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유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력
진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-
Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.
김일규,박형준,최진호,장금수,김왕식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1
Hemangiomas are benign tumors in blood vessels that occur by traumatic or congenital origin. Lesions are appeared early in life, with 73% present at birth and 85% developing by the end of the first year. Head & neck hamangiomas represent about 25%∼33% of all hemangiomas. Kaban & Mulliken divided vascular birthmarks into two major categories : hemangioma and vascular malformation. Case 1 was diagnosed as cavernous hemangioma and the mass was excised completely and defected space was reconstructed with fat tissue. Case 2 was diagnosed definitely as traumatic A-V malformation by post-op histopathological examination and the mass was excised completely. This report describes two cases that were successfully treated by complete surgical excision for hemangioma in maxillofacial region.
Jun Wang,Li Jiang,Sheng Ding,Si-Yi He,Shun-Bi Liu,Zhong-Jie Lu,Yuan-Zhang Liu,Li-Wen Hou,Bin-Su Wang,Jin-Bao Zhang 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.4
Purpose: We aimed to analyze the optimal timing of enteral nutrition (EN) in the treatment of sepsis and its effect on sepsis-asso ciated acute kidney injury (SA-AKI.)Materials and Methods: The MIMIC-III database was employed to identify patients with sepsis who had received EN. With AKI as the primary outcome variable, receiver operating characteristic (ROC) curves were utilized to calculate the optimal cut-off time of early EN (EEN). Propensity score matching (PSM) was employed to control confounding effects. Logistic regressions and propen sity score-based inverse probability of treatment weighting were utilized to assess the robustness of our findings. Comparisons within the EEN group were performed. Results: 2364 patients were included in our study. With 53 hours after intensive care units (ICU) admission as the cut-off time of EEN according to the ROC curve, 1212 patients were assigned to the EEN group and the other 1152 to the delayed EN group. The risk of SA-AKI was reduced in the EEN group (odds ratio 0.319, 95% confidence interval 0.245–0.413, p<0.001). The EEN patients re ceived fewer volumes (mL) of intravenous fluid (IVF) during their ICU stay (3750 mL vs. 5513.23 mL, p<0.001). The mediating ef fect of IVF was significant (p<0.001 for the average causal mediation effect). No significant differences were found within the EEN group (0–48 hours vs. 48–53 hours), except that patients initiating EN within 48 hours spent fewer days in ICU and hospital. Conclusion: EEN is associated with decreased risk of SA-AKI, and this beneficial effect may be proportionally mediated by IVF volume.
The Synthetic Approaches to Modify Methyl (Pyro)pheophorbide a
Wang, Jin-Jun,Han, Guang-Fan,Lee, Jong-Cheol,Shim, Young-Key Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Pyropheophorbide and pheophorbide-photosensitizers as chlorin analogues are promising new compounds for PDT because the chlorin analogues are activated with much longer red light at > 670nm and produce less long-term normal tissue phototoxicity than Photofrin. The various chlorin derivatives can be obtained by moditying peripheral substituted group among which meso-H, vinyl group and exocyclic ring are the most active positions. These characteristics prompted us to introduce various groups for constructing modified pyropheophorbide and pheophorbide a compounds. A stereospecific introduction of various double bonds at 3-position was performed to methylpheophorbide a to give a long hydrophobic moiety and cyclic derivatives. Chlorin-C$_{60}$ dyad and chlorin- $C_{60}$-porphyrin triad also were easily prepared by the reaction of terminal aldehyde of methyl pyropheophorbide a. For the reaction on meso $\delta$-position bromination and Vismeier formylation can occur. N,N-dimethylaminoacrolein also reacted on $\delta$-position and was cyclized to isobacteriochlorin, but other modification has not been succeeded. Exocyclic keto function was also modified to give purpurin derivatives, bicyclic and spiro compounds. In this presentation we report a series of modified pyropheophorbide and pheophorbide a derivatives.s.
Wang, Jin-Jun,Han, Guang-Fan,Shim, Young-Key Korean Society of Photoscience 2001 Journal of Photosciences Vol.8 No.1
The methyl pheophorbide-a (MP-a) and methyl pyropheophorbide-a (MPP-a) were modified by reaction of exocyclic ketone in E-ring with nucleophilic reagent and several chlorin derivatives were synthesized. The change of the structure in E-ring served an expanding conjugation region and introduction of electron-withdrawing group, which strongly influenced the visible spectra. The Qy bands of synthesized compounds were affected by the substituents on the Qy axis(N$\sub$21/-N$\sub$23/).
Wang, Xiao,Fan, Jin-Chuan,Wang, An-Rong,Leng, Yue,Li, Jun,Bao, Yu,Wang, Ying,Yang, Qing-Feng,Ren, Yu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Background and Objectives: Yanting in Sichuan Province is one of the highest risk areas of esophageal cancer (EC) in the world. We here summarize the epidemiology of EC in Yanting using data from the national screening programme during 2006-2011. Methods: Random cluster sampling was used to select a proportion of natural villages from six towns in Yanting, and residents aged 40-69 years old were invited for screening. Participants were screened using endoscopy with iodine staining and then confirmed by histological examinations. Results: The overall detection rates of low-grade hyperplasia (LH), moderate hyperplasia (MH), high-grade hyperplasia (HH), carcinoma in situ (CIS), intramucosal carcinoma (IC) and invasive carcinoma (INC) were 5.33%, 1.28%, 0.68%, 0.15%, 0.06% and 0.29%, respectively. The detection rates of LH, MH, HH and INC increased with age, reaching the peak among those aged 60-65 years, and the prevalences of LH and MH were higher among men than among women. In addition, the detection rates of hyperplasia were much higher in mountainous than in hilly areas. Conclusions: Among the high risk population, there are a great number of people with early-stage EC or precancerous conditions who do not have presenting symptoms. In particular, the elderly, men, or those living in mountainous areas are the most vulnerable population. It is therefore important to reinforce health education and screening services among such high risk populations.
( Wang Yong Choi ),( Woo Jin Chung ),( Si Hyun Bae ),( Do Seon Song ),( Myeong Jun Song ),( Young Seok Kim ),( Hyung Joon Yim ),( Young Kul Jung ),( Sang Jun Suh ),( Jun Yong Park ),( Do Young Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The treatment responses of advanced hepatocellular carcinoma( HCC) with portal vein tumor thrombosis(PVTT) were not acceptable and treatment modalities were limited. So, we compared effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy( HAIC). Methods: We prospectively collected data of 58 advanced HCC with PVTT patients whose Child-Turcotte-Pugh(CTP) score range 5 to 7 in 6 university hospitals from January 2013 to Oct 2015. Each twenty nine patients were treated with sorafenib or HAIC. Results: 1. The mean age was 60.2±8.4 years old and 89.7% of the patients were male. Causes of HCC were HBV (67.3%), HCV (8.6%), alcohol (19.0%) and others (5.2%). CTP class A was 89.7%, modified Union for International Cancer Control (mUICC) stage IVa was 63.8%, tumor diameter >10cm was 55.2%, multiple tumor was 60.3%, infiltrative type was 56.9%, main PVTT was 63.8%, median AFP value was 240.4 ng/ml. 2. 29 patients were enrolled to each groups. Baseline characteristics( sex, mean age, cause of HCC, mUICC stage, size of tumor, number of tumor, type of tumor(nodular, massive, infiltrative, diffuse), location of PVTT(main, main+branch, branch). CTP class, median value of AFP) has no significant difference between two groups. 3. The objective response rate was 38.1% in HAIC and 4.5% in sorafenib group (p=0.003). In univariate analysis, treatment modality, main portal vein invasion, objective response, massive tumor type were significant prognostic factors of overall survival (p=0.012, 0.046, 0.011, 0.041) and treatment modality, tumor number, massive tumor type were significant prognostic factors of time to progress (p=0.004, 0.043, <0.01). In multivariate analysis, objective response was a significant prognostic factor of overall survival (p=0.048) and treatment modality was a significant prognostic factor of time to progress (p=0.016). 4. Major complications were neutropenia (6.9%, more than grade 3) and catheter-related complication (3.4%) in HAIC group, hand-foot syndrome (20.7%) and diarrhea (3.4%) in sorafenib group. Conclusions: For treatment of advanced HCC with PVTT patient, HAIC can be a valuable treatment modality like as sorafenib and more large size of study is needed.