산업단지 및 일반생활 지역의 공기 중 톨루엔에 대한 개인노출 및 생체시료의 상관성 분석

이병준(Byoungjun Lee),허 정(Jung Heo),정다영(Dayoung Jung),김순신(Sunshin Kim),류현수(Hyeon-Su Ryu),최민지(Min-Ji Choi),솨이지엔페이(Jian-Fei Shuai),임성국(Sung-Guk Im),양원호(Wonho Yang) 한국환경보건학회 2017 한국환경보건학회지 Vol.43 No.4

Objectives: The purpose of this study was to assess the correlation relationship between personal exposure and urinary hippuric acid in biological monitoring for airborne toluene in an industrial complex and in general environments. Methods: Personal exposure to toluene and its metabolite, hippuric acid, in urine were simultaneously measured in occupational environments area near an industrial complex and in general environments. The study subjects were divided into three types: 137 workers who use organic solvents in the workplace, 210 residents living near a dyeing industrial complex, and 379 residents living in general environments. The toluene exposures of workers and residents were measured by a passive sampler for four days. The urine of participants was sampled when the passive samplers of personal exposure were collected. Results: The toluene and hippuric acid concentrations of workers were the highest, followed by the concentrations of residents living near a dyeing industrial complex and residents living in general environments. The coefficient of correlation between the concentrations of toluene and hippuric acid among workers was 0.749 (p<0.01) in the workplace. On the contrary, correlations between the concentrations of toluene and hippuric acid among residents living near a dyeing industrial complex and residents living in general environments were all not significant. The relationship between the concentrations of hippuric acid and toluene in three types could be described by the exponential growth model. Conclusions: This study analyzed the relationships between toluene exposure and the concentrations of hippuric acid in urine in high, middle, and low exposure environments, and could be described by the exponential growth model.

Usefulness of the Cytomegalovirus Antigenemia Assay in Patients With Ulcerative Colitis

( Jaeyoung Chun ),( Changhyun Lee ),( Ji Eun Kwon ),( Sung Wook Hwang ),( Sang Gyun Kim ),( Joo Sung Kim ),( Hyun Chae Jung ),( Jong Pil Im ) 대한장연구학회 2015 Intestinal Research Vol.13 No.1

Background/Aims: Patients with ulcerative colitis (UC) are at high risk for cytomegalovirus (CMV) reactivation. The useful-ness of the CMV antigenemia assay in active UC patients has rarely been studied. We assessed whether the assay detects CMV colitis and predicts clinical outcomes in patients with UC. Methods: We retrospectively reviewed the medical records of pa-tients hospitalized for moderate-to-severe UC from 2003 to 2012. Positive CMV antigenemia was defined as ≥1 pp65-positive cell per 2×105 polymorphonuclear neutrophils. CMV colitis was defined as the presence of inclusion bodies and/or positive im-munohistochemistry in the colonic mucosa. The primary outcome was steroid refractoriness, defined as the absence of clinical improvement after intravenous high-dose steroid administration. Results: A total of 43 patients were enrolled. CMV antigen-emia was detected in 12 (27.9%) patients. Positive CMV antigenemia was significantly associated with CMV colitis (P=0.001). The sensitivity and specificity of positive CMV antigenemia for diagnosing CMV colitis were 66.7% and 87.1%, respectively. Steroid refractoriness was found in 11 of 12 (91.7%) and 12 of 31 (38.7%) patients with positive and negative CMV antigenemia, respectively (P=0.002). The independent predictors for steroid refractoriness were positive CMV antigenemia (adjusted odds ratio [OR], 7.73; 95% confidence interval [CI], 1.22-49.19; P=0.030) and a shorter duration from the diagnosis of UC (adjusted OR, 0.99; 95% CI, 0.98-0.99; P=0.025). Conclusions: The CMV antigenemia assay shows low sensitivity but high specificity for detecting CMV colitis and may predict steroid-refractory UC. Early rescue therapy might be considered in UC patients positive for CMV antigenemia. (Intest Res 2015;13:50-59)

기관지폐 이형성증의 임상 양상: 다기관 연구

성기혜 ( Ki Hye Sung ),김민희 ( Min Hee Kim ),김은령 ( Eun Ryoung Kim ),심재원 ( Jae Won Shim ),이정주 ( Jung Ju Lee ),임재우 ( Jae Woo Im ),진현승 ( Hyun Seung Jin ) 대한주산의학회 2009 Perinatology Vol.20 No.3

목적: 최근 극소 저출생 체중아의 생존율의 개선으로 기관지폐 이형성증(bronchopulmonary dysplasia, BPD)이 늘고 있다. 다기관 연구에 의해 전국적인 BPD의 역학, 임상 양상과 각 병원 간의 차이를 조사하여 향후 우리나라의 BPD 감소와 중증도를 줄이는 것을 목적으로 본 연구를 시행하였다. 방법: 2005년 6월부터 2007년 5월까지 건국대학교병원, 영등포 성애병원, 강북삼성병원, 중앙대학교병원, 건양대학교병원, 강릉아산병원의 신생아 집중 치료실에 입원하였던 신생아 4,476명을 대상으로 하였다. BPD의 진단 기준은 비전형적인 BPD를 포함하여 병인적인 분류를 하고 있는 Ogawa 등의 분류법을 이용하여 신생아 호흡 곤란 증후군(respiratory distress syndrome, RDS)과 전형적 또는 미만성 혼탁의 방사선 소견, 산전 감염의 유무에 따라 6가지 type으로 분류하였다. 또한 전체 신생아의 출생체중 분포와 생존율, 각 출생체중 군별 BPD의 발생률, 병태 비율, 사망률 등을 조사하고, 이 후 재택 산소요법 시행 여부와 미숙아 망막증, 괴사성 장염 등의 합병증 여부를 조사하였다. 결과: 생후 28일째 산소 치료가 필요한 신생아는 89명이었고, 이 중 Ogawa 분류법에 의한 BPD 환아는 70명(1.6%)이었으며, 특히 1,500 g 미만의 환아 237명 중 60명(25.3%)이었다. 생후 28일 이상 생존율은 98.7%이고, 사망 예는 없었으며 평균 재원 기간은 97.8±51.2일(43~405일)이었다. BPD는 900~999 g, 1,000~1,249 g의 체중 군에서 발생률이 각각 15명(21.4%)으로 가장 높았으며, 교정 36주 이후에도 산소투여가 필요한 중증 BPD의 경우 900~999 g의 체중 군에서 7명(23.3%)로 가장 높았다. Ogawa 분류법으로 BPD의 각 병태 비율로는 RDS 이후에 나타나는 I, II형이 각각 전체의 17예(24.3%), 44예(62.9%)로 대다수를 차지하였다. 이외에도 III`형은 2예(2.9%), IV형은 2예(2.9%), V형은 5예(7.1%)이었고, III형, VI형은 없었다. 재택 산소요법은 8예에서 시행되어 전체의 11.4%였으며, 이 중 BPD I형이 7예로 87.5%를 차지하였다. 미숙아 망막증은 35명(50.0%)에서 발생하였으며, 700 g 이하 신생아에서 9예(26.5%)로 가장 많았다. 또한 괴사성 장염은 3명(4.3%)이었다. 결론: 본 연구는 국내에서 처음으로 진행된 BPD의 전국적인 다기관 역학 조사로, 대상 신생아의 Ogawa 분류에 의한 BPD 유병률은 1.6% 이었고 1,500 g 미만 신생아의 25.3%이었으며, 전체 신생아의 BPD 70명 중 Ogawa 분류의 I, II형이 각각 24.3%, 62.9%로 대다수를 차지하였다. Purpose: As the neonatal intensive care advanced, the incidence of neonatal bronchopulmonary dysplasia (BPD) has increased. We conducted a multi-center investigation of the prevalence of BPD in six hospitals to investigate the epidemiology of BPD in Korea. Methods: Retrospective reviews ware performed for survival rate, prevalence of BPD of total 4,476 newborn infants who were admitted to neonatal intensive care unit in Konkuk university hospital, Sung-Ae General hospital, Kangbuk Samsung hospital, Chung-Ang university hospital, Konyang university hospital, and Gangneung Asan hospital between June, 2005 and May, 2007. By Ogawa, BPD was defined as oxygen dependency at 28 days after birth, with respiratory distress symptoms and the change of chest x-ray finding, and classified as 6 subtypes. Classic BPD was defined as oxygen dependency at 36 weeks of postmenstrual age. Results: Survival rate at 28 day after birth was 98.7%. BPD infants by Ogawa classification were 70 (1.6% of overall newborn infants), classic BPD infants were 30 (0.7%). Especially, among 237 preterm infants with birth weight less than 1,500 gram who survived to 28 days of life, 60 (25.3%) had BPD by Ogawa classification and 23 (9.7%) had classic BPD. In Ogawa classification, infants with RDS as type I and II, were 17 infants (24.3%) and 44 infants (62.9%). Home oxygen therapy was performed 8 infants (11.4%). Prevalence of retinopathy of prematurity was 35 infants (50.0%), necrotizing enterocolitis was 3 infants (4.3%), and intraventricular hemorrhage was 6 infants (8.6%). Conclusion: Prevalence of BPD infants was 1.6% of overall newborn, 25.3% of preterm infants with birth weight less than 1,500 gram. Among 70 BPD infants, BPD by Ogawa classification with history of RDS as type I and II were 24.3%, 62.9% as the majority of BPD. This study would be the first report of epidemiology of Korean BPD infants by multi-center study.

위화(胃火) 1호(號)로 호전(好轉)된 만성위염(慢性胃炎) 환자(患者) 치험(治驗) 2례(例)

이경민,이세연,임성철,서정철,한상원,Lee, Kyung-min,Lee, Se-yun,Im, Sung-chul,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.6

Objective: This study was designed to investigate the effect of Wihwa herbal-acupuncture on chronic gastritis. Methods: Wihwa herbal-acupuncture was administered two times a week. The following points were selected: CV12(中脘), CV13(上脘), S36(足三里), Liv3(太衝). We checked pain rating score(P.R.S.), visual analogue scale (V.A.S.) and Gastroscopy. Results: After 6 weeks of treatment, the patient showed that clinical symtoms was disappeared, Lee's P.R.S. changed from 77 to 8 and Park's P.R.S. from 55 to 0 and gastric erosion disappeared on gastroscopy. Conclusions: These results suggest that and Wihwa herbal-acupuncture has good effect on chronic gastritis. But further studies are required to concretely prove the effectiveness of Wihwa herbal-acupuncture for treating chronic gastritis.

Low-voltage pentacene transistor inverters using micro-contact printed nano-layer

Lee, Kwang H.,Oh, Min Suk,Lee, Byoung H.,Sung, Myung M.,Im, Seongil Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.4

<P>We report on low-voltage inverters with two pentacene-based thin-film transistors (TFTs), one of which has been fabricated on a dielectric surface selected by micro-contact printing (μCP). When a self-assembled monolayer (SAM) of 7-octenyltrichlorosilane (7-OTS) was printed on AlO<SUB><I>x</I></SUB> dielectric oxide, the TFT with the μCP-SAM displayed a large threshold voltage (<I>V</I><SUB>th</SUB>) shift (3 V shift under −5 V operation), increased device current, and clearly changed pentacene surface morphology as compared to those of the other TFT without μCP-SAM. Those results are attributed to the 7-OTS-modified pentacene/AlO<SUB><I>x</I></SUB> interface. Our inverter, composed of two TFTs with and without μCP-SAM, shows a high gain of ∼50 at a supply voltage (<I>V</I><SUB>DD</SUB>) of −20 V.</P> <P>Graphic Abstract</P><P>Micro-contact printing of a hydrophobic nano-layer provides selective channel patterning for a pentacene organic inverter with two thin-film transistors (TFTs), of which the load-TFT is selected by the process, to control the inverter properties. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b922675c'> </P>

Synthesis and cellular uptake properties of guanidine-containing molecular transporters built on the sucrose scaffold

Lee, Woo Sirl,Im, Chang-Nim,Teng, Qi Ying,Chang, Young-Tae,Kim, Dong-Chan,Kim, Kyong-Tae,Chung, Sung-Kee Royal Society of Chemistry 2009 Molecular bioSystems Vol.5 No.8

<P>Novel sucrose-based G7 molecular transporters show different patterns of intracellular localization depending on the nature of the linker chains as well as the fluorescent dyes.</P> <P>Graphic Abstract</P><P>Novel sucrose-based G7 molecular transporters show different patterns of intracellular localization depending on the nature of the linker chains as well as the fluorescent dyes. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b901846h'> </P>

Performance Evaluation of Two-Stage Spiral Wound Forward Osmosis (SWFO) Elements at Various Operation Conditions

Sung-Ju Im,Gyeong-Wan Go,Sang-Hak Lee,Gi-Ho Park,Am Jang 대한환경공학회 2015 대한환경공학회 학술발표논문집 Vol.2015 No.10

Characterisation of the major carotenoids in the plasma of the Eurasian magpie (Pica pica) nestlings

Sang-im Lee,Min Jung Baek,Jae Chun Choe,Piotr G. Jablonski 한국조류학회II 2017 한국조류학회지 Vol.24 No.1

Since carotenoids can serve as antioxidants and/or immune stimulants, it has been assumed that deposition of carotenoids in feathers or bills can reveal the health status in birds. In order to study the function of carotenoids as signals or immune stimulants, it is necessary to characterise the types of carotenoid molecules in the study species. In this preliminary study, we examined the types of carotenoids in the plasma of four nestlings of the Eurasian magpie (Pica pica) using mass spectrometry. We found that lutein or zeaxanthin is the major carotenoid in the plasma of magpie nestlings. Some minor constituents of carotenoids could be regarded as the metabolized forms of lutein or zeaxanthin. The plasma of magpie nestlings contained both yellow carotenoids such as lutein and zeaxanthin and red carotenoids such as astaxanthin, which may result in the varying degrees of redness in the plasma among the individuals.

Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome

Lee, S H,Yoo, K H,Sung, K W,Koo, H H,Kwon, Y J,Kwon, M M,Park, H J,Park, B-K,Kim, Y Y,Park, J A,Im, H J,Seo, J J,Kang, H J,Shin, H Y,Ahn, H S Macmillan Publishers Limited 2010 Bone marrow transplantation Vol.45 No.8

Four hundred and sixty-seven hematopoietic stem cell transplantations (HSCTs) (217 autologous and 250 allogeneic HSCT) were performed in 374 children at four pediatric HSCT centers in Korea from January 2005 to December 2007. Among 467 transplants, veno-occlusive disease (VOD) developed in 72 transplants (15.4%) at a median of 10 days after HSCT. Multivariate analysis showed that BU or TBI-containing regimen (P=0.002), VOD prophylaxis without lipo-prostaglandin E1 (PGE1) (P=0.012), number of previous HSCT (P=0.014), and pretransplant serum ferritin (P=0.018) were independent risk factors for developing VOD. Mean serum ferritin levels were significantly higher in HSCT with VOD (2109.6±2842.5 ng/ml) than in HSCT without VOD (1315.9±1094.4 ng/ml) (P<0.001). The relative risk of death within 100 days of HSCT in transplants with VOD compared with transplants without VOD was 3.39 (confidence interval: 1.78–6.45). Our results suggest that lipo-PGE1 might have a protective effect against the development of VOD, and pretransplant serum ferritin could act as a risk factor for VOD. A larger prospective study is needed to confirm a possible role of lipo-PGE1 and iron chelation therapy in reducing the incidence of VOD.

Current status and prospect of ceramic permanent magnets

Sang-Im Yoo,Kang-Hyuk Lee 한국자기학회 2020 한국자기학회 학술연구발표회 논문개요집 Vol.30 No.1