Differential Diagnosis of Axillary Inflammatory and Metastatic Lymph Nodes in Rabbit Models by Using Diffusion-Weighted Imaging: Compared with Conventional Magnetic Resonance Imaging

Junping Wang,Qian Liao,Yunting Zhang,Chunshui Yu,Renju Bai,Haoran Sun 대한영상의학회 2012 Korean Journal of Radiology Vol.13 No.4

Objective: This experiment aims to determine the diagnostic value of diffusion-weighted imaging (DWI) in the differentiation of axillary inflammatory lymph nodes from metastatic lymph nodes in rabbit models in comparison with conventional magnetic resonance imaging (MRI). Materials and Methods: Conventional MRI and DWI were performed at 4 weeks after successful inoculation into the forty female New Zealand white rabbits’ mammary glands. The size-based and signal-intensity-based criteria and the relative apparent diffusion coefficient (rADC) value were compared between the axillary inflammatory lymph nodes and metastatic lymph nodes, with histopathological findings as the reference standard. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of the aforementioned criteria and rADC value in differentiating the axillary inflammatory lymph nodes from metastatic lymph nodes. Results: Thirty-two axillary inflammatory lymph nodes and 46 metastatic ones were successfully isolated and taken into pathological analysis. The differences of the aforementioned criteria between the two groups were not statistically significant (p > 0.05). However, the rADC value of the inflammatory lymph nodes (0.9 ± 0.14) was higher than that of metastatic ones (0.7 ± 0.18), with significant difference (p = 0.016). When the rADC value was chosen as 0.80, the area under the ROC curve is greater than all other criteria, and the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for differentiating two groups were 86.2%, 79.3%, 81.2%, 84.2%, and 85.6%, respectively. Conclusion: Diffusion-weighted imaging is a promising new technique for differentiating axillary inflammatory lymph nodes from metastatic lymph nodes. Compared with routine magnetic resonance sequences, DWI could provide more useful physiological and functional information for diagnosis. Objective: This experiment aims to determine the diagnostic value of diffusion-weighted imaging (DWI) in the differentiation of axillary inflammatory lymph nodes from metastatic lymph nodes in rabbit models in comparison with conventional magnetic resonance imaging (MRI). Materials and Methods: Conventional MRI and DWI were performed at 4 weeks after successful inoculation into the forty female New Zealand white rabbits’ mammary glands. The size-based and signal-intensity-based criteria and the relative apparent diffusion coefficient (rADC) value were compared between the axillary inflammatory lymph nodes and metastatic lymph nodes, with histopathological findings as the reference standard. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of the aforementioned criteria and rADC value in differentiating the axillary inflammatory lymph nodes from metastatic lymph nodes. Results: Thirty-two axillary inflammatory lymph nodes and 46 metastatic ones were successfully isolated and taken into pathological analysis. The differences of the aforementioned criteria between the two groups were not statistically significant (p > 0.05). However, the rADC value of the inflammatory lymph nodes (0.9 ± 0.14) was higher than that of metastatic ones (0.7 ± 0.18), with significant difference (p = 0.016). When the rADC value was chosen as 0.80, the area under the ROC curve is greater than all other criteria, and the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for differentiating two groups were 86.2%, 79.3%, 81.2%, 84.2%, and 85.6%, respectively. Conclusion: Diffusion-weighted imaging is a promising new technique for differentiating axillary inflammatory lymph nodes from metastatic lymph nodes. Compared with routine magnetic resonance sequences, DWI could provide more useful physiological and functional information for diagnosis.

Effect of kaolin additive on PM_2.5 reduction during pulverized coal combustion: Importance of sodium and its occurrence in coal

Si, Junping,Liu, Xiaowei,Xu, Minghou,Sheng, Lei,Zhou, Zijian,Wang, Chao,Zhang, Yang,Seo, Yong-Chil Elsevier 2014 APPLIED ENERGY Vol.114 No.-

<P><B>Abstract</B></P> <P>Little work has been performed on the importance of sodium and its occurrence in coal to PM<SUB>2.5</SUB> (particles less than 2.5μm in aerodynamic diameter) reduction by kaolin during O<SUB>2</SUB>/N<SUB>2</SUB> combustion and O<SUB>2</SUB>/CO<SUB>2</SUB> combustion at high temperatures. In this study, the combustion experiment of a treated low-sodium coal with sodium aluminosilicate additive was conducted in a lab-scale drop tube furnace (DTF) at 1500°C to reveal the contribution of mineral melting and coalescence to PM<SUB>2.5</SUB> reduction. Meanwhile, two typical Na-loaded coals (in which the sodium was loaded in the form of NaCl and sodium carboxylate, respectively) with kaolin added were also burnt under O<SUB>2</SUB>/N<SUB>2</SUB> and O<SUB>2</SUB>/CO<SUB>2</SUB> atmospheres to investigate the effect of interaction between kaolin and different chemical form sodium on PM<SUB>2.5</SUB> reduction. The results show that sodium aluminosilicate is able to promote the migration of PM<SUB>0.5–2.5</SUB> (particles in aerodynamic diameter of 0.5–2.5μm) to form coarse particles. Due to the stronger reactivity of sodium carboxylate reacting with kaolin than that of NaCl, PM<SUB>0.2–0.5</SUB> (particles in aerodynamic diameter of 0.2–0.5μm) decreases more significantly in the combustion when adding kaolin into the NaAc-loaded coal than into NaCl-loaded coal. In addition, the PM<SUB>0.2–0.5</SUB> reduction in O<SUB>2</SUB>/CO<SUB>2</SUB> combustion is lower than that in O<SUB>2</SUB>/N<SUB>2</SUB> combustion owing to the less vaporization of metals and the slower diffusion rate of vapors in the O<SUB>2</SUB>/CO<SUB>2</SUB> atmosphere in comparison to those in the O<SUB>2</SUB>/N<SUB>2</SUB> atmosphere. The mineral coalescence varied in interactions of kaolin with NaAc and NaCl. Besides, the PM<SUB>0.5–2.5</SUB> emission differed as a result of differences in coal characteristic and the atmosphere, and this would cause the difference of collision frequency between particles and additive. With the joint actions of mineral coalescence and particle collision, the NaAc-loaded coal has a higher PM<SUB>0.5–2.5</SUB> reduction by kaolin than NaCl-loaded coal, especially under the O<SUB>2</SUB>/N<SUB>2</SUB> combustion. An expression describing the relationship of PM<SUB>0.5–2.5</SUB> reduction, mineral coalescence and particle collision was fitted and it is found that the mineral coalescence has a stronger influence than particle collision on PM<SUB>0.5–2.5</SUB> reduction by kaolin.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The sodium aluminosilicate plays an important role in PM<SUB>2.5</SUB> reduction by kaolin. </LI> <LI> The capability of kaolin to reduce PM<SUB>2.5</SUB> depends on the sodium occurrence in coals. </LI> <LI> The effect of kaolin on PM<SUB>2.5</SUB> reduction becomes weaker during O<SUB>2</SUB>/CO<SUB>2</SUB> combustion. </LI> <LI> Particle collision may be taken into consideration for PM<SUB>2.5</SUB> reduction. </LI> </UL> </P>

Effects of Copper Oxide and Carbon Nanotubes on Thermal Stability of Silicone Rubber Nanocomposites

Qiang Zhang,Lu Bai,Junping Zheng 한국고분자학회 2016 폴리머 Vol.40 No.2

Silicone rubber (SR) filled with carbon nanotubes (CNTs), copper oxide (CuO) and CuO modified CNTs (CuO-CNTs) were prepared to detect the effects of these additives on thermal stability of SR by thermogravimetric analysis and tensile testing before and after aging. Flynn-Wall-Ozawa method was also employed to analyze the thermal degradation kinetics. The results indicated that all the additives could increase the initial thermal degradation temperature and thermal oxidative aging properties of SR and a synergistic effect was found in CuO-CNTs/SR. Meanwhile, activation energies of SR filled with additives increased significantly relative to neat SR and found to be optimal for CuO-CNTs/SR with activation energy increasing to 231.29, 121.68 kJ·mol-1 larger than that of blank sample. It is because that CNTs and CuO could promote each other to capture the free radicals generated by thermal oxidative reaction of the methyl side groups and thereby terminate the process.

A Unequalven Clustering Routing Protocol in Wireless Sensor Networks

Deyu Zhang,Le Jiao,Yanjun Chen,Junping Shao 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.9

Effect of Sheep and Chicken Antibodies to Rat Adipocytes Plasma Membranes on Rat Carcass Fat

Wang, Jundong,Zhang, Jianfeng,Li, Junping,Hao, Junhu,Wang, Shaolin,Zhang, Jianhai Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.8

Polyclonal anti-sera were collected from sheep and chicken immunized with adipocytes plasma membranes. Thirty two male wistar rats, weighing 185-215 grams, were divided randomly into 4 groups (trial 1: control group and treat group, trial 2: control group and treat group), with 8 rats in each group. The experiment lasted for 7 weeks. Trial one: The control group received four consecutive daily intraperitoneal injections of 1ml of sheep normal sera. The same 4 day daily dose of group sheep anti-rats sera adipocyte plasma membrane anti-sera was administered to the treat group. The results showed that the treatment for treat group increased body weight by 6.35% (p<0.05) and food intake by 6.85%, and improved food conversion efficiency (Food intake/gain) by 45.00% (p<0.05). Periernal, epididymal and omental adipose deposit weights were decreased by 23.92% (p<0.05), 34.45% (p<0.05) and 0.98% respectively, while total fat content decreased by 20.92%. Trial two: The control group received four consecutive daily intraperitoneal injections of 1 ml of chicken normal sera, the results of injections of chicken anti-rats sera adipocyte plasma membrane antis-era administered to the treat group indicated that chicken anti-rats adipocyte plasma membranes immunization had an disadvantageous effect on the growth of the wistar rats by the end of 7th wk, compared with the control group. The immunized group decreased in total weight by 40 gram (p<0.05) an averagely and in food intake noticeably (p<0.01). The deposition of fat and the rates of TG and FFA in serum had no statistical significance.

A Pipelined-Based Multi-Thread Acceleration Method for Remote Sensing Image Progressive Transmission

Haicheng Qu,Junping Zhang,Yu Meng 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.9

In order to meet the different data browsing requests for different users to the visual quality of remote sensing images in heterogeneous network especially under narrow bandwidth environments, an online remote sensing image progressive transmission model is constructed in which remote sensing image compression and decompression are synchronized with transmission. At the same time, a pipeline-based multi-threaded acceleration method has been proposed through solving the asynchronous problem between compression decompression and transmission to improve the efficiency of remote sensing progressive transmission. At last, an idea of retry broken downloads transmission interruption has been implemented to improve end-user interactive experience. Experimental results show that the whole processing speed has been improved nearly twice without reducing image transmission quality and the amount of data transmission was reduced evidently by using the proposed progressive transmission and real-time compression model.

Modeling and Input-Output Decoupling of Hypersonic Vehicles

Xiaofeng Su,Yingmin Jia,Junping Du,Jun Zhang 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.1

This paper studies the problems of modeling and input-output decoupling of generic hyper-sonic vehicles. Dynamical equations of hypersonic vehicles are derived using Lagrangian approach, which capture the dominating characteristics and primary interactions. Then, based on the simplified model, the original decoupling problem is reformulated as an asymptotical stability problem of the cor-responding error system. The popular dynamic inversion is employed to design the decoupling controller, which can achieve steady-state decoupling. However, external disturbance will greatly destroy the effect of decoupling before the system reaches steady state. To this end, based on the error system, ro-bust H∞ theorem can be easily used to address this issue by reducing the impact of disturbance on error system outputs, which ultimately results in approximate decoupling. Moreover, the degree of approximate decoupling can be enhanced by choosing a small performance index γ. Simulations verify the effectiveness of proposed controllers.

Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy

Jingui Hu,Ling Zhang,Fei Fu,Qiong Lai,Lu Zhang,Tao Liu,Boyang Yu,Junping Kou,Fang Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2

Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase a (AMPKa), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKa phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.

Online Adaptive Optimal Tracking Control of Nonholonomic Mobile Robot

Kai Wang,Yingmin Jia,Junping Du,Jun Zhang 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10

A velocity control law is developed for the kinematic steering system of nonholonomic mobile robot to track a reference trajectory not only to make the posture error asymptotically stable but also considered optimality based on a pre-defined cost function. In order to make the cost function finite, we transformed the tracking problem into a regulation problem by redefining system states and inputs. The proposed online and forward-in-time policy iteration (PI) algorithm based on approximate dynamic programming (ADP) to solve the continuous-time(CT) optimal control problem with infinite horizon cost by solving of Hamilton-Jacobi-Bellman (HJB) equation. This method learns online in real-time to approximate the cost function by using a single neural networks (NNs), and then the near optimal control policy can be computed directly according to the cost function, which removes the action network appearing in the ordinary ADP methods. Simulation results are provided to demonstrate the effectiveness of the proposed approach.

Experimental and finite element studies of special-shape arch bridge for self-balance

Lu, Pengzhen,Zhao, Renda,Zhang, Junping Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.35 No.1

Special-shape arch bridge for self-balance (SBSSAB) in Zhongshan City is a kind of new fashioned spatial combined arch bridge composed of inclined steel arch ribs, curved steel box girder and inclined suspenders, and the mechanical behavior of the SBSSAB is particularly complicated. The SBSSAB is aesthetic in appearance, and design of the SBSSAB is artful and particular. In order to roundly investigate the mechanical behavior of the SBSSAB, 3-D finite element models for spatial member and shell were established to analyze the mechanical properties of the SBSSAB using ANSYS. Finite element analyses were conducted under several main loading cases, moreover deformation and strain values for control section of the SBSSAB under several main loading cases were proposed. To ensure the safety and rationality for optimal design of the SBSSAB and also to verify the reliability of its design and calculation theories, the 1/10 scale model tests were carried out. The measured results include the load checking calculation, lane loading and crowd load, and dead load. A good agreement is achieved between the experimental and analytical results. Both experimental and analytical results have shown that the SBSSAB is in the elastic state under the planned test loads, which indicates that the SBSSAB has an adequate load-capacity. The calibrated finite-element model that reflects the as-built conditions can be used as a baseline for health monitoring and future maintenance of the SBSSAB.