Large infantile hemangioma with subfascial location: a case with difficulty of clinical diagnosis

( Dae-lyong Ha ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hoon-soo K 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

The unexpected finding of newly growing lump in an infant induces anxiety to parents and results in an urgent visit to hospital. Before performing invasive interventions for this infant patient, benign conditions like infantile hemangioma (IH) should be excluded as it could show variable clinical characteristics. A 6-month-old girl was presented with protruding skin-colored tumor on right upper back, with approximately 10cm in diameter and without surface change. The tumor abruptly enlarged over the period of 2 weeks without any previous episode. MRI showed a lobulated hypervascular mass in the subfascial layer with neovascularization inside. Through this findings, thought by radiologist and orthopedic surgeon to be malignant tumor, exploratory surgery was planned. Before surgical excision, this patient was consulted to our department. As the lesion was softly palpable and movable, incisional biopsy was performed to rule out the benign tumor like deep type IH. Histopathologic examination showed numerous vessels lined by plump endothelial cells. Immunohistochemical staining revealed the positivity of endothelial cells for CD-31, GLUT-1. Under the diagnosis of IH, the patient received oral propranolol medication for 1 year. Following the patient, we found the tumor diminished dramatically in volume. Although IHs are common benign tumor in infancy, Subfascial location is unfamiliar and rare. So, we herein report a case of subfascial lH.

치과용 도재분말의 제조 및 물리적 성질

염근창,고대진,장감용,이서영,김경남 大韓齒科器材學會 1994 대한치과재료학회지 Vol.21 No.1

In this study, the prepared glasses were heat-treated to precipitate the leucite crystal in order to control the thermal expansion coefficient which is an important property of dental porcelain powder. The effect of addition of Li₂O and Na₂O on the amount of the precipitated leucite crystal were also examined. The mixing ratio of the leucite-containing glass must be controlled to match the thermal expansion coefficient of dental porcelain to that of metal. The physical properties of the dental porcelain powder prepared in this study were characterized. The results of this study were obtained as follows : 1. Conditions for the preparation of the maximum amount of leuctie crystal were compostion L-2(2.0 wt% Li₂O added) heat-treated at 950℃. 2. The phase of the precipitated crystals was turned out to be the tetragonal leucite crystal. 3. Maximum relative crystallinity was 64.2% for composition L-2, heat-treated at 950℃. Its linear thermal expansion coefficient was 16.1×10-6/℃ in the range of room temperature to 500℃. 4. The optimum mixing ratio of the leucite-containing glass was 45% in order to match the thermal expansion coefficient of dental porcelain to that of metal. In this case, the thermal expansion coefficient of the prepared dental porcelain was 10.6×10-6/℃ (∼500℃). 5. The physical and chemical properties of the prepared dental porcelain were suitable for the requirements of ISO 6872 and 9693.

Cefotaxime과 Furosemide의 賢排泄 및 血漿蛋白 結合에 미치는 影響

鄭址昌,金載學,韓大燮,高啓昌 慶熙大學校 1984 論文集 Vol.13 No.-

The cephalosporins are eliminated by both glomerular filtration and tubular excretion. Chronic administration of cephalosporins may cause renal tubular necrosis. Cefotaxime is a new semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum. Therefore, to determine whether any variations at plasma protein binding with furosemide by cefotaxime were responsible for its diuretic action of urine volume and electrolytes in rabbits, author studies effects on drug-interaction of cefotaxime and furosemide. The following results were obtained. 1. The group, administrated simultaneously furosemide and cefotaxime, was significantly increased compared with furosemide alone group on the urine volume, urinary electrolytes, because markedly increased the inhibition of Na^+ and Cl^- reabsorption in the renal tubule, and glomerular filtration rate without any differences. 2. Serum concentration of cefotaxime in rabbits was significanly elevated by the combination with furosemide, and markedly inhibited the elimination levels of cefotaxime in urine of rabbits. Conclusion of above results; Synergistic effect of cefotaxime on diuretic action of furosemide showed the comparative inhibition of plasma protein binding with furosemide by cefotaxime, and the continuation of diuretic effect seems excretion of furosemide on the in-hibited by competition between furosemide and cefotaxime in renal tubular excretion.

자재소요계획용 유연정보시스템 개발사례에 관한 연구

유대훈,이양우,조성훈,고창성 경성대학교 생산기술연구소 1997 생산기술연구지 Vol.4 No.-

This study suggests a procedure for construction flexible information systems for material requirement planning(MRP) under the circumstances of small and medium enterprises. To this end, a methodology in algorithmic expression is presented, in which learning curve is applied for calculating the practical lead-time, and real-time calculation of inventory for parts is performed condering all possible situations occurred in manufacturing as well as procurement sites. Finally, a case study is carried out for a small and medium enterprise producing several type of valves for ships in order to demonstrate the procedure proposed.

Ampicillin과 Furosemide의 相互作用에 관한 硏究

李昇宰,鄭址昌,高啓昌,韓大燮 慶熙大學校 1986 論文集 Vol.15 No.-

In order to investigate the durg-interaction between furosemide and ampicillin, the influences of ampicillin on the diuretic action of furosemide and the effects of furosemide on the urinary elimination rate and serum concentration of ampicillin were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-ampicillin combined group, the furosemide-ampicillin combined group showed significant increase in urine flow and urinary electrolytes amounts. Those findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. Throughout the combined administration of furosemide and ampicillin. the serum concentration of ampicillin were significantly elevated, but the urinary elimination rate of ampicillin were markedly decreased in the observed rabbits. It is concluded from the results that synergistic effect of ampicillin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by ampicillin. It is also postulated that the competition between furosemide and ampicillin in renal tubular secretion.

양이온 고분자전해질의 수중 입자의 응집에 미치는 교반강도 및 주입량의 영향

감상규,문창성,김대경,고병철,허철구 濟州大學校 海洋硏究所 2002 해양과환경연구소 연구논문집 Vol.26 No.-

Using several cationic polyelectrolytes of different charge density and molecular weight as flocculants and a simple continuous optical technique(photometric dispersion analyzer, PDA), the effects of mixing intensity and polyelectrolyte dosage on flocculation of kaoline particles(35 NTU) and particles(34.7 NTU) in Kangjung reversior of heavy rainfall have been examined. The optimum mixing was obtained at the stirring of 200rpm(G= 869 s^-1). The charge density of a polyelectrolyte is important in determining the optimum dosage and in the removl of particles. The optimum dosage is less for the polyelectrolyte of higher charge density and at the dosage, the removal of particles is higher for the polyelectrolyte of higher charge density and zeta potential of particles reaches to near zero. The optimum dosage for the removal of particles should be determined by flocculation test and not be determined by the turbidity of particles in water.

Genome-Wide Analysis of DNA Methylation before- and after Exercise in the Thoroughbred Horse with MeDIP-Seq

Gim, Jeong-An,Hong, Chang Pyo,Kim, Dae-Soo,Moon, Jae-Woo,Choi, Yuri,Eo, Jungwoo,Kwon, Yun-Jeong,Lee, Ja-Rang,Jung, Yi-Deun,Bae, Jin-Han,Choi, Bong-Hwan,Ko, Junsu,Song, Sanghoon,Ahn, Kung,Ha, Hong-Seok Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.3

Athletic performance is an important criteria used for the selection of superior horses. However, little is known about exercise-related epigenetic processes in the horse. DNA methylation is a key mechanism for regulating gene expression in response to environmental changes. We carried out comparative genomic analysis of genome-wide DNA methylation profiles in the blood samples of two different thoroughbred horses before and after exercise by methylated-DNA immunoprecipitation sequencing (MeDIP-Seq). Differentially methylated regions (DMRs) in the pre-and post-exercise blood samples of superior and inferior horses were identified. Exercise altered the methylation patterns. After 30 min of exercise, 596 genes were hypomethy-lated and 715 genes were hypermethylated in the superior horse, whereas in the inferior horse, 868 genes were hypomethylated and 794 genes were hypermethylated. These genes were analyzed based on gene ontology (GO) annotations and the exercise-related pathway patterns in the two horses were compared. After exercise, gene regions related to cell division and adhesion were hypermethylated in the superior horse, whereas regions related to cell signaling and transport were hypermethylated in the inferior horse. Analysis of the distribution of methylated CpG islands confirmed the hypomethylation in the gene-body methylation regions after exercise. The methylation patterns of transposable elements also changed after exercise. Long interspersed nuclear elements (LINEs) showed abundance of DMRs. Collectively, our results serve as a basis to study exercise-based reprogramming of epigenetic traits.

Clinical characteristics of green nail syndrome: A retrospective analysis

( Gi-wook Lee ),( Dae-lyong Ha ),( Jin-hwa Son ),( Jung-soo Lee ),( Kihyuk Shin ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Green nail syndrome (GNS) is an infectious disease developing greenish discoloration of the nail with accompanying nail disorder such as onycholysis and paronychia. However the data about its clinical characteristics and treatment response has been limited. Objectives: To investigate the clinical characteristics of green nail syndrome in Korean patients. Methods: We retrospectively reviewed medical records and clinical photos of 80 patients with 96 GNS lesions who diagnosed with GNS in the Pusan National University Hospitals (Busan and Yangsan) from 2009 through 2020. Results: 52 patients (65%) had risk factors for GNS include frequent wet conditions, immunosuppressive conditions, and trauma. Involvement of the thumbnail or great toenail was found in 62 lesions (64.6%). Pseudomonas aeruginosa was detected on 23 nails (48.9%) among 47 nails showing positive bacterial culture, and fungal infection was found on 19 nails (19.7%). Several treatments including bleaching and drying nail, topical antibiotics, topical antifungals, and surgical avulsion were tried. And there were some differences of therapeutic responses according to the selected treatment modalities. Bleaching and drying showed better effect on color changes of nail, while topical antibiotics and antifungal cream showed better effect on preventing spreading. Conclusion: The result of this study could be helpful for dermatologists when encountering patients with greenish nail change.

말단비대증 환자에서의 수술전 Octreotide 투여 효과

박경수,김현규,조보연,이홍규,고창순,민헌기,김성연,고경수,이석인,한대희,최길수,정희원,김현집 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1

Seven patients with previously untreated acromegaly and invasive pituitary macroadenomas were treated with the long-acting somatostatin analog, octreotide (San- dostatin*, Sandoz) for 3~6 months, before transsphenoidal pituitary adenomectomy. Preoperatively, treatment with octreotide for 3 months reduced the pituitary tumor size by 55~60% in 2 patients, 20~39% in 3 patients and little in the remaining 2 patients. Six patients were treated for another 3 monts, but the size of the pituiary tumor showed no further remarkable changes. Mean basal serum GH concentration fell from 251.6(53.0~470.0) ng/ml to 80.1(9.5~308.0) ng/ml after 3~6months treatment with octreotide. Postopercentrationn of one patient whose pituitary tumor size decreased 65% fell into the normal range. Thus, preoperative administration of octreotide induced shrinkage of GH-producing pituitary rumors in some patients and might have favorable effects on the remission rate in the treated patients. (J Kor Endocrinol 8:35~41, 1993)

난소 절제술을 시행한 흰쥐 등뼈의 해면골과 피질골의 구조적 특성 추적관찰 및 기계적 특성 분석

고창용(Chang Yong Ko),우대곤(Dae Gon Woo),이태우(Tae Woo Lee),김한성(Han Sung Kim),이법이(Beob Yi Lee),탁계래(Gye Rae Tack) Korean Society for Precision Engineering 2007 한국정밀공학회지 Vol.24 No.1

This study investigated changes of mechanical characteristics of the trabecular and cortical bone in the lumbar vertebrae of the ovariectomised (OVX) rat. In previous researches, there were many studies for morphology of osteoporotic bones based on Micro-Computed Tomography (Micro-CI'), However, there were few studies for detecting and tracking changes of mechanical characteristics of the trabecular and cortical bone in the lumbar vertebrae of the OVX rat. For this study, the 4th lumbar of the OVX rat (female Sprague-Dawley) was utilized as a specimen. An OVX rat was scanned at week 0 Oust before surgery), at week 4, and week 8 after surgery. Micro-finite element (μ-FE) analysis was used to investigate mechanical characteristics of the trabecular and cortical bone in the lumbar vertebrae for an OVX rat. When the OVX rat (at week 8) was compared with the OVX rat (at week 0), the structural modulus of cortical and trabecualr bone was decreased by 52% and 99%, respectively. This study showed the change of mechanical characteristics of cortical bone as well as trabecular bone of an OVX rat. Detecting and tracking changes of mechanical characteristics could greatly contribute to an experiment test for the trabecular and cortical bone in the lumbar vertebrae of an OVX rat by using In-vivo Micro-CT.