상악동에 발생한 동석의 증례보고

고지영,김선용,조정신,박창서,신인숙,이장렬,김기덕 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

The antrolith is a rare disease in the maxillary sinus. We experienced a 67-year-old female whose chief complaint was intermittent dull pain of clinical, radiological and histological findings, we diagnosed it as antrolith in the left maxillary sinus and obtained results as follows : 1. Three radiopaque substances in the left maxillary sinus was revealed as "Antroliths" 2. These antroliths were movable in the left maxillary antrum and combined with maxillary sinusitis. 3. We supposed it internal origin of nidus in this case.

두부에 발생한 신경섬유종증의 증례보고

고지영,김선용,신인숙,박창서,조정신,이장렬,김기덕 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

Neurofibromatosis, or Von Recklinghausen's disease is inhereted as an autosomal dominent neurocutaneous systemic disease. It is characterized by multiple Cafe-au-lait spots, generlaized cutaneous neurofibromas. It affects one in 3000 births. We observed the clinical, radiologic and histopathologic findings of 3 cases of neurofibromatosis and obtained following results. 1. All patients had multiple Cafe-au-lait spots and neufibromas. 2. Two patients had radiographic changes of pressive erosion and mesodermal dysplasia. 3. Two patients had plexiform neurofibromas and 1 patient had diffuse neurofibromas. Conclusively, we classified these 3 cases as NF-Ⅰ.

모바일 무선인터넷 서비스의 문제점과 개선방안 - 대학생소비자를 대상으로

이희숙(Hee Sook Lee),안정은(Jeong Eun An),윤정아(Jeong Ah Yun),최고은(Go Eun Choi) 충북대학교 생활과학연구소 2007 생활과학연구논총 Vol.11 No.1

  The purpose of this study was to find the problems and problem solving strategies in mobile internet services among college students. The questionnaire survey method was utilized to collect data during May 2006, and 315 Chungbuk National University students were selected as a sample.<BR>  The major findings as follows;<BR>First, 58.1% of respondents said that they had experiences of using mobile internet. However, they seldom used mobile internet and had a little using time, and therefore spent a little money on mobile internet service. Further, they were using mostly music, bell sound, collaring services out of variety of mobile internet services. Second, university students had experiences of financial damages resulting from lack of knowledges and no interest in how the mobile internet bill has been charged. Third, the respondents were aware that the service charge of mobile internet services were too expensive.

High MET gene copy number leads to shorter survival in patients with non-small cell lung cancer.

Go, Heounjeong,Jeon, Yoon Kyung,Park, Hyo Jin,Sung, Sook-Whan,Seo, Jeong-Wook,Chung, Doo Hyun Lippincott Williams Wilkins 2010 JOURNAL OF THORACIC ONCOLOGY Vol.5 No.3

<P>Activation of MET, either by increased gene copy number (GCN) or mutation, has been detected in various cancers. We investigate the clinicopathologic features of MET gene copy in nonsmall cell lung cancer (NSCLC).</P>

Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model

Kim, Sook-Jin,Choi, Eun-Jeong,Choi, Go-Wun,Lee, Yong-Bok,Cho, Hea-Young Springer-Verlag 2019 Archives of toxicology Vol.93 No.2

Synthesis of Selective Butyrylcholinesterase Inhibitors Coupled between α-Lipoic Acid and Polyphenols by Using 2-(Piperazin-1-yl)ethanol Linker

Yeun, Go Heum,Lee, Seung Hwan,Lim, Yong Bae,Lee, Hye Sook,Won, Moo-Ho,Lee, Bong Ho,Park, Jeong Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.4

In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between ${\alpha}$-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2-aminoethoxy)ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy)ethanol (linker 1) was switched to the cationic 2-(piperazin-1-yl)ethanol linker (linker 2). The $IC_{50}$ values of the linker-2 hybrid molecules for BuChE inhibition were lower than those of linker-1 hybrid molecules (except 9-2) and they also had the same great selectivity for BuChE over AChE (> 800 fold) as linker-1 hybrid molecules. ALA-acetyl caffeic acid (10-2, ALA-AcCA) was shown as an effective inhibitor of BuChE ($IC_{50}=0.44{\pm}0.24{\mu}M$). A kinetic study using 7-2 showed that it is the same mixed type inhibition as 7-1. Its inhibition constant (Ki) to BuChE is $4.3{\pm}0.09{\mu}M$.

유아의 기질이 또래유능성에 미치는 영향 : 정서지능의 매개효과

고정완(Go Jeong Wan),류혜숙(Ryu Hye sook) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.24

본 연구의 목적은 유아의 기질 및 또래유능성과 정서지능의 상관관계를 분석하고 기질이 또래유능성에 미치는 영향에 있어 정서지능이 가지는 매개효과를 분석하고자 하였다. 연구대상으로 G지역 만 5세 유아 208명을 선정하였고, 유아의 기질, 또래유능성, 그리고 정서지능에 관한 조사를 실시하였다. 조사한 자료들은 SPSS 22.0프로그램을 사용하였으며, Pearson 상관관계분석과 다중회귀분석, 그리고 매개효과를 검증하기 위해 Sobel test를 실시하였다. 자료를 분석한 결과는 다음과 같다. 첫째, 유아의 적응성 기질 및 또래유능성과 정서지능은 전체적으로 유의미한 정적 상관관계가 나타났다. 둘째, 유아의 적응성 기질 중 적응성은 또래유능성을 의미 있게 예측하는 변인으로 나타났다. 이 과정에서 정서지능이 매개효과를 갖는 것으로 나타났다. 본 연구는 유아의 또래유능성 발달을 위한 기초 자료로 활용될 수 있을 것이라 사료된다. As young children sociality is emphasized, interest in peer competence is increasing. The study suggested the correlation of temperament, peer competence and emotional intelligence in young children and the mediation effect of emotional intelligence on the relationship between temperament and peer competence. The subjects of this study were 208 5 - year - old infants in the G region, and their young children temperament, peer competence, and emotional intelligence were investigated. Pearson correlation analysis, multiple regression analysis and Sobel test were performed using the SPSS 22.0 program. The results were as follows: First, the temperament and the peer competence and the emotional intelligence of the young children showed a statistically significant positive correlation. Second, temperament was an important factor in predicting peer competence of young children, and emotional intelligence had a mediating effect on the relationship between temperament and peer competence. These results suggest that young children’s temperament and emotion intelligence in relation to their peer competence should be addressed in childhood education classrooms.

소아 측두엽 간질의 임상 양상

정고운(Go Un Jeong),조안나(An Na Cho),이진숙(Jin Sook Lee),박지윤(Jee Yoon Park),문진화(Jin Hwa Moon),황희(Hee Hwang),황용승(Yong Seung Hwang),김기중(Ki Joong Kim),채종희(Jong Hee Chae) 대한소아신경학회 2006 대한소아신경학회지 Vol.14 No.2

목 적 : 비교적 전형적인 임상양상을 보이는 성인의 측두엽과는 달리 소아의 측두엽 간질은 정보가 부족하다. 소아의 측두엽 간질의 정의가 내려져 있지 않고 전기생리현상과 임상양상, 병리 소견과의 상관관계도 명확하지 않다. 난치성 측두엽 간질로 수술을 받은 소아 환자를 대상으로 임상 양상, 뇌신경영상, 뇌파 및 수술 소견 등을 기술하였고 소아 측두엽 간질의 특징을 정의하고 뇌파와 병리 소견 사이의 관계를 비교해보고자 하였다. 방 법 : 1995년 1월부터 2005년 12월까지 서울대학교 병원에서 난치성 간질로 수술을 받았던 17세 이하의 측두엽 간질환자 중에서 Engel class II 이상이었던 18명을 대상으로 하여 이들의 연령 및 성별 분포, 경련 발작의 임상적 특징, 원인 질환, 수술 치료 및 경과 등에 대해 조사하였다. 모든 환아에서 MRI, SPECT, PET 검사 소견과 뇌파, 병리 소견을 비교하였다. 결 과: 소아의 난치성 측두엽 간질의 수술 요법은 성적이 우수하였다. 소아의 측두엽 간질은 성인과 달리 외측두엽 간질이 대부분(61.1%)이었고 원인 질환이 두 가지 이상인 경우(44.4%)가 흔하였다. MRI는 병리 소견을 예측할 수 있는 지표가 되지 못하였다. 발작 양상은 전형적인 측두엽 간질보다 복잡하였고 손의 이긴장증이나 강직, 고개 돌리기는 편측화에 도움이 되었다. 뇌파 소견과 병변이 항상 일치하는 것은 아니었고 이는 외측두엽 간질에서 보다 뚜렷하였다. 발작파가 델타파로 시작하는 경우 외측두엽 간질을 의심할 수 있었고 측두엽의 앞쪽에서 시작하는 경우에는 내측두엽 간질을 시사하였다. 신경절교종은 규칙적인 베타파로 시작하는 경향이 있었다. 결 론: 소아의 측두엽 간질은 성인보다 복잡한 임상 양상을 보이며 원인 질환이 다양하여 쉽게 편측화, 국소화할 수 없다. 따라서 정밀한 국소화를 통해 절제 부위를 정하기 위해서는 임상 양상, 신경방사선학적 소견, 뇌파 소견 등을 종합적으로 평가해야 할 것이다. Purpose : Temporal lobe epilepsy(TLE) is now recognized as a distinct syndrome in adults. The seizure evolution in adult patients is well characterized, manifesting initially with an aura, behavioral arrest, automatism, and secondary generalized tonic-clonic seizures. In contrast, relatively few studies are available for the pediatric age group. In the present study, we investigated children undergoing temporal lobectomy for refractory seizures and correlated the pathologic findings with clinical presentations. Methods : The records of the pediatric patients admitted at the Seoul National Children's Hospital for epilepsy surgery between January 1995 and December 2005 were reviewed. Then, eighteen patients were included in this study. The clinical records were reviewed in terms of the patient profiles imaging findings, surgical techniques, and pathologic findings. The seizure outcomes were described according to the Engel's classification. Results : The postsurgical outcomes were favorable. Lateral temporal epilepsy was more common in childhood than in adulthood. Dual pathology was commonly found. Arm dystonia or tonic arm elevation have a lateralizing value. Head turning may have a lateralizing value based upon a time sequence. The brain MRI was less predictable for pathologic findings. The ictal EEG cannot always have a localizing value. Delta beginning in the ictal rhythm may suggest lateral lobe epilepsy. Anterior temporal beginning of the ictal location may suggest mesial temporal lobe epilepsy. Ganglioglioma tends to cause rhythmic beta activities at the beginning of the ictal event. Conclusion : TLE in childhood shows more complex and atypical clinical manifestations and have more variable etiologies. No single presurgical investigation can be a good predictable value to localization or lateralization.

상황역할극 중심의 안전교육이 유아의 안전문제해결사고와 자기조절력에 미치는 영향

고정완 ( Go Jeong Wan ),최미숙 ( Choi Mi Sook ) 한국아동교육학회 2016 아동교육 Vol.25 No.3

본 연구의 목적은 상황역할극 중심의 안전교육이 유아의 안전문제해결사고와 자기조절력에 미치는 영향을 알아보는데 있다. 연구 대상은 G시에 위치한 사립유치원 만 5세 유아 46명으로 실험집단과 비교집단을 각각 23명씩 선정하였다. 실험집단은 상황역할극 중심의 안전교육을 실시하였고, 비교집단은 이야기나누기를 활용한 안전교육을 실시하였다. 실험의 효과를 검증하기 위해 Scott(1992)의 Preventing Injury; A Safety Curriculum 내용을 중심으로 곽은복(2000)이 수정·보완한 것을 본 연구자가 연구목적에 맞게 수정·보완한 안전문제해결사고검사와 Kendall과 Wilcox(1979)가 개발한 SCRS를 유혜정(1998)이 번안하고, 이지현(2001)이 수정한 자기조절력 검사를 실시하였다. 자료 분석은 SPSS WIN 21.0 프로그램을 사용하여 ANCOVA를 실시하였다. 연구결과, 상황역할극 중심의 안전교육은 유아의 안전문제해결사고 총점과 하위 영역인 안전하게 놀이하기, 교통안전 규칙 지키기, 비상시 적절히 대처하기를 향상시켰으며, 유아의 자기조절력 총점과 하위영역인 자기통제력, 충동성 감소에 긍정적인 영향을 미치는 것으로 나타났다. 이러한 연구 결과는 상황역할극 중심의 안전교육이 유아의 안전문제해결사고 및 자기조절력을 향상시키는데 효과적임을 시사한다. The purpose of this study was to examine the influence of situational role play oriented safety education on safety problem solving ability and self-regulation of young children. The subjects were 46 five-year-olds, at S kindergarten in G city. 23 children in one class became experimental group and 23 children in the other class became comparative group. Situational role play oriented safety education was applied to children in the experimental group, whereas a class involving safety discussion was applied to the children in the comparative group. As a test instrument, Scott’s (1992) Preventing Injury; A Safety Curriculum scale supplemented y Kwak Eun Bok was used. Also, in order to assess the self-regulation of the children, SCRS (Self-Control Rating Scale) developed by Kendall and Wilcox(1979) and revised by Lee (2001) was used. The data were analyzed through a covariate analysis (ANCOVA) using SPSS 21.0 statistics program. The results suggested that situational role play oriented safety education has positive influence on increasing both safety problem solving ability and self-regulation of young children. Therefore, the study indicates that the situational role play oriented safety education provides positive effects for the improvement of safety problem solving ability and self-regulation.

Layered Double Hydroxide and Polypeptide Thermogel Nanocomposite System for Chondrogenic Differentiation of Stem Cells

Lee, Seon Sook,Choi, Go Eun,Lee, Hyun Jung,Kim, Yelin,Choy, Jin-Ho,Jeong, Byeongmoon American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.49

<P>Stem cell therapy for damaged cartilage suffers from low rates of retention, survival, and differentiation into chondrocytes at the target site. To solve these problems, here we propose a two-dimensional/three-dimensional (2D/3D) nanocomposite system. As a new two-dimensional (2D) material, hexagonal layered double hydroxides (LDHs) with a uniform lateral length of 23 pcm were prepared by a hydrothermal process. Then, tonsil-derived mesenchymal stem cells (TMSCs), arginylglycylaspartic acid-coated LDHs, and kartogenin (KGN) were incorporated into the gel through the thermal-energy driven gelation of the system. The cells exhibited a tendency to aggregate in the nanocomposite system. In particular, chondrogenic biomarkers of type II collagen and transcription factor SOX 9 significantly increased at both the mRNA and protein levels in the nanocomposite system, compared to the pure thermogel systems. The inorganic 2D materials increased the rigidity of the matrix, slowed down the release of a soluble factor (KGN), and improved cell material interactions in the gel. The current 2D/3D nanocomposite system of bioactive LDH/thermogel can be a new platform material overcoming drawbacks of hydrogel-based 3D cell culture systems and is eventually expected to be applied as an injectable stem cell therapy.</P>