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Propylthiouracil에 의한 중증 급성간염 1예
임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2
PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.
Sodium Azide와 2-AF에 대한 마(Dioscorea batatas Decene)의 항변이원성
이임선,정세영,심창섭,구성자 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2
The objective of this study was to screen the antimutagenicity of yam enzymatic browning reaction product(YEBRP), mucopolysaccharide and dietary fiber from yam to the mutagen of sodium azide and 2-aminoflourene(2-AF). Antimutagenicity of YEBRP on the mutagenicity of sodium azide showed no difference compared to control without YEBRP but that of 2-AF was high in all substrate.(P<0.01) On the mutagenicity of sodium azide and 2-AF, antimutagenicity of mucopolysaccharide and dietary fiber were high (p<0.01) in α-cellulose and hemicellulose. Antimutagenicity of α-cellulose on the mutagenicity of 2-AF was high at 5 hours reaction time but that was decreased as the reaction time increased.
황선성,임미경,이용근 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1
The aim of this study was to measure the regional mictr-shear bond strength of dentin bonding sgents to dentin, and to investigate the relationship between the micro-shear bond strength and two dentinal characteristics ; Vickers hardness and remaining dentin thickness. Twenty-four freshly extracted, noncarious human molars were selected for this study. The materials tested in this study consisted of two commercially available dentin bonding agents(MAC-BOND, ONE-STEP) and two restorative light-cured composite resins (AELITEFIL, Z100). The occlusal of side surface of tooth crown was sectioned to expose dentin, and the exposed surface was finally polished with # 600 sandpaper, Four groups of application methods were used combining the filling materials and the dentin bonding agents. The composite resin-attached tooth specimens were embeded in a cold cure acrylic resin. and were obtained from each tooth. The cut spectimens were divided into three groups depending on the position of the dentin bonding wurface. The micro-shear bond strength. remaining dentin thickness, and dentinal hardness were measured. Experimental results were then statestically analyzed with ANOVA, t-test, Scheffe test. and regression analysis. From this experiment, the following results were obtained : 1. In the case of occlusal surface bonding, the pooled micro-shear bond strength of ONSTAELIT group (16.62 MPa) was singificantly higher than that of MACB-AELIT group (9.91 MPa) (p<0.05). However, there was no significant difference in the mictr-shear bond strength depending on the centin positon (p>0.05). 2. In the case of side surface bonding of crown, the pooled micro-shear bond strength of four different bonding groups was not significantly different among each other (p>0.05). However, in three of the test groups (ONST-AELIT, MACB-Z100, ONST-Z100), the micro-sheer bond strength to the lower 1/3(Ⅲ) position was sugnuficantly lower than that to middle 1/3(Ⅱ) position of surface (p<0.05). 3. In the ONST-AELIT bonding group, the pooled micro-shear bond strength to the occlusal surface was significantly lower than that to the side surface of crown (p<0.05). 4. There was no significant correlation between the micro-shear bond strength and dentin hardness / remaining dentin thickness (p>0.05).
Lee, Im-Seon,Jung, Keun-Young,Oh, Sei-Ryang,Kim, Dong-Seon,Kim, Jung-Hee,Lee, Jung-Joon,Lee, Hyeong-Kyu,Lee, Seung-Ho,Kim, Eun-Hee,Cheong, Chae-Joon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.6
In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the $IC_{50}$ values were $4.8{\times}10^{-5} M and 1.2{\times}10^{-4}M,$ respectively. In addition, the $^{13}C$ NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
Lee, Im Seon,Jung, Keun Young,Oh, Sei Ryang,Kim, Dong Seon,Kim, Jung Hee,Lee, Jung Joon,Lee, Hyeong-Kyu,Lee, Seung-Ho,Kim, Eun-Hee,Cheong, Chaejoon 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits of Schizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC_(50) values were 4.8×10^(-5) M and 1.2×10^(-4) M, respectively. In addition, the ^(13)C NMR assignments of 1 and 2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
이강숙,이정운,이원철,맹광호,양선임,김대석,이선영,이경화 가톨릭대학산업의학센타 산업의학연구소 2003 韓國의 産業醫學 Vol.42 No.2
This study was carried out to find the factors associated with relapse of smoking in mail workers. The data were obtained from 513 workers of an electronics industries in October 2002 about nicotine dependence, withdrawal symptom, and knowledge for smoking. The results of this study can be summarized as follows; 1. Amount and duration of smoking, irregular eating and non-exercise were higher in re-smokers. 2. The rate of high nicotine dependency and craving for smoking was increased in re-smoker. 3. Mean of quitting trial was 2.39 in ex-smokers and 2.17 in re-smokers, the duration of first quitting were 10.43 days in ex-smokers and 3.73 days in re-smokers. 4. The top reason for re-smoking was 'job-stress' in ex-smokers and re-smokers. 5. The mean score of knowledge about smoking was 7.88 in ex-smokers and 7.83 in re-smokers. 6. The more nicotine dependency increased, the more withdrawal symptom becomes. And increased withdrawal symptoms are correlated with frequency of quitting trial positively. In conclusion, it was suggested that factors of re-smoking were job-stress and nicotine dependency. Therefore comprehensive smoking cessation program including stress management and nicotine replace therapy was needed.
Spatholobus suberectus inhibits osteoclastogenesis and stimulates chondrogenesis.
Im, Nam-Kyung,Lee, Sung-Gyu,Lee, Dong-Sung,Park, Pil-Hoon,Lee, In-Seon,Jeong, Gil-Saeng Institute for Advanced Research in Asian Science a 2014 The American journal of Chinese medicine Vol.42 No.5
<P>This study was carried out to investigate the effect of Spatholobus suberectus Dunn (SS) on the protection of chondral defect and inhibition of osteoclastogenesis. To examine these effects, we measured the matrix metalloproteinase (MMP) levels in SW1353 chondrosarcoma cells and performed tartrate-resistant acid phosphatase (TRAP) staining in bone marrow macrophage (BMM)-derived osteoclasts. To investigate the anti-osteoarthritis (OA) effects, we assessed TNF-α-induced MMP-1, -3, -9 and tissue inhibitors of matrix metalloproteinase (TIMP) expression levels in SW1353 cells. We observed that SS extract significantly inhibited MMP and TIMP expression in SW1353 cells. Also, SS extract inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. These results suggest that SS extract may have a potential in the treatment of bone loss and chondral defect by suppressing osteoclast differentiation and decreasing the expression of OA factors. Therefore, clarification of the mechanism of the action of SS extract and its active components is needed.</P>