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Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
P090 : Assessment of characteristics of itch in patients with hand eczema
( Won Jeong Kim ),( Hyun Ju Jin ),( Hyun Ho Jo ),( Je Ho Mun ),( Mar Garet Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Hand eczema is a common inflammatory dermatosis which influences the quality of life especially when it comes to accompanying itching. However, there is no research regarding the characteristics of itch and neurologic association in hand eczema so far. Objectives: To objectify the influence on quality of life in patients with hand eczema and to investigate the association with cutaneous nerve, Methods: we conduct a hand eczema severity scoring using HECSI score, a questionnaire contains Leuvin itch scale and dermatology life quality index(DLQI), and a neurologic exam using von-Frey filament and neurometer. Results: Forty-four patients were enrolled the study and 36 patients were also done neurologic examination. Itch occurred at least once daily in all study patients, and finger and palm were the most commonly affected itch areas (25.0%). The Leuvin itch scale was directly proportional to HECSI score (p=0.272), and DLQI was inversely proportional to it (p=0.019). The sensory threshold force measured by von-Frey filament was significantly higher in lesion than normal skin (p<0.05) and the pain threshold using neurometer was also significantly decreased in lesion (p<0.05). Conclusion: This study is a unique trial which describes the characteristics of itch experienced in hand eczema and investigates the relationship between hand eczema and cutaneous nerve. We thought it could be a good basis in development of future therapeutic modalities such as neurotransmitters in hand eczema.
P253 : A clinical study of atopic eruption of pregnancy
( Won Ku Lee ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: There is limited literature on clinical characteristics of specific dermatoses of pregnancy and their terminology has been confusing and misleading. Simplified classification is proposed with new terminology of atopic eruption of pregnancy (AEP). Objectives: To analyze and quantify the frequency and clinical characteristics of AEP. Methods: We retrospectively reviewed medical records of 46 patients who were diagnosed with AEP during recent 10 years. Results: The mean age of patients was 31.3 and the mean gestational age 19.3 weeks. In 93% of cases, AEP started before the third trimester of pregnancy. The most affected site was flexural surfaces of extremities, followed by neck and trunk. Twenty percentages of patients had a personal and/or family history of atopic eczema and/or elevated total IgE levels. The prognosis of patients with AEP was good as 83 % of patients were improved after delivery. Major fetal problems were not seen. Conclusion: AEP represents a new concept comprising several disease entities such as prurigo of pregnancy and eczema in pregnancy. We reclassified the pregnant patients visiting our hospital and analyzed clinical characteristics of AEP.
P212 : The impact of Vitamin D seems to be overestimated in some dermatoses
( Won Jeong Kim ),( Min Young Park ),( Gun Wook Kim ),( Hyun Ho Jo ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Deficiency of vitamin D is reported as an important associated factor of various dermatoses such as atopic dermatitis, psoriasis, urticaria, and skin cancers in these days. However, the association between them is disputable and has not been clarified. Objectives: To evaluate the status of serum 25-hydroxyvitamin D in patients with psoriasis and chronic urticaria, and the relationship between vitamin D levels and disease activity compared with sex and age matched healthy control. Methods: A cross-sectional study of 34 patients with psoriasis, 73 patients with chronic idiopathic urticaria and sex and age matched healthy controls was conducted. An objective severity scoring of psoriasis (PASI) and urticaria (UAS) and a serum 25-hydroxyvitamin D level was measured for each subject. Results: Serum 25-hydroxyvitamin D levels in patients with psoriasis were not significantly lower than healthy control (P>0.05). The patients with chronic idiopathic urticaria also showed no significant differences compared with control subjects. Furthermore, no significant inverse correlation was found between disease severity and serum 25-hydroxyvitamin D level in both psoriasis and chronic idiopathic urticaria patients (P>0.05). Conclusion: Deficiency of vitamin D in patients with psoriasis and chronic idiopathic urticaria was not common than healthy control. The impact of vitamin D in these dermatoses seems to be overestimated and needs more study to prove its real association.
Genipin inhibits allergic responses in ovalbumin-induced asthmatic mice
Ko, Je-Won,Shin, Na-Rae,Park, Sung-Hyeuk,Cho, Young-Kwon,Kim, Jong-Choon,Seo, Chang-Seob,Shin, In-Sik ELSEVIER 2017 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.53 No.-
<P><B>Abstract</B></P> <P>Genipin is a natural compound isolated from the fruit of <I>Gardenia jasminoides</I> with various pharmacological effects. In this study, we investigated whether genipin effectively alleviates allergic responses in a murine model of ovalbumin (OVA)-induced asthma. The mice were administered an intraperitoneal injection of OVA on day 0 and 14 to boost the immune response; genipin was then administered from day 18 to 23 by oral gavage. On days 21 to 23, mice were OVA-challenged using am ultrasonic nebulizer, and airway hyperresponsiveness (AHR) was determined on day 24 by plethysmography. Genipin significantly reduced the inflammatory cell count in bronchoalveolar lavage fluids (BALF) and AHR, which were accompanied by lower interleukin-5 (IL-5), IL-13 and OVA-specific immunoglobulin (Ig) E levels in the BALF or serum from OVA-induced asthmatic mice. In histology, genipin significantly decreased airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice. Additionally, genipin inhibited OVA-induced increases in the expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins. Further, genipin reduced the activity and protein levels of matrix metalloproteinase-9 in lung tissue from OVA induced asthmatic mice. Overall, genipin effectively alleviated the asthmatic inflammatory response in an OVA-induced asthmatic model. Therefore, our results suggest that genipin has therapeutic potential for treating asthma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of genipin on ovalbumin (OVA)-induced asthmatic mice </LI> <LI> Genipin decreased airway hyperresponsiveness and eosinophilia in asthmatic mice </LI> <LI> Genipin reduced IL-5, IL-13 and OVA-specific IgE in asthmatic mice </LI> <LI> Genipin suppressed airway inflammation and mucus production in asthmatic mice </LI> <LI> Genipin inhibited iNOS, COX-2 and MMP-9 in lung tissue from asthmatic mice </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ko, Je-Won,Park, So-Won,Shin, Na-Rae,Kim, Woong-Il,Kim, Jong-Choon,Shin, In-Sik,Shin, Dong-Ho Korean Association for Laboratory Animal Science 2018 Laboratory Animal Research Vol.34 No.3
<P>Benign prostate hyperplasia (BPH) is a male reproductive disease that has gained increasing importance in recent years. The present study investigated whether Pycnogenol® (PYC), a standardized French maritime pine bark extract, could prevent BPH induced by testosterone propionate (TP) in rats. Male Sprague-Dawley rats were randomly divided into five groups of six rats. One group was used as a normal control rats and the other groups received subcutaneous injections of TP for 4 weeks to induce BPH. In the two treatment groups, PYC (20 or 40 mg/kg) was administered daily for 4 weeks by oral gavage concurrently with the induction of TP. All rats were sacrificed at the scheduled termination time, the prostates were weighed, and histopathologic examinations were conducted. Dihydrotestosterone (DHT) levels in serum and the prostate were measured, and the expression of proliferating cell nuclear antigen (PCNA) and Ki-67 proteins was investigated. BPH-treated animals showed increases in the relative weight of the prostate, higher concentrations of DHT in serum and the prostate, and higher expression of PCNA and Ki-67 in the prostate; in contrast, PYC-treated animals had significant reductions in these factors compared with the BPH animals. These findings indicated that PYC inhibited the development of BPH and that this was closely associated with a reduction in DHT concentration.</P>
Je-Won Ko,In-Chul Lee,Sung-Hyuk Park,Changjong Moon,Seong-Soo Kang,Sung-Ho Kim,Jong-Choon Kim 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.4
We investigated the protective effects of pine bark extract (pycnogenol<SUP>®</SUP>, PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1) vehicle control, (2) cisplatin (7.5 mg/kg), (3) cisplatin & PYC 10 (10 mg/kg/day), and (4) cisplatin & PYC 20 (20 mg/kg/day). A single intraperitoneal injection of cisplatin induced hepatotoxicity, as evidenced by an increase in serum aminotransferase and histopathological alterations, including degeneration/necrosis of hepatocytes, vacuolation, and sinusoidal dilation. In addition, an increase in the malondialdehyde (MDA) concentration and a decrease in the reduced glutathione (GSH) content and catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities were observed in the cisplatin-treated rat hepatic tissues. In contrast, PYC treatment effectively prevented cisplatin-induced hepatotoxicity, including the elevation of aminotransferase and histopathological lesions, in a dosedependent manner. Moreover, PYC treatment also induced antioxidant activity by decreasing MDA level and increasing GSH content and SOD and GST activities in liver tissues. These results indicate that PYC has a protective effect against acute hepatotoxicity induced by cisplatin in rats, and that the protective effects of PYC may be due to inhibiting lipid peroxidation and increasing antioxidant activity.