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( Lai Wei ),( Qing Xie ),( Jin Lin Hou ),( Hong Tang ),( Qin Ning ),( Jun Cheng ),( Yuemin Nan ),( Lunli Zhang ),( Jun Li ),( Jianning Jiang ),( Megan Kim ),( Brian Mcnabb ),( Fangqiu Zhang ),( Gregor 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Chronic hepatitis C virus (HCV) infection remains a major health threat in China, affecting at least 10 million people, with approximately 58% having genotype (GT) 1 infection. There is a critical need for simple, all oral, direct-acting antiviral regimens to treat GT1 HCV in this region. Treatment with ledipasvir (LDV)/sofosbuvir (SOF) results in high sustained virologic response rates 12 weeks after therapy (SVR12) in GT1 HCV infected patients in clinical trials and real-world settings. This study evaluated the efficacy and safety of LDV/SOF for 12 weeks in Chinese patients with chronic GT1 HCV infection. Methods: Treatment experienced and treatment naïve patients with chronic GT1 HCV infection with no cirrhosis or with compensated cirrhosis were eligible to enroll in a single-arm, openlabel trial to receive a fixed dosed combination of LDV/SOF 90/400 mg daily for 12 weeks. The primary efficacy endpoint was SVR12 using the CAP/CTM HCV 2.0 assay (LLOQ =15 IU/mL) and the primary safety endpoint was adverse events (AEs) leading to LDV/SOF discontinuation. Results: A total of 206 Chinese patients were enrolled and treated. Of these, 50% were male, 16% had compensated cirrhosis, 49% were treatment-experienced, 76% had IL28B CC genotype, and 100% had GT1b HCV infection. The mean (range) age and body mass index of enrolled subjects were 47 (21-72) years and 23 (14-34) kg/m2, respectively. The overall SVR12 rate is 100% (206/206). All 32 patients with cirrhosis (15 of whom were treatment-experienced), achieved SVR12. There were no discontinuations due to AEs. No serious or severe AEs were assessed by the investigator as related to study drug and there were no deaths. Conclusions: Treatment with the single tablet regimen of LDV/SOF for 12 weeks resulted in 100% SVR12 and was well tolerated in treatment experienced and treatment naïve GT1 HCVinfected Chinese patients with and without cirrhosis.
Wei-Jen Lai,Kuo-Chung Cheng 한국섬유공학회 2018 Fibers and polymers Vol.19 No.1
Polypropylene (PP) fibers with a sorbital derivative nucleating agent (SDN) and rare earth aluminates (SrAl2O4:Eu2+,Dy3+) were prepared via melt compounding and melt-spinning. Non-isothermal crystallization kinetics and luminescence properties of PP and luminous PP fibers were studied by differential scanning calorimetry (DSC), polarized optical microscopy (POM), and decay of the afterglow test. The crystallization temperature determined by DSC increasedwith the addition of the nucleating agent during the cooling process from 200 oC. The Jeziorny model successfully described the non-isothermal crystallization behavior of the luminous PP with various SDN contents. The crystal grain size and morphology of the sample with the SDN was different from that without nucleating agent. The luminous PP fabric having high initial brightness intensity, approximately 461 mcd g-1m-2, can be prepared with addition of 10 wt% of rare earthaluminates and 0.5 % of SDN.
Home Energy Management System for Interconnecting and Sensing of Electric Appliances
( Wei-ting Cho ),( Chin-feng Lai ),( Yueh-min Huang ),( Wei-tsong Lee ),( Sing-wei Huang ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.7
Due to the variety of household electric devices and different power consumption habits of consumers at present, general home energy management (HEM) systems suffer from the lack of dynamic identification of various household appliances and a unidirectional information display. This study presented a set of intelligent interconnection network systems for electric appliances, which can measure the power consumption of household appliances through a current sensing device based on OSGi platform. The system establishes the characteristics and categories of related electric appliances, and searches the corresponding cluster data and eliminates noise for recognition functionality and error detection mechanism of electric appliances by applying the clustering algorithm. The system also integrates household appliance control network services so as to control them according to users` power consumption plans or through mobile devices, thus realizing a bidirectional monitoring service. When the system detects an abnormal operating state, it can automatically shut off electric appliances to avoid accidents. In practical tests, the system reached a recognition rate of 95%, and could successfully control general household appliances through the ZigBee network.
Particle Size and Loading Effects on Particle-Laden Flow with Mono-sized Droplets
( Wei Hsiang Lai ),( Wei Fu Lu ),( Keh Chin Chang ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-
Turbulence modulation is an interaction between phases that occurs in multiphase flow, and turbulence intensity traditionally can be represented as an indicator of turbulence modulation. Many researchers paid attention on the subject, but no coincident conclusion can be proposed. A general cognition is that larger particles induced wake to enhance the fluid turbulence intensity and smaller particles suppressed the fluid turbulence intensity since the fluid eddy imparted energy to the smaller particle. Here, the authors orderly changed particle size of dispersed phase and mass loading ratio (LR) to study the change on fluid turbulence intensity. Mono-dispersed droplets with a narrow size distribution were used to load into a homogeneous turbulence to investigate the turbulence modulation. Particle Dynamic Analyzer (PDA) was used to measure the particle (droplets and tracers) dynamic information. The particle concentration effect can be significantly observed. After coupling particle concentration and particle wetting area (πd2), a linear relationship can be obtained and it represents the turbulence modulation dominated the dilute two-phase flow as our expectation.
Investigation of in-train stability and safety assessment for railway vehicles during braking
Lai Wei,Jing Zeng,Qunsheng Wang 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.4
In-train stability of railway vehicles has becoming a major concern for railway vehicles, which refers to the jackknifing behavior of couplers under large in-train forces. For the train to train rescue scenario, braking induced impacts from couplers can adversely affect the dynamic performance of the coupled train. It is indicated from field tests that in-train forces if combined with large rotational angles of couplers can produce vertical components, which will further lead to the interference of adjacent carbodies and structural damages. In this paper, the dynamic model of the train and coupler system is developed. The model verifications are conducted by comparing the calculated responses with the tested results. The safety indices are formulated on the basis of which the running safety of the coupled train is evaluated. The propelling test in the laboratory is conducted to reproduce the coupler jackknifing behavior. The quasi-static analysis and anti-jackknifing mechanism under compressing in-train forces are analysed. Parametric studies are then conducted to propose some limitations for the application of train to train rescue. It is indicated from numerical and testing results that the decrease of the braking deceleration or a limitation of the free rotational angle of couplers is beneficial to lower the amplitude of braking induced impacts.
A Tracking System Using Location Prediction and Dynamic Threshold for Minimizing SMS Delivery
Lai, Yuan-Cheng,Lin, Jian-Wei,Yeh, Yi-Hsuan,Lai, Ching-Neng,Weng, Hui-Chuan The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.1
In this paper, a novel method called location-based delivery (LBD), which combines the short message service (SMS) and global position system (GPS), is proposed, and further, a realistic system for tracking a target's movement is developed. LBD reduces the number of short message transmissions while maintaining the location tracking accuracy within the acceptable range. The proposed approach, LBD, consists of three primary features: Short message format, location prediction, and dynamic threshold. The defined short message format is proprietary. Location prediction is performed by using the current location, moving speed, and bearing of the target to predict its next location. When the distance between the predicted location and the actual location exceeds a certain threshold, the target transmits a short message to the tracker to update its current location. The threshold is dynamically adjusted to maintain the location tracking accuracy and the number of short messages on the basis of the moving speed of the target. The experimental results show that LBD, indeed, outperforms other methods because it satisfactorily maintains the location tracking accuracy with relatively fewer messages.
Lai Wei,Rajan Singh,Uday C Ghoshal 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3
Disorders of gut-brain interaction (DGBIs) are common conditions in community and clinical practice. As specialized enteroendocrine cells, enterochromaffin (EC) cells produce up to 95% of total body serotonin and coordinate luminal and basolateral communication in the gastrointestinal (GI) tract. EC cells affect a broad range of gut physiological processes, such as motility, absorption, secretion, chemo/mechanosensation, and pathologies, including visceral hypersensitivity, immune dysfunction, and impaired gastrointestinal barrier function. We aim to review EC cell and serotonin-mediated physiology and pathophysiology with particular emphasis on DGBIs. We explored the knowledge gap and attempted to suggest new perspectives of physiological and pathophysiological insights of DGBIs, such as (1) functional heterogeneity of regionally distributed EC cells throughout the entire GI tract; (2) potential pathophysiological mechanisms mediated by EC cell defect in DGBIs; (3) cellular and molecular mechanisms characterizing EC cells and gut microbiota bidirectional communication; (4) differential modulation of EC cells through GI segment-specific gut microbiota; (5) uncover whether crosstalk between EC cells and (i) luminal contents; (ii) enteric nervous system; and (iii) central nervous system are core mechanisms modulating gut-brain homeostasis; and (6) explore the therapeutic modalities for physiological and pathophysiological mechanisms mediated through EC cells. Insights discussed in this review will fuel the conception and realization of pathophysiological mechanisms and therapeutic clues to improve the management and clinical care of DGBIs.