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( Sung Gyu Im ),( Sun Hong Yoo ),( Young Min Park ),( Sang Jin Lee ),( Sun Kyung Jang ),( Dong Ok Jeon ),( Hyo Jin Cho ),( Mi Jung Oh ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33 yearold male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine. (Clin Mol Hepatol 2015;21:180-182)
Developmental Transcriptomic Features of the Carcinogenic Liver Fluke, <i>Clonorchis sinensis</i>
Yoo, Won Gi,Kim, Dae-Won,Ju, Jung-Won,Cho, Pyo Yun,Kim, Tae Im,Cho, Shin-Hyeong,Choi, Sang-Haeng,Park, Hong-Seog,Kim, Tong-Soo,Hong, Sung-Jong Public Library of Science 2011 PLoS neglected tropical diseases Vol.5 No.6
<▼1><P><I>Clonorchis sinensis</I> is the causative agent of the life-threatening disease endemic to China, Korea, and Vietnam. It is estimated that about 15 million people are infected with this fluke. <I>C. sinensis</I> provokes inflammation, epithelial hyperplasia, and periductal fibrosis in bile ducts, and may cause cholangiocarcinoma in chronically infected individuals. Accumulation of a large amount of biological information about the adult stage of this liver fluke in recent years has advanced our understanding of the pathological interplay between this parasite and its hosts. However, no developmental gene expression profiles of <I>C. sinensis</I> have been published. In this study, we generated gene expression profiles of three developmental stages of <I>C. sinensis</I> by analyzing expressed sequence tags (ESTs). Complementary DNA libraries were constructed from the adult, metacercaria, and egg developmental stages of <I>C. sinensis</I>. A total of 52,745 ESTs were generated and assembled into 12,830 <I>C. sinensis</I> assembled EST sequences, and then these assemblies were further categorized into groups according to biological functions and developmental stages. Most of the genes that were differentially expressed in the different stages were consistent with the biological and physical features of the particular developmental stage; high energy metabolism, motility and reproduction genes were differentially expressed in adults, minimal metabolism and final host adaptation genes were differentially expressed in metacercariae, and embryonic genes were differentially expressed in eggs. The higher expression of glucose transporters, proteases, and antioxidant enzymes in the adults accounts for active uptake of nutrients and defense against host immune attacks. The types of ion channels present in <I>C. sinensis</I> are consistent with its parasitic nature and phylogenetic placement in the tree of life. We anticipate that the transcriptomic information on essential regulators of development, bile chemotaxis, and physico-metabolic pathways in <I>C. sinensis</I> that presented in this study will guide further studies to identify novel drug targets and diagnostic antigens.</P></▼1><▼2><P><B>Author Summary</B></P><P><I>Clonorchis sinensis</I> is a significant pathogen that causes clonorchiasis, which is endemic to East Asian countries. This fluke provokes acute inflammation and chronic hyperplasic changes in the biliary tracts. <I>C. sinensis</I> promotes cholangiocarcinoma, and has been classified as a Group 1 biological carcinogen, alongside <I>Opisthorchis viverrini</I>, by the World Health Organization. Recently, transcriptomes for adult liver flukes have been reported with the molecular functionalities predicted on the bases of their transcriptomic data sets. We generated the developmental <I>C. sinensis</I> transcriptome for three different developmental stages, revealing that most functional genes were differentially expressed in each developmental stage; only a small proportion of the expressed genes were shared between the three stages. The developmental transcriptome describes the gene expression landscapes of <I>C. sinensis</I> adults, metacercariae, and eggs, and provides insight into how this fluke adapts to the distinctly different environments provided by its various hosts. We anticipate that the transcriptome will contribute significantly to the identification of intervention points along the developmental stages and allow the exploitation of novel potential targets for diagnostic, drug, and vaccine development purposes.</P></▼2>
Strategic Role of ICT for E-Education
Im, Jin-Hyouk,Yoo, Sang-Jin Korea Association of Information Systems 2009 情報시스템硏究 Vol.18 No.2
The daunting challenge thai today's educational organizations face is how to improve academic quality while containing or reducing costs. This paper discusses major changes in the educational environment and ICT-based course improvement efforts; examines some successful cases for course redesign, and proposes an e-education strategy for an educational institution to use ICT strategically in order to achieve both academic quality improvement and cost reduction together. 모든 대학들이 예외없이 경쟁력 강화에 전력을 다하고 있는 현실에서 교육의 질 향상과 비용절감은 대학들이 당면하고 있는 긴급하고도 중대한 과제이다. 이를 위하여 본 논문은 변화하는 대학교육환경, 정보통신기술(ICT)을 바탕으로 한 교육 개선 방법들, 그리고 교과목 개편의 성공적 사례들에 대한 기술을 한 후에 질 향상과 비용절감을 동시에 추구하려는 e-Education 실행을 위하여 어떻게 ICT를 이용해야 하는가에 대한 전략적 틀을 제시한다.
Im, Ha-Ni,Kim, In-Ho,Singh, Bhupendra,Jeon, Sang-Yun,Yoo, Young-Sung,Song, Sun-Ju The Electrochemical Society 2017 Journal of the Electrochemical Society Vol.164 No.4
<P>In this work, we investigated charge transport properties of La0.1Sr0.9Co0.8Fe0.2O3-delta (LSCF1982) by a blocking cell experiment in isothermal conditions in 800-950 degrees C range. By measuring the ionic charge of transport (alpha(*)(i)) vs. oxygen partial pressure (pO(2)), the cross-effect between ionic and electronic flows were investigated. The values of alpha(*)(i) were found to be non-zero with a magnitude of 0.43-1.15 in 800-950 degrees C range, indicating that even in the absence of a direct cause of electron flow a significant number of electrons are dragged by the cations. By constructing an Onsager matrix, the values of Onsager transport coefficients were extracted. It was observed that the Onsager coefficients related with the cross-effect (L-ie = L-ei) have nearly of the same order of magnitude that of the Onsager coefficient for ionic flow (L-ii) and therefore cannot be ignored. The values of partial ionic conductivity were calculated from Onsager matrix and which showed an exponential increase (sigma O-2-alpha pO(2)(m), m = 1/2) with increasing pO(2) and temperature at 800 degrees C but less dependence on pO(2) at the higher temperatures. (C) 2017 The Electrochemical Society. All rights reserved.</P>
A continuous droplet electroporation system for high throughput processing
Yoo, Byeong Sun,Im, Do Jin,Ahn, Myung Mo,Park, Sung Jin,Kim, Yeong Hun,Um, Tae Woong,Kang, In Seok The Royal Society of Chemistry 2018 The Analyst Vol.143 No.23
<P>A continuous droplet electroporation (EP) system capable of handling a billion cells has been proposed and demonstrated using a proof-of-concept prototype design. Numerical simulations were conducted to design the new system and to compare the continuous droplet EP system with the previous single droplet EP system. Through parametric studies on the applied voltage and flow rate, a much higher cyan fluorescent protein transgene expression efficiency (38.8 ± 8.9%) was accomplished over that of the previous single droplet EP system. A parallel continuous droplet EP system is also demonstrated by introducing additional electrode pairs into the continuous droplet EP system to achieve ultrahigh throughput. Finally, the significance and meaning of the present work and future development direction have been discussed.</P>
Smallest-Small-World Cellular Harmony Search for Optimization of Unconstrained Benchmark Problems
Im, Sung Soo,Yoo, Do Guen,Kim, Joong Hoon Hindawi Limited 2013 Journal of applied mathematics (JAM) Vol.2013 No.-
<P>We presented a new hybrid method that combines cellular harmony search algorithms with the Smallest-Small-World theory. A harmony search (HS) algorithm is based on musical performance processes that occur when a musician searches for a better state of harmony. Harmony search has successfully been applied to a wide variety of practical optimization problems. Most of the previous researches have sought to improve the performance of the HS algorithm by changing the pitch adjusting rate and harmony memory considering rate. However, there has been a lack of studies to improve the performance of the algorithm by the formation of population structures. Therefore, we proposed an improved HS algorithm that uses the cellular automata formation and the topological structure of Smallest-Small-World network. The improved HS algorithm has a high clustering coefficient and a short characteristic path length, having good exploration and exploitation efficiencies. Nine benchmark functions were applied to evaluate the performance of the proposed algorithm. Unlike the existing improved HS algorithm, the proposed algorithm is expected to have improved algorithmic efficiency from the formation of the population structure.</P>
Probing Electronic Structures of Melts and Glasses under Compression
Sung Keun Lee(이성근),Sun Young Park(박선영),Yoo Soo Yi(이유수),Eun Jeong Kim(김은정),Yong-Hyun Kim(김용현),Hyo-Im Khim(김효임),A Chim Lee(이아침),Saebom Ryu(류새봄),Hoon Khim(김훈),Kwan Young Mun(문관영),Juho Lhee(이주호) 한국암석학회 2020 한국암석학회 학술발표회 논문집 Vol.2020 No.8
( Sung Yun Lee ),( Duk Keun Yoo ),( Sang Im Yoo ) 대한금속재료학회 ( 구 대한금속학회 ) 2007 ELECTRONIC MATERIALS LETTERS Vol.3 No.1
We report the important roles of Cu composition in CaCu3Ti4O(12) (CCTO) polycrystalline ceramics. These roles include influencing the microstructural change and remarkably high dielectric constant, ε(r) in a relatively low frequency region. For this purpose, CaCu(2.8)Ti4O(12) (Cu2.8) and CaCu(2.9)Ti4O(12) (Cu2.9) powders with a Cu-deficient composition, CaCu(3.1)Ti4O(12)(Cu3.l) and CaCu(3.2)Ti4O(12) (Cu3.2) powders with a Cu-excess composition and CaCu3Ti4O(12) (Cu3.0) (CCTO) powder were prepared. All of these samples were calcined at 950℃ for 24h, and then sintered at 1060℃ for 12h using a conventional solid-state ceramic process. As the Cu composition decreased, the Cu-deficient samples changed from a duplex microstructure including abnormally grown grains and fine grains to a microstructure almost fully covered with fine grains without any abnormally grown grains. However, the Cu-excess samples showed fine-grained microstructures in which no abnormally grown grains were observed with Cu-rich seco1ldary phases segregated at the grain boundaries compared with CCTO. Relative dielectric constants of the, ε(r) values of the samples were strongly affected by the size and population of abnormally grown grains which were varied with the amount of Cu-rich secondary phases.