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에너지 안보관점에서 본 동북아 석유수송로의 지정학적 분석
이준범(Joon bum Yi),장지호(JI HO JANG) 21세기정치학회 2005 21세기 정치학회보 Vol.15 No.2
When the oil economy of Northeast Asia begins to expose itself to the substantial influence of globalization which have concurrently been taking place since 1980, the importance of Malace's lane has been grown. With the help of steady economic growth, oil, an essential energy source for the region, is very likely to continue as the primary energy for the region's sustainable development. However, since there is possibility of disorder in Malace's lane, it is very probable that the structure of oil supply in the region may get worse rather than better. Among possible problems such as terror, pirates, accident, and military trouble, terror and accident can be serious obstacle of petroleum transportation. In order to lowering overdependence on this area, thus, an intensity of cooperation is needed in such areas as oil products trade, oil development business, governments, and participation in regional cooperation institutions.
홍삼유출액으로부터 분리한 조사포닌이 TCDD (2,3,7,8-Tetrachlorodibenzo-ρ-dioxin)로 급성독성을 유도한 흰쥐의 혈액 생화학지수에 미치는 영향
곽이성(Yi-Seong Kwak),경종수(Jong-Soo Kyung),송용범(Young-Bum Song),위재준(Jae-Joon Wee),박종대(Jong-Dae Park) 고려인삼학회 2006 Journal of Ginseng Research Vol.30 No.1
본 연구는 랫드에서 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD)로 유도된 급성독성에 대한 홍삼유출액으로부터 분리한 조사포닌의 방어효과를 조사하기 위해 수행되었다. 40 마리의 웅성 랫드를 4 군으로 나누어 정상군에 대해서는 TCDD의 운반체를, TCDD 단독투여군 (TT)에게는 TCDD (5 ㎛/㎖)와 생리식염수를 1 회 복강주사하였다. 한편, 조사포닌 투여군 (RGE-CS20, RGE-CS40)은 조사포닌을 각각 20 및 40 ㎎/㎏,b.w./day의 용량으로 TCDD 투여 1 주 전부터 총 4 주간 복강주사하였다. TCDD 단독투여군의 체중은 TCDD 투여 1 주째부터 유의하게 감소한 반면, 조사포닌 투여군은 TCDD 단독투여군에 비해 완만하기는 하지만 유의하게 증가하여 체중감소가 억제되었다. 조사포닌 투여군은 TCDD 독성에 의해 증가한 TG, TC, LDL, AST, ALT, Fe²? 함량은 감소시켰고, TCDD 독성에 의해 감소된 glucose, amylase, LDH, CK 활성을 증가시켜 혈액 임상화학지수를 유의하게 개선시키는 것으로 나타났다. 이상의 결과로부터 홍삼유출액으로부터 분리한 조사포닌은 TCDD에 의해 유도된 체중감소와 장기 기능저하에 대해서 현저한 방어효과를 나타낸다는 사실을 알 수 있었다.
홍삼산성다당체 (RGAP)의 경구투여에 의한 항종양 효과
곽이성(Yi-Seong Kwak),신한재(Han-Jae Shin),송용범(Yong-Bum Song),경종수(Jong-Soo Kyung),위재준(Jae-Joon Wee),박종대(Jong-Dae Park) 고려인삼학회 2005 Journal of Ginseng Research Vol.29 No.4
Our previous reports demonstrated that i.p. administration of Korean red ginseng acidic polysaccharide (RGAP) exerts antitumor activity in mice. The present study was carried out to compare the effects of i.p. and p.o. routes of administration of RGAP on either normal or tumor-bearing BALB/c mice. RGAP was administered either i.p. or p.o. at doses of 100, 300, 500, 1000 ㎎/㎏ for 1 or 5 weeks. Peritoneal macrophages from mice treated with RGAP p.o. at a dose of 300 ㎎/㎏either for 1 or 5 weeks did not exhibit growth inhibition activity toward WEHI-164 tumor cells. However, administration of RGAP at a dose of 600 ㎎/㎏ for both 1 and 5 weeks increased the antitumor activity of macrophages. Oral administration of RGAP (600 ㎎/㎏) for 5 weeks and i.p. administration of RGAP (300 ㎎/㎏) for 1 week resulted in antitumor activities of 40% and 45%, respectively, indicating that the effect of i.p. injection is more potent 2 and 5 times than that of p.o. one in terms of dose and duration, respectively. Tumor inhibition rates of RGAP at doses of 300, 500, 1000 ㎎/㎏ in mice transplanted with B16-F10 melanoma were 4.4, 12.0, and 45.4%, respectively, meaning that p.o. dose higher than 500 ㎎/㎏ possess marked antitumor activity. The results above suggests that p.o. administration of RGAP also show antitumor activity in vivo depending on the dose.
TCDD (2,3,7,8-tetrachlorodibenzodioxin)로 급성독성을 유도한 자성 기니픽의 대퇴골 무게감소에 대한 홍삼사포닌의 방어효과
곽이성(Yi-Seong Kwak),경종수(Jong-Soo Kyung),송용범(Yong-Bum Song),위재준(Jae-Joon Wee),박종대(Jong-Dae Park),김시관(Si-Kwan Kim),황미선(Mi-Sun Hwang),김석창(Seok-Chang Kim),박채규(Chae-Kyu Park),도재호(Jae-Ho Do) 고려인삼학회 2006 Journal of Ginseng Research Vol.30 No.3
본 연구는 TCDD로 급성독성을 유도한 자성 기니픽의 대퇴골 무게감소에 대한 홍삼사포닌의 효과를 조사하기 위해 수행하였다. 48 마리의 자성기니픽 (820±25 g)을 6 군으로 나누어 정상군 (NC), TCDD 단독투여군 (TT), 사포닌 전투여군 (PE10, 20), 사포닌후투여군 (CE10, 20)으로 나누었다. NC군은 vehicle과 saline 만을 투여하였고, TT군은 TCDD를 단회투여 (5.0 ㎍/㎏, i.p) 하였다. PE10 및 20군은 TCDD 투여 1 주일 전부터 총 3 주동안 사포닌을 투여 (복강) 하였다. 반면 CE10 및 20군은 TCDD 투여한 직후부터 총 3 주동안 사포닌을 투여 (복강) 하였다. 사포닌 투여군의 체중변화를 살펴보면 TT군은 TCDD 투여후 유의적인 체중감소 현상이 관찰되었으나 PE10, 20 및 CE10, 20 등 사포닌 투여군에서는 TT군에 비해 체중이 모두 증가하는 경향을 보였다. TCDD 투여는 자성기니픽의 대퇴골 무게를 유의적으로 감소시키는 반면 홍삼사포닌의 투여는 대퇴골 무게감소를 억제하는 경향을 보였다. 대퇴골 무게감소 억제현상은 PE20군에서 가장 높게 나타났다. 대퇴골의 Ca²? 도 TT군은 NC군 대비 약 20.4% 감소하는데 반해 사포닌 투여군은 TT군 대비 Ca²? 함량이 증가되는 경향을 나타내었다. 이러한 결과로부터 홍삼사포닌은 TCDD에 의해 억제된 기니픽의 대퇴골내 Ca²? 함량을 증가시킴으로써 대퇴골의 무게감소를 회복시키는 것으로 추론할 수 있겠다. To investigate the protective effect of saponin from red ginseng extract, 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) was exposed to female guinea pigs and then femur weights was measured. Forty eight female guinea pigs (820±25 g) were divided into 6 groups. Normal control group (NC) received vehicle and saline; only TCDD-treated group (TT) received TCDD (5.0 ㎍/㎏, single dose) intraperitoneally; pretreated group of saponin 10 (PE 10) received 10 ㎎/㎏ of saponin i.p. for 4 weeks from 1 week before TCDD-exposure; pretreated group of saponin 20 (PE 20) also received 20 ㎎/㎏ of saponin i.p. for 4 weeks from 1 week before TCDD-exposure. While, post-treated group of saponin 10 (CE 10) received 10 ㎎/㎏ of saponin i.p for 3 weeks after TCDD-exposure. Post-treated group of saponin 20 (CE 20) received 20 ㎎/㎏ saponin i.p for 3 weeks after TCDD-exposure. Body weight of TT group was significantly decreased after TCDD-exposure. However, body weight in all saponin-treated gropus increased throughout the experimental period, although the increasing rate was slower than that of NC group. Body weights of PE 10 and 20 groups showed more higher increase than those of CE groups during the experimental period. Decrease of femur weights in female guinea pigs by TCDD intoxification was significantly recovered by the saponin treatment. Decrease of Ca²? level of femurs in female guinea pigs exposed TCDD also recovered by the treatment of saponin from red ginseng extract. Especially, PE20 group showed the highest increase of the Ca²? level in femur among the saponin treated groups. These results suggest that ginseng saponin might be a useful protective agent against femur damage caused to decrease of Ca²? by TCDD.
Kim, Joon-Seok,Kim, Sung-Bum,Yi, Hyeong-Joong,Chung, Won-Sang The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.37 No.2
Most primary spinal abscesses, irrespective of pathogens and anatomical locations, have better prognosis than that of secondary abscesses with spondylitis. We report a 68-year-old man, previously undertaken pulmonary resection due to tuberculosis, presented with paraparesis. Imaging studies showed primary intraspinal abscesses at T-1 and T-3 vertebral levels, semi-invasive pulmonary Aspergillosis and inflammation of the posterior mediastinum. Operative procedure and histopathological examination revealed interdural Aspergillus abscess. Despite chemotherapy, he deteriorated progressively, and spondylitis developed at corresponding vertebrae. He eventually died 6 weeks postoperatively due to pulmonary complication. The authors intended to inform that such an extradural inflammatory lesion of Aspergillus abscess should be treated carefully.
Jae Joon Wee,Jong Soo Kyung,Na Mi Kim,Yong-Bum Song,Yi-Seong Kwak,Jong Dae Park 한국생약학회 2005 Natural Product Sciences Vol.11 No.4
Anti-amnestic activities of Korean red ginseng (Ginseng Radix Rubra) and crude drug-combined preparations (RGCDP-1, RGCDP-2, and RGCDP-3) were evaluated by the animal experiment. RGCDP-1 and RGCDP-2 were prepared based on Korean folk prescriptions, “Chongmyongtang” and Guibitang”, respectively,while RGCDP-3, by a combination of both. Among the three preparations, RGCDP-3 was found to show the most potent anti-amnestic activity as evaluated by the passive avoidance test with mice, indicating synergistic action by combined effects of RGCDP-1 and RGCDP-2.