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Hayeon Kim(Hayeon Kim),Bumhee Park(Bumhee Park),Shin-Young Kim(Shin-Young Kim),Jiyea Kim(Jiyea Kim),Bora Kim(Bora Kim),Kyu-In Jung(Kyu-In Jung),Seung-Yup Lee(Seung-Yup Lee),Yerin Hyun(Yerin Hyun),Bung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: This research measures the regional GMV (rGMV) of the cerebellum, attention, Executive Function (EF) and we aimed to identify their correlation and sex differences in children and adolescents. Methods: Subjects comprised 114 children (male = 62, female = 52, 12.44 ± 2.99 years old) from South Korea. Participants were divided into three groups by age (age 6−9, 10−13, and 14−17). The Stroop Color and Word Test (SCWT), Wisconsin Card Sorting Test (WCST), and Advanced Test of Attention (ATA) were used to estimate executive function. Magnetic resonance imaging (MRI) images were analyzed with Regional Voxel-Based Morphometry Analysis. Results: The correlations between cerebellar rGMV and SCWT, WCST, and ATA subcategories showed difference by age and sex. In 6−9 age group, girls showed more overall correlations with cerebellar regions than boys, in WCST Categories Completed and ATA results. In age 10−13 group, more regions of cerebellum corresponded to SCWT subcategories in girls. Nevertheless, more correlation between cerebellar rGMV, WCST subcategories and some ATA subtests were observed in boys in the same age group. In the adolescent group, aged 14−17, boys showed more correlation with cerebellar rGMV, while girls showed little correlation. Conclusion: This study highlights that sex-different cerebellum maturation in adolescence might be correlated with EF and attention. These results provides evidence that cerebellum modulates higher cognitive functioning during child development.
Kim Sukyung,Han Song-Yi,Lee Jinyoung,Kim Na-Rae,Lee Bora,Kim Hyunmi,Kwon Mijeoung,Ahn Kangmo,Noh Youngbae,Kim Sang Jong,Lee Phyrim,Kim Dongki,Kim Byung Eui,김지현 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.5
Purpose: The beneficial effects of a combination therapy using Bifidobacterium longum and galactooligosaccharide (GOS) for the treatment of atopic dermatitis (AD) have not been elucidated. Methods: Gene expressions of interleukin (IL)-4 and IL-13 from peripheral blood mononuclear cells and fecal abundance of B. longum from 12-month-old infants were evaluated. Human primary epidermal keratinocytes (HEKs) and hairless mice were treated with B. longum, GOS, B. longum-derived extracellular vesicles (BLEVs), dinitrochlorobenzene (DNCB), or a synbiotic mixture of B. longum and GOS. Expression of epidermal barrier proteins and cytokines as well as serum immunoglobulin E (IgE) levels were analyzed in HEKs and mice. Dermatitis scores, transepidermal water loss (TEWL), epidermal thickness, and fecal B. longum abundance were evaluated in mice. Results: Fecal abundance of B. longum was negatively correlated with blood IL-13 expression in infants. B. longum or BLEVs increased expression of filaggrin (FLG) and loricrin (LOR) in HEKs. B. longum increased the efficacy of GOS to upregulate FLG and LOR expressions in HEKs. Oral administration of GOS increased fecal abundance of B. longum in mice. Oral administration of B. longum attenuated DNCB-induced skin inflammation, abnormal TEWL, AD-like skin, and deficiency of epidermal barrier proteins. Moreover, the combination of B. longum and GOS showed greater effects to improve DNCB-induced skin inflammation, abnormal TEWL, AD-like skin, serum IgE levels, IL-4 over-expression, and the deficiency of epidermal barrier proteins than the administration of B. longum alone. Conclusions: B. longum and GOS improve DNCB-induced skin barrier dysfunction and AD-like skin.
( Byung Chang Kim ),( Cheol Hee Park ),( Tae Il Kim ),( Suck-Ho Lee ),( Jin-Oh Kim ),( Hyun Soo Kim ),( Dong-Hoon Yang ),( Bora Keum ),( Sung Pil Hong ),( Seong-Eun Kim ),( Hyun Gun Kim ),( Jeong Eun 대한장연구학회 2013 Intestinal Research Vol.11 No.1
The incidence of colorectal carcinoid tumor is recently increasing as screening colonoscopy increased. Traditional carcinoid tumor had been known as low grade, malignant neuroendocrine cell orign tumor. In 2000, World Health Organization (WHO) suggested that carcinoid was called well-differentiated neuroendocrine tumor (NET). It recently updated in 2010 by WHO; according to the differentiation and malignant potential, NET classified with NET Grade 1, Grade 2, and neuroendocrine carcinoma. They suggested that NET had malignant potential in accordance with histopathologic characteristics. Therefore, WHO recommended the behavior code of NET as malignant. However, European Neuroendocrine Tumor Society (ENETS) proposed the behavior of NET to four grades based on the histopathologic features; benign, benign or low grade malignant, low grade malignant, and high grade malignant. Also, American Joint Committee on Cancer (AJCC) suggested that topography codes of NET were defined as malignant. Korean Standard Classification of Diseases (KCD) described the different codings of carcinoid (NET). The discrepancies of behavior code or coding system exist among WHO, ENETS, AJCC and KCD. Also, there were differences in the perception for topographic coding system between clinicians and pathologists. NETs of colorectum were reported with the variable clinical characteristics (especially, metastasis) and long term prognosis from many studies. Especially, risk of metastasis and long term prognosis of small sized NET (<1 cm) had some discrepancies and should be investigated prospectively. Therefore, the consensus about topographic codes of NET should be needed with multidisplinary approach among gastroenterologists, pathologists and surgeons. (Intest Res 2013;11:14-22)
( Bora Kim ),( Jin Eun Kim ),( Byung Kook Choi ),( Hyun Soo Kim ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.1
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-α- and interleukin-6-induced nuclear factor-κB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.
Kim, Bora,Antonyraj, Churchil A.,Kim, Yong Jin,Kim, Baekjin,Shin, Seunghan,Kim, Sangyong,Lee, Kwan-Young,Cho, Jin Ku American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.12
<P>Petroleum-independent and economically viable production of 5-hydroxymethyl-2-furfural (HMF) from industrially supplied high fructose corn syrup (HFCS) using a wood powder-derived carbonaceous solid acid in an ethylene glycol (EG)-based solvent was developed. EG-based solvents were preferable to the dehydration of HFCS into HMF owing to stabilizing reversible intermediates. In addition, low boiling EG-based solvents were readily removed to isolate HMF. As a parametric study on the dehydration of HFCS into HMF in an EG-based solvent, effects of reaction temperature, initial concentration of fructose, catalyst dosage, and water content on reaction rate and HMF yield were investigated. Sulfonated amorphous carbonaceous materials (∼0.7 mmol of SO<SUB>3</SUB>H/g) were prepared from wood powder via incomplete hydrothermal carbonization and then sulfonization, and they were applied to the dehydration of HFCS in glyme, affording HMF in 80% yield. It was also found that a prolonged reaction enabled further conversion of HMF into levulinic acid in a highly selective manner.</P>
Catalytically-etched hexagonal boron nitride flakes and their surface activity
Kim, Do-Hyun,Lee, Minwoo,Ye, Bora,Jang, Ho-Kyun,Kim, Gyu Tae,Lee, Dong-Jin,Kim, Eok-Soo,Kim, Hong Dae Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.402 No.-
<P><B>Abstract</B></P> <P>Hexagonal boron nitride (h-BN) is a ceramic compound which is thermally stable up to 1000°C in air. Due to this, it is a very challenging task to etch h-BN under air atmosphere at low temperature. In this study, we report that h-BN flakes can be easily etched by oxidation at 350°C under air atmosphere in the presence of transition metal (TM) oxide. After selecting Co, Cu, and Zn elements as TM precursors, we simply oxidized h-BN sheets impregnated with the TM precursors at 350°C in air. As a result, microscopic analysis revealed that an etched structure was created on the surface of h-BN flakes regardless of catalyst type. And, X-ray diffraction patterns indicated that the air oxidation led to the formation of Co<SUB>3</SUB>O<SUB>4</SUB>, CuO, and ZnO from each precursor. Thermogravimetric analysis showed a gradual weight loss in the temperature range where the weight of h-BN flakes increased by air oxidation. As a result of etching, pore volume and pore area of h-BN flakes were increased after catalytic oxidation in all cases. In addition, the surface of h-BN flakes became highly active when the h-BN samples were etched by Co<SUB>3</SUB>O<SUB>4</SUB> and CuO catalysts. Based on these results, we report that h-BN flakes can be easily oxidized in the presence of a catalyst, resulting in an etched structure in the layered structure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hexagonal boron nitride flakes are etched at low temperature in air by catalysts. </LI> <LI> The presence of transition metal oxides produces an etched structure in the flakes. </LI> <LI> Etched surfaces become highly active due to vacancy defects formed in the flakes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Bora Kim ),( Hyun Jung Kim ),( Jin Eun Kim ),( Seung Hun Lee ) 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.5
Topical retinoids have been an important therapy used in the treatment of acne. However, retinoids often have adverse effects that range from mild to moderate local irritation. Retinyl retinoate is a member of a new generation of well-tolerated synthetic retinoids used as a topical retinoid treatment. To assess retinyl retinoate 0.05% for acne vulgaris therapy, fifteen female patients with mild to moderate facial acne prevalence were included in a double- blind, placebo-controlled, split-face trial for 8 weeks by investigators and measurement of sebum amount. In addition, retinyl retinoate was measured in anti-bacterial efficacy by an agar plate diffusion assay. Retinyl retinoate showed a significant decrease in both inflammatory and non-inflammatory lesions, and in sebum amount at 8 weeks (P < 0.05). The application of retinyl retinoate is effective and no local side effects for acne lesions. Retinyl retinoate had somewhat anti-bacterial activity against Propionibacterium acnes (P. acnes). These results indicate that retinyl retinoate can be used as treatment for mild acne or could potentiate the efficiency of an additive anti-acne agent. Retinyl retinoate is possible to be suggested as a topical anti-acne treatment with excellent tolerance.