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장혜연,On-Yu Hong,Hyun Jo Youn,김민걸,Cheorl-Ho Kim,정성후,Jong-Suk Kim 생화학분자생물학회 2020 BMB Reports Vol.53 No.4
Activation of peroxisome proliferator-activated receptor (PPAR) serves as a key factor in the proliferation and invasion of breast cancer cells and is a potential therapeutic target for breast cancer. However, the mechanisms underlying this effect remain largely unknown. Heme oxygenase-1 (HO-1) is induced and overexpressed in various cancers and is associated with features of tumor aggressiveness. Recent studies have shown that HO-1 is a major downstream target of PPAR. In this study, we investigated the effects of induction of HO-1 by PPAR on TPAinduced MMP-9 expression and cell invasion using MCF-7 breast cancer cells. TPA treatment increased NF-B /AP-1 DNA binding as well as MMP-9 expression. These effects were significantly blocked by 15d-PGJ2, a natural PPAR ligand. 15d-PGJ2 induced HO-1 expression in a dose-dependent manner. Interestingly, HO-1 siRNA significantly attenuated the inhibition of TPA-induced MMP-9 protein expression and cell invasion by 15d-PGJ2. These results suggest that 15d-PGJ2 inhibits TPA-induced MMP- 9 expression and invasion of MCF-7 cells by means of a heme oxygenase-1-dependent mechanism. Therefore, PPAR/HO-1 signaling- pathway inhibition may be beneficial for prevention and treatment of breast cancer.
대학생의 여가 인식에 관한 연구 : 경주대학교 재학생을 대상으로 focused on KYONGJU University student
조현호,유영준 경주대학교 2000 論文集 Vol.13 No.-
Korean is exposed to a rapid growth in economy and considerable amount of time for leisure. There is no doubt that the leisure industry is playing a significant role in making our lives enjoyable and therefore leading a quality lift. In a range of research. it has been shown that the essence of leisure functions properly where the degree of leisure satisfaction is high. Thus, this study attempts to identify the cognition of leisure by undergraduate students in Kyongju University and to suggest alternative solutions for then. The research findings and their implications are summarized as follows. Firstly, a large percentage of the students take a serious view of work and leisure. Secondly, the satisfiers of own leisure activity are rather than dissatisfied students, because they regard their leisure activities as reasonableness and soundness. Lastly, students consider leisure as their mental state of comformt and pleasure. The results implies that systematic and in-depth education on the leisure and enrichment of leisure facilities are required in order to become higher students' satisfaction of own leisure activities.
조현숙,김세종,최승욱,백영호 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.2
The purpose of this study was to compare the obese and the normal weight girls in high school on the level of the recommended dietary allowances for the Koreans based on total energy intake, the ratio of 3nutrients intake, micro-nutrients intake, daily dietary intake and the ratio of 4nutrients intake by animality and vegetability. The results of this study are as follows:...............
한국인의 해외관광 행태에 관한 연구 : 1985~1994년 4대 일간지 기사를 대상으로
조현호 경주대학교 1996 論文集 Vol.8 No.-
Tourist have been, is now, and will be increasing all over the world. Therefore we need to tourist activities which are playing an most important role in modern society, in order to manage the activities reasonably. But the tourist behavior of Koreans visiting foreign countries is now in serous problems. The purpose of this study is to analyze this behavior by examining several news in the past 7 years. In result, it is revealed that bad behavior of Korean tourists in foreign countries includes excessive consumption, ignorance of public orders and other unhealthy activities. And short and long term steps are suggested here to eliminate such bad behavior. As for short term steps, we need to control tourist activities directly, to campaigndesirable tourism movement, and to provide information for tourists to choose reasonably. And as for long term and fundamental steps, we need to lead tourists to perform desirable tourist activities by teaching them the true meaning of tourism and the importance of community through lifetime education.
고대소설에 나타난 여가의 사회적 의미에 관한 연구(1) : 춘향전을 대상으로
조현호 경주대학교 1997 論文集 Vol.9 No.-
After analysis of Korean ancient novel CHUNHYANGIUN, it is revealed that 73 expressions are related to leisure. of these expressions, 41 expressions are related to religion and 24 expressions to mirth or pleasure in life. These two types of leisure comprise 89% of this novel. It means that Korean people in the past put stress on th pursuit of pleasure and religious life in the pross of laborious life. The novel has an attribute of leisure in its structure. Koreans in the past tried to be mirthful through leisure, but within the limits of regulations of their communities. In order to shed light on this spirit, we are supposed to make every effort to educate our ancestor's cultural life, especially leisure culture and resonable leisure behaviour.
고주파수 근사 이론을 이용한 결함으로부터의 초음파 산란장 해석
정현조,김진호 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.2
본 논문에서는 체적형 결함과 균열형 결함에 대한 초음파 산란 현상을 모델링하기 위한 두 가지 이론을 설명하였다. 동탄성 Kirchhoff 근사 (EKA)와 기하학적 회절이론 (GTD)이 각각 원주형 기공과 반무한 균열에 적용되었다. 이 두 이론은 고주파수 근사법으로 알려져 있다. 모델 결함들에 평면파가 입사하는 경우의 2차원 동탄성 산란 문제를 고려하였으며 산란장을 반사계수와 회절계수의 항으로 구하였다. 원거리에서 산란파의 변위에 대한 입사파 변위의 비를 관찰 방향의 함수로 구했으며 그 결과를 경계요소법과 비교하였다. This paper describes two different theories used to model the scattering of ultrasound by a volumetric flaw and a crack-like flaw. The elastodynamic Kirchhoff approximation (EKA) and the geometrical theory of diffraction(GTD) are applied respectively to a cylindrical cavity and a semi-infinite crack. These methods are known as high frequency approximations. The 2-D elastodynamic scattering problems of a plane wave incident on these model defects are considered and the scattered fields are expressed in terms of the reflection and diffraction coefficients. The ratio of the scattered far field amplitude to the incident wave amplitude is computed as a function of the angular location and compared with the boundary element solutions.
중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예
강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1
The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.