Activated Protein C Protects Myocardium Via Activation of Anti-apoptotic Pathways of Survival in Ischemia-reperfused Rat Heart

Jia-Wang Ding,Xiao-Hong Tong,Jun Yang,Zhao-Qi Liu,Yan Zhang,Jian Yang,Song Li,Li Li 대한의학회 2010 Journal of Korean medical science Vol.25 No.11

Activated protein C (APC) is known to be beneficial on ischemia reperfusion injury in myocardium. However, the protection mechanism of APC is not fully understood. The purpose of this study was to investigate the effects and possible mechanisms of APC on myocardial ischemic damage. Artificially ventilated anaesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 hr of reperfusion. Rats were randomly divided into four groups; Sham, I/R, APC preconditioning and postconditioning group. Myocardial infarct size, apoptosis index, the phosphorylation of ERK1/2, Bcl-2, Bax and cytochrome c genes and proteins were assessed. In APC-administrated rat hearts, regardless of the timing of administration, infarct size was consistently reduced compared to ischemia/reperfusion (I/R) rats. APC improved the expression of ERK1/2 and anti-apoptotic protein Bcl-2 which were significantly reduced in the I/R rats. APC reduced the expression of pro-apoptotic genes, Bax and cytochrome c. These findings suggest that APC produces cardioprotective effect by preserving the expression of proteins and genes involved in anti-apoptotic pathways, regardless of the timing of administration.

Research on Preparation of Sheath-Core Bicomponent Composite Ion Exchange Fibers and Absorption Properties to Metal Ion

Ding, Zhi-Jia,Qi, Lu,Ye, Jian-Zhong The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.1

Based on the sheath-core bicomponent composite fibers with modified polystyrene (PS) and the modified polypropylene (PP), composite fibers obtained were further cross-linked and sulphonated with chlorosulphonic acid to produce strong acidic cation ion exchange fibers. The structures of the fibers obtained were characterized using Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC) etc. The optimal technology of the fibers obtained is discussed. The static absorption capacity of the sheath-core bicomponent composite cation exchange fibers for $Zn^{2+}$, $Cu^{2+}$ was determined. The absorption kinetics and major factors affecting the absorption capacities of $Zn^{2+}$, $Cu^{2+}$ were studied, and its chemical stability and regenerating properties were probed. The results suggest that cation exchange fibers with better mechanical properties and higher exchange capability were obtained. Moreover, this type of ion exchange fiber has good absorption properties and working stability to various metal ions. Hence, they have higher practicability.

A Retrospective Study of the Effect of Spinopelvic Parameters on Fatty Infiltration in Paraspinal Muscles in Patients With Lumbar Spondylolisthesis

Jia-Chen Yang,Jia-Yu Chen,Yin Ding,Yong-Jie Yin,Zhi-Ping Huang,Xiu-Hua Wu,Zu-Cheng Huang,Yi-Kai Li,Qing-An Zhu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

Objective: The effect on fat infiltration (FI) of paraspinal muscles in degenerative lumbar spinal diseases has been demonstrated except for spinopelvic parameters. The present study is to identify the effect of spinopelvic parameters on FI of paraspinal muscle (PSM) and psoas major muscle (PMM) in patients with degenerative lumbar spondylolisthesis. Methods: A single-center, retrospective cross-sectional study of 160 patients with degenerative lumbar spondylolisthesis (DLS) and lumbar stenosis (LSS) who had lateral full-spine x-ray and lumbar spine magnetic resonance imaging was conducted. PSM and PMM FIs were defined as the ratio of fat to its muscle cross-sectional area. The FIs were compared among patients with different pelvic tilt (PT) and pelvic incidence (PI), respectively. Results: The PSM FI correlated significantly with pelvic parameters in DLS patients, but not in LSS patients. The PSM FI in pelvic retroversion (PT > 25°) was 0.54 ± 0.13, which was significantly higher in DLS patients than in normal pelvis (0.41 ± 0.14) and pelvic anteversion (PT < 5°) (0.34 ± 0.12). The PSM FI of DLS patients with large PI ( > 60°) was 0.50 ± 0.13, which was higher than those with small ( < 45°) and normal PI (0.37 ± 0.11 and 0.36 ± 0.13). However, the PSM FI of LSS patients didn’t change significantly with PT or PI. Moreover, the PMM FI was about 0.10–0.15, which was significantly lower than the PSM FI, and changed with PT and PI in a similar way of PSM FI with much less in magnitude. Conclusion: FI of the PSMs increased with greater pelvic retroversion or larger pelvic incidence in DLS patients, but not in LSS patients.

Research on Preparation of Sheath-Core Bicomponent Composite Ion Exchange Fibers and Absorption Properties to Metal Ion

Zhi Jia Ding,Lu Qi,Jian Zhong Ye 한국고분자학회 2008 Macromolecular Research Vol.16 No.1

Associations of TNF-RII rs1061622 With Post-Traumatic Stress Disorder and Their Interplays on Serum Lipids Levels in Adolescents

Ji Cheng Zhang,Jin Hua Wang,Jun Yi Liu,Qi Wei Guo,Jia Lin,Yi Lin Shen,Ke Xin Jia,Jia Jing Cai,Guo Ming Su,Ding Zhi Fang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.11

Objective To verify effects of rs1061622 at tumor necrosis factor-α receptor II (TNF-RII) gene (<i>TNF-RII</i>) on post-traumatic stress disorder (PTSD) and its interactive effects with PTSD on serum lipids levels in adolescents.Methods PTSD was measured by PTSD Checklist-Civilian Version (PCL-C) in 699 adolescent survivors at 6 months after Wenchuan earthquake in China. A polymerase chain reaction and restriction fragment length polymorphism assay were utilized for <i>TNF-RII</i> rs1061622 genotyping followed by verification using DNA sequencing. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were tested using routine methods.Results G (deoxyguanine) allele carriers had higher PCL-C scores than TT (deoxythymidine) homozygotes in female subjects. Female adolescents had higher PCL-C scores than male subjects in TT homozygotes. Predictors of PTSD prevalence and severity were different between G allele carriers and TT homozygotes. Subjects with PTSD had lower TG, TG/HDL-C, TC/HDL-C, and higher HDL-C than adolescents without PTSD in male G allele carriers. G allele carriers had higher TG/HDL-C and TC/HDL-C than TT homozygotes in male adolescents without PTSD, and lower TG and TG/HDL-C in male PTSD patients. G allele carriers had higher TG than TT homozygotes only in female adolescents without PTSD.Conclusion These results suggest reciprocal actions of <i>TNF-RII</i> rs1061622 with other factors on PTSD severity, interplays of <i>TNF-RII</i> rs1061622 with PTSD on serum lipid levels, and novel treatment strategies for PTSD and comorbidities of PTSD with hyperlipidemia among adolescents with different genetic backgrounds of <i>TNF-RII</i> rs1061622 after experiencing traumatic events.

Composition modulation of Cu/Cu2O/CuO nanoparticles supported on carbon for p-nitrophenol reduction

Jia Li,Wei Liu,Yongxin Ding,Likui Liu,Fang Li,Qiming Li 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.6

Porous carbon supported Cu/Cu2O/CuO ternary catalysts were fabricated by pyrolysis, in which composition modulation of Cu/Cu2O/CuO was successfully realized by adjusting annealing atmosphere. The correlation between annealing atmosphere and composition of Cu/Cu2O/CuO ternary nanoparticles was deeply investigated. XRD and SEM measurement shows that the composition proportion of Cu/Cu2O/CuO can be effectively controlled by adjusting the annealing atmosphere. HR-TEM and EDS analysis showed that Cu/Cu2O/CuO ternary nanoparticles are highly dispersed into the carbon matrix and harvest more hetero-junction active sites. The effect of Cu/Cu2O/CuO composition on their catalytic activity was investigated in catalytic reduction from p-nitrophenol to p-aminophenol. The experimental result indicated that the catalytic activity of Cu/Cu2O/CuO ternary catalysts exhibits higher catalytic activity than Cu2O/CuO or CuO particles. This work provides a new strategy for synthesizing and modulating porous carbon-supported Cu/Cu2O/CuO ternary nanoparticles.

Application of contrast-enhanced ultrasound for evaluation of thyroid nodules

Jia Zhan,Hong Ding 대한초음파의학회 2018 ULTRASONOGRAPHY Vol.37 No.4

Contrast-enhanced ultrasound (CEUS) is widely used to evaluate tumor microcirculation, whichis useful in the differential diagnosis between benignity and malignancy. In the last 10 years, theapplicability of CEUS to thyroid nodules has greatly improved due to technological refinementsand the development of second-generation contrast agents. In this review, we summarize theapplications of CEUS for thyroid nodules, focusing on the imaging findings of malignant andbenign nodules in the existing literature and the use of those findings to predict malignancies,with an additional brief description of the utilization of CEUS for other thyroid-related diseases.

A Data Fusion Method for Small Sample Model Testing and Finite Element Simulation: Taking π-Shaped Beam Column Nodes as an Example

Ding Wei,Jia Suizi 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.4

The analysis and research of composite structure specimens depend on test methods. However, due to the high cost, complex test conditions, time-consuming, and other problems, it is diffi cult to carry out a large number of tests. A large amount of data is often required for parametric analysis and structural optimization of composite structure specimens. Therefore, to solve the problem of insuffi cient data samples in the analysis and research of specimens. In this paper, a fi nite element model updating method based on Bayesian theory and a Gaussian process data fusion method is proposed, that is, the amount of data is expanded by the proposed model updating method, and then the experimental and numerical simulation data are fused based on the Gaussian process data fusion method. Finally, the eff ectiveness of the proposed model updating method and data fusion method is verifi ed by a numerical example of π type beam-column joints. The results show that the method has high generalization ability and prediction accuracy in the case of small samples through the fusion of numerical simulation and experimental data.

A New Modulation to Eliminate the Impact of Overlap Time for Three-Phase Current Source Converters

Ding Hao,Guo Xiaoqiang,He Meiling,Shi Changli,Jia Dongqiang,Chen Chao,Guerrero Josep M. 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.5

Three-phase current source converter tends to be attractive in future industrial applications. In order to ensure the continuous current for the dc-link inductor of the current source converter (CSC), an overlap time is mandatory for each switch, so as to avoid the over-voltage spike caused by the dc-link inductor current interruption. However, the overlap time results in the undesirable harmonics and current distortion, which fails to comply with the relevant IEEE Standard in terms of power quality. Especially, the negative infl uence caused by overlap time eff ect is much more serious with the increasing of the switching frequency applied to CSC. In order to solve the problem, the impact of the overlap time on the CSC is investigated, and the error resulted from the overlap time is clearly demonstrated. Based on the pulse equivalent principle and the Fourier analysis, the quantitative relationship between the current harmonic and the overlap time is obtained. And then, a new approach to eliminate the impact of overlap time on the CSC is proposed. Finally, the simulation and experimental results are carried out to verify the eff ectiveness of the proposed solution.

An On-line Adaptive Glucose Feeding System Incorporating Patterns Recognition for Glucose Concentration Control in Glutamate Fermentations

Jian Ding,Luqiang Jia,Enock Mpofu,Minjie Gao,Xidong Ren 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.6

In glutamate fermentation, intermittent feeding is the most widely used glucose feed strategy. This feeding strategy causes severe fluctuations of glucose concentration and osmotic pressure in fermentation broth, which deteriorates the viability of the cell and reduces glutamate production in turn. In order to maintain glucose concentration at stable and constant levels, an on-line prediction and feedback control system based an empiric mass balance model was developed. However, the control system did not work properly and sometimes glucose concentration could even decline to 0 level (glucose exhaustion), as the model parameter varies in different runs. As a result, a novel model-based adaptive feedback control system incoporating with an artificial neural network (ANN) based pattern reconition unit for on-line diagnosizing the fault of glucose exhaustion was proposed and applied for glutamate fermentation. This adaptive control system could accurately detect glucose exhaustion when it occurs, and then immediately updates the control parameter based on some pre-defined rule. With the proposed control system, glucose was automatically fed, and its concentration could be maintained at desired levels constantly. As a result, glutamate concentration was 17 ~ 30% higher than that of the traditional fermentations using the intermittent glucose feed strategy.