시간 후에 가장 낮았다. 아침 식사를 하지 않는 경우에는 혈장 그렐린 농도가 오전 7시 30분에 가장 낮았다. Background : Recently, the particular interest is on ghrelin, the dietary control factor among many scientists and it a toxic diurnal variations has been demonstrated before and after meal. However, the experimental approach has been only to see the changes in the concentration of ghrelin after intake of meals standardized with fixed calories at scheduled meal hours. the authors of this particular experiment have tried to observe and record the changes in concentrations of plasma ghrelin of persons with different breakfast hours. This might help in providing a basis for further possible studies in outpatient setting. Method : A group of four relatively healthy males whose ages between 23.4 and 35.5 with prior agreements were selected for this study. After body measurements, body lipid status was measured based on Lunar prodigy (GE medical systems, Waukesha, Wisconsin, USA) which is also referred to as DEXA. All of the selected persons had somewhat fixed breakfast time; however, they were asked to strictly keep their breakfast time fixed and steady starting two weeks before the beginning of experiment. The bloods of those who skip their breakfast without any particular stress were sampled at 6:30 AM, whereas the rest had different schedule, whose bloods were sampled every hour starting 1 hour before the first meal of the day till just before lunch (11:30 Am). From each blood sample, the level of plasma ghrelin was measured using the commercial radioimmune assay (Phoenix Pharmaceuticals, Inc., Belmont, CA). Leptin was measured with double antibody radioimmune assay using Ⅰ-125 labelled leptin, plasma insulin with radioimmune assay using antibody attachment tube, and blood sugar with Synchron LX20 (Beckman Coulter, Inc, Fullerton, USA) using glucosylation enzyme method. Result : The body mass index of the volunteers was 22.9 ~ 27.1 kg/㎡, with 80.3 ~ 93.3 cm waist circumference. Based on measurements by DEXA, the rates of total body lipid and trunk lipid were each 27.1 ~ 31.8% and 32.7 ~ 32.4%, respectively. The concentrations of plasma ghrelin of those who consume their breakfast before and 2 hour after their breakfast are 113.0 ~ 800.0 pg/mL and 78.3 ~ 553.0 pg/mL. The concentrations of leptin are 4.9 ~ 5.1 ng/mL and 4.4 ~ 4.7 ng/mL. Compared to the concentration of plasma ghrelin and of leptin recorded just before breakfast, it showed 7.2 ~ 30.9% and 7.8 ~ 10.2% decrease, respectively, 2 hours after breakfast. For those who skip their breakfast, the plasma concentration of ghrelin was recorded the lowest at 7:30 AM, even though there was no change in insulin and blood sugar. The rest of the subjects had their lowest plasma ghrelin concentration at 2 hours after breakfast, despite their different meal schedule. Conclusion : The persons with different breakfast hours had their lowest plasma concentration of ghrelin at 2 hours after breakfast. In contrast, the persons who skip their breakfast had their lowest concentration at 7: 30 AM.

농아에서의 측두골 전산화 단층촬영 소견과 다른검사 요인과의 연관성

조태환,이상흔,권대구,엄규상,성창섭,김용선,한기원 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Temporal bone high resolution computed tomogram(TBHRCT)is a essential diagnostic tool in considering for cochlear implantation in patients with profound sensorineural hearing loss. This study was designed for an effort to provide and efficacy of TBHRCT in determination of inner ear malformations for the patients who have profound sensorineural hearing loss and to examine the relationships between TBHRCT findings and other preoperative evalutions for cochlear implantation in that patients. Authors examined 68 deaf patients to provide fundamental data for cochlear implantation. Inner ear abnormalities were founded in 13(19%) patients, among which 10(14.7%) patients had Mondini'dysplasia in which 5 patients were hypoplastic type and 5 patients were hydrops type. Other inner ear abnormalities were as follows : lateral semicircular canal hypoplasia ; internal auditory canal abnormality ; cochlear aqueduct widening ; vestibular aqueduct widening. No relationships were found between TBHRCT findings and other test results. : promontory test, K-WISC cognitive test etc.(Korean J Otolaryngol 39 : 8, 1996)

폴리머 물질 첨가를 통한 중금속 오염 광미의 고형화 처리

김태풍,민경원,이현철,서의영,이원섭 江原大學校 産業技術硏究所 2010 産業技術硏究 Vol.30 No.A

Polymeric materials in addition to Portland cement and hydrated limes were used to solidify heavy metal contaminated tailings from five abandoned metal mines in Korea. Mine tailings were mixed separately with Portland cement and hydrated lime at a concentration of 20-30 wt% and 6-9 wt%, respectively and Ethylene Vinyl Acetate(EVA) powder was added to each specimen at a ratio of 2.5 and 5.0 wt% to binders. Polymer-added and polymer-free solidified forms were evaluated for their appropriateness in accordance with the suggested test methods. Regardless of addition of polymeric materials, all solidified forms satisfy the uniaxial compressive strength(UCS) requirements(0.35MPa) for land reclamation and show remarkably reduced leaching concentrations of heavy metals such as As, Cd, Cu, Pb and Zn less than the toxicity criteria of Korean standard leaching test(KSLT). The addition of polymeric materials increased the UCS of solidified forms to improve a long-term stability of solidified mine tailings.

풍향에 따른 아파트 단지내 기체유동 및 온도 분포해석

변용섭,조재광,엄태인,장재덕,이상길 大田産業大學校 2000 한밭대학교 논문집 Vol.17 No.1

In this study, velocity and temperature profiles are calculated on the apartment complex at Dunsan area in Taejon using FLUENT code based on computational fluid dynamics (CFD). Input weather conditions which maximum atmospheric is 38.6℃, wind speed is 1.7m/sec, wind direction is west-south-west and maximum wall of apartment is 58.0℃ in summer are used to calculate the results. The simulation results are as follow ; First. velocity vectors at vertical cross section of apartment complex are influenced by the thermal buoyancy force in hot wall of apartment due to weak wind speed in the case of wind direction : west-south-west, south-west, west. Second, temperature profiles at vertical cross section of apartment complex are strongly influenced by the wind direction. Atmospheric temperature in wide area is higher 1℃ in south-west wind direction than west wind direction. Calculation results show that island in enormous apartment complex in summer. Third, temperature profiles at horizontal cross section of apartment complex present wider and more definite high temperature area than at vertical cross section of apartment complex according to wind direction. This consequence shows the effect of convective heat transfer in the rear heated wall of apartment is dominant by solar radiation. Fourth, It is necessary that an arrangement of apartments with a view of wind direction and distance of each apartments to reduce heat island in apartment and industrial factory complex in the condition of same apartment direction and area capacity. And an arrangement of apartments considering wind direction is able to enhance convective heat transfer between heated wall and wind.

강우시 불포화 토사사면의 간극수압 변화 특성

심태섭,김선학,신태욱,이광모 朝鮮大學校 建設技術硏究所 2004 建設技術硏究 Vol.24 No.2

This study manufactured model slope in soil. When it is rainfall. It experimented weathered granite soil to be distributed in korea mostly as dividing into two soil sample SP, SM, Moreover, inclination of slope(1:1~1:2) and rainfall strength (50~150mm/hr) divided into five step and it observed seepage behavior of slope according to inclination of slope and rainfall strength. It has manufactured six pore water pressure cells in the lower end of model soil box for measuring pore water pressure to be most important factor of slope failure and analyzed change of pore water pressure according to location of slope when rainfall is continued. Change of saturation depth according to experiment condition is measured through the whole soil box by eyes. In result, in case of being in different rainfall strength in sample inclination. The higher rainfall strength rises, The faster seepage of rain progresses. If angle become gentle from 1:1 to 1:2, The seepage velocity increase, too. If compared theoretical number to calculate by ◁수식 삽입▷ (원문을 참조하세요), that Lumb propose with seepage depth to be measured through indoor model test. As a result, Seepage velocity to measure actually is faster than seepage velocity by formula for Lumb to propose If angle become steep, If shows a tendency for pore water pressure to increase in slope angle from 1:22 to 1:1.5. But in angle from 1:1.5 to 1:1, If angle become steep, It shows a tendency for pore water pressure to decrease gradually as standardizing slope angle 1:1.5, According to rainfall strength increases from 50mm/hr to 150mm/hr. Pore water pressure increases in proportion to rainfall strength.es with the much increase of the pore water pressure.

양극성 장애 1형에서 종양괴사인자 베타 유전자 다형성

전태연,이경욱,배치운,김원,우영섭,채정호,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : Bipolar disorder is known to have a high genetic predisposition. Recently, the main focus of etiologic studies in bipolar disorder has been concentrated on molecular genetic approach including gene polymorphism analysis. The present study was conducted to investigate whether TNFB polymorphism is associated with bipolar I disorder in the Korean population. Methods : 89 bipolar I disorder patients diagnosed by DSM-IV criteria were assigned as the patient group and 202 normal population, matched on age and sex from Catholic hemopoietic stem cell bank (Seoul, Korea), were enrolled as the control group in this study. Genotyping was performed by a polymerase chain reaction-restriction fragment length polymorphism method. All data was analyzed by x² test. Results : There were no significant differences in frequency of TNFB*1/1,TNFB*1/2 and TNFB*2/2 between bipolar I disorder patient group and normal control group. The frequency of TNFB*1 was not statistically different between bipolar I disorder patient group and normal control group. Conclusion : The difference of frequency in TNFB*1/TNFB*2 gene between the bipolar I disorder gropup and the normal contro1 could not be verified. The present result suggested that the gene polymorphism of TNFB may not play a significant role in susceptibility to bipolar I disorder. Studies with a larger number of subjects from different ethnic backgrounds, considring clinical phenotype and controlling various factors, should be launched to further determine the role of TNFB in bipolar I disorder.

3차원 직육면체 대공간 내에서의 열 및 기류 유동에 관한 연구

박원희,이상엽,황문섭,김태국 중앙대학교 기술과학연구소 2002 기술과학연구소 논문집 Vol.32 No.-

본 연구에서는 대공간 내에서의 열 및 기류 유동 현상을 연구하기 위하여 464×300× 950mm^3크기의 축소 모형으로 아트리움을 제작하였다. 가상 화재를 모사하기 위하여 대공간 하단에 히터를 설치하였으며, 히터의 온도에 따른 대공간 내의 온도분포를 측정하였다. 본 실험에서 얻은 결과는 아트리움과 같은 대공간에서 화재가 발생하였을 경우에 열 및 기류 현상을 해석하기 위한 기초자료 및 열유동 현상을 해석하는 수치해석 프로그램의 계산 결과의 기준 데이터로도 이용될 수 있을 것이다.

키랄 HPLC를 이용한 라세미 케토프로펜의 광학분할

김소영,이중기,서성섭,최민호,박태진,박달근 한국화학공학회 2001 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.39 No.6

케토프로펜은 비스테로이드 계통의 진통 및 소염제로서 류마티즘, 관절염 등을 위한 진통제나 해열제로 널리 사용되고 있다. 그러나 케토프로펜이 치료약으로 사용될 때 S-(+)-Ketoprofen이 주로 약리적 활성을 나타내고 R-(-)-Ketoprofen은 불활성이거나 오히려 부작용을 일으키는 문제점을 나타내고 있다. 본 연구에서는 케토프로펜 대장체(enantiomer)를 다양한 키랄 HPLC 칼럼을 이용하여 광학분할을 수행하면서 적합한 분리조건을 조사하였다. 고정상을 찾는 실험에서는 β-CD(β-cyclodextrin) BR®과 Kromasil® 칼럼을 이용하여 실험을 하였고, 이동상의 최적의 조성비를 찾는 실험도 수행하였다. 이 과정에서 라세미 Ketoprofen의 분리도는 사용된 키랄 고정상과 이동상의 조성비에 크게 영향을 받는다는 것을 알 수 있었다. 따라서 고정상으로는 Kromasil® 칼럼을 선택하고 이동상의 유속, 주입부피 그리고 주입농도가 라세미 Ketoprofen의 분리에 미치는 영향을 조사하였다. 실험결과 주입부피가 증가함에 따라서 분리도는 감소하였으나 이동상 유속이 증가함에 따라서 주입부피의 증가가 분리도에 미치는 영향은 점차 감소하는 것을 알 수 있었다. Ketoprofen, a phenylpropionic acid derivative, is a non-steroidal anti-inflammatory drug(NSAID) that has analgesic, anti-inflammatory and antipyretic properties. Pharmacological activity has been attributed mainly to the S-(+)-enantiomer, while the R-(-)-enantiomer is either inactive or has side effect. The optical separation of Ketoprofen enantiomers was carried out by various chiral HPLC(chiral high-performance liquid chromatography) columns and most compatible separation conditions of Ketoprofen enantiomers were investigated. The resolution and enantio selectivity of Ketoprofen were found to be strongly influenced by the employed chiral stationary phases(CSPs) and composition of eluents. The employed chiral stationary phases(CSPs) in this study were β-CD BR® and Kromasil®. The optimum composition of eluent was obtained differently for stationary material phase. The effects of process variables such as flow rate, injection volume, and concentration of eluent on Ketoprofen enantiomers separation were investigated using Kromasil® columns. The resolution decreased with the increase of injection volume, however, the effect became insignificant at higher flow rate.