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Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation
Kim, Jeongeun,Ahn, Huijeong,Han, Byung-Cheol,Shin, Hyunjung,Kim, Jin-Chul,Jung, Eui-Man,Kim, Juyeol,Yang, Heejung,Lee, Jeonghyun,Kang, Seung Goo,Lee, Seung-Ho,Lee, Geun-Shik Elsevier 2019 Phytomedicine Vol.63 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Obovatol, a biphenolic chemical originating from <I>Magnolia obovata</I>, has been utilized as a traditional medicine for the treatment of inflammatory diseases. Inflammasome induces maturation of inflammatory cytokines in response to intracellular danger signals, and its dysregulation induces inflammatory diseases.</P> <P><B>Purpose</B></P> <P>The effect of obovatol on inflammasome activation has not been reported, although its anti-inflammatory properties have been studied.</P> <P><B>Study design/methods</B></P> <P>Obovatol was treated to macrophages with inflammasome triggers, and secretions of interleukin (IL)-1β, IL-18, and caspase-1 were measured as readouts of inflammasome activation. In addition, Asc pyroptosome formation, caspase-1 activity, and mitochondrial reactive oxygen species (ROS) production were analyzed in mechanical studies. Anti-inflammasome properties of obovatol were confirmed in an animal model.</P> <P><B>Results</B></P> <P>Obovatol inhibited NLRP3, AIM2, and non-canonical inflammasomes through inhibition of Asc pyroptosome formation and mitochondrial ROS generation. In addition, obovatol disrupted the priming step of inflammasome activation and inhibited transcription of inflammatory cytokines. In mice, obovatol attenuated serum IL-1β elevation in response to monosodium urate crystals.</P> <P><B>Conclusion</B></P> <P>Obovatol is suggested as an inhibitor of NLRP3, AIM2, and non-canonical inflammasomes.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Design Integrated Parametric Modeling Methodology for Han-ok
Kim, Jeonghyun,Jeon, Bong Hee Architectural Institute of Japan 2012 JOURNAL OF ASIAN ARCHITECTURE AND BUILDING ENGINEE Vol.11 No.2
<P> Han-ok, the traditional Korean house, has the timber frame structure which is common in East Asia. Because the timber frame structure requires a vast amount of hand-cutting woodwork, prefabrication based on computer aided manufacturing (CAM) should be applied to reduce the construction cost of Han-ok. In order to implement them successfully, it is necessary to manage the building information in an organized system based on data handling technology, such as building information modeling (BIM) and parametric modeling. Three-dimensional, object-based parametric modeling technology not only enhances the construction process but also associates well with design study, especially when applying it to Han-ok. By applying the principle of Kan, the Korean traditional concept of a bay, this paper suggests a parametric modeling methodology that reduces modeling tasks and increases the efficiency of design study. </P>
Seasonal Variations of the Zodiacal Light toward the Ecliptic Poles at the Infrared Wavelengths
Jeonghyun Pyo,Il-Joong Kim,Woong-Seob Jeong,Dae-Hee Lee,Bongkon Moon,Youngsik Park,Sung-Joon Park,Won-Kee Park,Duk-Hang Lee,Uk-Won Nam,Wonyong Han,Kwang-Il Seon,Toshio Matsumoto,Min Gyu Kim,Hyung Mok 한국천문학회 2016 天文學會報 Vol.41 No.1
Wet Area and Puddle Detection for Advanced Driver Assistance Systems (ADAS) Using a Stereo Camera
Kim, Jisu,Baek, Jeonghyun,Choi, Hyukdoo,Kim, Euntai Institute of Control, Robotics and Systems 2016 International Journal of Control, Automation, and Vol.14 No.1
Wet area or puddle detection is one of the key issues for safe driving and future Advanced Driver Assistance Systems (ADAS). A new methodology for the detection of wet areas and puddles using a stereo camera is presented in this paper. Because wet areas and puddles have different characteristics, the two areas are separately treated and different detection algorithms are proposed. For the detection of wet areas, color information is used for hypothesis generation (HG) and a support vector machine (SVM) is employed for hypothesis verification (HV). In HV, three features are proposed for classification; these are the polarization difference, graininess and gradient magnitude. For the detection of puddles, the depth map obtained by a stereo camera is used to exploit the fact that abrupt depth changes are detected around the puddles. In the experiment, it is shown that the proposed methods have a robust performance for the detection of wet areas or puddles.
Kim, Hwajin,Kang, Heeyoung,Heo, Rok Won,Jeon, Byeong Tak,Yi, Chin-ok,Shin, Hyun Joo,Kim, Jeonghyun,Jeong, Seon-Yong,Kwak, Woori,Kim, Won-Ho,Kang, Sang Soo,Roh, Gu Seob SAGE Publications 2016 Journal of cerebral blood flow and metabolism Vol.36 No.6
<P> Diabetes-induced cognitive decline has been recognized in human patients of type 2 diabetes mellitus and mouse model of obesity, but the underlying mechanisms or therapeutic targets are not clearly identified. We investigated the effect of caloric restriction on diabetes-induced memory deficits and searched a molecular mechanism of caloric restriction-mediated neuroprotection. C57BL/6 mice were fed a high-fat diet for 40 weeks and RNA-seq analysis was performed in the hippocampus of high-fat diet-fed mice. To investigate caloric restriction effect on differential expression of genes, mice were fed high-fat diet for 20 weeks and continued on high-fat diet or subjected to caloric restriction (2 g/day) for 12 weeks. High-fat diet-fed mice exhibited insulin resistance, glial activation, blood-brain barrier leakage, and memory deficits, in that we identified neurogranin, a down-regulated gene in high-fat diet-fed mice using RNA-seq analysis; neurogranin regulates Ca<SUP>2+</SUP>/calmodulin-dependent synaptic function. Caloric restriction increased insulin sensitivity, reduced high-fat diet-induced blood-brain barrier leakage and glial activation, and improved memory deficit. Furthermore, caloric restriction reversed high-fat diet-induced expression of neurogranin and the activation of Ca<SUP>2+</SUP>/calmodulin-dependent protein kinase II and calpain as well as the downstream effectors. Our results suggest that neurogranin is an important factor of high-fat diet-induced memory deficits on which caloric restriction has a therapeutic effect by regulating neurogranin-associated calcium signaling. </P>
( Jeonghyun Kim ),( Soo-jin Park ),( Seok Kim ) 한국공업화학회 2019 공업화학 Vol.30 No.3
Petal-like nickel cobaltite (NiCo<sub>2</sub>O<sub>4</sub>)/reduced graphene oxide (rGO) composites with different rGO-to-NiCo<sub>2</sub>O<sub>4</sub> weight ratios were synthesized using a simple hydrothermal method and subsequent thermal treatment. In the NiCo<sub>2</sub>O<sub>4</sub>/rGO composite, the NiCo<sub>2</sub>O<sub>4</sub> 3-dimensional nanomaterials contributed to the improvement of electrochemical properties of the final composite material by preventing the restacking of the rGO sheet and securing ion movement passages. The composite structure was examined by field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and Fourier-transform infrared (FT-IR) spectroscopy. The FE-SEM and TEM images showed that petal-like NiCo<sub>2</sub>O<sub>4</sub> was supported on the rGO surface. Cyclic voltammetry (CV), galvanostatic charge-discharge (GCD), and electrochemical impedance spectroscopy (EIS) were used for the electrochemical analysis of composites. Among the prepared composites, 0.075 g rGO/NiCo<sub>2</sub>O<sub>4</sub> composite showed the highest specific capacitance of 1,755 Fg<sup>-1</sup> at a current density of 2 Ag<sup>-1</sup>. The cycle performance and rate capability of the composite material were higher than those of using the single NiCo<sub>2</sub>O<sub>4</sub> material. These nano-structured composites could be regarded as valuable electrode materials for supercapacitors that require superior performance.
An Assessment Protocol on Accessibility of Smart-Home Environment for People with Disability
( Jeonghyun Kim ),( Jongbae Kim ),( Myoungjun Lim ),( Hyosoon Kwon ),( Heesuk Lee ),( Kyungsun Pyo ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
A Quality of Life Technology (QoLT) research team at NRRI design and build a QoLT testbed for assessing QoLT products, i.e., highly advanced assistive devices, and prescribing appropriate living environment for the individuals with disability. The QoLT testbed is possible by Focus Group`s participation in user needs analysis, design, and building of the testbed. To design effective and efficient method of prescription and delivery of appropriate independent living environment for the individuals with disability, the QoLT team at NRRI designs a tentative assessment protocol focused on performance and satisfaction, parts of accessibility and usability, and evaluate the tentative protocol for seven months. The tentative assessment protocol for accessibility and usability of assistive devices in testbed environment for independent living of individuals with disability including Spinal Cord Injury (SCI) is designed and verified with outcomes of 15 cases. The tentative assessment protocol is designed by referring Canadian Occupational Performance Measurement (COPM) with ten scale-based scoring and performed by an Occupational Therapist. The 15 subjects are 10 individuals with SCI - seven cervical spinal cord injury, two thoracic spinal cord injury, one lumbar spinal cord injury - and five individuals with stroke - three individuals with left hemiplegia and two individuals with right hemiplegia. 15 subjects are taken surveys before and after living in the testbed from one week up to four weeks, which is a part of the tentative assessment protocol.