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Naeem, Muhammad,Bae, Junhwan,Oshi, Murtada A,Kim, Min-Soo,Moon, Hyung Ryong,Lee, Bok Luel,Im, Eunok,Jung, Yunjin,Yoo, Jin-Wook Dove Medical Press 2018 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.13 No.-
<P><B>Background</B></P><P>Colon-targeted oral nanoparticles (NPs) have emerged as an ideal, safe, and effective therapy for ulcerative colitis (UC) owing to their ability to selectively accumulate in inflamed colonic mucosa. Cyclosporine A (CSA), an immunosuppressive agent, has long been used as rescue therapy in severe steroid-refractory UC. In this study, we developed CSA-loaded dual-functional polymeric NPs composed of Eudragit<SUP>®</SUP> FS30D as a pH-sensitive polymer for targeted delivery to the inflamed colon, and poly(lactic-co-glycolic acid) (PLGA) as a sustained-release polymer.</P><P><B>Methods</B></P><P>CSA-loaded Eudragit FS30D nanoparticles (ENPs), PLGA nanoparticles (PNPs), and Eudragit FS30D/PLGA nanoparticles (E/PNPs) were prepared using the oil-in-water emulsion method. Scanning electron microscope images and zeta size data showed successful preparation of CSA-loaded NPs.</P><P><B>Results</B></P><P>PNPs exhibited a burst drug release of >60% at pH 1.2 (stomach pH) in 0.5 h, which can lead to unwanted systemic absorption and side effects. ENPs effectively inhibited the burst drug release at pH 1.2 and 6.8 (proximal small intestine pH); however, nearly 100% of the CSA in ENPs was released rapidly at pH 7.4 (ileum–colon pH) owing to complete NP dissolution. In contrast to single-functional PNPs and ENPs, the dual-functional E/PNPs minimized burst drug release (only 18%) at pH 1.2 and 6.8, and generated a sustained release at pH 7.4 thereafter. Importantly, in distribution studies in the gastrointestinal tracts of mice, E/PNPs significantly improved CSA distribution to the colon compared with PNPs or ENPs. In a mouse model of colitis, E/PNP treatment improved weight loss and colon length, and decreased rectal bleeding, spleen weight, histological scoring, myeloperoxidase activity, macrophage infiltration, and expression of proinflammatory cytokines compared with PNPs or ENPs.</P><P><B>Conclusion</B></P><P>Overall, this work confirms the benefits of CSA-loaded E/PNPs for efficiently delivering CSA to the colon, suggesting their potential for UC therapy.</P>
공항산업 동향분석을 위한 텍스트 애널리틱스 모델에 관한 연구
남승주(Seungju Nam),최솔샘(Solsaem Choi),김준환(Junhwan Kim),김진기(Jin Ki Kim) 한국경영과학회 2020 經營 科學 Vol.37 No.1
Analyzing current trends and identifying future prospects is one of the important tasks to establish a successful strategy for airport development. In this study, we use latent Dirichlet allocation (LDA), a typical topic modeling technique, to supplement the traditional qualitative methodologies and find a major trend of airport industry. Specifically, we deduct major topic from three different data sources related to airport (academic article, policy study report and news article) and compare each topic to find out the differences of each topic. In addition, we investigate the changing trend in each data source through longitudinal analysis. Our results show that three data sources have distinguishing trends which reflect their own characteristics. We find that most of data usually focus on the future situation for sustainable development rather than concentrating on the current issues. This study suggests a methodology using large amounts of text data to explore future promising trend from sperate data sources and provide insights for stakeholders of airport industry. The analyzing methodology we proposed has also significant meaning in that it can be applied comprehensively for trend analysis of other industry including tourism and hospitality as well as airport industry.
Seung Jun Han,Dong-Ho Shin,Nak-Hyun Kim,Eun Sun Kim,Junhwan Kim,Hye Won Kim,Sung do Moon,Sang Wook Park,Jung Hun Ohn,Chang-Yun Woo,Ki Byung Lee,Jae Hyun Lee,Han Sung Lee,Yejee Lim,Seungha Hwang 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.3
Background/Aims: Although a management fee for hospitalist service was established in Korea, the number of hospitalists required for the system to run remains outmatched. Methods: In January 2020 and February 2022, before and after the establishment of the hospitalist fee system respectively, cross-sectional online surveys were conducted among internal medicine board-certified hospitalists. Results: There were 59 and 64 respondents in the 2020 and 2022 surveys, respectively. The percentage of respondents who cited financial benefits as a motive for becoming a hospitalist was higher in the 2022 survey than in the 2020 survey (34.4% vs. 10.2%; p = 0.001). The annual salary of respondents was also higher in the 2022 survey than in the 2020 survey (mean, 182.9 vs. 163.0 million in South Korean Won; p = 0.006). A total of 81.3% of the respondents were willing to continue a hospitalist career in the 2022 survey. In multivariate regression analysis, the possibility of being appointed as a professor was found to be an independent predictive factor of continuing a hospitalist career (odds ratio, 4.00; 95% confidence interval, 1.09–14.75; p = 0.037). Conclusions: Since the establishment of the hospitalist fee system, monetary compensation has improved for hospitalists. The possibility of being appointed as a professor could predict long-term work as hospitalists.